NmrA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IIA0_LEIDO

TriTrypDb:

LdBPK_340800.1 , LdCL_340013500 , LDHU3_34.1290

Length:

469

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A0A3Q8IIA0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IIA0

Function

Biological processes
Term	Name	Level	Count
GO:0006091	generation of precursor metabolites and energy	3	1
GO:0006120	mitochondrial electron transport, NADH to ubiquinone	7	1
GO:0008152	metabolic process	1	1
GO:0009060	aerobic respiration	6	1
GO:0009987	cellular process	1	1
GO:0010257	NADH dehydrogenase complex assembly	6	1
GO:0015980	energy derivation by oxidation of organic compounds	4	1
GO:0016043	cellular component organization	3	1
GO:0019646	aerobic electron transport chain	6	1
GO:0022607	cellular component assembly	4	1
GO:0022900	electron transport chain	4	1
GO:0022904	respiratory electron transport chain	5	1
GO:0032981	mitochondrial respiratory chain complex I assembly	7	1
GO:0033108	mitochondrial respiratory chain complex assembly	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0044237	cellular metabolic process	2	1
GO:0045333	cellular respiration	5	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0051082	unfolded protein binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	452	456	PF00656	0.708
CLV_NRD_NRD_1	112	114	PF00675	0.488
CLV_NRD_NRD_1	171	173	PF00675	0.603
CLV_NRD_NRD_1	267	269	PF00675	0.574
CLV_NRD_NRD_1	280	282	PF00675	0.476
CLV_NRD_NRD_1	306	308	PF00675	0.497
CLV_PCSK_KEX2_1	112	114	PF00082	0.492
CLV_PCSK_KEX2_1	158	160	PF00082	0.641
CLV_PCSK_KEX2_1	171	173	PF00082	0.499
CLV_PCSK_KEX2_1	267	269	PF00082	0.576
CLV_PCSK_KEX2_1	280	282	PF00082	0.476
CLV_PCSK_KEX2_1	306	308	PF00082	0.498
CLV_PCSK_PC1ET2_1	158	160	PF00082	0.565
CLV_PCSK_SKI1_1	128	132	PF00082	0.460
CLV_PCSK_SKI1_1	159	163	PF00082	0.615
CLV_PCSK_SKI1_1	175	179	PF00082	0.397
CLV_PCSK_SKI1_1	203	207	PF00082	0.491
CLV_PCSK_SKI1_1	306	310	PF00082	0.515
DEG_APCC_DBOX_1	202	210	PF00400	0.567
DEG_APCC_DBOX_1	376	384	PF00400	0.491
DOC_CKS1_1	7	12	PF01111	0.667
DOC_CYCLIN_RxL_1	122	136	PF00134	0.536
DOC_MAPK_gen_1	112	119	PF00069	0.429
DOC_MAPK_gen_1	126	134	PF00069	0.439
DOC_MAPK_gen_1	371	378	PF00069	0.613
DOC_MAPK_gen_1	399	409	PF00069	0.631
DOC_MAPK_MEF2A_6	112	119	PF00069	0.429
DOC_MAPK_MEF2A_6	126	134	PF00069	0.439
DOC_PP1_RVXF_1	64	71	PF00149	0.653
DOC_PP2B_LxvP_1	130	133	PF13499	0.530
DOC_USP7_MATH_1	196	200	PF00917	0.694
DOC_USP7_MATH_1	335	339	PF00917	0.565
