MMS19 nucleotide excision repair protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8II73_LEIDO

TriTrypDb:

LdBPK_353440.1 , LdCL_350039400 , LDHU3_35.4520

Length:

262

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 7
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8II73

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8II73

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	202	206	PF00656	0.593
CLV_NRD_NRD_1	228	230	PF00675	0.525
CLV_PCSK_KEX2_1	228	230	PF00082	0.525
CLV_PCSK_SKI1_1	183	187	PF00082	0.465
CLV_PCSK_SKI1_1	228	232	PF00082	0.334
CLV_PCSK_SKI1_1	28	32	PF00082	0.530
CLV_Separin_Metazoa	15	19	PF03568	0.524
DEG_SCF_FBW7_1	172	179	PF00400	0.596
DEG_SPOP_SBC_1	176	180	PF00917	0.536
DOC_CKS1_1	173	178	PF01111	0.729
DOC_PP4_FxxP_1	146	149	PF00568	0.478
DOC_PP4_FxxP_1	93	96	PF00568	0.626
DOC_PP4_MxPP_1	235	238	PF00568	0.442
DOC_USP7_MATH_1	122	126	PF00917	0.540
DOC_USP7_MATH_1	160	164	PF00917	0.640
DOC_USP7_MATH_1	176	180	PF00917	0.444
DOC_WW_Pin1_4	127	132	PF00397	0.402
DOC_WW_Pin1_4	172	177	PF00397	0.722
DOC_WW_Pin1_4	83	88	PF00397	0.582
DOC_WW_Pin1_4	92	97	PF00397	0.539
LIG_14-3-3_CanoR_1	121	127	PF00244	0.471
LIG_14-3-3_CanoR_1	189	193	PF00244	0.417
LIG_14-3-3_CanoR_1	28	37	PF00244	0.549
LIG_BIR_II_1	1	5	PF00653	0.604
LIG_EVH1_1	146	150	PF00568	0.434
LIG_FHA_1	194	200	PF00498	0.473
LIG_FHA_2	10	16	PF00498	0.525
LIG_FHA_2	51	57	PF00498	0.559
LIG_LIR_Apic_2	90	96	PF02991	0.624
LIG_LIR_Gen_1	115	124	PF02991	0.423
LIG_LIR_Gen_1	31	39	PF02991	0.482
LIG_LIR_LC3C_4	218	221	PF02991	0.350
LIG_LIR_Nem_3	115	119	PF02991	0.426
LIG_LIR_Nem_3	12	16	PF02991	0.527
LIG_LIR_Nem_3	31	37	PF02991	0.339
LIG_LIR_Nem_3	42	47	PF02991	0.469
LIG_REV1ctd_RIR_1	41	49	PF16727	0.410
LIG_SH2_PTP2	123	126	PF00017	0.378
LIG_SH2_STAT5	123	126	PF00017	0.444
LIG_SH2_STAT5	127	130	PF00017	0.476
LIG_SH2_STAT5	184	187	PF00017	0.476
LIG_SH3_3	141	147	PF00018	0.493
LIG_SH3_3	170	176	PF00018	0.626
LIG_SH3_3	227	233	PF00018	0.424
LIG_SH3_3	8	14	PF00018	0.540
LIG_WRC_WIRS_1	113	118	PF05994	0.311
MOD_CK1_1	35	41	PF00069	0.367
MOD_CK2_1	105	111	PF00069	0.656
MOD_CK2_1	255	261	PF00069	0.506
MOD_CK2_1	50	56	PF00069	0.563
MOD_CK2_1	75	81	PF00069	0.502
MOD_CK2_1	9	15	PF00069	0.512
MOD_Cter_Amidation	226	229	PF01082	0.448
MOD_DYRK1A_RPxSP_1	83	87	PF00069	0.524
MOD_GlcNHglycan	160	163	PF01048	0.637
MOD_GSK3_1	101	108	PF00069	0.531
MOD_GSK3_1	122	129	PF00069	0.404
MOD_GSK3_1	172	179	PF00069	0.695
MOD_GSK3_1	28	35	PF00069	0.602
MOD_GSK3_1	50	57	PF00069	0.494
MOD_GSK3_1	83	90	PF00069	0.626
MOD_N-GLC_1	256	261	PF02516	0.465
MOD_NEK2_1	126	131	PF00069	0.378
MOD_NEK2_1	22	27	PF00069	0.466
MOD_NEK2_2	122	127	PF00069	0.350
MOD_OFUCOSY	128	135	PF10250	0.416
MOD_PIKK_1	193	199	PF00454	0.398
MOD_PKA_1	228	234	PF00069	0.360
MOD_PKA_2	188	194	PF00069	0.427
MOD_PKA_2	228	234	PF00069	0.516
MOD_PKB_1	52	60	PF00069	0.484
MOD_Plk_1	255	261	PF00069	0.450
MOD_Plk_2-3	256	262	PF00069	0.409
MOD_Plk_2-3	9	15	PF00069	0.515
MOD_Plk_4	122	128	PF00069	0.359
MOD_Plk_4	231	237	PF00069	0.458
MOD_Plk_4	39	45	PF00069	0.662
MOD_ProDKin_1	127	133	PF00069	0.395
MOD_ProDKin_1	172	178	PF00069	0.709
MOD_ProDKin_1	83	89	PF00069	0.587
MOD_ProDKin_1	92	98	PF00069	0.540
MOD_SUMO_rev_2	208	216	PF00179	0.478
TRG_ENDOCYTIC_2	123	126	PF00928	0.500
TRG_ER_diArg_1	228	230	PF00400	0.463
TRG_NES_CRM1_1	66	81	PF08389	0.464

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1X1	Leptomonas seymouri	38%	97%
A0A3R7KJU0	Trypanosoma rangeli	24%	100%
A4HN06	Leishmania braziliensis	74%	100%
A4IBM9	Leishmania infantum	98%	100%
E9AFG3	Leishmania major	90%	100%
E9B6L8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5BYA4	Trypanosoma cruzi	24%	100%