DNA ligase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

DNA ligase

Gene product:

DNA ligase I, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8II77_LEIDO

TriTrypDb:

LdBPK_303490.1 , LdCL_300040500 , LDHU3_30.4650

Length:

767

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8II77

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8II77

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006260	DNA replication	5	11
GO:0006281	DNA repair	5	12
GO:0006310	DNA recombination	5	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0006950	response to stress	2	12
GO:0006974	DNA damage response	4	12
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	12
GO:0009059	macromolecule biosynthetic process	4	12
GO:0009987	cellular process	1	12
GO:0018130	heterocycle biosynthetic process	4	12
GO:0019438	aromatic compound biosynthetic process	4	12
GO:0033554	cellular response to stress	3	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034654	nucleobase-containing compound biosynthetic process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0044271	cellular nitrogen compound biosynthetic process	4	12
GO:0046483	heterocycle metabolic process	3	12
GO:0050896	response to stimulus	1	12
GO:0051716	cellular response to stimulus	2	12
GO:0071704	organic substance metabolic process	2	12
GO:0071897	DNA biosynthetic process	5	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1901362	organic cyclic compound biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12
GO:0006266	DNA ligation	5	1
GO:0006271	DNA strand elongation involved in DNA replication	6	1
GO:0006273	lagging strand elongation	7	1
GO:0022616	DNA strand elongation	5	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003676	nucleic acid binding	3	12
GO:0003677	DNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0003909	DNA ligase activity	4	12
GO:0003910	DNA ligase (ATP) activity	5	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016874	ligase activity	2	12
GO:0016886	ligase activity, forming phosphoric ester bonds	3	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140097	catalytic activity, acting on DNA	3	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	342	346	PF00656	0.491
CLV_C14_Caspase3-7	552	556	PF00656	0.307
CLV_C14_Caspase3-7	569	573	PF00656	0.286
CLV_C14_Caspase3-7	603	607	PF00656	0.478
CLV_NRD_NRD_1	273	275	PF00675	0.292
CLV_NRD_NRD_1	40	42	PF00675	0.676
CLV_NRD_NRD_1	497	499	PF00675	0.304
CLV_NRD_NRD_1	533	535	PF00675	0.305
CLV_PCSK_KEX2_1	272	274	PF00082	0.304
CLV_PCSK_KEX2_1	380	382	PF00082	0.441
CLV_PCSK_KEX2_1	42	44	PF00082	0.573
CLV_PCSK_KEX2_1	533	535	PF00082	0.304
CLV_PCSK_KEX2_1	592	594	PF00082	0.304
CLV_PCSK_KEX2_1	625	627	PF00082	0.304
CLV_PCSK_PC1ET2_1	380	382	PF00082	0.441
CLV_PCSK_PC1ET2_1	42	44	PF00082	0.586
CLV_PCSK_PC1ET2_1	592	594	PF00082	0.304
CLV_PCSK_PC1ET2_1	625	627	PF00082	0.304
CLV_PCSK_PC7_1	268	274	PF00082	0.374
CLV_PCSK_PC7_1	38	44	PF00082	0.636
CLV_PCSK_SKI1_1	161	165	PF00082	0.314
CLV_PCSK_SKI1_1	253	257	PF00082	0.429
CLV_PCSK_SKI1_1	279	283	PF00082	0.339
CLV_PCSK_SKI1_1	30	34	PF00082	0.739
CLV_PCSK_SKI1_1	381	385	PF00082	0.451
CLV_PCSK_SKI1_1	415	419	PF00082	0.303
CLV_PCSK_SKI1_1	534	538	PF00082	0.318
DEG_Nend_UBRbox_1	1	4	PF02207	0.521
DOC_ANK_TNKS_1	567	574	PF00023	0.374
DOC_CDC14_PxL_1	351	359	PF14671	0.349
DOC_CYCLIN_RxL_1	273	284	PF00134	0.339
DOC_CYCLIN_yClb1_LxF_4	545	550	PF00134	0.451
DOC_MAPK_DCC_7	349	359	PF00069	0.353
DOC_MAPK_gen_1	380	388	PF00069	0.422
DOC_MAPK_gen_1	592	600	PF00069	0.304
DOC_MAPK_MEF2A_6	161	170	PF00069	0.331
DOC_MAPK_MEF2A_6	283	292	PF00069	0.320
DOC_PP1_RVXF_1	159	166	PF00149	0.396
DOC_PP1_RVXF_1	532	539	PF00149	0.425
DOC_PP1_RVXF_1	545	551	PF00149	0.425
DOC_USP7_MATH_1	132	136	PF00917	0.640
DOC_USP7_MATH_1	152	156	PF00917	0.200
DOC_USP7_MATH_1	263	267	PF00917	0.333
DOC_USP7_MATH_1	306	310	PF00917	0.314
DOC_USP7_MATH_1	374	378	PF00917	0.476
DOC_USP7_MATH_1	401	405	PF00917	0.391
DOC_USP7_MATH_1	591	595	PF00917	0.320
DOC_USP7_MATH_2	465	471	PF00917	0.374
DOC_USP7_UBL2_3	380	384	PF12436	0.559
DOC_WW_Pin1_4	55	60	PF00397	0.653
DOC_WW_Pin1_4	586	591	PF00397	0.320
DOC_WW_Pin1_4	703	708	PF00397	0.304
LIG_14-3-3_CanoR_1	2	7	PF00244	0.504
LIG_14-3-3_CanoR_1	272	281	PF00244	0.421
LIG_14-3-3_CanoR_1	66	72	PF00244	0.508
LIG_Actin_WH2_2	511	529	PF00022	0.451
LIG_AP_GAE_1	107	113	PF02883	0.512
LIG_APCC_ABBA_1	478	483	PF00400	0.451
LIG_APCC_ABBAyCdc20_2	427	433	PF00400	0.413
LIG_BIR_III_4	284	288	PF00653	0.304
LIG_CSL_BTD_1	119	122	PF09270	0.574
LIG_CtBP_PxDLS_1	175	179	PF00389	0.425
LIG_deltaCOP1_diTrp_1	687	696	PF00928	0.292
LIG_FHA_1	162	168	PF00498	0.396
LIG_FHA_1	400	406	PF00498	0.296
LIG_FHA_1	482	488	PF00498	0.364
LIG_FHA_1	607	613	PF00498	0.415
LIG_FHA_1	662	668	PF00498	0.304
LIG_FHA_2	112	118	PF00498	0.549
LIG_FHA_2	2	8	PF00498	0.677
LIG_FHA_2	256	262	PF00498	0.413
LIG_FHA_2	340	346	PF00498	0.455
LIG_FHA_2	550	556	PF00498	0.372
LIG_FHA_2	562	568	PF00498	0.334
LIG_FHA_2	579	585	PF00498	0.204
LIG_GBD_Chelix_1	293	301	PF00786	0.320
LIG_LIR_Apic_2	117	123	PF02991	0.443
LIG_LIR_Apic_2	69	74	PF02991	0.603
LIG_LIR_Gen_1	114	123	PF02991	0.555
LIG_LIR_Gen_1	164	171	PF02991	0.352
LIG_LIR_Gen_1	4	14	PF02991	0.661
LIG_LIR_Gen_1	594	605	PF02991	0.304
LIG_LIR_Gen_1	643	651	PF02991	0.302
LIG_LIR_Nem_3	107	113	PF02991	0.464
LIG_LIR_Nem_3	114	119	PF02991	0.431
LIG_LIR_Nem_3	164	168	PF02991	0.356
LIG_LIR_Nem_3	254	259	PF02991	0.360
LIG_LIR_Nem_3	4	9	PF02991	0.668
LIG_LIR_Nem_3	435	441	PF02991	0.328
LIG_LIR_Nem_3	449	455	PF02991	0.243
LIG_LIR_Nem_3	535	541	PF02991	0.335
LIG_LIR_Nem_3	549	553	PF02991	0.272
LIG_LIR_Nem_3	594	600	PF02991	0.304
LIG_LIR_Nem_3	627	633	PF02991	0.297
LIG_LIR_Nem_3	643	648	PF02991	0.276
LIG_LIR_Nem_3	85	89	PF02991	0.472
LIG_LYPXL_yS_3	452	455	PF13949	0.304
LIG_NRBOX	162	168	PF00104	0.425
LIG_NRBOX	335	341	PF00104	0.483
LIG_Pex14_2	116	120	PF04695	0.470
LIG_Pex14_2	318	322	PF04695	0.450
LIG_SH2_CRK	645	649	PF00017	0.327
LIG_SH2_CRK	86	90	PF00017	0.508
LIG_SH2_GRB2like	519	522	PF00017	0.304
LIG_SH2_NCK_1	352	356	PF00017	0.415
LIG_SH2_SRC	553	556	PF00017	0.366
LIG_SH2_STAP1	316	320	PF00017	0.317
LIG_SH2_STAP1	382	386	PF00017	0.468
LIG_SH2_STAP1	79	83	PF00017	0.514
LIG_SH2_STAT3	729	732	PF00017	0.451
LIG_SH2_STAT3	751	754	PF00017	0.448
LIG_SH2_STAT3	78	81	PF00017	0.461
LIG_SH2_STAT5	183	186	PF00017	0.304
LIG_SH2_STAT5	519	522	PF00017	0.320
LIG_SH2_STAT5	54	57	PF00017	0.730
LIG_SH2_STAT5	553	556	PF00017	0.334
LIG_SH2_STAT5	588	591	PF00017	0.291
LIG_SH2_STAT5	729	732	PF00017	0.425
LIG_SH3_2	390	395	PF14604	0.357
LIG_SH3_3	116	122	PF00018	0.523
LIG_SH3_3	123	129	PF00018	0.626
LIG_SH3_3	387	393	PF00018	0.416
LIG_SH3_3	459	465	PF00018	0.374
LIG_SH3_3	503	509	PF00018	0.297
LIG_SH3_3	90	96	PF00018	0.537
LIG_SUMO_SIM_anti_2	356	362	PF11976	0.424
LIG_SUMO_SIM_anti_2	402	410	PF11976	0.390
LIG_SUMO_SIM_anti_2	609	616	PF11976	0.367
LIG_SUMO_SIM_par_1	166	172	PF11976	0.451
LIG_SUMO_SIM_par_1	402	410	PF11976	0.430
LIG_SUMO_SIM_par_1	464	470	PF11976	0.371
LIG_TRAF2_1	25	28	PF00917	0.808
LIG_TRAF2_1	44	47	PF00917	0.660
LIG_TYR_ITIM	181	186	PF00017	0.320
LIG_UBA3_1	408	416	PF00899	0.425
LIG_WRC_WIRS_1	113	118	PF05994	0.541
LIG_WRC_WIRS_1	468	473	PF05994	0.320
LIG_WRC_WIRS_1	562	567	PF05994	0.341
LIG_WW_3	121	125	PF00397	0.638
MOD_CDK_SPxK_1	586	592	PF00069	0.320
MOD_CDK_SPxxK_3	586	593	PF00069	0.320
MOD_CK1_1	251	257	PF00069	0.451
MOD_CK1_1	403	409	PF00069	0.390
MOD_CK1_1	442	448	PF00069	0.311
MOD_CK1_1	53	59	PF00069	0.768
MOD_CK1_1	549	555	PF00069	0.391
MOD_CK2_1	1	7	PF00069	0.659
MOD_CK2_1	111	117	PF00069	0.551
MOD_CK2_1	152	158	PF00069	0.304
MOD_CK2_1	211	217	PF00069	0.160
MOD_CK2_1	255	261	PF00069	0.384
MOD_CK2_1	561	567	PF00069	0.401
MOD_CK2_1	578	584	PF00069	0.204
MOD_CK2_1	67	73	PF00069	0.605
MOD_Cter_Amidation	28	31	PF01082	0.728
MOD_Cter_Amidation	413	416	PF01082	0.425
MOD_Cter_Amidation	496	499	PF01082	0.304
MOD_Cter_Amidation	623	626	PF01082	0.420
MOD_GlcNHglycan	149	153	PF01048	0.304
MOD_GlcNHglycan	19	22	PF01048	0.758
MOD_GlcNHglycan	226	229	PF01048	0.451
MOD_GlcNHglycan	250	253	PF01048	0.332
MOD_GlcNHglycan	265	268	PF01048	0.337
MOD_GlcNHglycan	307	311	PF01048	0.339
MOD_GlcNHglycan	361	364	PF01048	0.484
MOD_GSK3_1	128	135	PF00069	0.629
MOD_GSK3_1	148	155	PF00069	0.304
MOD_GSK3_1	251	258	PF00069	0.451
MOD_GSK3_1	335	342	PF00069	0.473
MOD_GSK3_1	399	406	PF00069	0.339
MOD_GSK3_1	442	449	PF00069	0.320
MOD_GSK3_1	50	57	PF00069	0.780
MOD_GSK3_1	549	556	PF00069	0.413
MOD_GSK3_1	58	65	PF00069	0.688
MOD_N-GLC_1	526	531	PF02516	0.437
MOD_N-GLC_1	586	591	PF02516	0.374
MOD_NEK2_1	1	6	PF00069	0.622
MOD_NEK2_1	105	110	PF00069	0.496
MOD_NEK2_1	339	344	PF00069	0.413
MOD_NEK2_1	526	531	PF00069	0.350
MOD_NEK2_1	566	571	PF00069	0.304
MOD_NEK2_1	663	668	PF00069	0.396
MOD_NEK2_1	67	72	PF00069	0.607
MOD_PIKK_1	661	667	PF00454	0.353
MOD_PK_1	384	390	PF00069	0.462
MOD_PKA_1	272	278	PF00069	0.425
MOD_PKA_1	30	36	PF00069	0.577
MOD_PKA_1	415	421	PF00069	0.390
MOD_PKA_2	1	7	PF00069	0.672
MOD_PKA_2	224	230	PF00069	0.339
MOD_PKA_2	272	278	PF00069	0.425
MOD_PKA_2	442	448	PF00069	0.334
MOD_PKA_2	67	73	PF00069	0.573
MOD_Plk_1	106	112	PF00069	0.524
MOD_Plk_1	384	390	PF00069	0.412
MOD_Plk_1	504	510	PF00069	0.366
MOD_Plk_1	526	532	PF00069	0.451
MOD_Plk_1	566	572	PF00069	0.320
MOD_Plk_1	701	707	PF00069	0.313
MOD_Plk_2-3	211	217	PF00069	0.160
MOD_Plk_2-3	353	359	PF00069	0.390
MOD_Plk_2-3	561	567	PF00069	0.341
MOD_Plk_4	161	167	PF00069	0.405
MOD_Plk_4	240	246	PF00069	0.304
MOD_Plk_4	335	341	PF00069	0.483
MOD_Plk_4	368	374	PF00069	0.481
MOD_Plk_4	467	473	PF00069	0.297
MOD_Plk_4	50	56	PF00069	0.560
MOD_Plk_4	549	555	PF00069	0.336
MOD_Plk_4	561	567	PF00069	0.273
MOD_ProDKin_1	55	61	PF00069	0.651
MOD_ProDKin_1	586	592	PF00069	0.320
MOD_ProDKin_1	703	709	PF00069	0.304
MOD_SUMO_rev_2	27	32	PF00179	0.749
MOD_SUMO_rev_2	35	44	PF00179	0.700
MOD_SUMO_rev_2	46	51	PF00179	0.658
MOD_SUMO_rev_2	692	701	PF00179	0.324
MOD_SUMO_rev_2	734	739	PF00179	0.464
TRG_DiLeu_BaEn_1	85	90	PF01217	0.485
TRG_DiLeu_BaEn_2	466	472	PF01217	0.451
TRG_DiLeu_BaEn_4	658	664	PF01217	0.425
TRG_ENDOCYTIC_2	183	186	PF00928	0.304
TRG_ENDOCYTIC_2	259	262	PF00928	0.425
TRG_ENDOCYTIC_2	452	455	PF00928	0.327
TRG_ENDOCYTIC_2	645	648	PF00928	0.320
TRG_ENDOCYTIC_2	86	89	PF00928	0.473
TRG_ER_diArg_1	271	274	PF00400	0.307
TRG_ER_diArg_1	41	44	PF00400	0.690
TRG_ER_diArg_1	730	733	PF00400	0.320
TRG_NES_CRM1_1	158	172	PF08389	0.337
TRG_Pf-PMV_PEXEL_1	295	299	PF00026	0.390
TRG_Pf-PMV_PEXEL_1	568	572	PF00026	0.353
TRG_Pf-PMV_PEXEL_1	580	584	PF00026	0.277
TRG_Pf-PMV_PEXEL_1	728	732	PF00026	0.374

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB08	Leptomonas seymouri	75%	100%
A0A0S4JHN9	Bodo saltans	62%	100%
A0A1X0P2U4	Trypanosomatidae	66%	100%
A0A422NMG1	Trypanosoma rangeli	65%	100%
A0B7F9	Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT)	28%	100%
A0RWD6	Cenarchaeum symbiosum (strain A)	34%	100%
A1RTK4	Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3)	34%	100%
A1RXA6	Thermofilum pendens (strain DSM 2475 / Hrk 5)	29%	100%
A1RY72	Thermofilum pendens (strain DSM 2475 / Hrk 5)	32%	100%
A2BJX6	Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5)	34%	100%
A2SR38	Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z)	28%	100%
A3CWP1	Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)	29%	100%
A3DP49	Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1)	34%	100%
A3MS62	Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1)	33%	100%
A4FY19	Methanococcus maripaludis (strain C5 / ATCC BAA-1333)	26%	100%
A4HIT2	Leishmania braziliensis	87%	100%
A4I634	Leishmania infantum	100%	100%
A4WH24	Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321 / PZ6)	33%	100%
A4YD25	Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)	32%	100%
A5UKX2	Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS)	28%	100%
A6UNY0	Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)	27%	100%
A6UVC4	Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)	26%	100%
A6VFQ9	Methanococcus maripaludis (strain C7 / ATCC BAA-1331)	26%	100%
A7IAA9	Methanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8)	28%	100%
A8AB20	Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)	35%	100%
A8MDU6	Caldivirga maquilingensis (strain ATCC 700844 / DSM 13496 / JCM 10307 / IC-167)	32%	100%
A8N936	Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003)	26%	75%
A9A3K1	Nitrosopumilus maritimus (strain SCM1)	33%	100%
A9AAX4	Methanococcus maripaludis (strain C6 / ATCC BAA-1332)	25%	100%
B0R4C9	Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)	27%	100%
B1L3K8	Korarchaeum cryptofilum (strain OPF8)	26%	100%
B1L3V2	Korarchaeum cryptofilum (strain OPF8)	33%	100%
B1YA52	Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / NBRC 100436 / V24Sta)	33%	100%
B5YD88	Dictyoglomus thermophilum (strain ATCC 35947 / DSM 3960 / H-6-12)	30%	100%
B6YTR4	Thermococcus onnurineus (strain NA1)	31%	100%
B8DZX8	Dictyoglomus turgidum (strain DSM 6724 / Z-1310)	29%	100%
B8GGB8	Methanosphaerula palustris (strain ATCC BAA-1556 / DSM 19958 / E1-9c)	29%	100%
B9LUZ9	Halorubrum lacusprofundi (strain ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34)	26%	100%
C0QSL7	Persephonella marina (strain DSM 14350 / EX-H1)	32%	100%
C3MJ14	Sulfolobus islandicus (strain L.S.2.15 / Lassen #1)	33%	100%
C3MYD2	Sulfolobus islandicus (strain M.14.25 / Kamchatka #1)	33%	100%
C3MZR1	Sulfolobus islandicus (strain M.16.27)	33%	100%
C3N834	Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1)	33%	100%
C3NF77	Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2)	33%	100%
C4KIZ2	Sulfolobus islandicus (strain M.16.4 / Kamchatka #3)	33%	100%
C9ZRF3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	100%
D2CJS7	Sulfophobococcus zilligii	34%	100%
E9B1B9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
G3GTP0	Cricetulus griseus	24%	84%
O29632	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	28%	100%
O59288	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	30%	100%
O67398	Aquifex aeolicus (strain VF5)	33%	100%
O93723	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	33%	100%
P04819	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	40%	100%
P0CL74	Pyrococcus abyssi	29%	100%
P0CL75	Pyrococcus abyssi (strain GE5 / Orsay)	30%	100%
P12000	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	40%	100%
P18858	Homo sapiens	44%	83%
P37913	Mus musculus	44%	84%
P49917	Homo sapiens	25%	84%
P51892	Xenopus laevis	45%	72%
P54875	Methanothermobacter thermautotrophicus	27%	100%
P56709	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	30%	100%
Q02093	Acidianus ambivalens	33%	100%
Q0W0X1	Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50)	29%	100%
Q12X08	Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)	28%	100%
Q18GX5	Haloquadratum walsbyi (strain DSM 16790 / HBSQ001)	26%	100%
Q18HT7	Haloquadratum walsbyi (strain DSM 16790 / HBSQ001)	25%	100%
Q1II25	Koribacter versatilis (strain Ellin345)	27%	100%
Q27474	Caenorhabditis elegans	43%	99%
Q2FTH4	Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)	27%	100%
Q2NHF9	Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)	25%	100%
Q3IPX0	Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / JCM 8858 / NBRC 14720 / NCIMB 2260 / Gabara)	29%	100%
Q42572	Arabidopsis thaliana	45%	97%
Q46BA3	Methanosarcina barkeri (strain Fusaro / DSM 804)	27%	100%
Q46C04	Methanosarcina barkeri (strain Fusaro / DSM 804)	30%	100%
Q4JAM1	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	32%	100%
Q4Q6U5	Leishmania major	97%	100%
Q50566	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	26%	100%
Q57635	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	27%	100%
Q5R6L3	Pongo abelii	24%	84%
Q5V4R0	Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809)	26%	100%
Q6L195	Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)	32%	100%
Q6LYM1	Methanococcus maripaludis (strain S2 / LL)	26%	100%
Q74M64	Nanoarchaeum equitans (strain Kin4-M)	27%	100%
Q7Z7W5	Coprinopsis cinerea	26%	75%
Q8BTF7	Mus musculus	24%	84%
Q8PTK1	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	28%	100%
Q8PVR7	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	30%	100%
Q8TMT1	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	27%	100%
Q8TSR7	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	30%	100%
Q8TWN3	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	30%	100%
Q976G4	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	32%	100%
Q979A1	Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)	32%	100%
Q980T8	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	33%	100%
Q9C1W9	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	99%
Q9HH07	Thermococcus fumicolans	30%	100%
Q9HHC4	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	30%	100%
Q9HJ26	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	32%	100%
Q9HR35	Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)	27%	100%
Q9JHY8	Rattus norvegicus	43%	84%
Q9P9K9	Saccharolobus shibatae	33%	100%
Q9W1H4	Drosophila melanogaster	42%	100%
Q9YD18	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	35%	100%
V5BSC7	Trypanosoma cruzi	66%	100%