DUF4201 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4201), putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IIC4_LEIDO

TriTrypDb:

LdBPK_140880.1 , LdCL_140014300 , LDHU3_14.1120

Length:

577

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	10
GO:0005856	cytoskeleton	5	9
GO:0043226	organelle	2	9
GO:0043228	non-membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043232	intracellular non-membrane-bounded organelle	4	9
GO:0110165	cellular anatomical entity	1	10
GO:0005815	microtubule organizing center	2	1
GO:0005930	axoneme	2	1
GO:0036064	ciliary basal body	3	1

Expansion

Sequence features

A0A3Q8IIC4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IIC4

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0030030	cell projection organization	4	1
GO:0030031	cell projection assembly	5	1
GO:0044782	cilium organization	5	1
GO:0060271	cilium assembly	6	1
GO:0070925	organelle assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0120031	plasma membrane bounded cell projection assembly	6	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	103	105	PF00675	0.676
CLV_NRD_NRD_1	13	15	PF00675	0.552
CLV_NRD_NRD_1	175	177	PF00675	0.571
CLV_NRD_NRD_1	182	184	PF00675	0.530
CLV_NRD_NRD_1	236	238	PF00675	0.546
CLV_NRD_NRD_1	252	254	PF00675	0.629
CLV_NRD_NRD_1	268	270	PF00675	0.727
CLV_NRD_NRD_1	298	300	PF00675	0.469
CLV_NRD_NRD_1	331	333	PF00675	0.282
CLV_NRD_NRD_1	463	465	PF00675	0.246
CLV_NRD_NRD_1	481	483	PF00675	0.449
CLV_NRD_NRD_1	532	534	PF00675	0.591
CLV_PCSK_FUR_1	329	333	PF00082	0.331
CLV_PCSK_FUR_1	394	398	PF00082	0.317
CLV_PCSK_KEX2_1	103	105	PF00082	0.676
CLV_PCSK_KEX2_1	13	15	PF00082	0.679
CLV_PCSK_KEX2_1	175	177	PF00082	0.570
CLV_PCSK_KEX2_1	181	183	PF00082	0.536
CLV_PCSK_KEX2_1	235	237	PF00082	0.518
CLV_PCSK_KEX2_1	268	270	PF00082	0.742
CLV_PCSK_KEX2_1	298	300	PF00082	0.409
CLV_PCSK_KEX2_1	331	333	PF00082	0.292
CLV_PCSK_KEX2_1	396	398	PF00082	0.292
CLV_PCSK_KEX2_1	481	483	PF00082	0.519
CLV_PCSK_KEX2_1	497	499	PF00082	0.439
CLV_PCSK_PC1ET2_1	396	398	PF00082	0.317
CLV_PCSK_PC1ET2_1	497	499	PF00082	0.534
CLV_PCSK_PC7_1	178	184	PF00082	0.659
CLV_PCSK_PC7_1	294	300	PF00082	0.415
CLV_PCSK_PC7_1	477	483	PF00082	0.540
CLV_PCSK_SKI1_1	197	201	PF00082	0.509
CLV_PCSK_SKI1_1	214	218	PF00082	0.519
CLV_PCSK_SKI1_1	249	253	PF00082	0.441
CLV_PCSK_SKI1_1	273	277	PF00082	0.587
CLV_PCSK_SKI1_1	397	401	PF00082	0.292
CLV_PCSK_SKI1_1	457	461	PF00082	0.331
CLV_PCSK_SKI1_1	526	530	PF00082	0.552
CLV_Separin_Metazoa	250	254	PF03568	0.452
CLV_Separin_Metazoa	291	295	PF03568	0.535
DEG_APCC_DBOX_1	181	189	PF00400	0.563
DEG_Nend_UBRbox_2	1	3	PF02207	0.700
DOC_MAPK_gen_1	178	188	PF00069	0.470
DOC_MAPK_gen_1	235	242	PF00069	0.449
DOC_MAPK_MEF2A_6	235	244	PF00069	0.468
DOC_MAPK_NFAT4_5	237	245	PF00069	0.429
DOC_USP7_MATH_1	127	131	PF00917	0.592
DOC_USP7_MATH_1	15	19	PF00917	0.739
DOC_USP7_MATH_1	156	160	PF00917	0.570
DOC_USP7_MATH_1	262	266	PF00917	0.576
DOC_USP7_MATH_1	302	306	PF00917	0.592
DOC_USP7_MATH_1	514	518	PF00917	0.664
DOC_USP7_MATH_1	521	525	PF00917	0.658
DOC_USP7_MATH_1	546	550	PF00917	0.615
DOC_USP7_MATH_1	572	576	PF00917	0.700
DOC_USP7_UBL2_3	396	400	PF12436	0.531
DOC_WW_Pin1_4	133	138	PF00397	0.697
DOC_WW_Pin1_4	152	157	PF00397	0.750
DOC_WW_Pin1_4	267	272	PF00397	0.693
DOC_WW_Pin1_4	539	544	PF00397	0.541
LIG_14-3-3_CanoR_1	175	181	PF00244	0.626
LIG_14-3-3_CanoR_1	182	186	PF00244	0.545
LIG_14-3-3_CanoR_1	298	307	PF00244	0.351
LIG_14-3-3_CanoR_1	487	493	PF00244	0.557
LIG_Actin_WH2_2	238	255	PF00022	0.438
LIG_CaM_IQ_9	418	433	PF13499	0.451
LIG_Clathr_ClatBox_1	185	189	PF01394	0.406
LIG_FHA_1	108	114	PF00498	0.445
LIG_FHA_1	139	145	PF00498	0.635
LIG_FHA_1	203	209	PF00498	0.524
LIG_FHA_1	370	376	PF00498	0.480
LIG_FHA_1	88	94	PF00498	0.500
LIG_FHA_2	208	214	PF00498	0.602
LIG_FHA_2	227	233	PF00498	0.400
LIG_FHA_2	285	291	PF00498	0.583
LIG_LIR_Gen_1	189	199	PF02991	0.436
LIG_LIR_Gen_1	336	346	PF02991	0.465
LIG_LIR_Gen_1	40	50	PF02991	0.535
LIG_LIR_Nem_3	189	194	PF02991	0.468
LIG_LIR_Nem_3	336	341	PF02991	0.465
LIG_LIR_Nem_3	40	45	PF02991	0.555
LIG_LIR_Nem_3	48	53	PF02991	0.483
LIG_PCNA_yPIPBox_3	43	52	PF02747	0.563
LIG_SH2_CRK	50	54	PF00017	0.443
LIG_SH2_GRB2like	493	496	PF00017	0.688
LIG_SH2_NCK_1	50	54	PF00017	0.465
LIG_SH2_STAP1	50	54	PF00017	0.522
LIG_SH2_STAT3	445	448	PF00017	0.436
LIG_SH2_STAT5	295	298	PF00017	0.527
LIG_SH2_STAT5	306	309	PF00017	0.386
LIG_SH2_STAT5	405	408	PF00017	0.436
LIG_SH2_STAT5	50	53	PF00017	0.422
LIG_SH3_3	108	114	PF00018	0.654
LIG_SH3_3	434	440	PF00018	0.449
LIG_SH3_3	540	546	PF00018	0.619
LIG_SUMO_SIM_par_1	184	189	PF11976	0.706
LIG_TRAF2_1	210	213	PF00917	0.561
LIG_TRAF2_1	229	232	PF00917	0.458
LIG_TRAF2_1	432	435	PF00917	0.531
LIG_TRAF2_1	85	88	PF00917	0.593
LIG_WRC_WIRS_1	46	51	PF05994	0.533
MOD_CDC14_SPxK_1	270	273	PF00782	0.529
MOD_CDK_SPK_2	152	157	PF00069	0.514
MOD_CDK_SPxK_1	267	273	PF00069	0.535
MOD_CK1_1	152	158	PF00069	0.622
MOD_CK1_1	27	33	PF00069	0.593
MOD_CK1_1	371	377	PF00069	0.436
MOD_CK1_1	48	54	PF00069	0.543
MOD_CK1_1	500	506	PF00069	0.624
MOD_CK1_1	524	530	PF00069	0.712
MOD_CK1_1	6	12	PF00069	0.627
MOD_CK2_1	207	213	PF00069	0.558
MOD_CK2_1	226	232	PF00069	0.419
MOD_CK2_1	285	291	PF00069	0.601
MOD_CK2_1	398	404	PF00069	0.467
MOD_CK2_1	541	547	PF00069	0.729
MOD_Cter_Amidation	173	176	PF01082	0.633
MOD_GlcNHglycan	118	121	PF01048	0.683
MOD_GlcNHglycan	128	132	PF01048	0.600
MOD_GlcNHglycan	15	18	PF01048	0.666
MOD_GlcNHglycan	158	161	PF01048	0.626
MOD_GlcNHglycan	168	171	PF01048	0.610
MOD_GlcNHglycan	263	267	PF01048	0.606
MOD_GlcNHglycan	281	284	PF01048	0.624
MOD_GlcNHglycan	30	33	PF01048	0.512
MOD_GlcNHglycan	300	303	PF01048	0.329
MOD_GlcNHglycan	488	491	PF01048	0.479
MOD_GlcNHglycan	502	505	PF01048	0.587
MOD_GlcNHglycan	510	513	PF01048	0.711
MOD_GlcNHglycan	523	526	PF01048	0.646
MOD_GlcNHglycan	55	58	PF01048	0.509
MOD_GlcNHglycan	554	558	PF01048	0.653
MOD_GlcNHglycan	82	86	PF01048	0.487
MOD_GSK3_1	129	136	PF00069	0.657
MOD_GSK3_1	152	159	PF00069	0.689
MOD_GSK3_1	166	173	PF00069	0.536
MOD_GSK3_1	23	30	PF00069	0.564
MOD_GSK3_1	298	305	PF00069	0.493
MOD_GSK3_1	367	374	PF00069	0.465
MOD_GSK3_1	400	407	PF00069	0.512
MOD_GSK3_1	41	48	PF00069	0.323
MOD_GSK3_1	5	12	PF00069	0.769
MOD_GSK3_1	502	509	PF00069	0.555
MOD_GSK3_1	70	77	PF00069	0.548
MOD_N-GLC_1	114	119	PF02516	0.663
MOD_N-GLC_1	27	32	PF02516	0.584
MOD_NEK2_1	278	283	PF00069	0.631
MOD_NEK2_1	367	372	PF00069	0.436
MOD_NEK2_1	45	50	PF00069	0.535
MOD_PIKK_1	207	213	PF00454	0.523
MOD_PKA_1	13	19	PF00069	0.548
MOD_PKA_1	181	187	PF00069	0.660
MOD_PKA_1	276	282	PF00069	0.549
MOD_PKA_1	298	304	PF00069	0.520
MOD_PKA_1	497	503	PF00069	0.626
MOD_PKA_2	13	19	PF00069	0.578
MOD_PKA_2	156	162	PF00069	0.608
MOD_PKA_2	181	187	PF00069	0.575
MOD_PKA_2	298	304	PF00069	0.520
MOD_PKA_2	486	492	PF00069	0.521
MOD_PKA_2	497	503	PF00069	0.545
MOD_PKA_2	506	512	PF00069	0.583
MOD_Plk_1	138	144	PF00069	0.648
MOD_Plk_1	546	552	PF00069	0.612
MOD_Plk_1	81	87	PF00069	0.581
MOD_Plk_2-3	547	553	PF00069	0.613
MOD_Plk_4	138	144	PF00069	0.676
MOD_Plk_4	302	308	PF00069	0.497
MOD_Plk_4	41	47	PF00069	0.666
MOD_ProDKin_1	133	139	PF00069	0.697
MOD_ProDKin_1	152	158	PF00069	0.752
MOD_ProDKin_1	267	273	PF00069	0.691
MOD_ProDKin_1	539	545	PF00069	0.542
MOD_SUMO_for_1	395	398	PF00179	0.517
MOD_SUMO_for_1	440	443	PF00179	0.446
MOD_SUMO_rev_2	189	199	PF00179	0.525
MOD_SUMO_rev_2	258	262	PF00179	0.525
MOD_SUMO_rev_2	270	278	PF00179	0.473
MOD_SUMO_rev_2	344	353	PF00179	0.471
MOD_SUMO_rev_2	363	370	PF00179	0.362
MOD_SUMO_rev_2	419	428	PF00179	0.453
TRG_DiLeu_BaEn_4	88	94	PF01217	0.476
TRG_ENDOCYTIC_2	50	53	PF00928	0.442
TRG_ER_diArg_1	103	105	PF00400	0.608
TRG_ER_diArg_1	175	178	PF00400	0.586
TRG_ER_diArg_1	180	183	PF00400	0.568
TRG_ER_diArg_1	234	237	PF00400	0.513
TRG_ER_diArg_1	328	331	PF00400	0.449
TRG_ER_diArg_1	481	483	PF00400	0.525
TRG_Pf-PMV_PEXEL_1	183	187	PF00026	0.591
TRG_Pf-PMV_PEXEL_1	362	366	PF00026	0.251
TRG_Pf-PMV_PEXEL_1	481	486	PF00026	0.642
TRG_Pf-PMV_PEXEL_1	526	531	PF00026	0.719

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5T9	Leptomonas seymouri	63%	100%
A0A1X0NNL2	Trypanosomatidae	40%	100%
A0A422N1M9	Trypanosoma rangeli	39%	100%
A4H7N6	Leishmania braziliensis	78%	100%
A4HW26	Leishmania infantum	99%	100%
C9ZT07	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9APS7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QFQ1	Leishmania major	93%	100%
V5BEA4	Trypanosoma cruzi	42%	100%