LeishMANIAdb
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Leucine_Rich_Repeat/Leucine_Rich_repeat_putative/ Pfam:PF00560/Pfam:PF13516

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Leucine_Rich_Repeat/Leucine_Rich_repeat_putative/ Pfam:PF00560/Pfam:PF13516
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3Q8II72_LEIDO
TriTrypDb:
LdBPK_282120.1 , LdCL_280026200 , LDHU3_28.2840
Length:
753

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0005929 cilium 4 9
GO:0042995 cell projection 2 9
GO:0043226 organelle 2 9
GO:0043227 membrane-bounded organelle 3 9
GO:0110165 cellular anatomical entity 1 9
GO:0120025 plasma membrane bounded cell projection 3 9

Phosphorylation

Promastigote: 435, 487, 516, 594
Promastigote/Amastigote: 596

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A0A3Q8II72
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8II72

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005096 GTPase activator activity 4 9
GO:0008047 enzyme activator activity 3 9
GO:0030234 enzyme regulator activity 2 9
GO:0030695 GTPase regulator activity 4 9
GO:0060589 nucleoside-triphosphatase regulator activity 3 9
GO:0098772 molecular function regulator activity 1 9
GO:0140677 molecular function activator activity 2 9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 402 406 PF00656 0.803
CLV_NRD_NRD_1 373 375 PF00675 0.560
CLV_NRD_NRD_1 381 383 PF00675 0.606
CLV_NRD_NRD_1 417 419 PF00675 0.835
CLV_NRD_NRD_1 454 456 PF00675 0.816
CLV_NRD_NRD_1 572 574 PF00675 0.637
CLV_NRD_NRD_1 745 747 PF00675 0.692
CLV_PCSK_KEX2_1 17 19 PF00082 0.583
CLV_PCSK_KEX2_1 373 375 PF00082 0.560
CLV_PCSK_KEX2_1 381 383 PF00082 0.606
CLV_PCSK_KEX2_1 417 419 PF00082 0.835
CLV_PCSK_KEX2_1 454 456 PF00082 0.816
CLV_PCSK_KEX2_1 572 574 PF00082 0.639
CLV_PCSK_PC1ET2_1 17 19 PF00082 0.614
CLV_PCSK_PC7_1 377 383 PF00082 0.624
CLV_PCSK_SKI1_1 33 37 PF00082 0.624
CLV_PCSK_SKI1_1 539 543 PF00082 0.604
CLV_Separin_Metazoa 228 232 PF03568 0.486
DEG_APCC_DBOX_1 349 357 PF00400 0.573
DEG_Kelch_Keap1_1 707 712 PF01344 0.843
DEG_SCF_FBW7_1 233 239 PF00400 0.584
DOC_ANK_TNKS_1 400 407 PF00023 0.819
DOC_CDC14_PxL_1 177 185 PF14671 0.498
DOC_CKS1_1 233 238 PF01111 0.586
DOC_CKS1_1 485 490 PF01111 0.741
DOC_CKS1_1 529 534 PF01111 0.739
DOC_CYCLIN_RxL_1 66 77 PF00134 0.565
DOC_MAPK_DCC_7 350 358 PF00069 0.642
DOC_MAPK_gen_1 553 561 PF00069 0.503
DOC_PP2B_LxvP_1 741 744 PF13499 0.741
DOC_PP4_FxxP_1 275 278 PF00568 0.426
DOC_PP4_FxxP_1 335 338 PF00568 0.532
DOC_PP4_FxxP_1 78 81 PF00568 0.495
DOC_USP7_MATH_1 368 372 PF00917 0.498
DOC_USP7_MATH_1 442 446 PF00917 0.702
DOC_USP7_MATH_1 450 454 PF00917 0.763
DOC_USP7_MATH_1 477 481 PF00917 0.778
DOC_USP7_MATH_1 498 502 PF00917 0.758
DOC_USP7_MATH_1 511 515 PF00917 0.652
DOC_USP7_MATH_1 591 595 PF00917 0.761
DOC_USP7_MATH_1 613 617 PF00917 0.757
DOC_USP7_MATH_1 667 671 PF00917 0.763
DOC_USP7_MATH_1 693 697 PF00917 0.826
DOC_USP7_MATH_1 725 729 PF00917 0.706
DOC_USP7_MATH_1 735 739 PF00917 0.640
DOC_USP7_UBL2_3 104 108 PF12436 0.539
DOC_USP7_UBL2_3 305 309 PF12436 0.596
DOC_USP7_UBL2_3 542 546 PF12436 0.685
DOC_WW_Pin1_4 232 237 PF00397 0.587
DOC_WW_Pin1_4 276 281 PF00397 0.510
DOC_WW_Pin1_4 432 437 PF00397 0.819
DOC_WW_Pin1_4 446 451 PF00397 0.652
DOC_WW_Pin1_4 456 461 PF00397 0.744
DOC_WW_Pin1_4 484 489 PF00397 0.773
DOC_WW_Pin1_4 528 533 PF00397 0.740
DOC_WW_Pin1_4 587 592 PF00397 0.793
DOC_WW_Pin1_4 689 694 PF00397 0.825
DOC_WW_Pin1_4 733 738 PF00397 0.765
LIG_14-3-3_CanoR_1 382 390 PF00244 0.572
LIG_14-3-3_CanoR_1 444 450 PF00244 0.757
LIG_14-3-3_CanoR_1 486 492 PF00244 0.761
LIG_14-3-3_CanoR_1 553 562 PF00244 0.618
LIG_14-3-3_CanoR_1 60 68 PF00244 0.533
LIG_14-3-3_CanoR_1 677 684 PF00244 0.748
LIG_14-3-3_CanoR_1 689 693 PF00244 0.800
LIG_14-3-3_CanoR_1 746 750 PF00244 0.817
LIG_APCC_ABBA_1 255 260 PF00400 0.411
LIG_BIR_III_4 645 649 PF00653 0.723
LIG_BRCT_BRCA1_1 749 753 PF00533 0.813
LIG_Clathr_ClatBox_1 296 300 PF01394 0.469
LIG_FHA_1 211 217 PF00498 0.409
LIG_FHA_1 235 241 PF00498 0.482
LIG_FHA_1 252 258 PF00498 0.375
LIG_FHA_1 264 270 PF00498 0.333
LIG_FHA_1 309 315 PF00498 0.551
LIG_FHA_1 367 373 PF00498 0.505
LIG_FHA_1 42 48 PF00498 0.512
LIG_FHA_1 535 541 PF00498 0.687
LIG_FHA_1 602 608 PF00498 0.804
LIG_FHA_1 690 696 PF00498 0.790
LIG_FHA_2 400 406 PF00498 0.815
LIG_FHA_2 529 535 PF00498 0.738
LIG_FHA_2 562 568 PF00498 0.583
LIG_FHA_2 59 65 PF00498 0.598
LIG_FHA_2 683 689 PF00498 0.815
LIG_LIR_Apic_2 334 338 PF02991 0.444
LIG_LIR_Apic_2 75 81 PF02991 0.573
LIG_LIR_Gen_1 623 632 PF02991 0.729
LIG_LIR_Nem_3 623 628 PF02991 0.751
LIG_LIR_Nem_3 636 640 PF02991 0.757
LIG_LIR_Nem_3 649 655 PF02991 0.659
LIG_LRP6_Inhibitor_1 92 98 PF00058 0.517
LIG_PCNA_yPIPBox_3 321 329 PF02747 0.509
LIG_SH2_CRK 190 194 PF00017 0.363
LIG_SH2_CRK 625 629 PF00017 0.719
LIG_SH2_CRK 637 641 PF00017 0.637
LIG_SH2_NCK_1 375 379 PF00017 0.709
LIG_SH2_PTP2 357 360 PF00017 0.475
LIG_SH2_STAT3 172 175 PF00017 0.420
LIG_SH2_STAT3 655 658 PF00017 0.813
LIG_SH2_STAT5 12 15 PF00017 0.501
LIG_SH2_STAT5 172 175 PF00017 0.420
LIG_SH2_STAT5 357 360 PF00017 0.475
LIG_SH2_STAT5 366 369 PF00017 0.490
LIG_SH3_3 457 463 PF00018 0.832
LIG_SH3_3 469 475 PF00018 0.685
LIG_SH3_3 529 535 PF00018 0.700
LIG_SUMO_SIM_anti_2 311 316 PF11976 0.501
LIG_SUMO_SIM_anti_2 518 527 PF11976 0.559
LIG_SUMO_SIM_anti_2 682 688 PF11976 0.689
LIG_SUMO_SIM_par_1 127 133 PF11976 0.363
LIG_SUMO_SIM_par_1 154 159 PF11976 0.402
LIG_SUMO_SIM_par_1 212 217 PF11976 0.432
LIG_SUMO_SIM_par_1 295 300 PF11976 0.391
LIG_SUMO_SIM_par_1 69 75 PF11976 0.563
LIG_TRAF2_1 317 320 PF00917 0.587
LIG_TRAF2_1 437 440 PF00917 0.799
LIG_TYR_ITIM 188 193 PF00017 0.363
LIG_TYR_ITIM 635 640 PF00017 0.730
LIG_UBA3_1 297 305 PF00899 0.406
LIG_Vh1_VBS_1 510 528 PF01044 0.612
LIG_WW_3 729 733 PF00397 0.736
MOD_CDC14_SPxK_1 590 593 PF00782 0.785
MOD_CDK_SPK_2 446 451 PF00069 0.832
MOD_CDK_SPK_2 456 461 PF00069 0.681
MOD_CDK_SPK_2 484 489 PF00069 0.765
MOD_CDK_SPxK_1 587 593 PF00069 0.786
MOD_CK1_1 428 434 PF00069 0.813
MOD_CK1_1 445 451 PF00069 0.817
MOD_CK1_1 470 476 PF00069 0.803
MOD_CK1_1 494 500 PF00069 0.783
MOD_CK1_1 587 593 PF00069 0.804
MOD_CK1_1 63 69 PF00069 0.484
MOD_CK1_1 676 682 PF00069 0.785
MOD_CK2_1 432 438 PF00069 0.818
MOD_CK2_1 513 519 PF00069 0.646
MOD_CK2_1 544 550 PF00069 0.508
MOD_CK2_1 561 567 PF00069 0.563
MOD_CK2_1 682 688 PF00069 0.771
MOD_DYRK1A_RPxSP_1 432 436 PF00069 0.744
MOD_GlcNHglycan 121 124 PF01048 0.491
MOD_GlcNHglycan 13 16 PF01048 0.636
MOD_GlcNHglycan 287 290 PF01048 0.427
MOD_GlcNHglycan 456 459 PF01048 0.848
MOD_GlcNHglycan 469 472 PF01048 0.807
MOD_GlcNHglycan 479 482 PF01048 0.715
MOD_GlcNHglycan 496 499 PF01048 0.665
MOD_GlcNHglycan 586 589 PF01048 0.755
MOD_GlcNHglycan 593 596 PF01048 0.807
MOD_GlcNHglycan 617 620 PF01048 0.786
MOD_GlcNHglycan 708 712 PF01048 0.815
MOD_GlcNHglycan 722 725 PF01048 0.618
MOD_GSK3_1 115 122 PF00069 0.539
MOD_GSK3_1 210 217 PF00069 0.419
MOD_GSK3_1 232 239 PF00069 0.580
MOD_GSK3_1 373 380 PF00069 0.570
MOD_GSK3_1 381 388 PF00069 0.602
MOD_GSK3_1 389 396 PF00069 0.619
MOD_GSK3_1 407 414 PF00069 0.803
MOD_GSK3_1 421 428 PF00069 0.594
MOD_GSK3_1 442 449 PF00069 0.763
MOD_GSK3_1 450 457 PF00069 0.676
MOD_GSK3_1 487 494 PF00069 0.777
MOD_GSK3_1 540 547 PF00069 0.586
MOD_GSK3_1 580 587 PF00069 0.722
MOD_GSK3_1 613 620 PF00069 0.727
MOD_GSK3_1 667 674 PF00069 0.745
MOD_GSK3_1 676 683 PF00069 0.758
MOD_GSK3_1 689 696 PF00069 0.728
MOD_LATS_1 452 458 PF00433 0.763
MOD_N-GLC_1 134 139 PF02516 0.496
MOD_N-GLC_1 264 269 PF02516 0.415
MOD_N-GLC_1 321 326 PF02516 0.470
MOD_N-GLC_1 680 685 PF02516 0.721
MOD_NEK2_1 11 16 PF00069 0.634
MOD_NEK2_1 119 124 PF00069 0.476
MOD_NEK2_1 214 219 PF00069 0.409
MOD_NEK2_1 548 553 PF00069 0.653
MOD_NEK2_1 671 676 PF00069 0.742
MOD_NEK2_1 720 725 PF00069 0.691
MOD_NEK2_1 745 750 PF00069 0.819
MOD_NEK2_2 368 373 PF00069 0.505
MOD_PIKK_1 442 448 PF00454 0.819
MOD_PIKK_1 554 560 PF00454 0.604
MOD_PIKK_1 613 619 PF00454 0.786
MOD_PIKK_1 63 69 PF00454 0.523
MOD_PIKK_1 676 682 PF00454 0.813
MOD_PIKK_1 693 699 PF00454 0.827
MOD_PIKK_1 735 741 PF00454 0.782
MOD_PK_1 425 431 PF00069 0.745
MOD_PKA_1 373 379 PF00069 0.569
MOD_PKA_1 381 387 PF00069 0.602
MOD_PKA_1 454 460 PF00069 0.766
MOD_PKA_2 219 225 PF00069 0.568
MOD_PKA_2 373 379 PF00069 0.569
MOD_PKA_2 381 387 PF00069 0.602
MOD_PKA_2 416 422 PF00069 0.802
MOD_PKA_2 450 456 PF00069 0.771
MOD_PKA_2 499 505 PF00069 0.820
MOD_PKA_2 535 541 PF00069 0.670
MOD_PKA_2 676 682 PF00069 0.757
MOD_PKA_2 688 694 PF00069 0.790
MOD_PKA_2 745 751 PF00069 0.818
MOD_Plk_1 156 162 PF00069 0.405
MOD_Plk_1 264 270 PF00069 0.411
MOD_Plk_1 321 327 PF00069 0.558
MOD_Plk_1 63 69 PF00069 0.558
MOD_Plk_1 680 686 PF00069 0.683
MOD_Plk_1 74 80 PF00069 0.431
MOD_Plk_4 168 174 PF00069 0.427
MOD_Plk_4 251 257 PF00069 0.499
MOD_Plk_4 264 270 PF00069 0.323
MOD_Plk_4 540 546 PF00069 0.602
MOD_ProDKin_1 232 238 PF00069 0.580
MOD_ProDKin_1 276 282 PF00069 0.505
MOD_ProDKin_1 432 438 PF00069 0.818
MOD_ProDKin_1 446 452 PF00069 0.653
MOD_ProDKin_1 456 462 PF00069 0.745
MOD_ProDKin_1 484 490 PF00069 0.773
MOD_ProDKin_1 528 534 PF00069 0.735
MOD_ProDKin_1 587 593 PF00069 0.795
MOD_ProDKin_1 689 695 PF00069 0.826
MOD_ProDKin_1 733 739 PF00069 0.766
MOD_SUMO_rev_2 32 38 PF00179 0.621
TRG_DiLeu_BaEn_4 348 354 PF01217 0.669
TRG_ENDOCYTIC_2 190 193 PF00928 0.363
TRG_ENDOCYTIC_2 625 628 PF00928 0.749
TRG_ENDOCYTIC_2 637 640 PF00928 0.747
TRG_ER_diArg_1 372 374 PF00400 0.536
TRG_ER_diArg_1 463 466 PF00400 0.828
TRG_Pf-PMV_PEXEL_1 546 550 PF00026 0.504
TRG_Pf-PMV_PEXEL_1 60 64 PF00026 0.508
TRG_Pf-PMV_PEXEL_1 69 74 PF00026 0.355

Homologs

Protein Taxonomy Sequence identity Coverage
A0A1X0NQV7 Trypanosomatidae 43% 100%
A0A422NBD9 Trypanosoma rangeli 43% 100%
A4HGP9 Leishmania braziliensis 75% 100%
A4I3S6 Leishmania infantum 100% 100%
D0A881 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 51% 100%
E9B018 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
Q4Q867 Leishmania major 93% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS