Membrane transporter protein, putative

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8II95_LEIDO

TriTrypDb:

LdBPK_353680.1 , LdCL_350041800 , LDHU3_35.4830

Length:

620

Annotations

LeishMANIAdb annotations

SLC47 family transporter, with potential detoxification functions

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 29
NetGPI	no	yes: 0, no: 29

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	30
GO:0110165	cellular anatomical entity	1	30

Expansion

Sequence features

A0A3Q8II95

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8II95

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0009987	cellular process	1	12
GO:0042908	xenobiotic transport	4	12
GO:0046618	xenobiotic export from cell	3	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0055085	transmembrane transport	2	12
GO:0140115	export across plasma membrane	3	12
GO:0140352	export from cell	2	12
GO:1990961	xenobiotic detoxification by transmembrane export across the plasma membrane	4	12

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	30
GO:0015291	secondary active transmembrane transporter activity	4	30
GO:0015297	antiporter activity	5	30
GO:0022804	active transmembrane transporter activity	3	30
GO:0022857	transmembrane transporter activity	2	30
GO:0042910	xenobiotic transmembrane transporter activity	3	30

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	437	441	PF00656	0.333
CLV_C14_Caspase3-7	5	9	PF00656	0.725
CLV_C14_Caspase3-7	55	59	PF00656	0.762
CLV_NRD_NRD_1	401	403	PF00675	0.270
CLV_NRD_NRD_1	47	49	PF00675	0.418
CLV_NRD_NRD_1	585	587	PF00675	0.541
CLV_PCSK_KEX2_1	155	157	PF00082	0.339
CLV_PCSK_KEX2_1	401	403	PF00082	0.241
CLV_PCSK_KEX2_1	47	49	PF00082	0.418
CLV_PCSK_KEX2_1	585	587	PF00082	0.546
CLV_PCSK_PC1ET2_1	155	157	PF00082	0.339
CLV_PCSK_SKI1_1	329	333	PF00082	0.396
CLV_PCSK_SKI1_1	396	400	PF00082	0.243
CLV_PCSK_SKI1_1	402	406	PF00082	0.250
CLV_PCSK_SKI1_1	531	535	PF00082	0.317
CLV_PCSK_SKI1_1	77	81	PF00082	0.272
DEG_COP1_1	592	602	PF00400	0.588
DOC_CKS1_1	520	525	PF01111	0.429
DOC_CYCLIN_RxL_1	103	111	PF00134	0.185
DOC_CYCLIN_yCln2_LP_2	253	259	PF00134	0.474
DOC_MAPK_DCC_7	586	596	PF00069	0.534
DOC_MAPK_gen_1	401	408	PF00069	0.446
DOC_MAPK_HePTP_8	398	410	PF00069	0.472
DOC_MAPK_MEF2A_6	188	195	PF00069	0.414
DOC_MAPK_MEF2A_6	401	410	PF00069	0.477
DOC_MAPK_MEF2A_6	447	454	PF00069	0.315
DOC_MAPK_MEF2A_6	477	485	PF00069	0.435
DOC_MAPK_NFAT4_5	188	196	PF00069	0.438
DOC_PIKK_1	10	18	PF02985	0.602
DOC_PP1_RVXF_1	308	314	PF00149	0.638
DOC_PP1_RVXF_1	399	406	PF00149	0.539
DOC_PP1_RVXF_1	529	536	PF00149	0.493
DOC_PP4_FxxP_1	233	236	PF00568	0.327
DOC_PP4_FxxP_1	424	427	PF00568	0.409
DOC_USP7_MATH_1	173	177	PF00917	0.502
DOC_USP7_MATH_1	214	218	PF00917	0.338
DOC_USP7_MATH_1	331	335	PF00917	0.293
DOC_USP7_MATH_1	375	379	PF00917	0.306
DOC_USP7_MATH_1	41	45	PF00917	0.682
DOC_USP7_MATH_1	572	576	PF00917	0.670
DOC_USP7_MATH_1	606	610	PF00917	0.726
DOC_WW_Pin1_4	281	286	PF00397	0.257
DOC_WW_Pin1_4	519	524	PF00397	0.429
DOC_WW_Pin1_4	575	580	PF00397	0.709
DOC_WW_Pin1_4	587	592	PF00397	0.681
LIG_14-3-3_CanoR_1	246	253	PF00244	0.492
LIG_Actin_WH2_2	288	306	PF00022	0.359
LIG_AP2alpha_1	458	462	PF02296	0.429
LIG_APCC_ABBA_1	538	543	PF00400	0.583
LIG_BIR_II_1	1	5	PF00653	0.760
LIG_BRCT_BRCA1_1	142	146	PF00533	0.470
LIG_CaM_IQ_9	238	253	PF13499	0.351
LIG_Clathr_ClatBox_1	107	111	PF01394	0.238
LIG_CORNRBOX	96	104	PF00104	0.168
LIG_FHA_1	252	258	PF00498	0.443
LIG_FHA_1	291	297	PF00498	0.330
LIG_FHA_1	362	368	PF00498	0.226
LIG_FHA_1	414	420	PF00498	0.296
LIG_FHA_1	434	440	PF00498	0.222
LIG_FHA_1	551	557	PF00498	0.727
LIG_FHA_1	65	71	PF00498	0.567
LIG_FHA_2	160	166	PF00498	0.535
LIG_FHA_2	167	173	PF00498	0.532
LIG_FHA_2	304	310	PF00498	0.598
LIG_FHA_2	354	360	PF00498	0.248
LIG_GBD_Chelix_1	295	303	PF00786	0.233
LIG_LIR_Gen_1	340	350	PF02991	0.232
LIG_LIR_Gen_1	448	459	PF02991	0.338
LIG_LIR_Gen_1	484	494	PF02991	0.402
LIG_LIR_Gen_1	495	504	PF02991	0.402
LIG_LIR_Gen_1	522	533	PF02991	0.325
LIG_LIR_Nem_3	143	149	PF02991	0.477
LIG_LIR_Nem_3	340	345	PF02991	0.252
LIG_LIR_Nem_3	484	490	PF02991	0.402
LIG_LIR_Nem_3	495	499	PF02991	0.367
LIG_LIR_Nem_3	522	528	PF02991	0.351
LIG_PCNA_PIPBox_1	73	82	PF02747	0.492
LIG_Pex14_1	510	514	PF04695	0.359
LIG_Pex14_2	202	206	PF04695	0.402
LIG_Pex14_2	275	279	PF04695	0.350
LIG_Pex14_2	370	374	PF04695	0.301
LIG_Pex14_2	424	428	PF04695	0.401
LIG_Pex14_2	458	462	PF04695	0.411
LIG_Pex14_2	496	500	PF04695	0.278
LIG_PTB_Apo_2	14	21	PF02174	0.722
LIG_REV1ctd_RIR_1	497	507	PF16727	0.387
LIG_SH2_PTP2	525	528	PF00017	0.284
LIG_SH2_SRC	525	528	PF00017	0.379
LIG_SH2_SRC	6	9	PF00017	0.593
LIG_SH2_STAP1	185	189	PF00017	0.398
LIG_SH2_STAP1	363	367	PF00017	0.339
LIG_SH2_STAT3	248	251	PF00017	0.441
LIG_SH2_STAT5	223	226	PF00017	0.267
LIG_SH2_STAT5	302	305	PF00017	0.382
LIG_SH2_STAT5	363	366	PF00017	0.317
LIG_SH2_STAT5	451	454	PF00017	0.319
LIG_SH2_STAT5	501	504	PF00017	0.304
LIG_SH2_STAT5	525	528	PF00017	0.282
LIG_SH2_STAT5	532	535	PF00017	0.483
LIG_SH3_3	263	269	PF00018	0.298
LIG_SH3_3	424	430	PF00018	0.288
LIG_SH3_3	449	455	PF00018	0.233
LIG_SH3_3	487	493	PF00018	0.288
LIG_SH3_3	517	523	PF00018	0.320
LIG_SH3_3	573	579	PF00018	0.581
LIG_SH3_3	585	591	PF00018	0.522
LIG_SH3_3	594	600	PF00018	0.569
LIG_SH3_3	613	619	PF00018	0.553
