LeishMANIAdb
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Leucine_Rich_Repeat/Leucine_Rich_repeat_putative/ Pfam:PF00560/Pfam:PF13516

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Leucine_Rich_Repeat/Leucine_Rich_repeat_putative/ Pfam:PF00560/Pfam:PF13516
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3Q8II72_LEIDO
TriTrypDb:
LdBPK_282120.1 , LdCL_280026200 , LDHU3_28.2840
Length:
753

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
TermNameLevelCount
GO:0005929 cilium 4 9
GO:0042995 cell projection 2 9
GO:0043226 organelle 2 9
GO:0043227 membrane-bounded organelle 3 9
GO:0110165 cellular anatomical entity 1 9
GO:0120025 plasma membrane bounded cell projection 3 9
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Phosphorylation

Promastigote: 435, 487, 516, 594
Promastigote/Amastigote: 596

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A0A3Q8II72
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8II72

Function

Could not find GO biological_process term for this entry.
Molecular functions
TermNameLevelCount
GO:0005096 GTPase activator activity 4 9
GO:0008047 enzyme activator activity 3 9
GO:0030234 enzyme regulator activity 2 9
GO:0030695 GTPase regulator activity 4 9
GO:0060589 nucleoside-triphosphatase regulator activity 3 9
GO:0098772 molecular function regulator activity 1 9
GO:0140677 molecular function activator activity 2 9
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 402 406 PF00656 0.803
CLV_NRD_NRD_1 373 375 PF00675 0.560
CLV_NRD_NRD_1 381 383 PF00675 0.606
CLV_NRD_NRD_1 417 419 PF00675 0.835
CLV_NRD_NRD_1 454 456 PF00675 0.816
CLV_NRD_NRD_1 572 574 PF00675 0.637
CLV_NRD_NRD_1 745 747 PF00675 0.692
CLV_PCSK_KEX2_1 17 19 PF00082 0.583
CLV_PCSK_KEX2_1 373 375 PF00082 0.560
CLV_PCSK_KEX2_1 381 383 PF00082 0.606
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Homologs

ProteinTaxonomySequence identityCoverage
A0A1X0NQV7 Trypanosomatidae 43% 100%
A0A422NBD9 Trypanosoma rangeli 43% 100%
A4HGP9 Leishmania braziliensis 75% 100%
A4I3S6 Leishmania infantum 100% 100%
D0A881 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 51% 100%
E9B018 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
Q4Q867 Leishmania major 93% 99%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS