Acyl-CoA_dehydrogenase_putative/GeneDB:LmjF.28.25 10

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

acyl-CoA dehydrogenase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IIB9_LEIDO

TriTrypDb:

LdBPK_282700.1 , LdCL_280032100 , LDHU3_28.3650

Length:

629

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	2

Expansion

Sequence features

A0A3Q8IIB9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IIB9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	13
GO:0003824	catalytic activity	1	13
GO:0005488	binding	1	13
GO:0016491	oxidoreductase activity	2	13
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	13
GO:0036094	small molecule binding	2	13
GO:0043167	ion binding	2	13
GO:0043168	anion binding	3	13
GO:0050660	flavin adenine dinucleotide binding	4	13
GO:0097159	organic cyclic compound binding	2	13
GO:1901265	nucleoside phosphate binding	3	13
GO:1901363	heterocyclic compound binding	2	13
GO:0003995	acyl-CoA dehydrogenase activity	5	5
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	4	5
GO:0043958	acryloyl-CoA reductase (NADH) activity	5	5
GO:0052890	oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	233	237	PF00656	0.513
CLV_C14_Caspase3-7	65	69	PF00656	0.615
CLV_C14_Caspase3-7	87	91	PF00656	0.533
CLV_NRD_NRD_1	3	5	PF00675	0.640
CLV_NRD_NRD_1	350	352	PF00675	0.493
CLV_NRD_NRD_1	482	484	PF00675	0.410
CLV_NRD_NRD_1	610	612	PF00675	0.429
CLV_PCSK_FUR_1	348	352	PF00082	0.524
CLV_PCSK_KEX2_1	3	5	PF00082	0.649
CLV_PCSK_KEX2_1	350	352	PF00082	0.524
CLV_PCSK_KEX2_1	495	497	PF00082	0.640
CLV_PCSK_KEX2_1	499	501	PF00082	0.617
CLV_PCSK_KEX2_1	610	612	PF00082	0.546
CLV_PCSK_PC1ET2_1	495	497	PF00082	0.640
CLV_PCSK_PC1ET2_1	499	501	PF00082	0.617
CLV_PCSK_SKI1_1	22	26	PF00082	0.605
CLV_PCSK_SKI1_1	315	319	PF00082	0.415
CLV_PCSK_SKI1_1	390	394	PF00082	0.492
CLV_PCSK_SKI1_1	483	487	PF00082	0.535
CLV_PCSK_SKI1_1	530	534	PF00082	0.492
DEG_APCC_DBOX_1	389	397	PF00400	0.492
DEG_APCC_DBOX_1	534	542	PF00400	0.468
DEG_Nend_Nbox_1	1	3	PF02207	0.663
DOC_CKS1_1	101	106	PF01111	0.470
DOC_CKS1_1	421	426	PF01111	0.410
DOC_PP1_RVXF_1	29	36	PF00149	0.418
DOC_PP4_FxxP_1	259	262	PF00568	0.397
DOC_PP4_FxxP_1	421	424	PF00568	0.410
DOC_USP7_MATH_1	20	24	PF00917	0.676
DOC_USP7_MATH_1	209	213	PF00917	0.541
DOC_USP7_MATH_1	547	551	PF00917	0.542
DOC_USP7_MATH_1	55	59	PF00917	0.773
DOC_USP7_MATH_1	9	13	PF00917	0.717
DOC_USP7_UBL2_3	286	290	PF12436	0.426
DOC_USP7_UBL2_3	48	52	PF12436	0.635
DOC_USP7_UBL2_3	495	499	PF12436	0.645
DOC_WW_Pin1_4	100	105	PF00397	0.477
DOC_WW_Pin1_4	420	425	PF00397	0.410
LIG_14-3-3_CanoR_1	164	170	PF00244	0.448
LIG_14-3-3_CanoR_1	22	27	PF00244	0.521
LIG_14-3-3_CanoR_1	245	251	PF00244	0.507
LIG_14-3-3_CanoR_1	350	354	PF00244	0.492
LIG_14-3-3_CanoR_1	530	539	PF00244	0.450
LIG_BIR_III_4	583	587	PF00653	0.546
LIG_BRCT_BRCA1_1	135	139	PF00533	0.426
LIG_BRCT_BRCA1_1	550	554	PF00533	0.492
LIG_CaM_IQ_9	522	537	PF13499	0.410
LIG_FHA_1	16	22	PF00498	0.575
LIG_FHA_1	188	194	PF00498	0.465
LIG_FHA_1	233	239	PF00498	0.438
LIG_FHA_1	251	257	PF00498	0.277
LIG_FHA_1	292	298	PF00498	0.444
LIG_FHA_1	470	476	PF00498	0.402
LIG_FHA_1	510	516	PF00498	0.546
LIG_FHA_1	531	537	PF00498	0.492
LIG_FHA_1	598	604	PF00498	0.492
LIG_FHA_1	61	67	PF00498	0.559
LIG_FHA_2	138	144	PF00498	0.465
LIG_FHA_2	205	211	PF00498	0.410
LIG_FHA_2	465	471	PF00498	0.410
LIG_FHA_2	588	594	PF00498	0.482
LIG_LIR_Apic_2	257	262	PF02991	0.397
LIG_LIR_Apic_2	418	424	PF02991	0.410
LIG_LIR_Gen_1	109	116	PF02991	0.513
LIG_LIR_Gen_1	558	568	PF02991	0.426
LIG_LIR_Gen_1	596	606	PF02991	0.482
LIG_LIR_Nem_3	109	114	PF02991	0.374
LIG_LIR_Nem_3	153	158	PF02991	0.444
LIG_LIR_Nem_3	38	44	PF02991	0.453
LIG_LIR_Nem_3	45	50	PF02991	0.487
LIG_LIR_Nem_3	551	557	PF02991	0.436
LIG_LIR_Nem_3	558	563	PF02991	0.387
LIG_LIR_Nem_3	596	602	PF02991	0.495
LIG_LIR_Nem_3	81	86	PF02991	0.540
LIG_Rb_pABgroove_1	38	46	PF01858	0.543
LIG_SH2_CRK	111	115	PF00017	0.465
LIG_SH2_CRK	155	159	PF00017	0.519
LIG_SH2_CRK	422	426	PF00017	0.397
LIG_SH2_CRK	47	51	PF00017	0.552
LIG_SH2_CRK	560	564	PF00017	0.524
LIG_SH2_NCK_1	37	41	PF00017	0.547
LIG_SH2_NCK_1	422	426	PF00017	0.409
LIG_SH2_SRC	305	308	PF00017	0.458
LIG_SH2_SRC	37	40	PF00017	0.566
LIG_SH2_STAP1	37	41	PF00017	0.542
LIG_SH2_STAT3	128	131	PF00017	0.444
LIG_SH2_STAT3	518	521	PF00017	0.524
LIG_SH2_STAT5	178	181	PF00017	0.410
LIG_SH2_STAT5	305	308	PF00017	0.445
LIG_SH2_STAT5	422	425	PF00017	0.410
LIG_SH2_STAT5	450	453	PF00017	0.426
LIG_SH2_STAT5	557	560	PF00017	0.436
LIG_SH2_STAT5	597	600	PF00017	0.477
LIG_SH3_3	98	104	PF00018	0.479
LIG_TYR_ITIM	563	568	PF00017	0.397
LIG_UBA3_1	538	542	PF00899	0.546
LIG_WRC_WIRS_1	317	322	PF05994	0.410
MOD_CDK_SPxxK_3	420	427	PF00069	0.410
MOD_CK1_1	153	159	PF00069	0.521
MOD_CK1_1	168	174	PF00069	0.518
MOD_CK1_1	249	255	PF00069	0.426
MOD_CK1_1	60	66	PF00069	0.677
MOD_CK1_1	88	94	PF00069	0.578
MOD_CK2_1	137	143	PF00069	0.490
MOD_CK2_1	204	210	PF00069	0.407
MOD_CK2_1	464	470	PF00069	0.410
MOD_CK2_1	86	92	PF00069	0.529
MOD_Cter_Amidation	481	484	PF01082	0.426
MOD_Cter_Amidation	497	500	PF01082	0.503
MOD_GlcNHglycan	155	158	PF01048	0.481
MOD_GlcNHglycan	183	186	PF01048	0.412
MOD_GlcNHglycan	187	190	PF01048	0.444
MOD_GlcNHglycan	210	214	PF01048	0.530
MOD_GlcNHglycan	227	230	PF01048	0.424
MOD_GlcNHglycan	309	313	PF01048	0.556
MOD_GlcNHglycan	7	10	PF01048	0.686
MOD_GSK3_1	133	140	PF00069	0.446
MOD_GSK3_1	181	188	PF00069	0.417
MOD_GSK3_1	200	207	PF00069	0.274
MOD_GSK3_1	214	221	PF00069	0.369
MOD_GSK3_1	246	253	PF00069	0.400
MOD_GSK3_1	291	298	PF00069	0.424
MOD_GSK3_1	460	467	PF00069	0.451
MOD_GSK3_1	5	12	PF00069	0.696
MOD_GSK3_1	555	562	PF00069	0.542
MOD_GSK3_1	587	594	PF00069	0.492
MOD_N-GLC_1	99	104	PF02516	0.557
MOD_NEK2_1	144	149	PF00069	0.403
MOD_NEK2_1	299	304	PF00069	0.463
MOD_NEK2_1	460	465	PF00069	0.485
MOD_NEK2_1	509	514	PF00069	0.448
MOD_NEK2_1	555	560	PF00069	0.426
MOD_NEK2_1	587	592	PF00069	0.478
MOD_NEK2_1	71	76	PF00069	0.513
MOD_NEK2_2	150	155	PF00069	0.528
MOD_NEK2_2	295	300	PF00069	0.429
MOD_NEK2_2	78	83	PF00069	0.528
MOD_PIKK_1	200	206	PF00454	0.546
MOD_PKA_1	499	505	PF00069	0.613
MOD_PKA_2	218	224	PF00069	0.462
MOD_PKA_2	349	355	PF00069	0.410
MOD_PKA_2	460	466	PF00069	0.450
MOD_PKA_2	499	505	PF00069	0.571
MOD_Plk_1	200	206	PF00069	0.546
MOD_Plk_2-3	268	274	PF00069	0.542
MOD_Plk_4	254	260	PF00069	0.449
MOD_Plk_4	464	470	PF00069	0.410
MOD_Plk_4	57	63	PF00069	0.640
MOD_Plk_4	78	84	PF00069	0.482
MOD_ProDKin_1	100	106	PF00069	0.477
MOD_ProDKin_1	420	426	PF00069	0.410
MOD_SUMO_rev_2	210	217	PF00179	0.448
MOD_SUMO_rev_2	279	287	PF00179	0.512
TRG_DiLeu_BaEn_4	72	78	PF01217	0.496
TRG_DiLeu_BaLyEn_6	395	400	PF01217	0.439
TRG_DiLeu_BaLyEn_6	437	442	PF01217	0.546
TRG_ENDOCYTIC_2	111	114	PF00928	0.426
TRG_ENDOCYTIC_2	155	158	PF00928	0.410
TRG_ENDOCYTIC_2	37	40	PF00928	0.484
TRG_ENDOCYTIC_2	422	425	PF00928	0.397
TRG_ENDOCYTIC_2	47	50	PF00928	0.443
TRG_ENDOCYTIC_2	560	563	PF00928	0.397
TRG_ENDOCYTIC_2	565	568	PF00928	0.397
TRG_ER_diArg_1	2	4	PF00400	0.651
TRG_ER_diArg_1	28	31	PF00400	0.477
TRG_ER_diArg_1	610	612	PF00400	0.429
TRG_Pf-PMV_PEXEL_1	22	27	PF00026	0.600
TRG_Pf-PMV_PEXEL_1	390	395	PF00026	0.442

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3D6	Leptomonas seymouri	76%	99%
A0A0S4IUT5	Bodo saltans	63%	87%
A0A0S4JQE6	Bodo saltans	53%	97%
A0A1X0NQM6	Trypanosomatidae	65%	100%
A0A1X0P5J1	Trypanosomatidae	25%	100%
A0A3S5H5T1	Leishmania donovani	26%	100%
A0A422NKY7	Trypanosoma rangeli	61%	100%
A4H4Q0	Leishmania braziliensis	27%	100%
A4H4Q2	Leishmania braziliensis	27%	100%
A4HGV3	Leishmania braziliensis	89%	100%
A4HMU0	Leishmania braziliensis	25%	100%
A4HSY0	Leishmania infantum	26%	100%
A4I3Y3	Leishmania infantum	100%	100%
D0A954	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AKW6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9B073	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O53666	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	31%	100%
P15650	Rattus norvegicus	26%	100%
Q0AVA8	Syntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen)	29%	100%
Q0AVM4	Syntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen)	32%	100%
Q3L887	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)	31%	100%
Q4Q812	Leishmania major	97%	100%
Q4QIY9	Leishmania major	26%	100%
Q5LLW7	Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3)	38%	100%
V5DCV2	Trypanosoma cruzi	63%	100%