LeishMANIAdb
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Hypothetical_protein_conserved

Quick info Annotations Function or PPIs Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Hypothetical_protein_conserved
Gene product:
hypothetical protein, unknown function
Species:
Leishmania donovani
UniProt:
A0A3Q8IID2_LEIDO
TriTrypDb:
LdBPK_282900.1 * , LdCL_280034100 , LDHU3_28.3890
Length:
463

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Phosphorylation

Amastigote: 191, 241
Promastigote: 159, 195
Promastigote/Amastigote: 177, 189

Expansion

Sequence features

A0A3Q8IID2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IID2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 157 161 PF00656 0.653
CLV_C14_Caspase3-7 429 433 PF00656 0.662
CLV_NRD_NRD_1 144 146 PF00675 0.675
CLV_NRD_NRD_1 193 195 PF00675 0.720
CLV_NRD_NRD_1 262 264 PF00675 0.695
CLV_NRD_NRD_1 295 297 PF00675 0.695
CLV_NRD_NRD_1 336 338 PF00675 0.719
CLV_NRD_NRD_1 423 425 PF00675 0.653
CLV_NRD_NRD_1 459 461 PF00675 0.654
CLV_PCSK_KEX2_1 144 146 PF00082 0.675
CLV_PCSK_KEX2_1 192 194 PF00082 0.720
CLV_PCSK_KEX2_1 262 264 PF00082 0.695
CLV_PCSK_KEX2_1 336 338 PF00082 0.616
CLV_PCSK_KEX2_1 423 425 PF00082 0.653
CLV_PCSK_KEX2_1 459 461 PF00082 0.654
CLV_PCSK_PC7_1 455 461 PF00082 0.620
CLV_PCSK_SKI1_1 174 178 PF00082 0.674
DEG_APCC_DBOX_1 14 22 PF00400 0.599
DEG_APCC_DBOX_1 192 200 PF00400 0.718
DEG_APCC_DBOX_1 423 431 PF00400 0.681
DEG_SCF_FBW7_2 163 169 PF00400 0.678
DEG_SPOP_SBC_1 205 209 PF00917 0.672
DEG_SPOP_SBC_1 298 302 PF00917 0.667
DEG_SPOP_SBC_1 370 374 PF00917 0.717
DOC_ANK_TNKS_1 289 296 PF00023 0.713
DOC_CKS1_1 163 168 PF01111 0.679
DOC_CKS1_1 175 180 PF01111 0.572
DOC_CYCLIN_yCln2_LP_2 176 182 PF00134 0.577
DOC_PP2B_LxvP_1 176 179 PF13499 0.574
DOC_PP2B_LxvP_1 225 228 PF13499 0.756
DOC_PP2B_LxvP_1 402 405 PF13499 0.657
DOC_PP4_FxxP_1 380 383 PF00568 0.686
DOC_USP7_MATH_1 154 158 PF00917 0.773
DOC_USP7_MATH_1 205 209 PF00917 0.708
DOC_USP7_MATH_1 238 242 PF00917 0.650
DOC_USP7_MATH_1 258 262 PF00917 0.687
DOC_USP7_MATH_1 298 302 PF00917 0.757
DOC_USP7_MATH_1 304 308 PF00917 0.699
DOC_USP7_MATH_1 316 320 PF00917 0.627
DOC_USP7_MATH_1 370 374 PF00917 0.671
DOC_USP7_MATH_1 70 74 PF00917 0.626
DOC_USP7_UBL2_3 121 125 PF12436 0.660
DOC_WW_Pin1_4 114 119 PF00397 0.720
DOC_WW_Pin1_4 125 130 PF00397 0.627
DOC_WW_Pin1_4 162 167 PF00397 0.736
DOC_WW_Pin1_4 174 179 PF00397 0.573
DOC_WW_Pin1_4 274 279 PF00397 0.706
DOC_WW_Pin1_4 418 423 PF00397 0.687
LIG_14-3-3_CanoR_1 144 149 PF00244 0.659
LIG_14-3-3_CanoR_1 156 164 PF00244 0.588
LIG_14-3-3_CanoR_1 192 197 PF00244 0.730
LIG_14-3-3_CanoR_1 206 212 PF00244 0.591
LIG_14-3-3_CanoR_1 262 270 PF00244 0.685
LIG_14-3-3_CanoR_1 296 304 PF00244 0.664
LIG_14-3-3_CanoR_1 455 463 PF00244 0.642
LIG_14-3-3_CanoR_1 84 88 PF00244 0.582
LIG_BIR_II_1 1 5 PF00653 0.665
LIG_deltaCOP1_diTrp_1 413 416 PF00928 0.639
LIG_FHA_1 175 181 PF00498 0.604
LIG_FHA_1 275 281 PF00498 0.687
LIG_FHA_1 398 404 PF00498 0.613
LIG_FHA_1 98 104 PF00498 0.584
LIG_FHA_2 251 257 PF00498 0.727
LIG_GBD_Chelix_1 95 103 PF00786 0.555
LIG_LIR_Apic_2 378 383 PF02991 0.686
LIG_LIR_Gen_1 221 229 PF02991 0.667
LIG_LIR_Gen_1 241 249 PF02991 0.604
LIG_LIR_Nem_3 221 225 PF02991 0.680
LIG_LIR_Nem_3 241 246 PF02991 0.604
LIG_SH2_CRK 222 226 PF00017 0.613
LIG_SH2_NCK_1 243 247 PF00017 0.595
LIG_SH2_STAP1 222 226 PF00017 0.613
LIG_SH2_STAT3 439 442 PF00017 0.621
LIG_SH2_STAT5 164 167 PF00017 0.789
LIG_SH2_STAT5 439 442 PF00017 0.543
LIG_SH2_STAT5 50 53 PF00017 0.579
LIG_SH2_STAT5 55 58 PF00017 0.512
LIG_SH2_STAT5 78 81 PF00017 0.589
LIG_SH3_3 160 166 PF00018 0.795
LIG_SH3_3 172 178 PF00018 0.620
LIG_SH3_3 213 219 PF00018 0.722
LIG_SH3_3 380 386 PF00018 0.668
LIG_SH3_3 444 450 PF00018 0.629
LIG_SUMO_SIM_par_1 99 106 PF11976 0.571
LIG_TRAF2_1 11 14 PF00917 0.659
MOD_CDC14_SPxK_1 421 424 PF00782 0.647
MOD_CDK_SPK_2 162 167 PF00069 0.712
MOD_CDK_SPK_2 418 423 PF00069 0.660
MOD_CDK_SPxK_1 418 424 PF00069 0.659
MOD_CDK_SPxxK_3 114 121 PF00069 0.611
MOD_CK1_1 117 123 PF00069 0.616
MOD_CK1_1 195 201 PF00069 0.675
MOD_CK1_1 204 210 PF00069 0.695
MOD_CK1_1 261 267 PF00069 0.700
MOD_CK1_1 281 287 PF00069 0.658
MOD_CK1_1 299 305 PF00069 0.802
MOD_CK1_1 307 313 PF00069 0.645
MOD_CK1_1 326 332 PF00069 0.638
MOD_CK1_1 357 363 PF00069 0.780
MOD_CK1_1 369 375 PF00069 0.602
MOD_CK2_1 238 244 PF00069 0.614
MOD_CK2_1 250 256 PF00069 0.603
MOD_CK2_1 372 378 PF00069 0.678
MOD_CK2_1 443 449 PF00069 0.612
MOD_CK2_1 68 74 PF00069 0.626
MOD_CMANNOS 411 414 PF00535 0.677
MOD_Cter_Amidation 294 297 PF01082 0.692
MOD_DYRK1A_RPxSP_1 174 178 PF00069 0.650
MOD_GlcNHglycan 1 4 PF01048 0.660
MOD_GlcNHglycan 139 142 PF01048 0.648
MOD_GlcNHglycan 188 191 PF01048 0.733
MOD_GlcNHglycan 203 206 PF01048 0.587
MOD_GlcNHglycan 313 316 PF01048 0.729
MOD_GlcNHglycan 317 321 PF01048 0.684
MOD_GlcNHglycan 323 326 PF01048 0.623
MOD_GlcNHglycan 356 359 PF01048 0.704
MOD_GlcNHglycan 368 371 PF01048 0.593
MOD_GlcNHglycan 70 73 PF01048 0.640
MOD_GSK3_1 188 195 PF00069 0.718
MOD_GSK3_1 201 208 PF00069 0.684
MOD_GSK3_1 257 264 PF00069 0.737
MOD_GSK3_1 274 281 PF00069 0.642
MOD_GSK3_1 298 305 PF00069 0.723
MOD_GSK3_1 307 314 PF00069 0.589
MOD_GSK3_1 321 328 PF00069 0.691
MOD_GSK3_1 366 373 PF00069 0.702
MOD_GSK3_1 70 77 PF00069 0.611
MOD_GSK3_1 79 86 PF00069 0.535
MOD_N-GLC_1 326 331 PF02516 0.671
MOD_N-GLC_2 438 440 PF02516 0.528
MOD_NEK2_1 103 108 PF00069 0.589
MOD_NEK2_1 188 193 PF00069 0.677
MOD_NEK2_1 4 9 PF00069 0.629
MOD_NEK2_1 443 448 PF00069 0.542
MOD_NEK2_1 79 84 PF00069 0.640
MOD_NEK2_2 238 243 PF00069 0.599
MOD_NEK2_2 304 309 PF00069 0.661
MOD_NEK2_2 415 420 PF00069 0.551
MOD_PIKK_1 228 234 PF00454 0.778
MOD_PIKK_1 278 284 PF00454 0.828
MOD_PIKK_1 336 342 PF00454 0.707
MOD_PK_1 58 64 PF00069 0.623
MOD_PKA_1 144 150 PF00069 0.658
MOD_PKA_1 192 198 PF00069 0.674
MOD_PKA_1 262 268 PF00069 0.694
MOD_PKA_1 296 302 PF00069 0.693
MOD_PKA_1 336 342 PF00069 0.604
MOD_PKA_2 144 150 PF00069 0.658
MOD_PKA_2 155 161 PF00069 0.588
MOD_PKA_2 192 198 PF00069 0.722
MOD_PKA_2 205 211 PF00069 0.590
MOD_PKA_2 256 262 PF00069 0.680
MOD_PKA_2 336 342 PF00069 0.604
MOD_PKA_2 366 372 PF00069 0.696
MOD_PKA_2 454 460 PF00069 0.644
MOD_PKA_2 79 85 PF00069 0.571
MOD_PKB_1 255 263 PF00069 0.689
MOD_PKB_1 309 317 PF00069 0.729
MOD_Plk_1 103 109 PF00069 0.562
MOD_Plk_4 74 80 PF00069 0.600
MOD_Plk_4 97 103 PF00069 0.482
MOD_ProDKin_1 114 120 PF00069 0.717
MOD_ProDKin_1 125 131 PF00069 0.628
MOD_ProDKin_1 162 168 PF00069 0.733
MOD_ProDKin_1 174 180 PF00069 0.575
MOD_ProDKin_1 274 280 PF00069 0.706
MOD_ProDKin_1 418 424 PF00069 0.687
TRG_ENDOCYTIC_2 222 225 PF00928 0.614
TRG_ENDOCYTIC_2 243 246 PF00928 0.727
TRG_ER_diArg_1 144 146 PF00400 0.714
TRG_ER_diArg_1 15 18 PF00400 0.652
TRG_ER_diArg_1 192 194 PF00400 0.674
TRG_ER_diArg_1 308 311 PF00400 0.766
TRG_ER_diArg_1 422 424 PF00400 0.628

Homologs

Protein Taxonomy Sequence identity Coverage
A4HGX3 Leishmania braziliensis 59% 93%
A4I403 Leishmania infantum 100% 100%
E9B093 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
Q4Q7Z2 Leishmania major 92% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS