RNA_recognition_motif._(A.k.a._RRM_RBD_or_RNP_dom ain)/RNA_recognition_motif_(A.k.a._RRM_RBD_or_RNP_domain)_p utative/Pfam:PF00076/Pfam:PF14259/Pfam:PF13893

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania donovani

UniProt:

A0A3Q8II67_LEIDO

TriTrypDb:

LdBPK_303220.1 , LdCL_300037800 , LDHU3_30.4310

Length:

141

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8II67

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8II67

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	14
GO:0003723	RNA binding	4	14
GO:0005488	binding	1	14
GO:0097159	organic cyclic compound binding	2	14
GO:1901363	heterocyclic compound binding	2	14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	53	57	PF00656	0.465
CLV_PCSK_KEX2_1	103	105	PF00082	0.572
CLV_PCSK_PC1ET2_1	103	105	PF00082	0.572
CLV_PCSK_SKI1_1	4	8	PF00082	0.469
DEG_Nend_UBRbox_3	1	3	PF02207	0.565
DOC_CYCLIN_RxL_1	103	115	PF00134	0.502
DOC_MAPK_DCC_7	103	111	PF00069	0.554
DOC_MAPK_gen_1	103	111	PF00069	0.530
DOC_MAPK_MEF2A_6	70	77	PF00069	0.413
DOC_PP1_RVXF_1	2	9	PF00149	0.489
DOC_USP7_MATH_1	127	131	PF00917	0.638
DOC_USP7_MATH_1	83	87	PF00917	0.441
DOC_WW_Pin1_4	135	140	PF00397	0.613
DOC_WW_Pin1_4	79	84	PF00397	0.460
LIG_14-3-3_CanoR_1	23	31	PF00244	0.475
LIG_APCC_ABBA_1	34	39	PF00400	0.515
LIG_FHA_2	49	55	PF00498	0.540
LIG_LIR_Gen_1	115	126	PF02991	0.519
LIG_LIR_Nem_3	115	121	PF02991	0.676
LIG_LIR_Nem_3	22	28	PF02991	0.481
LIG_LIR_Nem_3	46	52	PF02991	0.445
LIG_PTB_Apo_2	14	21	PF02174	0.475
LIG_PTB_Phospho_1	14	20	PF10480	0.475
LIG_SH2_CRK	118	122	PF00017	0.546
LIG_SH2_CRK	28	32	PF00017	0.545
LIG_SH2_NCK_1	44	48	PF00017	0.464
LIG_SH2_SRC	44	47	PF00017	0.502
LIG_SH2_STAT3	88	91	PF00017	0.497
LIG_SH2_STAT5	20	23	PF00017	0.487
LIG_SH3_3	102	108	PF00018	0.499
LIG_SH3_3	120	126	PF00018	0.466
LIG_SUMO_SIM_par_1	107	113	PF11976	0.507
LIG_SUMO_SIM_par_1	73	79	PF11976	0.433
LIG_TRAF2_1	99	102	PF00917	0.558
LIG_TYR_ITIM	47	52	PF00017	0.475
LIG_WW_3	104	108	PF00397	0.555
MOD_CK1_1	10	16	PF00069	0.532
MOD_CK1_1	79	85	PF00069	0.452
MOD_CK2_1	125	131	PF00069	0.517
MOD_GlcNHglycan	25	28	PF01048	0.275
MOD_GSK3_1	23	30	PF00069	0.553
MOD_GSK3_1	7	14	PF00069	0.532
MOD_GSK3_1	79	86	PF00069	0.367
MOD_N-GLC_1	10	15	PF02516	0.316
MOD_NEK2_1	7	12	PF00069	0.505
MOD_NEK2_2	27	32	PF00069	0.490
MOD_NEK2_2	83	88	PF00069	0.504
MOD_OFUCOSY	64	69	PF10250	0.514
MOD_PIKK_1	76	82	PF00454	0.423
MOD_Plk_1	10	16	PF00069	0.515
MOD_Plk_1	45	51	PF00069	0.492
MOD_Plk_4	83	89	PF00069	0.501
MOD_ProDKin_1	135	141	PF00069	0.615
MOD_ProDKin_1	79	85	PF00069	0.460
MOD_SUMO_rev_2	95	105	PF00179	0.532
TRG_ENDOCYTIC_2	118	121	PF00928	0.692
TRG_ENDOCYTIC_2	28	31	PF00928	0.440
TRG_ENDOCYTIC_2	44	47	PF00928	0.464
TRG_ENDOCYTIC_2	49	52	PF00928	0.457
TRG_Pf-PMV_PEXEL_1	107	112	PF00026	0.508

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Z2	Leptomonas seymouri	86%	100%
A0A0S4J311	Bodo saltans	32%	100%
A0A0S4JKJ5	Bodo saltans	47%	76%
A0A1X0P0Y7	Trypanosomatidae	28%	100%
A0A1X0P2H6	Trypanosomatidae	53%	100%
A4HIQ2	Leishmania braziliensis	92%	100%
A4I5Z5	Leishmania infantum	100%	100%
C9ZRC4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	92%
D0A516	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9B192	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
Q4Q6X2	Leishmania major	99%	100%
V5BSJ4	Trypanosoma cruzi	55%	93%