Rhodanese domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

selenoprotein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IIB2_LEIDO

TriTrypDb:

LdBPK_341000.1 , LdCL_340015500 , LDHU3_34.1570

Length:

901

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IIB2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IIB2

Function

Biological processes
Term	Name	Level	Count
GO:0006518	peptide metabolic process	4	1
GO:0006575	cellular modified amino acid metabolic process	3	1
GO:0006749	glutathione metabolic process	4	1
GO:0006790	sulfur compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0043603	amide metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0070813	hydrogen sulfide metabolic process	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016491	oxidoreductase activity	2	1
GO:0016701	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	3	1
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	4	1
GO:0050313	sulfur dioxygenase activity	5	1
GO:0051213	dioxygenase activity	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	604	608	PF00656	0.397
CLV_C14_Caspase3-7	683	687	PF00656	0.346
CLV_NRD_NRD_1	192	194	PF00675	0.637
CLV_NRD_NRD_1	523	525	PF00675	0.592
CLV_NRD_NRD_1	590	592	PF00675	0.452
CLV_NRD_NRD_1	62	64	PF00675	0.459
CLV_NRD_NRD_1	634	636	PF00675	0.452
CLV_NRD_NRD_1	665	667	PF00675	0.380
CLV_NRD_NRD_1	867	869	PF00675	0.491
CLV_PCSK_FUR_1	60	64	PF00082	0.573
CLV_PCSK_KEX2_1	192	194	PF00082	0.637
CLV_PCSK_KEX2_1	523	525	PF00082	0.517
CLV_PCSK_KEX2_1	590	592	PF00082	0.452
CLV_PCSK_KEX2_1	62	64	PF00082	0.459
CLV_PCSK_KEX2_1	634	636	PF00082	0.452
CLV_PCSK_KEX2_1	665	667	PF00082	0.374
CLV_PCSK_SKI1_1	417	421	PF00082	0.291
CLV_PCSK_SKI1_1	440	444	PF00082	0.711
CLV_PCSK_SKI1_1	543	547	PF00082	0.338
CLV_PCSK_SKI1_1	55	59	PF00082	0.563
CLV_PCSK_SKI1_1	727	731	PF00082	0.441
CLV_PCSK_SKI1_1	73	77	PF00082	0.380
CLV_PCSK_SKI1_1	756	760	PF00082	0.425
DEG_APCC_DBOX_1	330	338	PF00400	0.310
DEG_APCC_DBOX_1	542	550	PF00400	0.435
DEG_APCC_DBOX_1	885	893	PF00400	0.342
DEG_COP1_1	385	392	PF00400	0.502
DEG_Nend_Nbox_1	1	3	PF02207	0.532
DEG_SPOP_SBC_1	216	220	PF00917	0.412
DOC_CDC14_PxL_1	36	44	PF14671	0.502
DOC_CKS1_1	761	766	PF01111	0.409
DOC_CYCLIN_RxL_1	412	421	PF00134	0.296
DOC_CYCLIN_yCln2_LP_2	241	247	PF00134	0.280
DOC_MAPK_gen_1	331	339	PF00069	0.294
DOC_MAPK_gen_1	634	640	PF00069	0.278
DOC_MAPK_gen_1	893	900	PF00069	0.501
DOC_MIT_MIM_1	662	670	PF04212	0.287
DOC_PP1_RVXF_1	725	732	PF00149	0.314
DOC_PP4_FxxP_1	112	115	PF00568	0.569
DOC_USP7_MATH_1	126	130	PF00917	0.655
DOC_USP7_MATH_1	247	251	PF00917	0.373
DOC_USP7_MATH_1	429	433	PF00917	0.562
DOC_USP7_MATH_1	441	445	PF00917	0.566
DOC_USP7_MATH_1	517	521	PF00917	0.275
DOC_USP7_MATH_1	577	581	PF00917	0.545
DOC_USP7_MATH_1	692	696	PF00917	0.625
DOC_USP7_MATH_2	213	219	PF00917	0.460
DOC_WW_Pin1_4	1	6	PF00397	0.507
DOC_WW_Pin1_4	209	214	PF00397	0.517
DOC_WW_Pin1_4	27	32	PF00397	0.532
DOC_WW_Pin1_4	326	331	PF00397	0.357
DOC_WW_Pin1_4	340	345	PF00397	0.220
DOC_WW_Pin1_4	422	427	PF00397	0.430
DOC_WW_Pin1_4	668	673	PF00397	0.320
DOC_WW_Pin1_4	760	765	PF00397	0.367
DOC_WW_Pin1_4	803	808	PF00397	0.297
DOC_WW_Pin1_4	861	866	PF00397	0.334
LIG_14-3-3_CanoR_1	235	240	PF00244	0.260
LIG_14-3-3_CanoR_1	278	284	PF00244	0.431
LIG_14-3-3_CanoR_1	333	338	PF00244	0.414
LIG_14-3-3_CanoR_1	554	562	PF00244	0.396
LIG_14-3-3_CanoR_1	570	574	PF00244	0.421
LIG_14-3-3_CanoR_1	591	597	PF00244	0.537
LIG_14-3-3_CanoR_1	665	672	PF00244	0.453
LIG_14-3-3_CanoR_1	73	79	PF00244	0.446
LIG_AP2alpha_2	243	245	PF02296	0.335
LIG_BIR_III_2	369	373	PF00653	0.303
LIG_EVH1_1	525	529	PF00568	0.499
LIG_FHA_1	146	152	PF00498	0.729
LIG_FHA_1	172	178	PF00498	0.662
LIG_FHA_1	321	327	PF00498	0.445
LIG_FHA_1	334	340	PF00498	0.372
LIG_FHA_1	360	366	PF00498	0.249
LIG_FHA_1	384	390	PF00498	0.723
LIG_FHA_1	482	488	PF00498	0.309
LIG_FHA_1	534	540	PF00498	0.317
LIG_FHA_1	56	62	PF00498	0.416
LIG_FHA_1	753	759	PF00498	0.337
LIG_FHA_1	817	823	PF00498	0.361
LIG_FHA_2	147	153	PF00498	0.501
LIG_FHA_2	180	186	PF00498	0.576
LIG_FHA_2	320	326	PF00498	0.417
LIG_FHA_2	511	517	PF00498	0.379
LIG_FHA_2	678	684	PF00498	0.314
LIG_FHA_2	700	706	PF00498	0.506
LIG_FHA_2	740	746	PF00498	0.477
LIG_FHA_2	761	767	PF00498	0.322
LIG_HP1_1	649	653	PF01393	0.271
LIG_LIR_Apic_2	421	426	PF02991	0.332
LIG_LIR_Gen_1	350	360	PF02991	0.254
LIG_LIR_Gen_1	597	605	PF02991	0.409
LIG_LIR_Gen_1	610	619	PF02991	0.416
LIG_LIR_Gen_1	742	752	PF02991	0.386
LIG_LIR_Gen_1	811	821	PF02991	0.251
LIG_LIR_Nem_3	195	200	PF02991	0.406
LIG_LIR_Nem_3	35	41	PF02991	0.478
LIG_LIR_Nem_3	421	427	PF02991	0.297
LIG_LIR_Nem_3	488	494	PF02991	0.371
LIG_LIR_Nem_3	516	521	PF02991	0.361
LIG_LIR_Nem_3	595	599	PF02991	0.484
