DNA topoisomerase 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

DNA topoisomerase 2

Gene product:

DNA topoisomerase ii

Species:

Leishmania donovani

UniProt:

A0A3Q8II93_LEIDO

TriTrypDb:

LdBPK_282450.1 , LdCL_280029500 , LDHU3_28.3310

Length:

1498

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8II93

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	13
GO:0006259	DNA metabolic process	4	13
GO:0006265	DNA topological change	5	13
GO:0006725	cellular aromatic compound metabolic process	3	13
GO:0006807	nitrogen compound metabolic process	2	13
GO:0006996	organelle organization	4	13
GO:0008152	metabolic process	1	13
GO:0009987	cellular process	1	13
GO:0016043	cellular component organization	3	13
GO:0034641	cellular nitrogen compound metabolic process	3	13
GO:0043170	macromolecule metabolic process	3	13
GO:0044237	cellular metabolic process	2	13
GO:0044238	primary metabolic process	2	13
GO:0044260	obsolete cellular macromolecule metabolic process	3	13
GO:0046483	heterocycle metabolic process	3	13
GO:0051276	chromosome organization	5	13
GO:0071103	DNA conformation change	6	13
GO:0071704	organic substance metabolic process	2	13
GO:0071840	cellular component organization or biogenesis	2	13
GO:0090304	nucleic acid metabolic process	4	13
GO:1901360	organic cyclic compound metabolic process	3	13
GO:0000712	resolution of meiotic recombination intermediates	4	1
GO:0000819	sister chromatid segregation	4	1
GO:0007059	chromosome segregation	2	1
GO:0022402	cell cycle process	2	1
GO:0022414	reproductive process	1	1
GO:0061982	meiosis I cell cycle process	3	1
GO:0098813	nuclear chromosome segregation	3	1
GO:1903046	meiotic cell cycle process	2	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	13
GO:0003676	nucleic acid binding	3	13
GO:0003677	DNA binding	4	13
GO:0003824	catalytic activity	1	13
GO:0003916	DNA topoisomerase activity	3	13
GO:0003918	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	3	13
GO:0005488	binding	1	13
GO:0005524	ATP binding	5	13
GO:0008094	ATP-dependent activity, acting on DNA	2	13
GO:0016853	isomerase activity	2	13
GO:0017076	purine nucleotide binding	4	13
GO:0030554	adenyl nucleotide binding	5	13
GO:0032553	ribonucleotide binding	3	13
GO:0032555	purine ribonucleotide binding	4	13
GO:0032559	adenyl ribonucleotide binding	5	13
GO:0035639	purine ribonucleoside triphosphate binding	4	13
GO:0036094	small molecule binding	2	13
GO:0043167	ion binding	2	13
GO:0043168	anion binding	3	13
GO:0043169	cation binding	3	13
GO:0046872	metal ion binding	4	13
GO:0097159	organic cyclic compound binding	2	13
GO:0097367	carbohydrate derivative binding	2	13
GO:0140097	catalytic activity, acting on DNA	3	13
GO:0140640	catalytic activity, acting on a nucleic acid	2	13
GO:0140657	ATP-dependent activity	1	13
GO:1901265	nucleoside phosphate binding	3	13
GO:1901363	heterocyclic compound binding	2	13
GO:0016491	oxidoreductase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1060	1064	PF00656	0.340
CLV_C14_Caspase3-7	1259	1263	PF00656	0.694
CLV_C14_Caspase3-7	1329	1333	PF00656	0.772
CLV_C14_Caspase3-7	1472	1476	PF00656	0.695
CLV_C14_Caspase3-7	430	434	PF00656	0.359
CLV_C14_Caspase3-7	493	497	PF00656	0.445
CLV_C14_Caspase3-7	683	687	PF00656	0.297
CLV_MEL_PAP_1	271	277	PF00089	0.246
CLV_NRD_NRD_1	1003	1005	PF00675	0.291
CLV_NRD_NRD_1	1028	1030	PF00675	0.299
CLV_NRD_NRD_1	1040	1042	PF00675	0.293
CLV_NRD_NRD_1	1099	1101	PF00675	0.392
CLV_NRD_NRD_1	1132	1134	PF00675	0.430
CLV_NRD_NRD_1	1173	1175	PF00675	0.479
CLV_NRD_NRD_1	1184	1186	PF00675	0.475
CLV_NRD_NRD_1	1216	1218	PF00675	0.647
CLV_NRD_NRD_1	1249	1251	PF00675	0.632
CLV_NRD_NRD_1	1317	1319	PF00675	0.772
CLV_NRD_NRD_1	1344	1346	PF00675	0.696
CLV_NRD_NRD_1	1458	1460	PF00675	0.625
CLV_NRD_NRD_1	161	163	PF00675	0.355
CLV_NRD_NRD_1	216	218	PF00675	0.343
CLV_NRD_NRD_1	256	258	PF00675	0.454
CLV_NRD_NRD_1	401	403	PF00675	0.460
CLV_NRD_NRD_1	48	50	PF00675	0.401
CLV_NRD_NRD_1	634	636	PF00675	0.264
CLV_NRD_NRD_1	692	694	PF00675	0.297
CLV_NRD_NRD_1	750	752	PF00675	0.425
CLV_NRD_NRD_1	993	995	PF00675	0.301
CLV_PCSK_FUR_1	1130	1134	PF00082	0.419
CLV_PCSK_FUR_1	1455	1459	PF00082	0.683
CLV_PCSK_KEX2_1	1003	1005	PF00082	0.297
CLV_PCSK_KEX2_1	1028	1030	PF00082	0.297
CLV_PCSK_KEX2_1	1040	1042	PF00082	0.297
CLV_PCSK_KEX2_1	1099	1101	PF00082	0.392
CLV_PCSK_KEX2_1	1132	1134	PF00082	0.377
CLV_PCSK_KEX2_1	1184	1186	PF00082	0.479
CLV_PCSK_KEX2_1	1215	1217	PF00082	0.600
CLV_PCSK_KEX2_1	1248	1250	PF00082	0.609
CLV_PCSK_KEX2_1	1303	1305	PF00082	0.758
CLV_PCSK_KEX2_1	1310	1312	PF00082	0.746
CLV_PCSK_KEX2_1	1343	1345	PF00082	0.654
CLV_PCSK_KEX2_1	1436	1438	PF00082	0.644
CLV_PCSK_KEX2_1	1455	1457	PF00082	0.632
CLV_PCSK_KEX2_1	1458	1460	PF00082	0.609
CLV_PCSK_KEX2_1	215	217	PF00082	0.344
CLV_PCSK_KEX2_1	701	703	PF00082	0.297
CLV_PCSK_KEX2_1	993	995	PF00082	0.297
CLV_PCSK_PC1ET2_1	1028	1030	PF00082	0.387
CLV_PCSK_PC1ET2_1	1248	1250	PF00082	0.633
CLV_PCSK_PC1ET2_1	1303	1305	PF00082	0.758
CLV_PCSK_PC1ET2_1	1310	1312	PF00082	0.746
CLV_PCSK_PC1ET2_1	1436	1438	PF00082	0.629
CLV_PCSK_PC1ET2_1	215	217	PF00082	0.411
CLV_PCSK_PC1ET2_1	701	703	PF00082	0.297
CLV_PCSK_PC1ET2_1	993	995	PF00082	0.392
CLV_PCSK_PC7_1	1306	1312	PF00082	0.744
CLV_PCSK_SKI1_1	1003	1007	PF00082	0.344
CLV_PCSK_SKI1_1	1032	1036	PF00082	0.344
CLV_PCSK_SKI1_1	1099	1103	PF00082	0.392
CLV_PCSK_SKI1_1	1175	1179	PF00082	0.583
CLV_PCSK_SKI1_1	1196	1200	PF00082	0.479
CLV_PCSK_SKI1_1	1205	1209	PF00082	0.500
CLV_PCSK_SKI1_1	1250	1254	PF00082	0.706
CLV_PCSK_SKI1_1	1348	1352	PF00082	0.595
CLV_PCSK_SKI1_1	1436	1440	PF00082	0.688
CLV_PCSK_SKI1_1	227	231	PF00082	0.411
CLV_PCSK_SKI1_1	517	521	PF00082	0.415
CLV_PCSK_SKI1_1	693	697	PF00082	0.301
CLV_PCSK_SKI1_1	770	774	PF00082	0.311
CLV_PCSK_SKI1_1	781	785	PF00082	0.311
CLV_PCSK_SKI1_1	902	906	PF00082	0.297
DEG_APCC_DBOX_1	606	614	PF00400	0.466
DEG_COP1_1	107	115	PF00400	0.366
DEG_SCF_TRCP1_1	1489	1495	PF00400	0.451
DOC_ANK_TNKS_1	1016	1023	PF00023	0.425
DOC_CDC14_PxL_1	405	413	PF14671	0.489
DOC_CKS1_1	541	546	PF01111	0.454
DOC_CYCLIN_RxL_1	1028	1037	PF00134	0.344
DOC_CYCLIN_RxL_1	1193	1202	PF00134	0.589
DOC_CYCLIN_RxL_1	689	698	PF00134	0.392
DOC_MAPK_gen_1	104	112	PF00069	0.297
DOC_MAPK_gen_1	1040	1046	PF00069	0.414
DOC_MAPK_gen_1	1184	1190	PF00069	0.503
DOC_MAPK_gen_1	402	408	PF00069	0.470
DOC_MAPK_MEF2A_6	205	214	PF00069	0.448
DOC_MAPK_MEF2A_6	268	275	PF00069	0.446
DOC_MAPK_MEF2A_6	327	334	PF00069	0.439
DOC_PP1_RVXF_1	556	563	PF00149	0.468
DOC_PP1_RVXF_1	607	613	PF00149	0.446
DOC_PP1_RVXF_1	691	698	PF00149	0.297
DOC_PP2B_LxvP_1	110	113	PF13499	0.311
DOC_PP2B_LxvP_1	1186	1189	PF13499	0.456
DOC_PP2B_LxvP_1	532	535	PF13499	0.351
DOC_PP4_FxxP_1	541	544	PF00568	0.446
DOC_PP4_FxxP_1	563	566	PF00568	0.446
DOC_PP4_FxxP_1	806	809	PF00568	0.414
DOC_PP4_FxxP_1	931	934	PF00568	0.311
DOC_USP7_MATH_1	1070	1074	PF00917	0.411
DOC_USP7_MATH_1	1252	1256	PF00917	0.646
DOC_USP7_MATH_1	1375	1379	PF00917	0.625
DOC_USP7_MATH_1	1380	1384	PF00917	0.638
DOC_USP7_MATH_1	1400	1404	PF00917	0.656
DOC_USP7_MATH_1	1476	1480	PF00917	0.653
DOC_USP7_MATH_1	183	187	PF00917	0.448
DOC_USP7_MATH_2	835	841	PF00917	0.369
DOC_USP7_UBL2_3	1028	1032	PF12436	0.376
DOC_USP7_UBL2_3	1175	1179	PF12436	0.450
DOC_USP7_UBL2_3	1201	1205	PF12436	0.499
DOC_USP7_UBL2_3	1243	1247	PF12436	0.632
DOC_USP7_UBL2_3	1316	1320	PF12436	0.700
DOC_USP7_UBL2_3	1421	1425	PF12436	0.539
DOC_USP7_UBL2_3	1447	1451	PF12436	0.655
DOC_USP7_UBL2_3	164	168	PF12436	0.468
DOC_USP7_UBL2_3	314	318	PF12436	0.449
DOC_USP7_UBL2_3	547	551	PF12436	0.446
DOC_USP7_UBL2_3	868	872	PF12436	0.326
DOC_WW_Pin1_4	1139	1144	PF00397	0.311
DOC_WW_Pin1_4	1298	1303	PF00397	0.669
DOC_WW_Pin1_4	51	56	PF00397	0.390
DOC_WW_Pin1_4	540	545	PF00397	0.316
LIG_14-3-3_CanoR_1	1003	1012	PF00244	0.425
LIG_14-3-3_CanoR_1	1437	1445	PF00244	0.658
LIG_14-3-3_CanoR_1	237	247	PF00244	0.460
LIG_14-3-3_CanoR_1	257	263	PF00244	0.232
LIG_14-3-3_CanoR_1	398	406	PF00244	0.536
LIG_14-3-3_CanoR_1	424	428	PF00244	0.419
LIG_14-3-3_CanoR_1	49	54	PF00244	0.375
LIG_14-3-3_CanoR_1	657	662	PF00244	0.513
LIG_14-3-3_CanoR_1	83	93	PF00244	0.425
LIG_APCC_ABBA_1	36	41	PF00400	0.432
LIG_BRCT_BRCA1_1	148	152	PF00533	0.297
LIG_Clathr_ClatBox_1	200	204	PF01394	0.342
LIG_Clathr_ClatBox_1	985	989	PF01394	0.297
LIG_CSL_BTD_1	110	113	PF09270	0.311
LIG_CSL_BTD_1	52	55	PF09270	0.377
LIG_deltaCOP1_diTrp_1	109	117	PF00928	0.344
LIG_deltaCOP1_diTrp_1	1264	1269	PF00928	0.633
LIG_deltaCOP1_diTrp_1	637	642	PF00928	0.537
LIG_DLG_GKlike_1	464	471	PF00625	0.498
LIG_EH1_1	299	307	PF00400	0.476
LIG_eIF4E_1	195	201	PF01652	0.343
LIG_eIF4E_1	771	777	PF01652	0.425
LIG_EVH1_1	1044	1048	PF00568	0.425
LIG_FHA_1	1004	1010	PF00498	0.371
LIG_FHA_1	1021	1027	PF00498	0.178
LIG_FHA_1	1349	1355	PF00498	0.481
LIG_FHA_1	31	37	PF00498	0.446
LIG_FHA_1	359	365	PF00498	0.388
LIG_FHA_1	424	430	PF00498	0.408
LIG_FHA_1	438	444	PF00498	0.348
LIG_FHA_1	52	58	PF00498	0.311
LIG_FHA_1	541	547	PF00498	0.441
LIG_FHA_1	817	823	PF00498	0.297
LIG_FHA_1	919	925	PF00498	0.425
LIG_FHA_1	957	963	PF00498	0.297
LIG_FHA_2	1055	1061	PF00498	0.346
LIG_FHA_2	11	17	PF00498	0.469
LIG_FHA_2	1140	1146	PF00498	0.323
LIG_FHA_2	1154	1160	PF00498	0.430
LIG_FHA_2	1359	1365	PF00498	0.609
LIG_FHA_2	18	24	PF00498	0.464
LIG_FHA_2	240	246	PF00498	0.382
LIG_FHA_2	250	256	PF00498	0.382
LIG_FHA_2	428	434	PF00498	0.373
LIG_FHA_2	862	868	PF00498	0.326
LIG_LIR_Apic_2	561	566	PF02991	0.446
LIG_LIR_Apic_2	803	809	PF02991	0.297
LIG_LIR_Apic_2	929	934	PF02991	0.311
LIG_LIR_Gen_1	1102	1113	PF02991	0.304
LIG_LIR_Gen_1	186	196	PF02991	0.327
LIG_LIR_Gen_1	197	206	PF02991	0.296
LIG_LIR_Gen_1	245	253	PF02991	0.368
LIG_LIR_Gen_1	261	267	PF02991	0.387
LIG_LIR_Gen_1	600	610	PF02991	0.446
LIG_LIR_Gen_1	87	94	PF02991	0.425
LIG_LIR_Gen_1	925	936	PF02991	0.297
LIG_LIR_LC3C_4	1021	1026	PF02991	0.395
LIG_LIR_LC3C_4	910	915	PF02991	0.446
LIG_LIR_Nem_3	1102	1108	PF02991	0.304
LIG_LIR_Nem_3	114	120	PF02991	0.297
LIG_LIR_Nem_3	186	192	PF02991	0.333
LIG_LIR_Nem_3	193	198	PF02991	0.301
LIG_LIR_Nem_3	241	246	PF02991	0.339
LIG_LIR_Nem_3	261	265	PF02991	0.216
LIG_LIR_Nem_3	447	453	PF02991	0.365
LIG_LIR_Nem_3	600	605	PF02991	0.446
LIG_LIR_Nem_3	660	664	PF02991	0.450
LIG_LIR_Nem_3	803	808	PF02991	0.297
LIG_LIR_Nem_3	87	93	PF02991	0.425
LIG_LIR_Nem_3	898	904	PF02991	0.297
LIG_LIR_Nem_3	925	931	PF02991	0.297
LIG_LIR_Nem_3	982	986	PF02991	0.311
LIG_LYPXL_S_1	194	198	PF13949	0.311
LIG_LYPXL_S_1	249	253	PF13949	0.388
LIG_LYPXL_yS_3	250	253	PF13949	0.388
LIG_Pex14_1	638	642	PF04695	0.455
LIG_Pex14_1	857	861	PF04695	0.297
LIG_Pex14_1	897	901	PF04695	0.297
LIG_Pex14_2	148	152	PF04695	0.297
LIG_Pex14_2	165	169	PF04695	0.375
LIG_Pex14_2	194	198	PF04695	0.311
LIG_Pex14_2	523	527	PF04695	0.376
LIG_Pex14_2	537	541	PF04695	0.237
LIG_PTB_Apo_2	337	344	PF02174	0.437
LIG_SH2_CRK	1105	1109	PF00017	0.297
LIG_SH2_CRK	189	193	PF00017	0.316
LIG_SH2_CRK	262	266	PF00017	0.363
LIG_SH2_CRK	587	591	PF00017	0.446
LIG_SH2_GRB2like	492	495	PF00017	0.497
LIG_SH2_NCK_1	189	193	PF00017	0.316
LIG_SH2_NCK_1	219	223	PF00017	0.333
LIG_SH2_NCK_1	262	266	PF00017	0.387
LIG_SH2_NCK_1	39	43	PF00017	0.434
LIG_SH2_NCK_1	492	496	PF00017	0.422
LIG_SH2_NCK_1	973	977	PF00017	0.414
LIG_SH2_PTP2	246	249	PF00017	0.364
LIG_SH2_PTP2	807	810	PF00017	0.297
LIG_SH2_PTP2	90	93	PF00017	0.425
LIG_SH2_SRC	39	42	PF00017	0.436
LIG_SH2_SRC	492	495	PF00017	0.381
LIG_SH2_SRC	807	810	PF00017	0.297
LIG_SH2_SRC	955	958	PF00017	0.309
LIG_SH2_STAP1	1105	1109	PF00017	0.297
LIG_SH2_STAT5	1043	1046	PF00017	0.344
LIG_SH2_STAT5	1049	1052	PF00017	0.344
LIG_SH2_STAT5	1107	1110	PF00017	0.297
LIG_SH2_STAT5	189	192	PF00017	0.318
LIG_SH2_STAT5	246	249	PF00017	0.438
LIG_SH2_STAT5	25	28	PF00017	0.387
LIG_SH2_STAT5	300	303	PF00017	0.446
LIG_SH2_STAT5	371	374	PF00017	0.464
LIG_SH2_STAT5	450	453	PF00017	0.359
LIG_SH2_STAT5	568	571	PF00017	0.446
LIG_SH2_STAT5	601	604	PF00017	0.446
LIG_SH2_STAT5	716	719	PF00017	0.297
LIG_SH2_STAT5	771	774	PF00017	0.297
LIG_SH2_STAT5	807	810	PF00017	0.321
LIG_SH2_STAT5	858	861	PF00017	0.297
LIG_SH2_STAT5	90	93	PF00017	0.425
LIG_SH2_STAT5	955	958	PF00017	0.309
LIG_SH2_STAT5	984	987	PF00017	0.340
LIG_SH2_STAT5	997	1000	PF00017	0.297
LIG_SH3_2	1290	1295	PF14604	0.687
LIG_SH3_3	1042	1048	PF00018	0.326
LIG_SH3_3	1174	1180	PF00018	0.545
LIG_SH3_3	1287	1293	PF00018	0.718
LIG_SH3_3	1299	1305	PF00018	0.556
LIG_SH3_3	1442	1448	PF00018	0.756
LIG_SH3_3	177	183	PF00018	0.371
LIG_SH3_3	70	76	PF00018	0.301
LIG_SH3_3	806	812	PF00018	0.297
LIG_SH3_4	1316	1323	PF00018	0.737
LIG_SH3_4	1447	1454	PF00018	0.705
LIG_SUMO_SIM_anti_2	1411	1418	PF11976	0.557
LIG_SUMO_SIM_par_1	1021	1027	PF11976	0.394
LIG_SUMO_SIM_par_1	425	431	PF11976	0.410
LIG_SUMO_SIM_par_1	834	840	PF11976	0.303
LIG_TRAF2_1	1058	1061	PF00917	0.425
LIG_TRAF2_1	1263	1266	PF00917	0.629
LIG_TRAF2_1	1480	1483	PF00917	0.747
LIG_TRAF2_1	473	476	PF00917	0.452
LIG_TRAF2_1	864	867	PF00917	0.339
LIG_TYR_ITIM	498	503	PF00017	0.383
LIG_UBA3_1	1108	1112	PF00899	0.392
LIG_UBA3_1	1414	1421	PF00899	0.569
LIG_UBA3_1	210	215	PF00899	0.423
LIG_UBA3_1	301	308	PF00899	0.552
LIG_UBA3_1	405	410	PF00899	0.489
LIG_UBA3_1	483	491	PF00899	0.332
LIG_WRC_WIRS_1	1158	1163	PF05994	0.553
LIG_WRC_WIRS_1	191	196	PF05994	0.311
MOD_CDC14_SPxK_1	1301	1304	PF00782	0.664
MOD_CDK_SPK_2	1139	1144	PF00069	0.311
MOD_CDK_SPK_2	1298	1303	PF00069	0.669
MOD_CDK_SPxK_1	1298	1304	PF00069	0.667
MOD_CDK_SPxxK_3	540	547	PF00069	0.297
MOD_CK1_1	1055	1061	PF00069	0.297
MOD_CK1_1	1330	1336	PF00069	0.727
MOD_CK1_1	1352	1358	PF00069	0.714
MOD_CK1_1	1462	1468	PF00069	0.668
MOD_CK1_1	1477	1483	PF00069	0.605
MOD_CK1_1	1484	1490	PF00069	0.581
MOD_CK1_1	1492	1498	PF00069	0.451
MOD_CK1_1	288	294	PF00069	0.442
MOD_CK1_1	434	440	PF00069	0.472
MOD_CK1_1	561	567	PF00069	0.448
MOD_CK1_1	680	686	PF00069	0.297
MOD_CK1_1	718	724	PF00069	0.392
MOD_CK2_1	1004	1010	PF00069	0.326
MOD_CK2_1	1054	1060	PF00069	0.395
MOD_CK2_1	1153	1159	PF00069	0.494
MOD_CK2_1	1260	1266	PF00069	0.678
MOD_CK2_1	1476	1482	PF00069	0.705
MOD_CK2_1	239	245	PF00069	0.342
MOD_CK2_1	249	255	PF00069	0.392
MOD_CK2_1	590	596	PF00069	0.529
MOD_CK2_1	837	843	PF00069	0.354
MOD_CK2_1	861	867	PF00069	0.356
MOD_CK2_1	971	977	PF00069	0.369
MOD_Cter_Amidation	1213	1216	PF01082	0.625
MOD_GlcNHglycan	1230	1233	PF01048	0.628
MOD_GlcNHglycan	1335	1338	PF01048	0.664
MOD_GlcNHglycan	1361	1364	PF01048	0.617
MOD_GlcNHglycan	1377	1380	PF01048	0.653
MOD_GlcNHglycan	1382	1385	PF01048	0.656
MOD_GlcNHglycan	1475	1479	PF01048	0.714
MOD_GlcNHglycan	1482	1487	PF01048	0.626
MOD_GlcNHglycan	1489	1492	PF01048	0.518
MOD_GlcNHglycan	185	188	PF01048	0.469
MOD_GlcNHglycan	374	377	PF01048	0.468
MOD_GlcNHglycan	433	436	PF01048	0.347
MOD_GlcNHglycan	592	595	PF01048	0.256
MOD_GlcNHglycan	719	723	PF01048	0.392
MOD_GSK3_1	1020	1027	PF00069	0.344
MOD_GSK3_1	1153	1160	PF00069	0.524
MOD_GSK3_1	1327	1334	PF00069	0.708
MOD_GSK3_1	1348	1355	PF00069	0.601
MOD_GSK3_1	1400	1407	PF00069	0.632
MOD_GSK3_1	142	149	PF00069	0.297
MOD_GSK3_1	1432	1439	PF00069	0.677
MOD_GSK3_1	1459	1466	PF00069	0.646
MOD_GSK3_1	1470	1477	PF00069	0.621
MOD_GSK3_1	1481	1488	PF00069	0.531
MOD_GSK3_1	183	190	PF00069	0.424
MOD_GSK3_1	281	288	PF00069	0.446
MOD_GSK3_1	289	296	PF00069	0.446
MOD_GSK3_1	353	360	PF00069	0.505
MOD_GSK3_1	392	399	PF00069	0.582
MOD_GSK3_1	419	426	PF00069	0.428
MOD_GSK3_1	427	434	PF00069	0.349
MOD_GSK3_1	637	644	PF00069	0.527
MOD_GSK3_1	726	733	PF00069	0.297
MOD_GSK3_1	817	824	PF00069	0.305
MOD_GSK3_1	918	925	PF00069	0.425
MOD_GSK3_1	971	978	PF00069	0.369
MOD_N-GLC_1	577	582	PF02516	0.337
MOD_N-GLC_1	648	653	PF02516	0.266
MOD_N-GLC_1	816	821	PF02516	0.297
MOD_NEK2_1	1024	1029	PF00069	0.297
MOD_NEK2_1	1054	1059	PF00069	0.366
MOD_NEK2_1	120	125	PF00069	0.298
MOD_NEK2_1	1388	1393	PF00069	0.656
MOD_NEK2_1	1481	1486	PF00069	0.580
MOD_NEK2_1	285	290	PF00069	0.446
MOD_NEK2_1	384	389	PF00069	0.485
MOD_NEK2_1	590	595	PF00069	0.455
MOD_NEK2_1	704	709	PF00069	0.297
MOD_NEK2_1	730	735	PF00069	0.297
MOD_NEK2_1	741	746	PF00069	0.297
MOD_NEK2_1	777	782	PF00069	0.232
MOD_NEK2_1	826	831	PF00069	0.446
MOD_NEK2_1	859	864	PF00069	0.326
MOD_NEK2_2	42	47	PF00069	0.439
MOD_PIKK_1	10	16	PF00454	0.430
MOD_PIKK_1	342	348	PF00454	0.446
MOD_PIKK_1	895	901	PF00454	0.297
MOD_PIKK_1	939	945	PF00454	0.232
MOD_PKA_1	1003	1009	PF00069	0.425
MOD_PKA_1	1052	1058	PF00069	0.311
MOD_PKA_1	1099	1105	PF00069	0.425
MOD_PKA_1	1132	1138	PF00069	0.369
MOD_PKA_1	1436	1442	PF00069	0.700
MOD_PKA_1	316	322	PF00069	0.498
MOD_PKA_1	49	55	PF00069	0.380
MOD_PKA_2	1003	1009	PF00069	0.425
MOD_PKA_2	1099	1105	PF00069	0.425
MOD_PKA_2	1132	1138	PF00069	0.369
MOD_PKA_2	1321	1327	PF00069	0.664
MOD_PKA_2	1401	1407	PF00069	0.653
MOD_PKA_2	1436	1442	PF00069	0.695
MOD_PKA_2	1443	1449	PF00069	0.621
MOD_PKA_2	273	279	PF00069	0.454
MOD_PKA_2	397	403	PF00069	0.541
MOD_PKA_2	423	429	PF00069	0.415
MOD_PKB_1	1130	1138	PF00069	0.420
MOD_PKB_1	1457	1465	PF00069	0.630
MOD_Plk_1	1348	1354	PF00069	0.676
MOD_Plk_1	1492	1498	PF00069	0.607
MOD_Plk_1	187	193	PF00069	0.321
MOD_Plk_1	225	231	PF00069	0.335
MOD_Plk_1	378	384	PF00069	0.468
MOD_Plk_1	42	48	PF00069	0.440
MOD_Plk_1	464	470	PF00069	0.387
MOD_Plk_1	648	654	PF00069	0.452
MOD_Plk_1	677	683	PF00069	0.326
MOD_Plk_1	718	724	PF00069	0.326
MOD_Plk_1	726	732	PF00069	0.264
MOD_Plk_1	922	928	PF00069	0.297
MOD_Plk_2-3	1134	1140	PF00069	0.411
MOD_Plk_2-3	1258	1264	PF00069	0.619
MOD_Plk_2-3	204	210	PF00069	0.383
MOD_Plk_2-3	30	36	PF00069	0.362
MOD_Plk_2-3	798	804	PF00069	0.304
MOD_Plk_4	1020	1026	PF00069	0.344
MOD_Plk_4	1157	1163	PF00069	0.525
MOD_Plk_4	1349	1355	PF00069	0.593
MOD_Plk_4	187	193	PF00069	0.321
MOD_Plk_4	281	287	PF00069	0.446
MOD_Plk_4	364	370	PF00069	0.363
MOD_Plk_4	423	429	PF00069	0.416
MOD_Plk_4	680	686	PF00069	0.287
MOD_Plk_4	726	732	PF00069	0.297
MOD_Plk_4	77	83	PF00069	0.355
MOD_Plk_4	975	981	PF00069	0.366
MOD_ProDKin_1	1139	1145	PF00069	0.311
MOD_ProDKin_1	1298	1304	PF00069	0.667
MOD_ProDKin_1	51	57	PF00069	0.385
MOD_ProDKin_1	540	546	PF00069	0.316
MOD_SUMO_rev_2	1145	1154	PF00179	0.395
MOD_SUMO_rev_2	124	134	PF00179	0.297
MOD_SUMO_rev_2	255	260	PF00179	0.408
MOD_SUMO_rev_2	395	405	PF00179	0.513
MOD_SUMO_rev_2	564	574	PF00179	0.466
TRG_DiLeu_BaEn_1	208	213	PF01217	0.369
TRG_DiLeu_BaEn_2	868	874	PF01217	0.297
TRG_DiLeu_BaEn_4	947	953	PF01217	0.311
TRG_DiLeu_BaLyEn_6	745	750	PF01217	0.311
TRG_ENDOCYTIC_2	1043	1046	PF00928	0.297
TRG_ENDOCYTIC_2	1105	1108	PF00928	0.297
TRG_ENDOCYTIC_2	189	192	PF00928	0.307
TRG_ENDOCYTIC_2	195	198	PF00928	0.299
TRG_ENDOCYTIC_2	246	249	PF00928	0.364
TRG_ENDOCYTIC_2	250	253	PF00928	0.375
TRG_ENDOCYTIC_2	262	265	PF00928	0.393
TRG_ENDOCYTIC_2	450	453	PF00928	0.359
TRG_ENDOCYTIC_2	500	503	PF00928	0.398
TRG_ENDOCYTIC_2	58	61	PF00928	0.297
TRG_ENDOCYTIC_2	587	590	PF00928	0.446
TRG_ENDOCYTIC_2	661	664	PF00928	0.446
TRG_ENDOCYTIC_2	807	810	PF00928	0.297
TRG_ENDOCYTIC_2	833	836	PF00928	0.299
TRG_ENDOCYTIC_2	858	861	PF00928	0.297
TRG_ENDOCYTIC_2	90	93	PF00928	0.425
TRG_ENDOCYTIC_2	901	904	PF00928	0.297
TRG_ER_diArg_1	1002	1004	PF00400	0.352
TRG_ER_diArg_1	1040	1042	PF00400	0.406
TRG_ER_diArg_1	1098	1100	PF00400	0.392
TRG_ER_diArg_1	1130	1133	PF00400	0.330
TRG_ER_diArg_1	1184	1187	PF00400	0.451
TRG_ER_diArg_1	1215	1217	PF00400	0.648
TRG_ER_diArg_1	1342	1345	PF00400	0.730
TRG_ER_diArg_1	1455	1458	PF00400	0.643
TRG_ER_diArg_1	216	218	PF00400	0.345
TRG_ER_diArg_1	607	610	PF00400	0.455
TRG_NES_CRM1_1	475	487	PF08389	0.399
TRG_NES_CRM1_1	637	650	PF08389	0.537
TRG_NES_CRM1_1	75	88	PF08389	0.392
TRG_NLS_Bipartite_1	1040	1055	PF00514	0.377
TRG_NLS_Bipartite_1	1303	1323	PF00514	0.733
TRG_NLS_MonoCore_2	1027	1032	PF00514	0.425
TRG_NLS_MonoCore_2	1246	1251	PF00514	0.652
TRG_NLS_MonoCore_2	1302	1307	PF00514	0.741
TRG_NLS_MonoCore_2	313	318	PF00514	0.537
TRG_NLS_MonoExtC_3	1027	1032	PF00514	0.425
TRG_NLS_MonoExtC_3	1173	1178	PF00514	0.600
TRG_NLS_MonoExtC_3	1246	1251	PF00514	0.621
TRG_NLS_MonoExtC_3	1317	1322	PF00514	0.687
TRG_NLS_MonoExtC_3	214	220	PF00514	0.408
TRG_NLS_MonoExtC_3	313	318	PF00514	0.446
TRG_NLS_MonoExtN_4	1048	1055	PF00514	0.326
TRG_NLS_MonoExtN_4	1174	1179	PF00514	0.599
TRG_NLS_MonoExtN_4	1247	1252	PF00514	0.614
TRG_NLS_MonoExtN_4	1302	1307	PF00514	0.737
TRG_NLS_MonoExtN_4	1316	1323	PF00514	0.616
TRG_NLS_MonoExtN_4	160	166	PF00514	0.355
TRG_NLS_MonoExtN_4	314	319	PF00514	0.466
TRG_Pf-PMV_PEXEL_1	1032	1036	PF00026	0.344
TRG_Pf-PMV_PEXEL_1	1196	1200	PF00026	0.609

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P778	Leptomonas seymouri	33%	100%
A0A0N1HUJ9	Leptomonas seymouri	78%	100%
A0A0S4IZ11	Bodo saltans	72%	100%
A0A0S4JGE3	Bodo saltans	36%	100%
A0A1X0NR68	Trypanosomatidae	75%	99%
A0A1X0NUH3	Trypanosomatidae	36%	100%
A0A3R7MTQ1	Trypanosoma rangeli	36%	100%
A0A3S7WTK8	Leishmania donovani	35%	100%
A0A422N9B0	Trypanosoma rangeli	67%	100%
A4H891	Leishmania braziliensis	35%	100%
A4HGT2	Leishmania braziliensis	95%	100%
A4HWL4	Leishmania infantum	35%	100%
A4I3V9	Leishmania infantum	100%	100%
C9ZXS6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
D0A926	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	100%
D0A927	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	100%
E9AQC1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9B049	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O16140	Bombyx mori	46%	97%
O24308	Pisum sativum	44%	100%
O42130	Gallus gallus	46%	96%
O42131	Gallus gallus	43%	92%
O46374	Sus scrofa	45%	98%
O61078	Leishmania chagasi	35%	100%
O93794	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	44%	100%
P06786	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	45%	100%
P08096	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	39%	100%
P0C9C0	African swine fever virus (isolate Tick/South Africa/Pretoriuskop Pr4/1996)	26%	100%
P0C9C1	African swine fever virus (isolate Warthog/Namibia/Wart80/1980)	25%	100%
P0C9C2	African swine fever virus (isolate Pig/Kenya/KEN-50/1950)	26%	100%
P11388	Homo sapiens	45%	98%
P12531	Trypanosoma brucei brucei	35%	100%
P15348	Drosophila melanogaster	45%	100%
P27570	Crithidia fasciculata	32%	100%
P30182	Arabidopsis thaliana	47%	100%
P30190	Trypanosoma cruzi	36%	100%
P34203	African swine fever virus (isolate Tick/Malawi/Lil 20-1/1983)	26%	100%
P34534	Caenorhabditis elegans	39%	100%
P41515	Cricetulus griseus	40%	98%
P41516	Rattus norvegicus	40%	98%
P87078	Candida albicans	44%	100%
P90520	Dictyostelium discoideum	41%	100%
Q00942	African swine fever virus (strain Badajoz 1971 Vero-adapted)	25%	100%
Q01320	Mus musculus	40%	98%
Q01879	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	43%	100%
Q02880	Homo sapiens	45%	92%
Q196X4	Invertebrate iridescent virus 3	34%	100%
Q23670	Caenorhabditis elegans	45%	99%
Q4Q836	Leishmania major	96%	100%
Q4QF53	Leishmania major	35%	100%
Q55BP5	Dictyostelium discoideum	41%	98%
Q64399	Cricetulus longicaudatus	45%	93%
Q64511	Mus musculus	45%	93%
Q9QSK1	Invertebrate iridescent virus 6	31%	100%
Q9Y8G8	Penicillium chrysogenum	46%	94%
V5B5B2	Trypanosoma cruzi	71%	100%
V5BUD4	Trypanosoma cruzi	36%	100%