DOC_WW_Pin1_4	255	260	PF00397	0.629
DOC_WW_Pin1_4	287	292	PF00397	0.508
DOC_WW_Pin1_4	297	302	PF00397	0.527
DOC_WW_Pin1_4	329	334	PF00397	0.537
DOC_WW_Pin1_4	371	376	PF00397	0.578
DOC_WW_Pin1_4	6	11	PF00397	0.738
LIG_14-3-3_CanoR_1	112	118	PF00244	0.534
LIG_14-3-3_CanoR_1	143	148	PF00244	0.642
LIG_14-3-3_CanoR_1	183	189	PF00244	0.605
LIG_14-3-3_CanoR_1	224	229	PF00244	0.453
LIG_14-3-3_CanoR_1	249	259	PF00244	0.713
LIG_14-3-3_CanoR_1	306	312	PF00244	0.543
LIG_14-3-3_CanoR_1	336	340	PF00244	0.616
LIG_14-3-3_CanoR_1	358	368	PF00244	0.604
LIG_14-3-3_CanoR_1	377	381	PF00244	0.366
LIG_14-3-3_CanoR_1	382	389	PF00244	0.504
LIG_Actin_WH2_2	434	450	PF00022	0.671
LIG_Actin_WH2_2	99	114	PF00022	0.477
LIG_APCC_ABBA_1	30	35	PF00400	0.721
LIG_BIR_II_1	1	5	PF00653	0.725
LIG_BRCT_BRCA1_1	226	230	PF00533	0.479
LIG_CSL_BTD_1	256	259	PF09270	0.617
LIG_deltaCOP1_diTrp_1	352	357	PF00928	0.604
LIG_eIF4E_1	303	309	PF01652	0.572
LIG_FHA_1	160	166	PF00498	0.548
LIG_FHA_1	214	220	PF00498	0.573
LIG_FHA_1	90	96	PF00498	0.456
LIG_FHA_2	41	47	PF00498	0.611
LIG_FHA_2	7	13	PF00498	0.666
LIG_GBD_Chelix_1	228	236	PF00786	0.514
LIG_LIR_Apic_2	253	259	PF02991	0.612
LIG_LIR_Gen_1	283	294	PF02991	0.491
LIG_LIR_Gen_1	359	369	PF02991	0.481
LIG_LIR_Gen_1	461	469	PF02991	0.661
LIG_LIR_Nem_3	129	134	PF02991	0.536
LIG_LIR_Nem_3	146	152	PF02991	0.676
LIG_LIR_Nem_3	283	289	PF02991	0.489
LIG_LIR_Nem_3	359	364	PF02991	0.473
LIG_LIR_Nem_3	385	391	PF02991	0.630
LIG_LIR_Nem_3	461	466	PF02991	0.655
LIG_LYPXL_yS_3	57	60	PF13949	0.666
LIG_Pex14_1	357	361	PF04695	0.503
LIG_SH2_CRK	149	153	PF00017	0.727
LIG_SH2_CRK	305	309	PF00017	0.532
LIG_SH2_STAT5	110	113	PF00017	0.555
LIG_SH2_STAT5	231	234	PF00017	0.453
LIG_SH2_STAT5	29	32	PF00017	0.721
LIG_SH2_STAT5	315	318	PF00017	0.451
LIG_SH2_STAT5	69	72	PF00017	0.610
LIG_SH3_3	185	191	PF00018	0.637
LIG_SH3_3	383	389	PF00018	0.595
LIG_SH3_3	4	10	PF00018	0.740
LIG_SUMO_SIM_anti_2	116	121	PF11976	0.415
LIG_SUMO_SIM_anti_2	91	97	PF11976	0.466
LIG_TRAF2_1	235	238	PF00917	0.585
LIG_WRC_WIRS_1	388	393	PF05994	0.597
MOD_CDC14_SPxK_1	374	377	PF00782	0.592
MOD_CDK_SPxK_1	371	377	PF00069	0.574
MOD_CDK_SPxxK_3	329	336	PF00069	0.586
MOD_CK1_1	192	198	PF00069	0.722
MOD_CK1_1	258	264	PF00069	0.701
MOD_CK1_1	297	303	PF00069	0.516
MOD_CK1_1	359	365	PF00069	0.611
MOD_CK2_1	167	173	PF00069	0.581
MOD_CK2_1	387	393	PF00069	0.564
MOD_CK2_1	40	46	PF00069	0.598
MOD_CK2_1	432	438	PF00069	0.635
MOD_CMANNOS	353	356	PF00535	0.571
MOD_Cter_Amidation	265	268	PF01082	0.683
MOD_DYRK1A_RPxSP_1	6	10	PF00069	0.679
MOD_GlcNHglycan	152	155	PF01048	0.654
MOD_GlcNHglycan	191	194	PF01048	0.762
MOD_GlcNHglycan	237	242	PF01048	0.558
MOD_GlcNHglycan	252	255	PF01048	0.711
MOD_GlcNHglycan	264	267	PF01048	0.422
MOD_GlcNHglycan	329	332	PF01048	0.596
MOD_GSK3_1	192	199	PF00069	0.725
MOD_GSK3_1	258	265	PF00069	0.673
MOD_GSK3_1	325	332	PF00069	0.650
MOD_GSK3_1	432	439	PF00069	0.597
MOD_N-GLC_1	196	201	PF02516	0.626
MOD_NEK2_1	161	166	PF00069	0.644
MOD_NEK2_1	182	187	PF00069	0.496
MOD_NEK2_1	219	224	PF00069	0.516
MOD_NEK2_1	250	255	PF00069	0.688
MOD_NEK2_1	327	332	PF00069	0.564
MOD_NEK2_1	369	374	PF00069	0.568
MOD_NEK2_1	426	431	PF00069	0.528
MOD_NEK2_1	432	437	PF00069	0.557
MOD_NEK2_2	28	33	PF00069	0.684
MOD_PIKK_1	213	219	PF00454	0.509
MOD_PIKK_1	325	331	PF00454	0.604
MOD_PK_1	113	119	PF00069	0.479
MOD_PK_1	224	230	PF00069	0.489
MOD_PKA_2	167	173	PF00069	0.588
MOD_PKA_2	182	188	PF00069	0.357
MOD_PKA_2	248	254	PF00069	0.725
MOD_PKA_2	335	341	PF00069	0.628
MOD_PKA_2	359	365	PF00069	0.644
MOD_PKA_2	376	382	PF00069	0.362
MOD_Plk_1	219	225	PF00069	0.524
MOD_Plk_1	322	328	PF00069	0.566
MOD_Plk_4	115	121	PF00069	0.439
MOD_Plk_4	126	132	PF00069	0.380
MOD_Plk_4	224	230	PF00069	0.424
MOD_Plk_4	258	264	PF00069	0.664
MOD_Plk_4	322	328	PF00069	0.566
MOD_Plk_4	40	46	PF00069	0.683
MOD_Plk_4	432	438	PF00069	0.621
MOD_Plk_4	91	97	PF00069	0.468
MOD_ProDKin_1	255	261	PF00069	0.620
MOD_ProDKin_1	287	293	PF00069	0.509
MOD_ProDKin_1	297	303	PF00069	0.516
MOD_ProDKin_1	329	335	PF00069	0.536
MOD_ProDKin_1	371	377	PF00069	0.574
MOD_ProDKin_1	6	12	PF00069	0.734
TRG_DiLeu_BaEn_1	91	96	PF01217	0.541
TRG_DiLeu_BaLyEn_6	304	309	PF01217	0.544
TRG_DiLeu_BaLyEn_6	417	422	PF01217	0.615
TRG_DiLeu_BaLyEn_6	63	68	PF01217	0.656
TRG_ENDOCYTIC_2	149	152	PF00928	0.681
TRG_ENDOCYTIC_2	29	32	PF00928	0.607
TRG_ENDOCYTIC_2	305	308	PF00928	0.518
TRG_ENDOCYTIC_2	57	60	PF00928	0.666
TRG_ER_diArg_1	111	113	PF00400	0.485
TRG_ER_diArg_1	17	20	PF00400	0.655
TRG_ER_diArg_1	267	269	PF00400	0.574
TRG_ER_diArg_1	280	282	PF00400	0.476
TRG_ER_diArg_1	305	307	PF00400	0.503
TRG_ER_diArg_1	357	360	PF00400	0.621
TRG_NES_CRM1_1	442	455	PF08389	0.512

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZN2	Leptomonas seymouri	67%	98%
A0A0S4IVY0	Bodo saltans	24%	100%
A0A1X0P965	Trypanosomatidae	33%	100%
A4HAI5	Leishmania braziliensis	80%	100%
E9AHS6	Leishmania infantum	99%	100%
E9B4P6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q3D0	Leishmania major	94%	100%
V5BEX5	Trypanosoma cruzi	34%	100%