Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8II63_LEIDO

TriTrypDb:

LdBPK_140050.1 , LdCL_140005400 , LDHU3_14.0070

Length:

733

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8II63

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8II63

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	548	552	PF00656	0.655
CLV_C14_Caspase3-7	711	715	PF00656	0.658
CLV_NRD_NRD_1	181	183	PF00675	0.491
CLV_NRD_NRD_1	371	373	PF00675	0.601
CLV_NRD_NRD_1	434	436	PF00675	0.700
CLV_NRD_NRD_1	532	534	PF00675	0.617
CLV_NRD_NRD_1	719	721	PF00675	0.663
CLV_NRD_NRD_1	76	78	PF00675	0.451
CLV_PCSK_KEX2_1	180	182	PF00082	0.483
CLV_PCSK_KEX2_1	2	4	PF00082	0.686
CLV_PCSK_KEX2_1	371	373	PF00082	0.624
CLV_PCSK_KEX2_1	415	417	PF00082	0.608
CLV_PCSK_KEX2_1	436	438	PF00082	0.684
CLV_PCSK_KEX2_1	530	532	PF00082	0.554
CLV_PCSK_KEX2_1	718	720	PF00082	0.669
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.686
CLV_PCSK_PC1ET2_1	415	417	PF00082	0.608
CLV_PCSK_PC1ET2_1	436	438	PF00082	0.684
CLV_PCSK_PC1ET2_1	530	532	PF00082	0.575
CLV_PCSK_PC7_1	527	533	PF00082	0.559
CLV_PCSK_SKI1_1	143	147	PF00082	0.690
CLV_PCSK_SKI1_1	173	177	PF00082	0.411
CLV_PCSK_SKI1_1	225	229	PF00082	0.460
CLV_PCSK_SKI1_1	281	285	PF00082	0.372
CLV_PCSK_SKI1_1	371	375	PF00082	0.535
CLV_PCSK_SKI1_1	456	460	PF00082	0.525
CLV_PCSK_SKI1_1	494	498	PF00082	0.503
CLV_PCSK_SKI1_1	6	10	PF00082	0.594
CLV_PCSK_SKI1_1	614	618	PF00082	0.595
CLV_PCSK_SKI1_1	628	632	PF00082	0.683
CLV_PCSK_SKI1_1	724	728	PF00082	0.695
CLV_Separin_Metazoa	440	444	PF03568	0.539
DEG_Nend_UBRbox_1	1	4	PF02207	0.693
DEG_SCF_FBW7_2	147	154	PF00400	0.581
DEG_SPOP_SBC_1	542	546	PF00917	0.767
DOC_ANK_TNKS_1	709	716	PF00023	0.699
DOC_CYCLIN_yCln2_LP_2	17	23	PF00134	0.550
DOC_CYCLIN_yCln2_LP_2	193	199	PF00134	0.520
DOC_MAPK_gen_1	2	13	PF00069	0.563
DOC_MAPK_gen_1	252	261	PF00069	0.543
DOC_MAPK_gen_1	77	84	PF00069	0.501
DOC_MAPK_MEF2A_6	16	24	PF00069	0.487
DOC_MAPK_MEF2A_6	252	261	PF00069	0.543
DOC_MAPK_MEF2A_6	262	269	PF00069	0.370
DOC_PP1_RVXF_1	279	285	PF00149	0.412
DOC_PP1_RVXF_1	91	97	PF00149	0.523
DOC_PP2B_LxvP_1	119	122	PF13499	0.672
DOC_SPAK_OSR1_1	580	584	PF12202	0.563
DOC_USP7_MATH_1	106	110	PF00917	0.577
DOC_USP7_MATH_1	145	149	PF00917	0.602
DOC_USP7_MATH_1	210	214	PF00917	0.463
DOC_USP7_MATH_1	386	390	PF00917	0.440
DOC_USP7_MATH_1	510	514	PF00917	0.584
DOC_USP7_MATH_1	543	547	PF00917	0.769
DOC_USP7_MATH_1	597	601	PF00917	0.719
DOC_USP7_MATH_1	729	733	PF00917	0.655
DOC_USP7_UBL2_3	658	662	PF12436	0.703
DOC_WW_Pin1_4	147	152	PF00397	0.536
DOC_WW_Pin1_4	371	376	PF00397	0.562
DOC_WW_Pin1_4	472	477	PF00397	0.494
DOC_WW_Pin1_4	536	541	PF00397	0.752
DOC_WW_Pin1_4	635	640	PF00397	0.741
DOC_WW_Pin1_4	682	687	PF00397	0.683
DOC_WW_Pin1_4	693	698	PF00397	0.693
LIG_14-3-3_CanoR_1	180	185	PF00244	0.508
LIG_14-3-3_CanoR_1	225	234	PF00244	0.521
LIG_14-3-3_CanoR_1	298	306	PF00244	0.445
LIG_14-3-3_CanoR_1	6	12	PF00244	0.562
LIG_14-3-3_CanoR_1	614	623	PF00244	0.685
LIG_14-3-3_CanoR_1	628	637	PF00244	0.532
LIG_14-3-3_CanoR_1	703	709	PF00244	0.643
LIG_14-3-3_CterR_2	728	733	PF00244	0.672
LIG_Actin_WH2_2	342	359	PF00022	0.539
LIG_BRCT_BRCA1_1	193	197	PF00533	0.505
LIG_FHA_1	126	132	PF00498	0.628
LIG_FHA_1	186	192	PF00498	0.534
LIG_FHA_1	341	347	PF00498	0.508
LIG_FHA_1	361	367	PF00498	0.225
LIG_FHA_1	418	424	PF00498	0.517
LIG_FHA_1	426	432	PF00498	0.568
LIG_FHA_1	615	621	PF00498	0.676
LIG_FHA_1	644	650	PF00498	0.717
LIG_FHA_1	667	673	PF00498	0.789
LIG_FHA_2	332	338	PF00498	0.504
LIG_FHA_2	543	549	PF00498	0.774
LIG_FHA_2	552	558	PF00498	0.636
LIG_FHA_2	573	579	PF00498	0.714
LIG_FHA_2	588	594	PF00498	0.521
LIG_HP1_1	20	24	PF01393	0.550
LIG_IRF3_LxIS_1	20	27	PF10401	0.588
LIG_LIR_Apic_2	337	342	PF02991	0.461
LIG_LIR_Apic_2	40	45	PF02991	0.616
LIG_LIR_Gen_1	194	204	PF02991	0.515
LIG_LIR_Gen_1	334	342	PF02991	0.376
LIG_LIR_Gen_1	452	459	PF02991	0.525
LIG_LIR_Gen_1	578	589	PF02991	0.741
LIG_LIR_LC3C_4	420	425	PF02991	0.512
LIG_LIR_Nem_3	194	200	PF02991	0.427
LIG_LIR_Nem_3	578	584	PF02991	0.733
LIG_MYND_1	147	151	PF01753	0.599
LIG_NRBOX	13	19	PF00104	0.602
LIG_Pex14_2	450	454	PF04695	0.506
LIG_PTB_Apo_2	502	509	PF02174	0.592
LIG_PTB_Phospho_1	502	508	PF10480	0.589
LIG_SH2_CRK	42	46	PF00017	0.603
LIG_SH2_GRB2like	503	506	PF00017	0.576
LIG_SH2_SRC	503	506	PF00017	0.576
LIG_SH2_STAP1	324	328	PF00017	0.569
LIG_SH2_STAT3	323	326	PF00017	0.474
LIG_SH2_STAT3	722	725	PF00017	0.695
LIG_SH2_STAT5	25	28	PF00017	0.597
LIG_SH2_STAT5	335	338	PF00017	0.449