LIG_LIR_Nem_3	610	614	PF02991	0.353
LIG_LIR_Nem_3	625	629	PF02991	0.396
LIG_LIR_Nem_3	705	711	PF02991	0.351
LIG_LIR_Nem_3	742	747	PF02991	0.392
LIG_LIR_Nem_3	811	816	PF02991	0.385
LIG_LIR_Nem_3	864	870	PF02991	0.329
LIG_LYPXL_S_1	38	42	PF13949	0.509
LIG_LYPXL_yS_3	39	42	PF13949	0.733
LIG_MAD2	756	764	PF02301	0.327
LIG_MYND_1	390	394	PF01753	0.778
LIG_NRBOX	541	547	PF00104	0.426
LIG_PCNA_yPIPBox_3	62	76	PF02747	0.456
LIG_Pex14_2	420	424	PF04695	0.409
LIG_SH2_CRK	200	204	PF00017	0.414
LIG_SH2_CRK	480	484	PF00017	0.313
LIG_SH2_CRK	611	615	PF00017	0.408
LIG_SH2_CRK	68	72	PF00017	0.415
LIG_SH2_CRK	846	850	PF00017	0.265
LIG_SH2_GRB2like	229	232	PF00017	0.447
LIG_SH2_GRB2like	599	602	PF00017	0.283
LIG_SH2_NCK_1	246	250	PF00017	0.419
LIG_SH2_NCK_1	480	484	PF00017	0.313
LIG_SH2_PTP2	599	602	PF00017	0.266
LIG_SH2_PTP2	813	816	PF00017	0.250
LIG_SH2_SRC	292	295	PF00017	0.392
LIG_SH2_STAP1	272	276	PF00017	0.307
LIG_SH2_STAT3	132	135	PF00017	0.506
LIG_SH2_STAT3	9	12	PF00017	0.547
LIG_SH2_STAT5	147	150	PF00017	0.502
LIG_SH2_STAT5	229	232	PF00017	0.314
LIG_SH2_STAT5	292	295	PF00017	0.273
LIG_SH2_STAT5	352	355	PF00017	0.428
LIG_SH2_STAT5	418	421	PF00017	0.294
LIG_SH2_STAT5	423	426	PF00017	0.258
LIG_SH2_STAT5	494	497	PF00017	0.281
LIG_SH2_STAT5	599	602	PF00017	0.454
LIG_SH2_STAT5	813	816	PF00017	0.460
LIG_SH2_STAT5	841	844	PF00017	0.353
LIG_SH3_1	523	529	PF00018	0.420
LIG_SH3_3	154	160	PF00018	0.589
LIG_SH3_3	313	319	PF00018	0.386
LIG_SH3_3	334	340	PF00018	0.289
LIG_SH3_3	34	40	PF00018	0.576
LIG_SH3_3	387	393	PF00018	0.663
LIG_SH3_3	428	434	PF00018	0.572
LIG_SH3_3	469	475	PF00018	0.330
LIG_SH3_3	523	529	PF00018	0.375
LIG_SH3_3	617	623	PF00018	0.254
LIG_SH3_3	640	646	PF00018	0.283
LIG_SH3_3	720	726	PF00018	0.325
LIG_SH3_3	758	764	PF00018	0.368
LIG_SUMO_SIM_anti_2	469	476	PF11976	0.304
LIG_SUMO_SIM_par_1	39	44	PF11976	0.486
LIG_SUMO_SIM_par_1	469	476	PF11976	0.337
LIG_SUMO_SIM_par_1	601	607	PF11976	0.275
LIG_SUMO_SIM_par_1	757	763	PF11976	0.310
LIG_SxIP_EBH_1	310	321	PF03271	0.292
LIG_TRAF2_1	10	13	PF00917	0.494
LIG_TRAF2_1	452	455	PF00917	0.468
LIG_TRAF2_1	655	658	PF00917	0.360
LIG_WRC_WIRS_1	593	598	PF05994	0.517
LIG_WW_2	526	529	PF00397	0.417
LIG_WW_3	690	694	PF00397	0.412
MOD_CDK_SPK_2	326	331	PF00069	0.401
MOD_CDK_SPK_2	803	808	PF00069	0.364
MOD_CDK_SPxK_1	27	33	PF00069	0.530
MOD_CDK_SPxxK_3	326	333	PF00069	0.331
MOD_CDK_SPxxK_3	668	675	PF00069	0.333
MOD_CDK_SPxxK_3	861	868	PF00069	0.327
MOD_CK1_1	145	151	PF00069	0.639
MOD_CK1_1	178	184	PF00069	0.582
MOD_CK1_1	234	240	PF00069	0.352
MOD_CK1_1	396	402	PF00069	0.458
MOD_CK1_1	432	438	PF00069	0.650
MOD_CK1_1	444	450	PF00069	0.699
MOD_CK1_1	533	539	PF00069	0.385
MOD_CK1_1	586	592	PF00069	0.483
MOD_CK1_1	595	601	PF00069	0.278
MOD_CK1_1	668	674	PF00069	0.402
MOD_CK1_1	873	879	PF00069	0.285
MOD_CK2_1	146	152	PF00069	0.506
MOD_CK2_1	209	215	PF00069	0.517
MOD_CK2_1	427	433	PF00069	0.567
MOD_CK2_1	510	516	PF00069	0.326
MOD_CK2_1	699	705	PF00069	0.542
MOD_CK2_1	739	745	PF00069	0.500
MOD_CK2_1	760	766	PF00069	0.317
MOD_GlcNHglycan	15	18	PF01048	0.653
MOD_GlcNHglycan	160	163	PF01048	0.618
MOD_GlcNHglycan	177	180	PF01048	0.541
MOD_GlcNHglycan	219	222	PF01048	0.539
MOD_GlcNHglycan	247	250	PF01048	0.563
MOD_GlcNHglycan	296	299	PF01048	0.353
MOD_GlcNHglycan	312	315	PF01048	0.225
MOD_GlcNHglycan	379	382	PF01048	0.531
MOD_GlcNHglycan	400	403	PF01048	0.525
MOD_GlcNHglycan	437	440	PF01048	0.631
MOD_GlcNHglycan	443	446	PF01048	0.609
MOD_GlcNHglycan	574	578	PF01048	0.530
MOD_GlcNHglycan	579	582	PF01048	0.528
MOD_GlcNHglycan	667	670	PF01048	0.330
MOD_GlcNHglycan	719	722	PF01048	0.453
MOD_GlcNHglycan	860	864	PF01048	0.545
MOD_GlcNHglycan	875	878	PF01048	0.378
MOD_GlcNHglycan	91	95	PF01048	0.623
MOD_GSK3_1	142	149	PF00069	0.606
MOD_GSK3_1	171	178	PF00069	0.706
MOD_GSK3_1	205	212	PF00069	0.549
MOD_GSK3_1	231	238	PF00069	0.293
MOD_GSK3_1	388	395	PF00069	0.526
MOD_GSK3_1	530	537	PF00069	0.561
MOD_GSK3_1	569	576	PF00069	0.453
MOD_GSK3_1	661	668	PF00069	0.489
MOD_GSK3_1	74	81	PF00069	0.593
MOD_GSK3_1	768	775	PF00069	0.320
MOD_GSK3_1	792	799	PF00069	0.466
MOD_GSK3_1	816	823	PF00069	0.242
MOD_GSK3_1	845	852	PF00069	0.321
MOD_N-GLC_1	209	214	PF02516	0.614
MOD_N-GLC_1	481	486	PF02516	0.302
MOD_N-GLC_1	586	591	PF02516	0.609
MOD_N-GLC_1	739	744	PF02516	0.368
MOD_N-GLC_1	768	773	PF02516	0.312
MOD_N-GLC_1	873	878	PF02516	0.304
MOD_NEK2_1	205	210	PF00069	0.476
MOD_NEK2_1	245	250	PF00069	0.411
MOD_NEK2_1	302	307	PF00069	0.467
MOD_NEK2_1	377	382	PF00069	0.422
MOD_NEK2_1	427	432	PF00069	0.622
MOD_NEK2_1	501	506	PF00069	0.348
MOD_NEK2_1	534	539	PF00069	0.338
MOD_NEK2_1	78	83	PF00069	0.488
MOD_NEK2_1	849	854	PF00069	0.410
MOD_NEK2_1	870	875	PF00069	0.290
