Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8II80_LEIDO

TriTrypDb:

LdBPK_351860.1 , LdCL_350023500 , LDHU3_35.2430

Length:

739

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8II80

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8II80

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	437	441	PF00656	0.817
CLV_NRD_NRD_1	294	296	PF00675	0.736
CLV_NRD_NRD_1	444	446	PF00675	0.741
CLV_NRD_NRD_1	562	564	PF00675	0.786
CLV_NRD_NRD_1	639	641	PF00675	0.753
CLV_NRD_NRD_1	683	685	PF00675	0.497
CLV_NRD_NRD_1	703	705	PF00675	0.542
CLV_NRD_NRD_1	729	731	PF00675	0.675
CLV_PCSK_FUR_1	560	564	PF00082	0.783
CLV_PCSK_KEX2_1	294	296	PF00082	0.736
CLV_PCSK_KEX2_1	33	35	PF00082	0.710
CLV_PCSK_KEX2_1	443	445	PF00082	0.741
CLV_PCSK_KEX2_1	562	564	PF00082	0.825
CLV_PCSK_KEX2_1	572	574	PF00082	0.649
CLV_PCSK_KEX2_1	639	641	PF00082	0.753
CLV_PCSK_KEX2_1	683	685	PF00082	0.502
CLV_PCSK_KEX2_1	729	731	PF00082	0.675
CLV_PCSK_PC1ET2_1	33	35	PF00082	0.710
CLV_PCSK_PC1ET2_1	572	574	PF00082	0.711
CLV_PCSK_PC7_1	568	574	PF00082	0.787
CLV_PCSK_SKI1_1	347	351	PF00082	0.728
CLV_PCSK_SKI1_1	456	460	PF00082	0.652
CLV_PCSK_SKI1_1	517	521	PF00082	0.609
CLV_PCSK_SKI1_1	609	613	PF00082	0.722
CLV_PCSK_SKI1_1	620	624	PF00082	0.607
CLV_PCSK_SKI1_1	91	95	PF00082	0.801
DEG_APCC_DBOX_1	516	524	PF00400	0.564
DEG_Nend_Nbox_1	1	3	PF02207	0.738
DEG_SPOP_SBC_1	342	346	PF00917	0.693
DEG_SPOP_SBC_1	348	352	PF00917	0.691
DEG_SPOP_SBC_1	72	76	PF00917	0.750
DOC_ANK_TNKS_1	414	421	PF00023	0.699
DOC_CDC14_PxL_1	52	60	PF14671	0.717
DOC_CKS1_1	159	164	PF01111	0.750
DOC_CKS1_1	262	267	PF01111	0.691
DOC_CKS1_1	281	286	PF01111	0.607
DOC_CYCLIN_yCln2_LP_2	94	100	PF00134	0.779
DOC_MAPK_gen_1	514	523	PF00069	0.565
DOC_MAPK_gen_1	704	712	PF00069	0.595
DOC_MAPK_gen_1	716	724	PF00069	0.420
DOC_MAPK_HePTP_8	511	523	PF00069	0.558
DOC_MAPK_JIP1_4	96	102	PF00069	0.712
DOC_MAPK_MEF2A_6	514	523	PF00069	0.565
DOC_MAPK_MEF2A_6	716	724	PF00069	0.602
DOC_PP1_RVXF_1	520	526	PF00149	0.571
DOC_PP2B_LxvP_1	98	101	PF13499	0.817
DOC_SPAK_OSR1_1	492	496	PF12202	0.629
DOC_USP7_MATH_1	237	241	PF00917	0.782
DOC_USP7_MATH_1	301	305	PF00917	0.640
DOC_USP7_MATH_1	341	345	PF00917	0.739
DOC_USP7_MATH_1	348	352	PF00917	0.772
DOC_USP7_MATH_1	353	357	PF00917	0.721
DOC_USP7_MATH_1	425	429	PF00917	0.765
DOC_USP7_MATH_1	47	51	PF00917	0.717
DOC_USP7_MATH_1	543	547	PF00917	0.765
DOC_USP7_MATH_1	549	553	PF00917	0.772
DOC_USP7_MATH_1	593	597	PF00917	0.797
DOC_USP7_MATH_1	631	635	PF00917	0.778
DOC_USP7_MATH_1	656	660	PF00917	0.684
DOC_USP7_UBL2_3	701	705	PF12436	0.470
DOC_WW_Pin1_4	158	163	PF00397	0.804
DOC_WW_Pin1_4	191	196	PF00397	0.742
DOC_WW_Pin1_4	241	246	PF00397	0.826
DOC_WW_Pin1_4	261	266	PF00397	0.520
DOC_WW_Pin1_4	280	285	PF00397	0.618
DOC_WW_Pin1_4	523	528	PF00397	0.642
DOC_WW_Pin1_4	553	558	PF00397	0.680
LIG_14-3-3_CanoR_1	170	176	PF00244	0.712
LIG_14-3-3_CanoR_1	300	310	PF00244	0.557
LIG_14-3-3_CanoR_1	426	431	PF00244	0.677
LIG_14-3-3_CanoR_1	630	636	PF00244	0.754
LIG_14-3-3_CanoR_1	640	646	PF00244	0.599
LIG_14-3-3_CanoR_1	683	692	PF00244	0.666
LIG_Actin_WH2_2	305	321	PF00022	0.591
LIG_Actin_WH2_2	394	412	PF00022	0.623
LIG_Actin_WH2_2	45	61	PF00022	0.573
LIG_APCC_ABBA_1	493	498	PF00400	0.607
LIG_APCC_ABBAyCdc20_2	492	498	PF00400	0.615
LIG_BIR_III_4	220	224	PF00653	0.695
LIG_CaM_IQ_9	722	737	PF13499	0.625
LIG_CSL_BTD_1	524	527	PF09270	0.575
LIG_CtBP_PxDLS_1	626	630	PF00389	0.735
LIG_EH1_1	15	23	PF00400	0.621
LIG_eIF4E_1	403	409	PF01652	0.713
LIG_eIF4E_1	515	521	PF01652	0.617
LIG_FHA_1	214	220	PF00498	0.810
LIG_FHA_1	242	248	PF00498	0.829
LIG_FHA_1	291	297	PF00498	0.681
LIG_FHA_1	33	39	PF00498	0.780
LIG_FHA_1	388	394	PF00498	0.594
LIG_FHA_1	707	713	PF00498	0.655
LIG_FHA_2	435	441	PF00498	0.817
LIG_FHA_2	455	461	PF00498	0.380
LIG_FHA_2	482	488	PF00498	0.650
LIG_FHA_2	674	680	PF00498	0.644
LIG_FHA_2	683	689	PF00498	0.667
LIG_FHA_2	692	698	PF00498	0.608
LIG_FHA_2	723	729	PF00498	0.551
LIG_LIR_Apic_2	158	162	PF02991	0.750
LIG_LIR_Gen_1	136	145	PF02991	0.691
LIG_LIR_Gen_1	308	318	PF02991	0.581
LIG_LIR_Nem_3	136	141	PF02991	0.689
LIG_LIR_Nem_3	308	313	PF02991	0.588
LIG_LIR_Nem_3	460	465	PF02991	0.604
LIG_Pex14_2	12	16	PF04695	0.621
LIG_SH2_CRK	462	466	PF00017	0.574
LIG_SH2_PTP2	138	141	PF00017	0.625
LIG_SH2_STAP1	515	519	PF00017	0.622
LIG_SH2_STAT3	515	518	PF00017	0.628
LIG_SH2_STAT5	138	141	PF00017	0.625
LIG_SH2_STAT5	536	539	PF00017	0.735
LIG_SH2_STAT5	674	677	PF00017	0.646
LIG_SH3_3	252	258	PF00018	0.819
LIG_SH3_3	278	284	PF00018	0.780
LIG_SH3_3	462	468	PF00018	0.464
LIG_SH3_3	485	491	PF00018	0.702
LIG_SH3_3	50	56	PF00018	0.784
LIG_SH3_3	596	602	PF00018	0.798
LIG_Sin3_3	310	317	PF02671	0.558
LIG_SUMO_SIM_anti_2	707	714	PF11976	0.642
LIG_SUMO_SIM_par_1	707	714	PF11976	0.653
LIG_WRC_WIRS_1	306	311	PF05994	0.582
MOD_CDC14_SPxK_1	194	197	PF00782	0.735
MOD_CDK_SPK_2	261	266	PF00069	0.685
MOD_CDK_SPxK_1	158	164	PF00069	0.751
MOD_CDK_SPxK_1	191	197	PF00069	0.742
MOD_CDK_SPxxK_3	163	170	PF00069	0.779
MOD_CDK_SPxxK_3	553	560	PF00069	0.620
MOD_CK1_1	174	180	PF00069	0.677
MOD_CK1_1	256	262	PF00069	0.678
MOD_CK1_1	308	314	PF00069	0.583
MOD_CK1_1	32	38	PF00069	0.767
MOD_CK1_1	379	385	PF00069	0.661
MOD_CK1_1	404	410	PF00069	0.730
MOD_CK1_1	451	457	PF00069	0.702
MOD_CK1_1	528	534	PF00069	0.638
MOD_CK1_1	634	640	PF00069	0.714
MOD_CK2_1	203	209	PF00069	0.727
MOD_CK2_1	673	679	PF00069	0.644
MOD_CK2_1	682	688	PF00069	0.667
MOD_CK2_1	691	697	PF00069	0.532
MOD_CK2_1	722	728	PF00069	0.544
MOD_Cter_Amidation	141	144	PF01082	0.627
MOD_DYRK1A_RPxSP_1	280	284	PF00069	0.777
MOD_GlcNHglycan	145	148	PF01048	0.596
MOD_GlcNHglycan	209	212	PF01048	0.789
MOD_GlcNHglycan	284	287	PF01048	0.813
MOD_GlcNHglycan	323	326	PF01048	0.587
MOD_GlcNHglycan	355	358	PF01048	0.820
MOD_GlcNHglycan	360	363	PF01048	0.696
MOD_GlcNHglycan	416	419	PF01048	0.793
MOD_GlcNHglycan	423	426	PF01048	0.704
MOD_GlcNHglycan	449	453	PF01048	0.733
MOD_GlcNHglycan	48	52	PF01048	0.720
MOD_GlcNHglycan	502	505	PF01048	0.520
MOD_GlcNHglycan	530	533	PF01048	0.664
MOD_GlcNHglycan	545	548	PF01048	0.620
MOD_GlcNHglycan	585	588	PF01048	0.675
MOD_GlcNHglycan	595	598	PF01048	0.584
MOD_GlcNHglycan	646	649	PF01048	0.713
MOD_GlcNHglycan	658	661	PF01048	0.572
MOD_GlcNHglycan	81	84	PF01048	0.792
MOD_GSK3_1	170	177	PF00069	0.724
MOD_GSK3_1	203	210	PF00069	0.765
MOD_GSK3_1	221	228	PF00069	0.510
MOD_GSK3_1	237	244	PF00069	0.724
MOD_GSK3_1	25	32	PF00069	0.726
MOD_GSK3_1	256	263	PF00069	0.525
MOD_GSK3_1	276	283	PF00069	0.620
MOD_GSK3_1	301	308	PF00069	0.587
MOD_GSK3_1	343	350	PF00069	0.733
MOD_GSK3_1	353	360	PF00069	0.614
MOD_GSK3_1	379	386	PF00069	0.669
MOD_GSK3_1	387	394	PF00069	0.483
MOD_GSK3_1	421	428	PF00069	0.786
MOD_GSK3_1	447	454	PF00069	0.725
MOD_GSK3_1	549	556	PF00069	0.828
MOD_GSK3_1	564	571	PF00069	0.608
MOD_GSK3_1	605	612	PF00069	0.657
MOD_GSK3_1	630	637	PF00069	0.719
MOD_GSK3_1	673	680	PF00069	0.522
MOD_GSK3_1	682	689	PF00069	0.604
MOD_GSK3_1	718	725	PF00069	0.539
MOD_N-GLC_1	553	558	PF02516	0.618
MOD_NEK2_1	171	176	PF00069	0.643
MOD_NEK2_1	213	218	PF00069	0.608
MOD_NEK2_1	318	323	PF00069	0.596
MOD_NEK2_1	486	491	PF00069	0.636
MOD_NEK2_1	607	612	PF00069	0.810
MOD_NEK2_1	629	634	PF00069	0.725
MOD_NEK2_2	491	496	PF00069	0.629
MOD_PIKK_1	184	190	PF00454	0.788
MOD_PIKK_1	370	376	PF00454	0.579
MOD_PIKK_1	722	728	PF00454	0.544
MOD_PK_1	34	40	PF00069	0.722
MOD_PK_1	718	724	PF00069	0.437
MOD_PKA_1	143	149	PF00069	0.524
MOD_PKA_1	225	231	PF00069	0.606
MOD_PKA_2	177	183	PF00069	0.773
MOD_PKA_2	318	324	PF00069	0.604
MOD_PKA_2	414	420	PF00069	0.724
MOD_PKA_2	425	431	PF00069	0.656
MOD_PKA_2	491	497	PF00069	0.619
MOD_PKA_2	629	635	PF00069	0.654
MOD_PKA_2	682	688	PF00069	0.556
MOD_PKB_1	445	453	PF00069	0.734
MOD_Plk_1	404	410	PF00069	0.730
MOD_Plk_1	47	53	PF00069	0.722
MOD_Plk_1	706	712	PF00069	0.656
MOD_Plk_1	718	724	PF00069	0.446
MOD_Plk_4	171	177	PF00069	0.644
MOD_Plk_4	213	219	PF00069	0.709
MOD_Plk_4	305	311	PF00069	0.594
MOD_Plk_4	388	394	PF00069	0.609
MOD_Plk_4	404	410	PF00069	0.467
MOD_Plk_4	609	615	PF00069	0.765
MOD_Plk_4	641	647	PF00069	0.629
MOD_Plk_4	677	683	PF00069	0.652
MOD_Plk_4	691	697	PF00069	0.618
MOD_ProDKin_1	158	164	PF00069	0.806
MOD_ProDKin_1	191	197	PF00069	0.742
MOD_ProDKin_1	241	247	PF00069	0.827
MOD_ProDKin_1	261	267	PF00069	0.520
MOD_ProDKin_1	280	286	PF00069	0.612
MOD_ProDKin_1	523	529	PF00069	0.641
MOD_ProDKin_1	553	559	PF00069	0.680
MOD_SUMO_rev_2	708	717	PF00179	0.544
TRG_DiLeu_BaEn_1	48	53	PF01217	0.722
TRG_DiLeu_BaEn_1	708	713	PF01217	0.551
TRG_ENDOCYTIC_2	138	141	PF00928	0.687
TRG_ENDOCYTIC_2	462	465	PF00928	0.580
TRG_ER_diArg_1	278	281	PF00400	0.684
TRG_ER_diArg_1	294	296	PF00400	0.637
TRG_ER_diArg_1	443	445	PF00400	0.824
TRG_ER_diArg_1	639	641	PF00400	0.691
TRG_ER_diArg_1	682	684	PF00400	0.501
TRG_NES_CRM1_1	305	315	PF08389	0.589
TRG_NES_CRM1_1	6	20	PF08389	0.576
TRG_Pf-PMV_PEXEL_1	266	271	PF00026	0.857
TRG_Pf-PMV_PEXEL_1	294	298	PF00026	0.726
TRG_Pf-PMV_PEXEL_1	444	449	PF00026	0.695
TRG_Pf-PMV_PEXEL_1	456	460	PF00026	0.554
TRG_Pf-PMV_PEXEL_1	684	688	PF00026	0.664

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HMK8	Leishmania braziliensis	70%	100%
A4IB87	Leishmania infantum	100%	100%
E9AF08	Leishmania major	90%	100%
E9B664	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%