LeishMANIAdb
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Major Facilitator Superfamily, putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Major Facilitator Superfamily, putative
Gene product:
major facilitator superfamily, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8IIA5_LEIDO
TriTrypDb:
LdBPK_342550.1 , LdCL_340033100 , LDHU3_34.4150
Length:
673

Annotations

LeishMANIAdb annotations

A family with high similarity to plant sugar transporters.. Might be an extensive family that already diverged in free-living Kinetoplastids

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 11
GO:0110165 cellular anatomical entity 1 11

Expansion

Sequence features

A0A3Q8IIA5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IIA5

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 11
GO:0022857 transmembrane transporter activity 2 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 229 231 PF00675 0.352
CLV_NRD_NRD_1 264 266 PF00675 0.479
CLV_NRD_NRD_1 410 412 PF00675 0.349
CLV_NRD_NRD_1 660 662 PF00675 0.388
CLV_PCSK_KEX2_1 229 231 PF00082 0.352
CLV_PCSK_KEX2_1 264 266 PF00082 0.445
CLV_PCSK_KEX2_1 409 411 PF00082 0.348
CLV_PCSK_KEX2_1 481 483 PF00082 0.275
CLV_PCSK_KEX2_1 660 662 PF00082 0.385
CLV_PCSK_PC1ET2_1 229 231 PF00082 0.352
CLV_PCSK_PC1ET2_1 481 483 PF00082 0.275
CLV_PCSK_SKI1_1 20 24 PF00082 0.348
CLV_PCSK_SKI1_1 264 268 PF00082 0.433
CLV_PCSK_SKI1_1 524 528 PF00082 0.373
CLV_Separin_Metazoa 10 14 PF03568 0.532
DEG_APCC_DBOX_1 158 166 PF00400 0.475
DEG_Nend_UBRbox_3 1 3 PF02207 0.563
DEG_SPOP_SBC_1 642 646 PF00917 0.632
DOC_CDC14_PxL_1 22 30 PF14671 0.563
DOC_CYCLIN_yCln2_LP_2 607 613 PF00134 0.585
DOC_MAPK_gen_1 159 167 PF00069 0.513
DOC_MAPK_MEF2A_6 107 115 PF00069 0.305
DOC_PP4_FxxP_1 23 26 PF00568 0.542
DOC_USP7_MATH_1 221 225 PF00917 0.490
DOC_USP7_MATH_1 323 327 PF00917 0.645
DOC_USP7_MATH_1 553 557 PF00917 0.310
DOC_USP7_MATH_1 619 623 PF00917 0.701
DOC_USP7_MATH_1 85 89 PF00917 0.288
DOC_WW_Pin1_4 278 283 PF00397 0.712
DOC_WW_Pin1_4 307 312 PF00397 0.666
DOC_WW_Pin1_4 630 635 PF00397 0.791
DOC_WW_Pin1_4 636 641 PF00397 0.833
LIG_14-3-3_CanoR_1 13 22 PF00244 0.594
LIG_14-3-3_CanoR_1 161 166 PF00244 0.483
LIG_14-3-3_CanoR_1 325 332 PF00244 0.693
LIG_14-3-3_CanoR_1 629 634 PF00244 0.652
LIG_14-3-3_CanoR_1 660 668 PF00244 0.629
LIG_Actin_WH2_2 139 157 PF00022 0.313
LIG_BIR_III_4 268 272 PF00653 0.674
LIG_BRCT_BRCA1_1 163 167 PF00533 0.475
LIG_BRCT_BRCA1_1 179 183 PF00533 0.313
LIG_BRCT_BRCA1_1 215 219 PF00533 0.369
LIG_CSL_BTD_1 54 57 PF09270 0.275
LIG_DLG_GKlike_1 161 169 PF00625 0.457
LIG_EH1_1 207 215 PF00400 0.313
LIG_eIF4E_1 442 448 PF01652 0.257
LIG_FHA_1 14 20 PF00498 0.581
LIG_FHA_1 200 206 PF00498 0.422
LIG_FHA_1 234 240 PF00498 0.562
LIG_FHA_1 256 262 PF00498 0.677
LIG_FHA_1 336 342 PF00498 0.649
LIG_FHA_1 368 374 PF00498 0.755
LIG_FHA_1 438 444 PF00498 0.288
LIG_FHA_1 455 461 PF00498 0.234
LIG_FHA_1 495 501 PF00498 0.325
LIG_FHA_1 529 535 PF00498 0.374