MOD_PIKK_1	482	488	PF00454	0.316
MOD_PIKK_1	55	61	PF00454	0.556
MOD_PIKK_1	796	802	PF00454	0.419
MOD_PIKK_1	8	14	PF00454	0.547
MOD_PIKK_1	881	887	PF00454	0.462
MOD_PK_1	893	899	PF00069	0.407
MOD_PKA_1	665	671	PF00069	0.455
MOD_PKA_2	234	240	PF00069	0.313
MOD_PKA_2	383	389	PF00069	0.627
MOD_PKA_2	435	441	PF00069	0.555
MOD_PKA_2	553	559	PF00069	0.418
MOD_PKA_2	569	575	PF00069	0.412
MOD_PKA_2	665	671	PF00069	0.455
MOD_PKA_2	692	698	PF00069	0.607
MOD_PKB_1	331	339	PF00069	0.294
MOD_Plk_1	274	280	PF00069	0.348
MOD_Plk_1	459	465	PF00069	0.399
MOD_Plk_1	496	502	PF00069	0.312
MOD_Plk_1	534	540	PF00069	0.437
MOD_Plk_1	739	745	PF00069	0.508
MOD_Plk_1	831	837	PF00069	0.468
MOD_Plk_1	893	899	PF00069	0.407
MOD_Plk_2-3	459	465	PF00069	0.399
MOD_Plk_4	235	241	PF00069	0.269
MOD_Plk_4	595	601	PF00069	0.390
MOD_Plk_4	850	856	PF00069	0.242
MOD_ProDKin_1	1	7	PF00069	0.507
MOD_ProDKin_1	209	215	PF00069	0.522
MOD_ProDKin_1	27	33	PF00069	0.530
MOD_ProDKin_1	326	332	PF00069	0.351
MOD_ProDKin_1	340	346	PF00069	0.216
MOD_ProDKin_1	422	428	PF00069	0.435
MOD_ProDKin_1	668	674	PF00069	0.317
MOD_ProDKin_1	760	766	PF00069	0.368
MOD_ProDKin_1	803	809	PF00069	0.289
MOD_ProDKin_1	861	867	PF00069	0.328
TRG_DiLeu_BaEn_1	469	474	PF01217	0.338
TRG_DiLeu_BaLyEn_6	67	72	PF01217	0.507
TRG_ENDOCYTIC_2	200	203	PF00928	0.412
TRG_ENDOCYTIC_2	39	42	PF00928	0.733
TRG_ENDOCYTIC_2	480	483	PF00928	0.312
TRG_ENDOCYTIC_2	490	493	PF00928	0.320
TRG_ENDOCYTIC_2	599	602	PF00928	0.464
TRG_ENDOCYTIC_2	611	614	PF00928	0.324
TRG_ENDOCYTIC_2	68	71	PF00928	0.420
TRG_ENDOCYTIC_2	744	747	PF00928	0.396
TRG_ENDOCYTIC_2	813	816	PF00928	0.250
TRG_ENDOCYTIC_2	846	849	PF00928	0.270
TRG_ER_diArg_1	191	193	PF00400	0.633
TRG_ER_diArg_1	330	333	PF00400	0.456
TRG_ER_diArg_1	523	525	PF00400	0.525
TRG_ER_diArg_1	60	63	PF00400	0.432
TRG_ER_diArg_1	64	67	PF00400	0.447
TRG_ER_diArg_1	665	667	PF00400	0.355
TRG_Pf-PMV_PEXEL_1	796	800	PF00026	0.437

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4J479	Bodo saltans	26%	84%
A0A1X0P997	Trypanosomatidae	34%	100%
A0A422N289	Trypanosoma rangeli	37%	100%
A4I9Q2	Leishmania infantum	99%	100%
C6K3V6	Leptomonas seymouri	55%	93%
C9ZMY7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9B4R6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q3B0	Leishmania major	92%	100%
V5AUV4	Trypanosoma cruzi	34%	100%