Cullin 2, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Cullin 2, putative

Gene product:

cullin 2, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8II83_LEIDO

TriTrypDb:

LdBPK_282270.1 , LdCL_280027800 , LDHU3_28.3080

Length:

717

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0000151	ubiquitin ligase complex	3	2
GO:0031461	cullin-RING ubiquitin ligase complex	4	2
GO:0032991	protein-containing complex	1	2
GO:0140535	intracellular protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:1990234	transferase complex	3	2

Expansion

Sequence features

A0A3Q8II83

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8II83

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	17
GO:0006511	ubiquitin-dependent protein catabolic process	7	17
GO:0006807	nitrogen compound metabolic process	2	17
GO:0008152	metabolic process	1	17
GO:0009056	catabolic process	2	17
GO:0009057	macromolecule catabolic process	4	17
GO:0009987	cellular process	1	17
GO:0019538	protein metabolic process	3	17
GO:0019941	modification-dependent protein catabolic process	6	17
GO:0043170	macromolecule metabolic process	3	17
GO:0043632	modification-dependent macromolecule catabolic process	5	17
GO:0044237	cellular metabolic process	2	17
GO:0044238	primary metabolic process	2	17
GO:0044248	cellular catabolic process	3	17
GO:0044260	obsolete cellular macromolecule metabolic process	3	17
GO:0044265	obsolete cellular macromolecule catabolic process	4	17
GO:0051603	proteolysis involved in protein catabolic process	5	17
GO:0071704	organic substance metabolic process	2	17
GO:1901564	organonitrogen compound metabolic process	3	17
GO:1901575	organic substance catabolic process	3	17
GO:0016567	protein ubiquitination	7	2
GO:0032446	protein modification by small protein conjugation	6	2
GO:0036211	protein modification process	4	2
GO:0043412	macromolecule modification	4	2
GO:0070647	protein modification by small protein conjugation or removal	5	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	17
GO:0005515	protein binding	2	17
GO:0019899	enzyme binding	3	17
GO:0031625	ubiquitin protein ligase binding	5	17
GO:0044389	ubiquitin-like protein ligase binding	4	17
GO:0030674	protein-macromolecule adaptor activity	2	2
GO:0060090	molecular adaptor activity	1	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	4	8	PF00656	0.483
CLV_NRD_NRD_1	117	119	PF00675	0.318
CLV_NRD_NRD_1	133	135	PF00675	0.291
CLV_NRD_NRD_1	324	326	PF00675	0.313
CLV_NRD_NRD_1	512	514	PF00675	0.321
CLV_NRD_NRD_1	710	712	PF00675	0.568
CLV_PCSK_KEX2_1	216	218	PF00082	0.276
CLV_PCSK_KEX2_1	417	419	PF00082	0.318
CLV_PCSK_KEX2_1	512	514	PF00082	0.271
CLV_PCSK_KEX2_1	692	694	PF00082	0.475
CLV_PCSK_PC1ET2_1	216	218	PF00082	0.260
CLV_PCSK_PC1ET2_1	417	419	PF00082	0.318
CLV_PCSK_PC1ET2_1	692	694	PF00082	0.442
CLV_PCSK_PC7_1	688	694	PF00082	0.455
CLV_PCSK_SKI1_1	138	142	PF00082	0.289
CLV_PCSK_SKI1_1	220	224	PF00082	0.299
CLV_PCSK_SKI1_1	404	408	PF00082	0.266
CLV_PCSK_SKI1_1	417	421	PF00082	0.253
CLV_PCSK_SKI1_1	449	453	PF00082	0.251
CLV_PCSK_SKI1_1	52	56	PF00082	0.294
CLV_PCSK_SKI1_1	675	679	PF00082	0.458
CLV_PCSK_SKI1_1	692	696	PF00082	0.389
CLV_PCSK_SKI1_1	701	705	PF00082	0.432
CLV_PCSK_SKI1_1	79	83	PF00082	0.266
CLV_PCSK_SKI1_1	89	93	PF00082	0.255
DEG_APCC_DBOX_1	133	141	PF00400	0.518
DEG_APCC_DBOX_1	687	695	PF00400	0.374
DEG_APCC_DBOX_1	78	86	PF00400	0.518
DEG_Nend_UBRbox_4	1	3	PF02207	0.458
DOC_ANK_TNKS_1	303	310	PF00023	0.415
DOC_CKS1_1	124	129	PF01111	0.518
DOC_CYCLIN_RxL_1	413	425	PF00134	0.518
DOC_CYCLIN_RxL_1	697	708	PF00134	0.384
DOC_MAPK_gen_1	118	125	PF00069	0.518
DOC_MAPK_gen_1	325	334	PF00069	0.432
DOC_MAPK_gen_1	383	392	PF00069	0.558
DOC_MAPK_gen_1	512	520	PF00069	0.439
DOC_MAPK_gen_1	76	85	PF00069	0.454
DOC_PP1_RVXF_1	515	521	PF00149	0.466
DOC_PP1_RVXF_1	545	551	PF00149	0.529
DOC_PP4_FxxP_1	520	523	PF00568	0.415
DOC_USP7_MATH_1	523	527	PF00917	0.502
DOC_USP7_MATH_1	534	538	PF00917	0.467
DOC_USP7_MATH_1	540	544	PF00917	0.437
DOC_USP7_MATH_1	587	591	PF00917	0.571
DOC_USP7_MATH_1	610	614	PF00917	0.535
DOC_USP7_MATH_2	623	629	PF00917	0.389
DOC_USP7_UBL2_3	27	31	PF12436	0.594
DOC_USP7_UBL2_3	413	417	PF12436	0.432
DOC_WW_Pin1_4	123	128	PF00397	0.459
DOC_WW_Pin1_4	20	25	PF00397	0.529
DOC_WW_Pin1_4	439	444	PF00397	0.518
LIG_14-3-3_CanoR_1	118	124	PF00244	0.518
LIG_14-3-3_CanoR_1	128	137	PF00244	0.518
LIG_14-3-3_CanoR_1	220	229	PF00244	0.528
LIG_14-3-3_CanoR_1	246	256	PF00244	0.560
LIG_14-3-3_CanoR_1	350	359	PF00244	0.529
LIG_14-3-3_CanoR_1	641	651	PF00244	0.727
LIG_14-3-3_CanoR_1	76	82	PF00244	0.469
LIG_BRCT_BRCA1_1	197	201	PF00533	0.518
LIG_Clathr_ClatBox_1	101	105	PF01394	0.511
LIG_EH1_1	226	234	PF00400	0.518
LIG_FHA_1	110	116	PF00498	0.460
LIG_FHA_1	21	27	PF00498	0.577
LIG_FHA_1	298	304	PF00498	0.586
LIG_FHA_1	455	461	PF00498	0.432
LIG_FHA_2	2	8	PF00498	0.478
LIG_FHA_2	221	227	PF00498	0.485
LIG_FHA_2	233	239	PF00498	0.460
LIG_FHA_2	331	337	PF00498	0.524
LIG_FHA_2	564	570	PF00498	0.528
LIG_FHA_2	667	673	PF00498	0.451
LIG_LIR_Apic_2	391	397	PF02991	0.518
LIG_LIR_Apic_2	519	523	PF02991	0.432
LIG_LIR_Gen_1	186	196	PF02991	0.529
LIG_LIR_Gen_1	202	211	PF02991	0.408
LIG_LIR_Gen_1	310	321	PF02991	0.585
LIG_LIR_Gen_1	549	556	PF02991	0.494
LIG_LIR_Gen_1	625	634	PF02991	0.528
LIG_LIR_Gen_1	7	16	PF02991	0.426
LIG_LIR_Gen_1	90	96	PF02991	0.591
LIG_LIR_Gen_1	97	104	PF02991	0.407
LIG_LIR_Nem_3	169	175	PF02991	0.463
LIG_LIR_Nem_3	186	192	PF02991	0.408
LIG_LIR_Nem_3	202	206	PF02991	0.405
LIG_LIR_Nem_3	267	272	PF02991	0.552
LIG_LIR_Nem_3	310	316	PF02991	0.448
LIG_LIR_Nem_3	318	323	PF02991	0.416
LIG_LIR_Nem_3	358	364	PF02991	0.494
LIG_LIR_Nem_3	391	396	PF02991	0.482
LIG_LIR_Nem_3	481	485	PF02991	0.467
LIG_LIR_Nem_3	625	629	PF02991	0.515
LIG_LIR_Nem_3	7	12	PF02991	0.379
LIG_LIR_Nem_3	77	81	PF02991	0.452
LIG_LIR_Nem_3	90	95	PF02991	0.458
LIG_LIR_Nem_3	97	102	PF02991	0.459
LIG_NRBOX	136	142	PF00104	0.518
LIG_PCNA_PIPBox_1	552	561	PF02747	0.498
LIG_PCNA_yPIPBox_3	428	437	PF02747	0.521
LIG_Pex14_2	269	273	PF04695	0.518
LIG_SH2_CRK	13	17	PF00017	0.360
LIG_SH2_CRK	172	176	PF00017	0.482
LIG_SH2_CRK	203	207	PF00017	0.505
LIG_SH2_CRK	313	317	PF00017	0.460
LIG_SH2_CRK	361	365	PF00017	0.518
LIG_SH2_SRC	424	427	PF00017	0.415
LIG_SH2_STAP1	313	317	PF00017	0.574
LIG_SH2_STAP1	524	528	PF00017	0.433
LIG_SH2_STAT3	43	46	PF00017	0.518
LIG_SH2_STAT5	180	183	PF00017	0.480
LIG_SH2_STAT5	187	190	PF00017	0.508
LIG_SH2_STAT5	394	397	PF00017	0.518
LIG_SH2_STAT5	461	464	PF00017	0.484
LIG_SH2_STAT5	74	77	PF00017	0.460
LIG_SH2_STAT5	9	12	PF00017	0.336
LIG_SH3_3	121	127	PF00018	0.488
LIG_SH3_3	480	486	PF00018	0.515
LIG_SH3_3	711	717	PF00018	0.401
LIG_SUMO_SIM_par_1	174	179	PF11976	0.502
LIG_SUMO_SIM_par_1	682	687	PF11976	0.428
LIG_TRAF2_1	566	569	PF00917	0.415
LIG_TRAF2_1	669	672	PF00917	0.524
LIG_TRFH_1	583	587	PF08558	0.435
LIG_TYR_ITIM	11	16	PF00017	0.381
LIG_UBA3_1	282	288	PF00899	0.574
LIG_WRC_WIRS_1	356	361	PF05994	0.432
LIG_WRC_WIRS_1	626	631	PF05994	0.538
MOD_CDK_SPK_2	123	128	PF00069	0.432
MOD_CDK_SPxxK_3	20	27	PF00069	0.572
MOD_CK1_1	355	361	PF00069	0.415
MOD_CK1_1	478	484	PF00069	0.488
MOD_CK1_1	492	498	PF00069	0.449
MOD_CK1_1	563	569	PF00069	0.548
MOD_CK1_1	604	610	PF00069	0.465
MOD_CK1_1	63	69	PF00069	0.510
MOD_CK1_1	77	83	PF00069	0.460
MOD_CK2_1	171	177	PF00069	0.474
MOD_CK2_1	239	245	PF00069	0.510
MOD_CK2_1	563	569	PF00069	0.541
MOD_CK2_1	574	580	PF00069	0.507
MOD_CK2_1	666	672	PF00069	0.426
MOD_CK2_1	684	690	PF00069	0.303
MOD_GlcNHglycan	241	244	PF01048	0.281
MOD_GlcNHglycan	491	494	PF01048	0.313
MOD_GlcNHglycan	519	523	PF01048	0.314
MOD_GlcNHglycan	525	528	PF01048	0.269
MOD_GlcNHglycan	589	592	PF01048	0.277
MOD_GlcNHglycan	596	599	PF01048	0.499
MOD_GlcNHglycan	644	647	PF01048	0.696
MOD_GlcNHglycan	664	667	PF01048	0.420
MOD_GlcNHglycan	678	681	PF01048	0.497
MOD_GSK3_1	119	126	PF00069	0.546
MOD_GSK3_1	14	21	PF00069	0.443
MOD_GSK3_1	195	202	PF00069	0.537
MOD_GSK3_1	293	300	PF00069	0.556
MOD_GSK3_1	351	358	PF00069	0.486
MOD_GSK3_1	452	459	PF00069	0.513
MOD_GSK3_1	481	488	PF00069	0.454
MOD_GSK3_1	518	525	PF00069	0.514
MOD_GSK3_1	570	577	PF00069	0.486
MOD_GSK3_1	600	607	PF00069	0.507
MOD_GSK3_1	63	70	PF00069	0.514
MOD_GSK3_1	658	665	PF00069	0.472
MOD_GSK3_1	87	94	PF00069	0.566
MOD_N-GLC_1	66	71	PF02516	0.215
MOD_N-GLC_2	338	340	PF02516	0.318
MOD_NEK2_1	1	6	PF00069	0.538
MOD_NEK2_1	232	237	PF00069	0.473
MOD_NEK2_1	272	277	PF00069	0.459
MOD_NEK2_1	287	292	PF00069	0.495
MOD_NEK2_1	299	304	PF00069	0.487
MOD_NEK2_1	376	381	PF00069	0.497
MOD_NEK2_1	407	412	PF00069	0.468
MOD_NEK2_1	452	457	PF00069	0.499
MOD_NEK2_1	489	494	PF00069	0.587
MOD_NEK2_1	546	551	PF00069	0.467
MOD_NEK2_1	570	575	PF00069	0.464
MOD_NEK2_1	594	599	PF00069	0.637
MOD_NEK2_1	662	667	PF00069	0.470
MOD_NEK2_1	676	681	PF00069	0.381
MOD_NEK2_1	684	689	PF00069	0.442
MOD_PIKK_1	128	134	PF00454	0.550
MOD_PIKK_1	247	253	PF00454	0.509
MOD_PIKK_1	454	460	PF00454	0.525
MOD_PIKK_1	560	566	PF00454	0.454
MOD_PIKK_1	60	66	PF00454	0.432
MOD_PIKK_1	653	659	PF00454	0.468
MOD_PIKK_1	706	712	PF00454	0.407
MOD_PK_1	119	125	PF00069	0.432
MOD_PKA_1	118	124	PF00069	0.518
MOD_PKA_2	239	245	PF00069	0.525
MOD_PKA_2	247	253	PF00069	0.554
MOD_PKA_2	258	264	PF00069	0.387
MOD_PKA_2	478	484	PF00069	0.540
MOD_Plk_1	151	157	PF00069	0.516
MOD_Plk_1	161	167	PF00069	0.418
MOD_Plk_1	611	617	PF00069	0.416
MOD_Plk_2-3	429	435	PF00069	0.488
MOD_Plk_4	1	7	PF00069	0.437
MOD_Plk_4	119	125	PF00069	0.482
MOD_Plk_4	161	167	PF00069	0.489
MOD_Plk_4	232	238	PF00069	0.477
MOD_Plk_4	264	270	PF00069	0.500
MOD_Plk_4	319	325	PF00069	0.480
MOD_Plk_4	330	336	PF00069	0.449
MOD_Plk_4	388	394	PF00069	0.494
MOD_Plk_4	456	462	PF00069	0.463
MOD_Plk_4	494	500	PF00069	0.515
MOD_Plk_4	546	552	PF00069	0.520
MOD_Plk_4	589	595	PF00069	0.474
MOD_Plk_4	601	607	PF00069	0.398
MOD_Plk_4	70	76	PF00069	0.543
MOD_Plk_4	87	93	PF00069	0.510
MOD_ProDKin_1	123	129	PF00069	0.459
MOD_ProDKin_1	20	26	PF00069	0.531
MOD_ProDKin_1	439	445	PF00069	0.518
MOD_SUMO_for_1	159	162	PF00179	0.518
MOD_SUMO_rev_2	212	218	PF00179	0.602
MOD_SUMO_rev_2	260	265	PF00179	0.554
MOD_SUMO_rev_2	687	694	PF00179	0.554
TRG_DiLeu_BaEn_1	136	141	PF01217	0.459
TRG_DiLeu_BaEn_1	700	705	PF01217	0.385
TRG_DiLeu_BaEn_3	671	677	PF01217	0.363
TRG_DiLeu_BaLyEn_6	415	420	PF01217	0.452
TRG_DiLeu_BaLyEn_6	680	685	PF01217	0.401
TRG_ENDOCYTIC_2	13	16	PF00928	0.358
TRG_ENDOCYTIC_2	172	175	PF00928	0.465
TRG_ENDOCYTIC_2	203	206	PF00928	0.476
TRG_ENDOCYTIC_2	313	316	PF00928	0.445
TRG_ENDOCYTIC_2	327	330	PF00928	0.391
TRG_ENDOCYTIC_2	361	364	PF00928	0.518
TRG_ENDOCYTIC_2	393	396	PF00928	0.513
TRG_ENDOCYTIC_2	9	12	PF00928	0.355
TRG_ER_diArg_1	246	249	PF00400	0.387
TRG_NES_CRM1_1	545	557	PF08389	0.462
TRG_Pf-PMV_PEXEL_1	138	143	PF00026	0.318

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILK0	Leptomonas seymouri	68%	93%
A0A0N1PDU6	Leptomonas seymouri	23%	93%
A0A0S4J5R6	Bodo saltans	23%	87%
A0A1X0NS98	Trypanosomatidae	24%	89%
A0A3R7K7T8	Trypanosoma rangeli	25%	89%
A0A3S7X1Q2	Leishmania donovani	22%	94%
A4HGR5	Leishmania braziliensis	22%	100%
A4HGR6	Leishmania braziliensis	90%	100%
A4I3U0	Leishmania infantum	22%	100%
A4I3U1	Leishmania infantum	100%	100%
D0A911	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	89%
E9B032	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	100%
E9B033	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4Q853	Leishmania major	98%	100%
Q4Q854	Leishmania major	22%	100%