Palmitoyltransferase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DHHC palmitoyltransferase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IIC8_LEIDO

TriTrypDb:

LdBPK_352630.1 , LdCL_350031200 , LDHU3_35.3390

Length:

279

Annotations

LeishMANIAdb annotations

Related to many other eukaryotic palmitoyltransferases (e.g. mammalian ZDHHC4/9/14/24)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005783	endoplasmic reticulum	5	1
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3Q8IIC8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IIC8

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	1
GO:0006605	protein targeting	5	1
GO:0006612	protein targeting to membrane	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018198	peptidyl-cysteine modification	6	1
GO:0018230	peptidyl-L-cysteine S-palmitoylation	7	1
GO:0018231	peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine	7	1
GO:0018345	protein palmitoylation	6	1
GO:0019538	protein metabolic process	3	1
GO:0033036	macromolecule localization	2	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043543	protein acylation	5	1
GO:0044238	primary metabolic process	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0071705	nitrogen compound transport	4	1
GO:0072657	protein localization to membrane	4	1
GO:0090150	establishment of protein localization to membrane	4	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016409	palmitoyltransferase activity	5	11
GO:0016417	S-acyltransferase activity	5	11
GO:0016740	transferase activity	2	11
GO:0016746	acyltransferase activity	3	11
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	11
GO:0019706	protein-cysteine S-palmitoyltransferase activity	4	11
GO:0019707	protein-cysteine S-acyltransferase activity	3	11
GO:0140096	catalytic activity, acting on a protein	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	262	264	PF00675	0.403
CLV_PCSK_KEX2_1	146	148	PF00082	0.261
CLV_PCSK_KEX2_1	262	264	PF00082	0.358
CLV_PCSK_KEX2_1	9	11	PF00082	0.362
CLV_PCSK_PC1ET2_1	146	148	PF00082	0.261
CLV_PCSK_PC1ET2_1	9	11	PF00082	0.362
CLV_PCSK_SKI1_1	262	266	PF00082	0.344
CLV_PCSK_SKI1_1	9	13	PF00082	0.388
DEG_APCC_DBOX_1	184	192	PF00400	0.220
DOC_CDC14_PxL_1	32	40	PF14671	0.296
DOC_MAPK_gen_1	9	17	PF00069	0.598
DOC_MAPK_MEF2A_6	185	193	PF00069	0.201
DOC_PP1_RVXF_1	14	20	PF00149	0.603
DOC_PP2B_LxvP_1	208	211	PF13499	0.374
DOC_USP7_MATH_1	221	225	PF00917	0.448
DOC_USP7_MATH_1	91	95	PF00917	0.623
DOC_WW_Pin1_4	263	268	PF00397	0.638
LIG_14-3-3_CanoR_1	116	125	PF00244	0.439
LIG_BRCT_BRCA1_1	175	179	PF00533	0.348
LIG_deltaCOP1_diTrp_1	26	32	PF00928	0.270
LIG_deltaCOP1_diTrp_1	53	59	PF00928	0.248
LIG_eIF4E_1	57	63	PF01652	0.355
LIG_FHA_1	109	115	PF00498	0.439
LIG_FHA_1	157	163	PF00498	0.322
LIG_FHA_1	194	200	PF00498	0.310
LIG_FHA_1	40	46	PF00498	0.411
LIG_FHA_1	63	69	PF00498	0.397
LIG_FHA_1	70	76	PF00498	0.397
LIG_FHA_1	94	100	PF00498	0.547
LIG_FHA_2	223	229	PF00498	0.400
LIG_GBD_Chelix_1	200	208	PF00786	0.257
LIG_LIR_Gen_1	159	168	PF02991	0.372
LIG_LIR_Gen_1	170	179	PF02991	0.373
LIG_LIR_Gen_1	26	36	PF02991	0.374
LIG_LIR_Gen_1	41	50	PF02991	0.282
LIG_LIR_Gen_1	53	63	PF02991	0.168
LIG_LIR_Nem_3	148	152	PF02991	0.430
LIG_LIR_Nem_3	159	164	PF02991	0.320
LIG_LIR_Nem_3	170	174	PF02991	0.373
LIG_LIR_Nem_3	26	31	PF02991	0.450
LIG_LIR_Nem_3	41	47	PF02991	0.210
LIG_LIR_Nem_3	53	58	PF02991	0.165
LIG_LIR_Nem_3	60	66	PF02991	0.269
LIG_PDZ_Class_2	274	279	PF00595	0.608
LIG_Pex14_1	28	32	PF04695	0.296
LIG_Pex14_2	151	155	PF04695	0.254
LIG_Pex14_2	40	44	PF04695	0.296
LIG_Pex14_2	55	59	PF04695	0.153
LIG_SH2_PTP2	165	168	PF00017	0.318
LIG_SH2_PTP2	216	219	PF00017	0.477
LIG_SH2_STAP1	275	279	PF00017	0.515
LIG_SH2_STAT5	165	168	PF00017	0.304
LIG_SH2_STAT5	216	219	PF00017	0.473
LIG_SH2_STAT5	257	260	PF00017	0.592
LIG_SH2_STAT5	57	60	PF00017	0.283
LIG_SH3_3	30	36	PF00018	0.296
LIG_SH3_3	44	50	PF00018	0.350
LIG_SH3_3	78	84	PF00018	0.474
LIG_SUMO_SIM_anti_2	170	178	PF11976	0.346
LIG_SUMO_SIM_par_1	170	178	PF11976	0.315
LIG_SUMO_SIM_par_1	64	69	PF11976	0.342
LIG_SUMO_SIM_par_1	71	76	PF11976	0.378
LIG_TYR_ITIM	163	168	PF00017	0.257
LIG_WRC_WIRS_1	158	163	PF05994	0.296
LIG_WRC_WIRS_1	168	173	PF05994	0.211
LIG_WW_3	116	120	PF00397	0.421
MOD_CDK_SPxxK_3	263	270	PF00069	0.551
MOD_CK1_1	222	228	PF00069	0.500
MOD_CK1_1	27	33	PF00069	0.205
MOD_CK2_1	222	228	PF00069	0.400
MOD_Cter_Amidation	144	147	PF01082	0.359
MOD_GlcNHglycan	219	222	PF01048	0.292
MOD_GlcNHglycan	238	241	PF01048	0.354
MOD_GlcNHglycan	253	256	PF01048	0.268
MOD_GSK3_1	217	224	PF00069	0.451
MOD_GSK3_1	39	46	PF00069	0.403
MOD_GSK3_1	53	60	PF00069	0.195
MOD_GSK3_1	62	69	PF00069	0.336
MOD_GSK3_1	85	92	PF00069	0.538
MOD_N-GLC_1	222	227	PF02516	0.200
MOD_N-GLC_2	256	258	PF02516	0.331
MOD_NEK2_1	156	161	PF00069	0.260
MOD_NEK2_1	167	172	PF00069	0.261
MOD_NEK2_1	191	196	PF00069	0.355
MOD_NEK2_1	219	224	PF00069	0.475
MOD_NEK2_1	38	43	PF00069	0.360
MOD_NEK2_1	62	67	PF00069	0.345
MOD_NEK2_1	71	76	PF00069	0.289
MOD_NEK2_2	145	150	PF00069	0.421
MOD_OFUCOSY	106	112	PF10250	0.239
MOD_OFUCOSY	137	143	PF10250	0.221
MOD_PIKK_1	229	235	PF00454	0.603
MOD_PIKK_1	85	91	PF00454	0.560
MOD_PKA_2	118	124	PF00069	0.421
MOD_Plk_1	222	228	PF00069	0.495
MOD_Plk_4	157	163	PF00069	0.336
MOD_Plk_4	27	33	PF00069	0.342
MOD_Plk_4	39	45	PF00069	0.368
MOD_Plk_4	93	99	PF00069	0.513
MOD_ProDKin_1	263	269	PF00069	0.639
MOD_SUMO_rev_2	176	182	PF00179	0.220
TRG_DiLeu_BaEn_1	184	189	PF01217	0.220
TRG_ENDOCYTIC_2	165	168	PF00928	0.356
TRG_ENDOCYTIC_2	216	219	PF00928	0.473
TRG_ER_diArg_1	14	17	PF00400	0.630
TRG_ER_diArg_1	261	263	PF00400	0.604
TRG_ER_diArg_1	270	273	PF00400	0.630

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P729	Leptomonas seymouri	30%	94%
A0A0N1HZ19	Leptomonas seymouri	25%	79%
A0A0S4INR8	Bodo saltans	31%	93%
A0A0S4IT15	Bodo saltans	28%	79%
A0A0S4IXZ6	Bodo saltans	27%	100%
A0A0S4KJ22	Bodo saltans	39%	91%
A0A0S4KJ92	Bodo saltans	27%	100%
A0A1X0NY23	Trypanosomatidae	25%	93%
A0A1X0P5Q8	Trypanosomatidae	42%	87%
A0A3Q8ICY2	Leishmania donovani	28%	79%
A0A3R7P4J6	Trypanosoma rangeli	33%	93%
A0A422NE16	Trypanosoma rangeli	44%	86%
A2VDT6	Bos taurus	26%	100%
A4HCH5	Leishmania braziliensis	26%	70%
A4HG63	Leishmania braziliensis	27%	78%
A4HMS9	Leishmania braziliensis	79%	100%
A4I395	Leishmania infantum	28%	79%
A4IBG8	Leishmania infantum	100%	100%
B3DN87	Arabidopsis thaliana	27%	83%
C9ZKD6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	91%
D0A7S1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	91%
E7F587	Danio rerio	22%	86%
E9AF82	Leishmania major	95%	100%
E9AVW7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	70%
E9AZI3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9B6D8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
O74384	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	80%
O80685	Arabidopsis thaliana	27%	68%
P0C7U3	Homo sapiens	24%	75%
Q2TGJ1	Rattus norvegicus	32%	72%
Q4Q8P8	Leishmania major	26%	100%
Q555N7	Dictyostelium discoideum	24%	78%
Q58DT3	Bos taurus	26%	81%
Q5PNZ1	Arabidopsis thaliana	27%	68%
Q5Y5T2	Mus musculus	31%	73%
Q6BHT4	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	24%	75%
Q6CQB5	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	29%	79%
Q7ZVN4	Danio rerio	33%	72%
Q8VYP5	Arabidopsis thaliana	24%	91%
Q8VYS8	Arabidopsis thaliana	27%	69%
Q9H8X9	Homo sapiens	23%	68%
Q9NUE0	Homo sapiens	30%	72%
Q9SB58	Arabidopsis thaliana	29%	69%
V5BC02	Trypanosoma cruzi	31%	93%
V5C316	Trypanosoma cruzi	43%	84%