LIG_FHA_1 591 597 PF00498 0.324
LIG_FHA_1 626 632 PF00498 0.762
LIG_FHA_1 644 650 PF00498 0.653
LIG_FHA_1 654 660 PF00498 0.560
LIG_FHA_2 142 148 PF00498 0.373
LIG_FHA_2 391 397 PF00498 0.528
LIG_GBD_Chelix_1 430 438 PF00786 0.271
LIG_HCF-1_HBM_1 399 402 PF13415 0.524
LIG_LIR_Apic_2 21 26 PF02991 0.528
LIG_LIR_Gen_1 180 188 PF02991 0.287
LIG_LIR_Gen_1 216 226 PF02991 0.468
LIG_LIR_Gen_1 497 506 PF02991 0.503
LIG_LIR_Gen_1 513 523 PF02991 0.203
LIG_LIR_Gen_1 549 557 PF02991 0.446
LIG_LIR_Gen_1 585 596 PF02991 0.311
LIG_LIR_Nem_3 135 141 PF02991 0.400
LIG_LIR_Nem_3 180 186 PF02991 0.298
LIG_LIR_Nem_3 21 25 PF02991 0.557
LIG_LIR_Nem_3 216 222 PF02991 0.484
LIG_LIR_Nem_3 440 445 PF02991 0.298
LIG_LIR_Nem_3 497 501 PF02991 0.444
LIG_LIR_Nem_3 513 519 PF02991 0.200
LIG_LIR_Nem_3 52 58 PF02991 0.300
LIG_LIR_Nem_3 549 554 PF02991 0.446
LIG_LIR_Nem_3 585 591 PF02991 0.311
LIG_PCNA_PIPBox_1 8 17 PF02747 0.535
LIG_Pex14_2 215 219 PF04695 0.369
LIG_Pex14_2 582 586 PF04695 0.313
LIG_Pex14_2 587 591 PF04695 0.313
LIG_PTAP_UEV_1 251 256 PF05743 0.647
LIG_SH2_CRK 138 142 PF00017 0.343
LIG_SH2_CRK 483 487 PF00017 0.475
LIG_SH2_CRK 502 506 PF00017 0.313
LIG_SH2_CRK 614 618 PF00017 0.625
LIG_SH2_NCK_1 402 406 PF00017 0.541
LIG_SH2_SRC 185 188 PF00017 0.271
LIG_SH2_SRC 397 400 PF00017 0.548
LIG_SH2_SRC 402 405 PF00017 0.522
LIG_SH2_STAP1 15 19 PF00017 0.578
LIG_SH2_STAP1 163 167 PF00017 0.475
LIG_SH2_STAT5 15 18 PF00017 0.578
LIG_SH2_STAT5 185 188 PF00017 0.303
LIG_SH2_STAT5 397 400 PF00017 0.570
LIG_SH2_STAT5 442 445 PF00017 0.339
LIG_SH2_STAT5 521 524 PF00017 0.308
LIG_SH2_STAT5 60 63 PF00017 0.257
LIG_SH3_2 252 257 PF14604 0.651
LIG_SH3_3 217 223 PF00018 0.503
LIG_SH3_3 249 255 PF00018 0.642
LIG_SH3_3 635 641 PF00018 0.698
LIG_SH3_3 92 98 PF00018 0.457
LIG_SUMO_SIM_anti_2 236 243 PF11976 0.576
LIG_SUMO_SIM_anti_2 429 436 PF11976 0.313
LIG_SUMO_SIM_par_1 236 243 PF11976 0.631
LIG_SUMO_SIM_par_1 429 436 PF11976 0.403
LIG_SUMO_SIM_par_1 609 615 PF11976 0.626
LIG_TYR_ITIM 500 505 PF00017 0.313
LIG_UBA3_1 209 217 PF00899 0.282
LIG_UBA3_1 445 449 PF00899 0.275
LIG_UBA3_1 499 508 PF00899 0.288
LIG_UBA3_1 567 575 PF00899 0.288
LIG_WRC_WIRS_1 19 24 PF05994 0.536
LIG_WRC_WIRS_1 464 469 PF05994 0.229
LIG_WRC_WIRS_1 495 500 PF05994 0.288
LIG_WRC_WIRS_1 583 588 PF05994 0.313
MOD_CDC14_SPxK_1 633 636 PF00782 0.649
MOD_CDK_SPxK_1 630 636 PF00069 0.651
MOD_CK1_1 168 174 PF00069 0.295
MOD_CK1_1 288 294 PF00069 0.695
MOD_CK1_1 299 305 PF00069 0.651
MOD_CK1_1 312 318 PF00069 0.710
MOD_CK1_1 44 50 PF00069 0.299
MOD_CK1_1 454 460 PF00069 0.373
MOD_CK1_1 556 562 PF00069 0.309
MOD_CK1_1 632 638 PF00069 0.679
MOD_CK1_1 664 670 PF00069 0.627
MOD_CK2_1 141 147 PF00069 0.342
MOD_CK2_1 348 354 PF00069 0.682
MOD_CK2_1 390 396 PF00069 0.528
MOD_CK2_1 619 625 PF00069 0.676
MOD_Cter_Amidation 479 482 PF01082 0.275
MOD_GlcNHglycan 252 255 PF01048 0.540
MOD_GlcNHglycan 350 353 PF01048 0.490
MOD_GlcNHglycan 364 367 PF01048 0.564
MOD_GlcNHglycan 403 408 PF01048 0.353
MOD_GlcNHglycan 435 438 PF01048 0.313
MOD_GlcNHglycan 558 561 PF01048 0.311
MOD_GlcNHglycan 562 565 PF01048 0.289
MOD_GlcNHglycan 593 596 PF01048 0.313
MOD_GlcNHglycan 87 90 PF01048 0.377
MOD_GSK3_1 141 148 PF00069 0.366
MOD_GSK3_1 161 168 PF00069 0.380
MOD_GSK3_1 305 312 PF00069 0.720
MOD_GSK3_1 317 324 PF00069 0.646
MOD_GSK3_1 368 375 PF00069 0.712
MOD_GSK3_1 41 48 PF00069 0.288
MOD_GSK3_1 433 440 PF00069 0.313
MOD_GSK3_1 463 470 PF00069 0.344
MOD_GSK3_1 506 513 PF00069 0.352
MOD_GSK3_1 528 535 PF00069 0.262
MOD_GSK3_1 556 563 PF00069 0.302
MOD_GSK3_1 625 632 PF00069 0.753
MOD_N-GLC_1 141 146 PF02516 0.280
MOD_N-GLC_1 305 310 PF02516 0.464
MOD_N-GLC_1 451 456 PF02516 0.457
MOD_N-GLC_1 528 533 PF02516 0.262
MOD_N-GLC_1 63 68 PF02516 0.475
MOD_N-GLC_2 307 309 PF02516 0.427
MOD_NEK2_1 1 6 PF00069 0.586
MOD_NEK2_1 141 146 PF00069 0.329
MOD_NEK2_1 178 183 PF00069 0.365
MOD_NEK2_1 28 33 PF00069 0.589
MOD_NEK2_1 372 377 PF00069 0.639
MOD_NEK2_1 41 46 PF00069 0.345
MOD_NEK2_1 433 438 PF00069 0.234
MOD_NEK2_1 463 468 PF00069 0.319
MOD_NEK2_1 515 520 PF00069 0.297
MOD_NEK2_1 528 533 PF00069 0.293
MOD_NEK2_1 582 587 PF00069 0.313
MOD_NEK2_1 590 595 PF00069 0.313
MOD_NEK2_1 63 68 PF00069 0.409
MOD_NEK2_1 643 648 PF00069 0.657
MOD_NEK2_1 80 85 PF00069 0.434
MOD_NEK2_2 145 150 PF00069 0.475
MOD_NEK2_2 619 624 PF00069 0.620
MOD_PKA_1 264 270 PF00069 0.636
MOD_PKA_2 264 270 PF00069 0.636
MOD_PKA_2 324 330 PF00069 0.669
MOD_PKA_2 546 552 PF00069 0.475
MOD_PKB_1 159 167 PF00069 0.475
MOD_PKB_1 627 635 PF00069 0.653
MOD_Plk_1 141 147 PF00069 0.333
MOD_Plk_1 451 457 PF00069 0.257
MOD_Plk_1 528 534 PF00069 0.313
MOD_Plk_4 145 151 PF00069 0.518
MOD_Plk_4 178 184 PF00069 0.321
MOD_Plk_4 208 214 PF00069 0.430
MOD_Plk_4 309 315 PF00069 0.733
MOD_Plk_4 368 374 PF00069 0.787
MOD_Plk_4 379 385 PF00069 0.657
MOD_Plk_4 45 51 PF00069 0.362
MOD_Plk_4 463 469 PF00069 0.396
MOD_Plk_4 494 500 PF00069 0.365
MOD_Plk_4 98 104 PF00069 0.415
MOD_ProDKin_1 278 284 PF00069 0.713
MOD_ProDKin_1 307 313 PF00069 0.667
MOD_ProDKin_1 630 636 PF00069 0.791
TRG_ENDOCYTIC_2 138 141 PF00928 0.350
TRG_ENDOCYTIC_2 185 188 PF00928 0.302
TRG_ENDOCYTIC_2 442 445 PF00928 0.342
TRG_ENDOCYTIC_2 483 486 PF00928 0.472
TRG_ENDOCYTIC_2 502 505 PF00928 0.189
TRG_ENDOCYTIC_2 60 63 PF00928 0.257
TRG_ER_diArg_1 264 266 PF00400 0.649
TRG_ER_diArg_1 409 411 PF00400 0.551
TRG_ER_diArg_1 659 661 PF00400 0.587
TRG_Pf-PMV_PEXEL_1 536 541 PF00026 0.275

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I5K5 Leptomonas seymouri 56% 100%
A0A0S4JGY0 Bodo saltans 25% 100%
A0A3S7WTH9 Leishmania donovani 27% 100%
A4HWI5 Leishmania infantum 26% 100%
A4IA48 Leishmania infantum 100% 100%
E9AQ86 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
E9B562 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 100%
Q4Q2S3 Leishmania major 87% 100%
Q4QF97 Leishmania major 26% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS