Cilia BBSome complex subunit 10 family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Bardet-Biedl syndrome 18 protein

Species:

Leishmania donovani

UniProt:

A0A3Q8II74_LEIDO

TriTrypDb:

LdBPK_140200.1 , LdCL_140006900 , LDHU3_14.0260

Length:

173

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	7
GO:0034464	BBSome	2	7
GO:0012506	vesicle membrane	4	1
GO:0016020	membrane	2	1
GO:0020018	ciliary pocket membrane	6	1
GO:0030659	cytoplasmic vesicle membrane	5	1
GO:0030662	coated vesicle membrane	5	1
GO:0030665	clathrin-coated vesicle membrane	6	1
GO:0031090	organelle membrane	3	1
GO:0031253	cell projection membrane	4	1
GO:0060170	ciliary membrane	5	1
GO:0098588	bounding membrane of organelle	4	1
GO:0098590	plasma membrane region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8II74

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8II74

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	7
GO:0009987	cellular process	1	7
GO:0016043	cellular component organization	3	7
GO:0022607	cellular component assembly	4	7
GO:0030030	cell projection organization	4	7
GO:0030031	cell projection assembly	5	7
GO:0044782	cilium organization	5	7
GO:0060271	cilium assembly	6	7
GO:0070925	organelle assembly	5	7
GO:0071840	cellular component organization or biogenesis	2	7
GO:0120031	plasma membrane bounded cell projection assembly	6	7
GO:0120036	plasma membrane bounded cell projection organization	5	7
GO:0008104	protein localization	4	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0051179	localization	1	1
GO:0051641	cellular localization	2	1
GO:0051668	localization within membrane	3	1
GO:0061512	protein localization to cilium	6	1
GO:0070727	cellular macromolecule localization	3	1
GO:0072657	protein localization to membrane	4	1
GO:0097499	protein localization to non-motile cilium	7	1
GO:0097500	receptor localization to non-motile cilium	6	1
GO:1903441	protein localization to ciliary membrane	5	1
GO:1990778	protein localization to cell periphery	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	65	69	PF00656	0.291
CLV_PCSK_KEX2_1	66	68	PF00082	0.312
CLV_PCSK_PC1ET2_1	66	68	PF00082	0.312
DEG_Nend_UBRbox_2	1	3	PF02207	0.316
DEG_SPOP_SBC_1	160	164	PF00917	0.616
DOC_MAPK_JIP1_4	38	44	PF00069	0.312
DOC_PP2B_LxvP_1	129	132	PF13499	0.548
DOC_USP7_MATH_1	113	117	PF00917	0.788
DOC_USP7_MATH_1	148	152	PF00917	0.639
DOC_USP7_MATH_1	165	169	PF00917	0.616
DOC_USP7_MATH_1	43	47	PF00917	0.312
DOC_USP7_UBL2_3	54	58	PF12436	0.312
DOC_WW_Pin1_4	161	166	PF00397	0.660
DOC_WW_Pin1_4	95	100	PF00397	0.663
LIG_14-3-3_CanoR_1	121	129	PF00244	0.677
LIG_14-3-3_CanoR_1	153	160	PF00244	0.599
LIG_FHA_1	13	19	PF00498	0.340
LIG_FHA_2	133	139	PF00498	0.595
LIG_FHA_2	79	85	PF00498	0.527
LIG_MYND_1	39	43	PF01753	0.312
LIG_SH3_3	102	108	PF00018	0.600
LIG_TRAF2_1	135	138	PF00917	0.569
MOD_CK1_1	116	122	PF00069	0.651
MOD_CK1_1	125	131	PF00069	0.488
MOD_CK1_1	152	158	PF00069	0.571
MOD_CK1_1	161	167	PF00069	0.688
MOD_CK2_1	132	138	PF00069	0.587
MOD_CK2_1	143	149	PF00069	0.622
MOD_CK2_1	83	89	PF00069	0.614
MOD_GlcNHglycan	108	111	PF01048	0.686
MOD_GlcNHglycan	116	119	PF01048	0.721
MOD_GlcNHglycan	129	132	PF01048	0.538
MOD_GlcNHglycan	145	148	PF01048	0.767
MOD_GlcNHglycan	167	170	PF01048	0.597
MOD_GlcNHglycan	81	84	PF01048	0.526
MOD_GSK3_1	113	120	PF00069	0.637
MOD_GSK3_1	148	155	PF00069	0.612
MOD_GSK3_1	159	166	PF00069	0.637
MOD_GSK3_1	79	86	PF00069	0.549
MOD_GSK3_1	95	102	PF00069	0.686
MOD_NEK2_1	78	83	PF00069	0.520
MOD_PIKK_1	122	128	PF00454	0.678
MOD_PKA_2	149	155	PF00069	0.574
MOD_Plk_1	12	18	PF00069	0.348
MOD_ProDKin_1	161	167	PF00069	0.658
MOD_ProDKin_1	95	101	PF00069	0.664
MOD_SUMO_rev_2	27	32	PF00179	0.302
MOD_SUMO_rev_2	50	60	PF00179	0.326
TRG_ENDOCYTIC_2	7	10	PF00928	0.255

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBP5	Leptomonas seymouri	49%	95%
A4H7I0	Leishmania braziliensis	67%	100%
A4HVW2	Leishmania infantum	99%	100%
E9APL3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4QFW5	Leishmania major	78%	100%