LIG_SH3_3	79	85	PF00018	0.478
LIG_Sin3_3	207	214	PF02671	0.214
LIG_SUMO_SIM_anti_2	190	195	PF11976	0.376
LIG_SUMO_SIM_anti_2	378	385	PF11976	0.362
LIG_SUMO_SIM_anti_2	416	421	PF11976	0.303
LIG_SUMO_SIM_anti_2	515	522	PF11976	0.416
LIG_SUMO_SIM_anti_2	592	598	PF11976	0.552
LIG_SUMO_SIM_par_1	190	197	PF11976	0.218
LIG_SUMO_SIM_par_1	257	263	PF11976	0.422
LIG_SUMO_SIM_par_1	84	90	PF11976	0.288
LIG_TRAF2_1	609	612	PF00917	0.731
LIG_UBA3_1	270	277	PF00899	0.362
LIG_UBA3_1	529	534	PF00899	0.509
LIG_WRC_WIRS_1	429	434	PF05994	0.323
MOD_CK1_1	19	25	PF00069	0.743
MOD_CK1_1	2	8	PF00069	0.735
MOD_CK1_1	575	581	PF00069	0.709
MOD_CK2_1	159	165	PF00069	0.535
MOD_CK2_1	166	172	PF00069	0.534
MOD_CK2_1	353	359	PF00069	0.246
MOD_CK2_1	601	607	PF00069	0.708
MOD_CMANNOS	227	230	PF00535	0.429
MOD_CMANNOS	313	316	PF00535	0.315
MOD_GlcNHglycan	216	219	PF01048	0.428
MOD_GlcNHglycan	26	29	PF01048	0.393
MOD_GlcNHglycan	262	265	PF01048	0.384
MOD_GlcNHglycan	377	380	PF01048	0.300
MOD_GSK3_1	19	26	PF00069	0.743
MOD_GSK3_1	2	9	PF00069	0.733
MOD_GSK3_1	555	562	PF00069	0.726
MOD_GSK3_1	606	613	PF00069	0.739
MOD_GSK3_1	64	71	PF00069	0.580
MOD_N-GLC_1	123	128	PF02516	0.273
MOD_N-GLC_1	16	21	PF02516	0.519
MOD_NEK2_1	142	147	PF00069	0.413
MOD_NEK2_1	194	199	PF00069	0.284
MOD_NEK2_1	303	308	PF00069	0.381
MOD_NEK2_1	381	386	PF00069	0.337
MOD_NEK2_1	462	467	PF00069	0.350
MOD_NEK2_1	548	553	PF00069	0.733
MOD_NEK2_1	86	91	PF00069	0.302
MOD_PIKK_1	606	612	PF00454	0.755
MOD_PKA_2	187	193	PF00069	0.503
MOD_PKA_2	303	309	PF00069	0.435
MOD_PKB_1	557	565	PF00069	0.600
MOD_Plk_1	16	22	PF00069	0.711
MOD_Plk_1	68	74	PF00069	0.532
MOD_Plk_2-3	69	75	PF00069	0.557
MOD_Plk_4	137	143	PF00069	0.283
MOD_Plk_4	187	193	PF00069	0.481
MOD_Plk_4	323	329	PF00069	0.512
MOD_Plk_4	382	388	PF00069	0.271
MOD_Plk_4	428	434	PF00069	0.271
MOD_Plk_4	462	468	PF00069	0.270
MOD_Plk_4	492	498	PF00069	0.339
MOD_ProDKin_1	281	287	PF00069	0.257
MOD_ProDKin_1	519	525	PF00069	0.429
MOD_ProDKin_1	575	581	PF00069	0.710
MOD_ProDKin_1	587	593	PF00069	0.679
MOD_SUMO_for_1	160	163	PF00179	0.491
MOD_SUMO_for_1	533	536	PF00179	0.566
MOD_SUMO_rev_2	152	157	PF00179	0.532
TRG_DiLeu_BaEn_4	152	158	PF01217	0.405
TRG_DiLeu_BaLyEn_6	103	108	PF01217	0.185
TRG_DiLeu_LyEn_5	394	399	PF01217	0.448
TRG_ENDOCYTIC_2	446	449	PF00928	0.243
TRG_ENDOCYTIC_2	451	454	PF00928	0.278
TRG_ENDOCYTIC_2	456	459	PF00928	0.293
TRG_ENDOCYTIC_2	501	504	PF00928	0.297
TRG_ENDOCYTIC_2	525	528	PF00928	0.290
TRG_ER_diArg_1	401	403	PF00400	0.448
TRG_ER_diArg_1	47	49	PF00400	0.631
TRG_ER_diArg_1	556	559	PF00400	0.681
TRG_ER_diArg_1	584	586	PF00400	0.753
TRG_Pf-PMV_PEXEL_1	106	111	PF00026	0.524

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P381	Leptomonas seymouri	21%	100%
A0A0N1I213	Leptomonas seymouri	69%	99%
A0A0N1I703	Leptomonas seymouri	23%	68%
A0A0N1IJ56	Leptomonas seymouri	40%	88%
A0A0N1ILQ1	Leptomonas seymouri	23%	100%
A0A0S4IHH9	Bodo saltans	33%	100%
A0A0S4INI5	Bodo saltans	37%	100%
A0A0S4JEP9	Bodo saltans	22%	100%
A0A0S4JTQ3	Bodo saltans	23%	100%
A0A0S4JV01	Bodo saltans	21%	100%
A0A0S4JV08	Bodo saltans	22%	100%
A0A0S4JVA6	Bodo saltans	23%	84%
A0A0S4JZ61	Bodo saltans	23%	91%
A0A1X0NM81	Trypanosomatidae	21%	100%
A0A1X0NU76	Trypanosomatidae	43%	100%
A0A1X0P579	Trypanosomatidae	52%	100%
A0A1X0P5F0	Trypanosomatidae	38%	100%
A0A1X0P8J4	Trypanosomatidae	20%	100%
A0A3Q8ID83	Leishmania donovani	22%	70%
A0A3Q8IGH9	Leishmania donovani	38%	100%
A0A3R7M3E2	Trypanosoma rangeli	43%	100%
A0A3R7NUJ8	Trypanosoma rangeli	52%	100%
A0A422NN08	Trypanosoma rangeli	22%	74%
A0A422NR58	Trypanosoma rangeli	37%	100%
A1L1P9	Danio rerio	26%	100%
A4HN33	Leishmania braziliensis	74%	100%
A4HN34	Leishmania braziliensis	78%	100%
A4IBQ2	Leishmania infantum	100%	100%
A4IIS8	Xenopus tropicalis	26%	100%
A7KAU2	Oryctolagus cuniculus	26%	100%
A7KAU3	Oryctolagus cuniculus	25%	100%
C9ZP79	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
C9ZP80	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
C9ZQ36	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
C9ZYX8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
C9ZYX9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
C9ZYY0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
C9ZYY1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
D0A551	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
E9AD56	Leishmania major	21%	70%
E9AFI2	Leishmania major	39%	100%
E9AFI7	Leishmania major	93%	100%
E9AHF1	Leishmania infantum	22%	70%
E9AHW7	Leishmania infantum	38%	100%
E9AYY1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	20%	70%
E9B6N7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9B6P2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
F4HPH2	Arabidopsis thaliana	24%	100%
F4HQ05	Arabidopsis thaliana	24%	100%
F4HZH9	Arabidopsis thaliana	23%	100%
F4I4Q3	Arabidopsis thaliana	23%	100%
F4IHU9	Arabidopsis thaliana	26%	100%
F4JH46	Arabidopsis thaliana	24%	100%
F4JTB3	Arabidopsis thaliana	21%	100%
O49660	Arabidopsis thaliana	21%	100%
O82752	Arabidopsis thaliana	25%	100%
P38767	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
P45272	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	24%	100%
Q05497	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	21%	89%
Q10085	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
Q1PDX9	Arabidopsis thaliana	24%	100%
Q1PFG9	Arabidopsis thaliana	24%	100%
Q38956	Arabidopsis thaliana	25%	100%
Q3V050	Mus musculus	27%	100%
Q4PSF4	Arabidopsis thaliana	23%	100%
Q5I0E9	Rattus norvegicus	26%	100%
Q5R7E4	Pongo abelii	23%	100%
Q5RFD2	Pongo abelii	26%	100%
Q6NB79	Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)	23%	100%
Q86VL8	Homo sapiens	23%	100%
Q89W72	Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110)	23%	100%
Q8GXM8	Arabidopsis thaliana	25%	100%
Q8K0H1	Mus musculus	25%	100%
Q8L731	Arabidopsis thaliana	24%	100%
Q8RWF5	Arabidopsis thaliana	25%	100%
Q8RXK1	Arabidopsis thaliana	24%	100%
Q8VYL8	Arabidopsis thaliana	23%	100%
Q8W488	Arabidopsis thaliana	23%	100%
Q94AL1	Arabidopsis thaliana	23%	100%
Q96FL8	Homo sapiens	26%	100%
Q98D15	Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099)	23%	100%
Q9C994	Arabidopsis thaliana	24%	100%
Q9C9M8	Arabidopsis thaliana	23%	100%
Q9C9U1	Arabidopsis thaliana	26%	100%
Q9FH21	Arabidopsis thaliana	23%	100%
Q9FHB6	Arabidopsis thaliana	28%	100%
Q9FJ87	Arabidopsis thaliana	24%	100%
Q9FKQ1	Arabidopsis thaliana	26%	100%
Q9LE20	Arabidopsis thaliana	25%	100%
Q9LPV4	Arabidopsis thaliana	25%	100%
Q9LS19	Arabidopsis thaliana	25%	100%
Q9LUH2	Arabidopsis thaliana	23%	100%
Q9LUH3	Arabidopsis thaliana	23%	100%
Q9LYT3	Arabidopsis thaliana	24%	100%
Q9SIA1	Arabidopsis thaliana	24%	100%
Q9SIA3	Arabidopsis thaliana	24%	100%
Q9SIA4	Arabidopsis thaliana	25%	100%
Q9SIA5	Arabidopsis thaliana	24%	100%
Q9SLV0	Arabidopsis thaliana	24%	100%
Q9SX83	Arabidopsis thaliana	24%	100%
Q9SZE2	Arabidopsis thaliana	23%	100%
Q9USK3	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	100%
Q9UT92	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
Q9ZVH5	Arabidopsis thaliana	22%	100%
V5BE59	Trypanosoma cruzi	21%	76%
V5BJE3	Trypanosoma cruzi	40%	100%
V5C2T9	Trypanosoma cruzi	51%	100%