LIG_SH2_STAT5	405	408	PF00017	0.418
LIG_SH2_STAT5	449	452	PF00017	0.430
LIG_SH2_STAT5	503	506	PF00017	0.539
LIG_SH3_3	120	126	PF00018	0.646
LIG_SH3_3	128	134	PF00018	0.630
LIG_SH3_3	537	543	PF00018	0.584
LIG_SH3_3	631	637	PF00018	0.758
LIG_SUMO_SIM_anti_2	419	426	PF11976	0.421
LIG_SUMO_SIM_anti_2	551	557	PF11976	0.685
LIG_SUMO_SIM_par_1	188	194	PF11976	0.349
LIG_SUMO_SIM_par_1	345	351	PF11976	0.536
LIG_SUMO_SIM_par_1	427	433	PF11976	0.495
LIG_TRAF2_1	151	154	PF00917	0.575
LIG_TRAF2_1	458	461	PF00917	0.508
LIG_TRAF2_1	499	502	PF00917	0.569
LIG_TRAF2_1	665	668	PF00917	0.804
LIG_WRC_WIRS_1	312	317	PF05994	0.398
MOD_CDK_SPK_2	693	698	PF00069	0.737
MOD_CK1_1	159	165	PF00069	0.559
MOD_CK1_1	235	241	PF00069	0.491
MOD_CK1_1	304	310	PF00069	0.438
MOD_CK1_1	351	357	PF00069	0.574
MOD_CK1_1	462	468	PF00069	0.512
MOD_CK1_1	513	519	PF00069	0.538
MOD_CK1_1	541	547	PF00069	0.733
MOD_CK1_1	676	682	PF00069	0.765
MOD_CK1_1	693	699	PF00069	0.498
MOD_CK2_1	331	337	PF00069	0.501
MOD_CK2_1	496	502	PF00069	0.522
MOD_CK2_1	551	557	PF00069	0.670
MOD_CK2_1	572	578	PF00069	0.704
MOD_CK2_1	599	605	PF00069	0.628
MOD_CK2_1	662	668	PF00069	0.803
MOD_Cter_Amidation	178	181	PF01082	0.512
MOD_GlcNHglycan	139	143	PF01048	0.557
MOD_GlcNHglycan	240	243	PF01048	0.494
MOD_GlcNHglycan	350	353	PF01048	0.511
MOD_GlcNHglycan	376	379	PF01048	0.468
MOD_GlcNHglycan	498	501	PF01048	0.510
MOD_GlcNHglycan	601	604	PF01048	0.761
MOD_GlcNHglycan	61	64	PF01048	0.476
MOD_GlcNHglycan	625	628	PF01048	0.737
MOD_GlcNHglycan	664	667	PF01048	0.699
MOD_GlcNHglycan	692	695	PF01048	0.750
MOD_GSK3_1	145	152	PF00069	0.599
MOD_GSK3_1	187	194	PF00069	0.514
MOD_GSK3_1	297	304	PF00069	0.495
MOD_GSK3_1	367	374	PF00069	0.612
MOD_GSK3_1	407	414	PF00069	0.515
MOD_GSK3_1	462	469	PF00069	0.502
MOD_GSK3_1	538	545	PF00069	0.731
MOD_GSK3_1	59	66	PF00069	0.401
MOD_GSK3_1	595	602	PF00069	0.730
MOD_GSK3_1	656	663	PF00069	0.783
MOD_GSK3_1	693	700	PF00069	0.728
MOD_N-GLC_1	296	301	PF02516	0.588
MOD_N-GLC_1	513	518	PF02516	0.623
MOD_N-GLC_1	551	556	PF02516	0.685
MOD_NEK2_1	138	143	PF00069	0.545
MOD_NEK2_1	24	29	PF00069	0.591
MOD_NEK2_1	283	288	PF00069	0.436
MOD_NEK2_1	459	464	PF00069	0.429
MOD_NEK2_1	496	501	PF00069	0.543
MOD_NEK2_1	560	565	PF00069	0.651
MOD_NEK2_1	623	628	PF00069	0.739
MOD_NEK2_1	702	707	PF00069	0.697
MOD_PIKK_1	149	155	PF00454	0.611
MOD_PIKK_1	225	231	PF00454	0.436
MOD_PIKK_1	351	357	PF00454	0.561
MOD_PIKK_1	360	366	PF00454	0.400
MOD_PIKK_1	462	468	PF00454	0.541
MOD_PKA_1	180	186	PF00069	0.496
MOD_PKA_1	77	83	PF00069	0.562
MOD_PKA_2	180	186	PF00069	0.539
MOD_PKA_2	297	303	PF00069	0.418
MOD_PKA_2	697	703	PF00069	0.654
MOD_Plk_1	37	43	PF00069	0.498
MOD_Plk_1	407	413	PF00069	0.382
MOD_Plk_1	459	465	PF00069	0.497
MOD_Plk_1	551	557	PF00069	0.685
MOD_Plk_1	587	593	PF00069	0.759
MOD_Plk_2-3	331	337	PF00069	0.471
MOD_Plk_2-3	551	557	PF00069	0.685
MOD_Plk_2-3	605	611	PF00069	0.646
MOD_Plk_4	187	193	PF00069	0.501
MOD_Plk_4	298	304	PF00069	0.565
MOD_Plk_4	311	317	PF00069	0.451
MOD_Plk_4	37	43	PF00069	0.627
MOD_Plk_4	407	413	PF00069	0.510
MOD_Plk_4	425	431	PF00069	0.266
MOD_Plk_4	459	465	PF00069	0.497
MOD_Plk_4	466	472	PF00069	0.501
MOD_Plk_4	587	593	PF00069	0.769
MOD_Plk_4	63	69	PF00069	0.425
MOD_ProDKin_1	147	153	PF00069	0.528
MOD_ProDKin_1	371	377	PF00069	0.560
MOD_ProDKin_1	472	478	PF00069	0.498
MOD_ProDKin_1	536	542	PF00069	0.752
MOD_ProDKin_1	635	641	PF00069	0.744
MOD_ProDKin_1	682	688	PF00069	0.684
MOD_ProDKin_1	693	699	PF00069	0.688
MOD_SUMO_for_1	107	110	PF00179	0.463
MOD_SUMO_rev_2	322	328	PF00179	0.481
MOD_SUMO_rev_2	487	496	PF00179	0.559
TRG_DiLeu_BaLyEn_6	13	18	PF01217	0.571
TRG_DiLeu_BaLyEn_6	170	175	PF01217	0.502
TRG_ENDOCYTIC_2	335	338	PF00928	0.413
TRG_ER_diArg_1	180	182	PF00400	0.483
TRG_ER_diArg_1	371	373	PF00400	0.604
TRG_ER_diArg_1	531	533	PF00400	0.589
TRG_ER_diArg_1	718	720	PF00400	0.581
TRG_NLS_MonoCore_2	529	534	PF00514	0.540
TRG_NLS_MonoExtC_3	434	439	PF00514	0.668
TRG_NLS_MonoExtN_4	527	534	PF00514	0.575
TRG_Pf-PMV_PEXEL_1	182	187	PF00026	0.487
TRG_Pf-PMV_PEXEL_1	255	260	PF00026	0.549
TRG_Pf-PMV_PEXEL_1	289	293	PF00026	0.469
TRG_Pf-PMV_PEXEL_1	628	632	PF00026	0.763

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Q1	Leptomonas seymouri	48%	96%
A0A1X0NNU6	Trypanosomatidae	25%	98%
A0A422NXG9	Trypanosoma rangeli	26%	100%
A4HVU7	Leishmania infantum	99%	100%
E9APJ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QFY0	Leishmania major	91%	100%
V5BM90	Trypanosoma cruzi	26%	100%