Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IIC9_LEIDO

TriTrypDb:

LdBPK_342830.1 , LdCL_340036400 , LDHU3_34.4840

Length:

628

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IIC9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IIC9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	109	113	PF00656	0.609
CLV_C14_Caspase3-7	387	391	PF00656	0.605
CLV_C14_Caspase3-7	47	51	PF00656	0.549
CLV_C14_Caspase3-7	569	573	PF00656	0.625
CLV_C14_Caspase3-7	595	599	PF00656	0.583
CLV_C14_Caspase3-7	610	614	PF00656	0.628
CLV_NRD_NRD_1	167	169	PF00675	0.509
CLV_NRD_NRD_1	215	217	PF00675	0.667
CLV_NRD_NRD_1	248	250	PF00675	0.692
CLV_NRD_NRD_1	486	488	PF00675	0.725
CLV_NRD_NRD_1	54	56	PF00675	0.471
CLV_NRD_NRD_1	618	620	PF00675	0.680
CLV_PCSK_KEX2_1	167	169	PF00082	0.509
CLV_PCSK_KEX2_1	192	194	PF00082	0.688
CLV_PCSK_KEX2_1	215	217	PF00082	0.574
CLV_PCSK_KEX2_1	54	56	PF00082	0.620
CLV_PCSK_KEX2_1	618	620	PF00082	0.680
CLV_PCSK_PC1ET2_1	192	194	PF00082	0.689
CLV_PCSK_SKI1_1	619	623	PF00082	0.701
DEG_APCC_DBOX_1	38	46	PF00400	0.495
DEG_APCC_DBOX_1	583	591	PF00400	0.549
DEG_APCC_DBOX_1	617	625	PF00400	0.640
DEG_Nend_UBRbox_1	1	4	PF02207	0.729
DEG_SCF_FBW7_1	290	295	PF00400	0.808
DEG_SCF_FBW7_1	335	341	PF00400	0.764
DEG_SPOP_SBC_1	418	422	PF00917	0.735
DEG_SPOP_SBC_1	477	481	PF00917	0.581
DOC_CKS1_1	13	18	PF01111	0.703
DOC_CKS1_1	335	340	PF01111	0.755
DOC_CYCLIN_yCln2_LP_2	519	525	PF00134	0.693
DOC_MAPK_gen_1	127	136	PF00069	0.440
DOC_MAPK_gen_1	33	42	PF00069	0.609
DOC_MAPK_gen_1	618	626	PF00069	0.678
DOC_MAPK_MEF2A_6	33	42	PF00069	0.574
DOC_MAPK_MEF2A_6	618	626	PF00069	0.678
DOC_PP2B_LxvP_1	155	158	PF13499	0.619
DOC_PP2B_LxvP_1	354	357	PF13499	0.676
DOC_PP2B_LxvP_1	513	516	PF13499	0.738
DOC_PP2B_LxvP_1	585	588	PF13499	0.630
DOC_PP4_FxxP_1	253	256	PF00568	0.720
DOC_USP7_MATH_1	106	110	PF00917	0.555
DOC_USP7_MATH_1	125	129	PF00917	0.255
DOC_USP7_MATH_1	16	20	PF00917	0.657
DOC_USP7_MATH_1	260	264	PF00917	0.594
DOC_USP7_MATH_1	292	296	PF00917	0.693
DOC_USP7_MATH_1	314	318	PF00917	0.698
DOC_USP7_MATH_1	355	359	PF00917	0.712
DOC_USP7_MATH_1	418	422	PF00917	0.706
DOC_USP7_MATH_1	427	431	PF00917	0.641
DOC_USP7_MATH_1	443	447	PF00917	0.749
DOC_USP7_MATH_1	476	480	PF00917	0.667
DOC_USP7_MATH_1	489	493	PF00917	0.740
DOC_USP7_MATH_1	551	555	PF00917	0.696
DOC_USP7_MATH_1	567	571	PF00917	0.661
DOC_USP7_MATH_1	580	584	PF00917	0.649
DOC_USP7_MATH_1	594	598	PF00917	0.580
DOC_USP7_MATH_1	605	609	PF00917	0.614
DOC_USP7_MATH_2	260	266	PF00917	0.621
DOC_USP7_UBL2_3	297	301	PF12436	0.795
DOC_USP7_UBL2_3	90	94	PF12436	0.485
DOC_WW_Pin1_4	12	17	PF00397	0.724
DOC_WW_Pin1_4	252	257	PF00397	0.748
DOC_WW_Pin1_4	26	31	PF00397	0.602
DOC_WW_Pin1_4	288	293	PF00397	0.663
DOC_WW_Pin1_4	331	336	PF00397	0.691
DOC_WW_Pin1_4	4	9	PF00397	0.721
DOC_WW_Pin1_4	541	546	PF00397	0.693
DOC_WW_Pin1_4	67	72	PF00397	0.546
DOC_WW_Pin1_4	80	85	PF00397	0.532
LIG_14-3-3_CanoR_1	221	229	PF00244	0.647
LIG_14-3-3_CanoR_1	233	238	PF00244	0.504
LIG_14-3-3_CanoR_1	316	325	PF00244	0.665
LIG_14-3-3_CanoR_1	521	526	PF00244	0.589
LIG_Actin_WH2_2	207	223	PF00022	0.566
LIG_APCC_ABBA_1	452	457	PF00400	0.800
LIG_BRCT_BRCA1_1	254	258	PF00533	0.737
LIG_BRCT_BRCA1_1	262	266	PF00533	0.692
LIG_BRCT_BRCA1_1	309	313	PF00533	0.662
LIG_BRCT_BRCA1_1	405	409	PF00533	0.476
LIG_BRCT_BRCA1_1	596	600	PF00533	0.621
LIG_Clathr_ClatBox_1	362	366	PF01394	0.794
LIG_EVH1_1	585	589	PF00568	0.685
LIG_FHA_1	13	19	PF00498	0.662
LIG_FHA_1	449	455	PF00498	0.682
LIG_FHA_1	479	485	PF00498	0.724
LIG_FHA_1	561	567	PF00498	0.798
LIG_FHA_2	136	142	PF00498	0.504
LIG_FHA_2	148	154	PF00498	0.503
LIG_FHA_2	42	48	PF00498	0.545
LIG_FHA_2	468	474	PF00498	0.786
LIG_FHA_2	56	62	PF00498	0.441
LIG_FHA_2	590	596	PF00498	0.605
LIG_Integrin_RGD_1	241	243	PF01839	0.746
LIG_LIR_Apic_2	251	256	PF02991	0.727
LIG_LIR_Gen_1	115	126	PF02991	0.492
LIG_LIR_Gen_1	19	28	PF02991	0.661
LIG_LIR_Gen_1	348	357	PF02991	0.697
LIG_LIR_Gen_1	376	385	PF02991	0.784
LIG_LIR_Gen_1	406	417	PF02991	0.678
LIG_LIR_Gen_1	53	64	PF02991	0.690
LIG_LIR_Nem_3	115	121	PF02991	0.471
LIG_LIR_Nem_3	19	24	PF02991	0.662
LIG_LIR_Nem_3	255	261	PF02991	0.717
LIG_LIR_Nem_3	348	354	PF02991	0.709
LIG_LIR_Nem_3	376	382	PF02991	0.778
LIG_LIR_Nem_3	406	412	PF02991	0.677
LIG_LIR_Nem_3	53	59	PF02991	0.679
LIG_LIR_Nem_3	597	603	PF02991	0.631
LIG_MLH1_MIPbox_1	309	313	PF16413	0.662
LIG_PCNA_yPIPBox_3	140	154	PF02747	0.512
LIG_PDZ_Class_2	623	628	PF00595	0.656
LIG_Pex14_1	52	56	PF04695	0.553
LIG_PTB_Apo_2	306	313	PF02174	0.642
LIG_PTB_Phospho_1	306	312	PF10480	0.640
LIG_SH2_CRK	118	122	PF00017	0.510
LIG_SH2_CRK	21	25	PF00017	0.655
LIG_SH2_GRB2like	21	24	PF00017	0.704
LIG_SH2_GRB2like	504	507	PF00017	0.636
LIG_SH2_SRC	21	24	PF00017	0.704
LIG_SH2_STAP1	276	280	PF00017	0.681
LIG_SH2_STAT5	306	309	PF00017	0.635
LIG_SH2_STAT5	312	315	PF00017	0.671
LIG_SH2_STAT5	504	507	PF00017	0.658
LIG_SH2_STAT5	603	606	PF00017	0.648
LIG_SH2_STAT5	615	618	PF00017	0.661
LIG_SH2_STAT5	9	12	PF00017	0.630
LIG_SH3_1	60	66	PF00018	0.690
LIG_SH3_2	335	340	PF14604	0.592
LIG_SH3_3	296	302	PF00018	0.657
LIG_SH3_3	332	338	PF00018	0.799
LIG_SH3_3	520	526	PF00018	0.759
LIG_SH3_3	583	589	PF00018	0.645
LIG_SH3_3	59	65	PF00018	0.594
LIG_SUMO_SIM_par_1	361	368	PF11976	0.786
LIG_SUMO_SIM_par_1	371	378	PF11976	0.528
LIG_SUMO_SIM_par_1	620	625	PF11976	0.639
LIG_TRAF2_1	138	141	PF00917	0.534
LIG_TRAF2_1	150	153	PF00917	0.473
LIG_TRAF2_1	44	47	PF00917	0.545
LIG_TRAF2_1	471	474	PF00917	0.571
LIG_WRC_WIRS_1	126	131	PF05994	0.443
LIG_WW_3	337	341	PF00397	0.588
MOD_CDK_SPK_2	252	257	PF00069	0.726
MOD_CDK_SPK_2	67	72	PF00069	0.546
MOD_CDK_SPxK_1	334	340	PF00069	0.649
MOD_CDK_SPxxK_3	26	33	PF00069	0.779
MOD_CDK_SPxxK_3	290	297	PF00069	0.813
MOD_CDK_SPxxK_3	541	548	PF00069	0.696
MOD_CK1_1	113	119	PF00069	0.524
MOD_CK1_1	191	197	PF00069	0.771
MOD_CK1_1	222	228	PF00069	0.794
MOD_CK1_1	232	238	PF00069	0.752
MOD_CK1_1	31	37	PF00069	0.686
MOD_CK1_1	317	323	PF00069	0.678
MOD_CK1_1	334	340	PF00069	0.707
MOD_CK1_1	368	374	PF00069	0.768
MOD_CK1_1	377	383	PF00069	0.611
MOD_CK1_1	400	406	PF00069	0.720
MOD_CK1_1	430	436	PF00069	0.775
MOD_CK1_1	448	454	PF00069	0.658
MOD_CK1_1	480	486	PF00069	0.715
MOD_CK1_1	570	576	PF00069	0.700
MOD_CK1_1	70	76	PF00069	0.524
MOD_CK1_1	83	89	PF00069	0.517
MOD_CK2_1	125	131	PF00069	0.470
MOD_CK2_1	135	141	PF00069	0.533
MOD_CK2_1	147	153	PF00069	0.496
MOD_CK2_1	159	165	PF00069	0.461
MOD_CK2_1	220	226	PF00069	0.723
MOD_CK2_1	256	262	PF00069	0.616
MOD_CK2_1	404	410	PF00069	0.715
MOD_CK2_1	41	47	PF00069	0.543
MOD_CK2_1	417	423	PF00069	0.548
MOD_CK2_1	467	473	PF00069	0.714
MOD_CK2_1	480	486	PF00069	0.728
MOD_CK2_1	543	549	PF00069	0.662
MOD_CK2_1	589	595	PF00069	0.611
MOD_Cter_Amidation	616	619	PF01082	0.680
MOD_DYRK1A_RPxSP_1	26	30	PF00069	0.672
MOD_GlcNHglycan	112	115	PF01048	0.559
MOD_GlcNHglycan	123	126	PF01048	0.579
MOD_GlcNHglycan	197	200	PF01048	0.755
MOD_GlcNHglycan	2	5	PF01048	0.726
MOD_GlcNHglycan	294	297	PF01048	0.671
MOD_GlcNHglycan	392	395	PF01048	0.669
MOD_GlcNHglycan	429	432	PF01048	0.618
MOD_GlcNHglycan	572	575	PF01048	0.738
MOD_GSK3_1	106	113	PF00069	0.616
MOD_GSK3_1	12	19	PF00069	0.714
MOD_GSK3_1	121	128	PF00069	0.404
MOD_GSK3_1	188	195	PF00069	0.728
MOD_GSK3_1	22	29	PF00069	0.639
MOD_GSK3_1	225	232	PF00069	0.737
MOD_GSK3_1	248	255	PF00069	0.676
MOD_GSK3_1	256	263	PF00069	0.628
MOD_GSK3_1	288	295	PF00069	0.810
MOD_GSK3_1	330	337	PF00069	0.725
MOD_GSK3_1	361	368	PF00069	0.693
MOD_GSK3_1	386	393	PF00069	0.731
MOD_GSK3_1	400	407	PF00069	0.671
MOD_GSK3_1	476	483	PF00069	0.694
MOD_GSK3_1	607	614	PF00069	0.633
MOD_GSK3_1	80	87	PF00069	0.561
MOD_LATS_1	239	245	PF00433	0.709
MOD_N-GLC_1	195	200	PF02516	0.756
MOD_N-GLC_1	22	27	PF02516	0.655
MOD_N-GLC_1	308	313	PF02516	0.642
MOD_N-GLC_1	314	319	PF02516	0.667
MOD_N-GLC_1	404	409	PF02516	0.771
MOD_N-GLC_1	80	85	PF02516	0.563
MOD_NEK2_1	121	126	PF00069	0.419
MOD_NEK2_1	220	225	PF00069	0.705
MOD_NEK2_1	229	234	PF00069	0.644
MOD_NEK2_1	307	312	PF00069	0.646
MOD_NEK2_1	404	409	PF00069	0.693
MOD_NEK2_1	417	422	PF00069	0.628
MOD_NEK2_1	622	627	PF00069	0.755
MOD_NEK2_2	125	130	PF00069	0.384
MOD_NEK2_2	16	21	PF00069	0.660
MOD_NEK2_2	314	319	PF00069	0.700
MOD_PIKK_1	136	142	PF00454	0.482
MOD_PIKK_1	355	361	PF00454	0.627
MOD_PIKK_1	404	410	PF00454	0.721
MOD_PIKK_1	490	496	PF00454	0.816
MOD_PIKK_1	589	595	PF00454	0.588
MOD_PIKK_1	9	15	PF00454	0.719
MOD_PKA_1	192	198	PF00069	0.674
MOD_PKA_2	192	198	PF00069	0.674
MOD_PKA_2	220	226	PF00069	0.628
MOD_PKA_2	232	238	PF00069	0.502
MOD_PKA_2	248	254	PF00069	0.570
MOD_PKB_1	231	239	PF00069	0.614
MOD_Plk_1	225	231	PF00069	0.776
MOD_Plk_1	308	314	PF00069	0.681
MOD_Plk_1	365	371	PF00069	0.774
MOD_Plk_1	377	383	PF00069	0.548
MOD_Plk_1	397	403	PF00069	0.705
MOD_Plk_1	404	410	PF00069	0.668
MOD_Plk_2-3	270	276	PF00069	0.579
MOD_Plk_2-3	41	47	PF00069	0.543
MOD_Plk_4	16	22	PF00069	0.661
MOD_Plk_4	262	268	PF00069	0.631
MOD_Plk_4	308	314	PF00069	0.614
MOD_Plk_4	368	374	PF00069	0.774
MOD_Plk_4	430	436	PF00069	0.580
MOD_Plk_4	450	456	PF00069	0.675
MOD_Plk_4	509	515	PF00069	0.740
MOD_Plk_4	607	613	PF00069	0.735
MOD_ProDKin_1	12	18	PF00069	0.722
MOD_ProDKin_1	252	258	PF00069	0.747
MOD_ProDKin_1	26	32	PF00069	0.602
MOD_ProDKin_1	288	294	PF00069	0.660
MOD_ProDKin_1	331	337	PF00069	0.692
MOD_ProDKin_1	4	10	PF00069	0.722
MOD_ProDKin_1	541	547	PF00069	0.694
MOD_ProDKin_1	67	73	PF00069	0.537
MOD_ProDKin_1	80	86	PF00069	0.533
MOD_SUMO_rev_2	480	490	PF00179	0.717
MOD_SUMO_rev_2	524	532	PF00179	0.588
TRG_DiLeu_BaEn_1	117	122	PF01217	0.517
TRG_DiLeu_BaEn_2	261	267	PF01217	0.584
TRG_DiLeu_BaEn_3	595	601	PF01217	0.715
TRG_DiLeu_BaLyEn_6	358	363	PF01217	0.788
TRG_DiLeu_BaLyEn_6	586	591	PF01217	0.635
TRG_DiLeu_BaLyEn_6	63	68	PF01217	0.669
TRG_ENDOCYTIC_2	118	121	PF00928	0.518
TRG_ENDOCYTIC_2	21	24	PF00928	0.657
TRG_ENDOCYTIC_2	56	59	PF00928	0.585
TRG_ER_diArg_1	166	168	PF00400	0.496
TRG_ER_diArg_1	214	216	PF00400	0.571
TRG_ER_diArg_1	280	283	PF00400	0.604
TRG_ER_diArg_1	32	35	PF00400	0.592
TRG_ER_diArg_1	54	56	PF00400	0.568
TRG_Pf-PMV_PEXEL_1	164	169	PF00026	0.504

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P512	Leptomonas seymouri	40%	99%
A4HB19	Leishmania braziliensis	59%	100%
A4IA76	Leishmania infantum	99%	100%
E9B589	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q2P4	Leishmania major	87%	100%