Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8II60_LEIDO

TriTrypDb:

LdBPK_341870.1 , LdCL_340026400 , LDHU3_34.3200

Length:

306

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3Q8II60

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8II60

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	230	234	PF00656	0.583
CLV_NRD_NRD_1	173	175	PF00675	0.346
CLV_NRD_NRD_1	280	282	PF00675	0.394
CLV_NRD_NRD_1	295	297	PF00675	0.387
CLV_NRD_NRD_1	53	55	PF00675	0.326
CLV_PCSK_FUR_1	51	55	PF00082	0.321
CLV_PCSK_KEX2_1	172	174	PF00082	0.333
CLV_PCSK_KEX2_1	280	282	PF00082	0.403
CLV_PCSK_KEX2_1	295	297	PF00082	0.470
CLV_PCSK_KEX2_1	53	55	PF00082	0.326
CLV_PCSK_PC1ET2_1	295	297	PF00082	0.474
CLV_PCSK_SKI1_1	176	180	PF00082	0.359
CLV_PCSK_SKI1_1	201	205	PF00082	0.389
CLV_PCSK_SKI1_1	54	58	PF00082	0.408
DEG_APCC_DBOX_1	53	61	PF00400	0.511
DOC_MAPK_FxFP_2	123	126	PF00069	0.314
DOC_MAPK_gen_1	172	179	PF00069	0.536
DOC_MAPK_gen_1	215	223	PF00069	0.611
DOC_MAPK_MEF2A_6	172	179	PF00069	0.554
DOC_PP1_RVXF_1	88	94	PF00149	0.314
DOC_PP4_FxxP_1	123	126	PF00568	0.314
DOC_USP7_UBL2_3	297	301	PF12436	0.676
DOC_WW_Pin1_4	190	195	PF00397	0.564
DOC_WW_Pin1_4	239	244	PF00397	0.633
LIG_14-3-3_CanoR_1	13	20	PF00244	0.614
LIG_14-3-3_CanoR_1	280	286	PF00244	0.606
LIG_14-3-3_CanoR_1	94	100	PF00244	0.249
LIG_BIR_II_1	1	5	PF00653	0.629
LIG_deltaCOP1_diTrp_1	247	255	PF00928	0.565
LIG_deltaCOP1_diTrp_1	49	56	PF00928	0.520
LIG_FHA_1	240	246	PF00498	0.635
LIG_FHA_2	228	234	PF00498	0.596
LIG_FHA_2	261	267	PF00498	0.601
LIG_FHA_2	282	288	PF00498	0.606
LIG_FHA_2	6	12	PF00498	0.591
LIG_GBD_Chelix_1	135	143	PF00786	0.375
LIG_LIR_Apic_2	121	126	PF02991	0.450
LIG_LIR_Gen_1	106	115	PF02991	0.271
LIG_LIR_Gen_1	24	35	PF02991	0.597
LIG_LIR_Gen_1	244	252	PF02991	0.584
LIG_LIR_Gen_1	96	105	PF02991	0.291
LIG_LIR_Nem_3	106	112	PF02991	0.271
LIG_LIR_Nem_3	121	127	PF02991	0.450
LIG_LIR_Nem_3	244	249	PF02991	0.591
LIG_LIR_Nem_3	253	257	PF02991	0.573
LIG_LIR_Nem_3	64	69	PF02991	0.348
LIG_LIR_Nem_3	96	102	PF02991	0.291
LIG_LYPXL_yS_3	125	128	PF13949	0.271
LIG_MYND_1	194	198	PF01753	0.572
LIG_Pex14_1	52	56	PF04695	0.617
LIG_Pex14_2	151	155	PF04695	0.349
LIG_Pex14_2	251	255	PF04695	0.561
LIG_Pex14_2	72	76	PF04695	0.404
LIG_SH2_CRK	66	70	PF00017	0.314
LIG_SH2_GRB2like	205	208	PF00017	0.587
LIG_SH2_STAP1	95	99	PF00017	0.292
LIG_SH2_STAT5	47	50	PF00017	0.545
LIG_SH2_STAT5	85	88	PF00017	0.339
LIG_SH2_STAT5	95	98	PF00017	0.261
LIG_SH3_3	246	252	PF00018	0.586
LIG_SUMO_SIM_par_1	135	141	PF11976	0.291
LIG_TRAF2_1	209	212	PF00917	0.615
LIG_TRAF2_1	263	266	PF00917	0.602
LIG_TYR_ITSM	62	69	PF00017	0.331
MOD_CK1_1	138	144	PF00069	0.556
MOD_CK1_1	18	24	PF00069	0.675
MOD_CK1_1	239	245	PF00069	0.671
MOD_CK2_1	260	266	PF00069	0.599
MOD_CK2_1	281	287	PF00069	0.608
MOD_CK2_1	43	49	PF00069	0.507
MOD_CK2_1	76	82	PF00069	0.351
MOD_GlcNHglycan	106	109	PF01048	0.404
MOD_GlcNHglycan	17	20	PF01048	0.459
MOD_GSK3_1	138	145	PF00069	0.404
MOD_GSK3_1	14	21	PF00069	0.620
MOD_GSK3_1	219	226	PF00069	0.678
MOD_GSK3_1	281	288	PF00069	0.609
MOD_N-GLC_1	239	244	PF02516	0.442
MOD_NEK2_1	104	109	PF00069	0.289
MOD_NEK2_1	14	19	PF00069	0.618
MOD_NEK2_1	56	61	PF00069	0.460
MOD_NEK2_1	76	81	PF00069	0.241
MOD_PIKK_1	138	144	PF00454	0.400
MOD_PKA_1	281	287	PF00069	0.608
MOD_PKA_2	76	82	PF00069	0.357
MOD_PKA_2	93	99	PF00069	0.193
MOD_Plk_1	227	233	PF00069	0.599
MOD_Plk_2-3	43	49	PF00069	0.543
MOD_Plk_4	146	152	PF00069	0.230
MOD_Plk_4	165	171	PF00069	0.438
MOD_Plk_4	233	239	PF00069	0.653
MOD_Plk_4	281	287	PF00069	0.616
MOD_Plk_4	43	49	PF00069	0.582
MOD_Plk_4	56	62	PF00069	0.418
MOD_ProDKin_1	190	196	PF00069	0.559
MOD_ProDKin_1	239	245	PF00069	0.632
MOD_SUMO_rev_2	211	217	PF00179	0.644
TRG_DiLeu_BaEn_1	265	270	PF01217	0.647
TRG_DiLeu_BaEn_1	289	294	PF01217	0.638
TRG_DiLeu_BaEn_4	265	271	PF01217	0.686
TRG_ENDOCYTIC_2	124	127	PF00928	0.273
TRG_ENDOCYTIC_2	200	203	PF00928	0.585
TRG_ENDOCYTIC_2	27	30	PF00928	0.586
TRG_ENDOCYTIC_2	303	306	PF00928	0.648
TRG_ENDOCYTIC_2	66	69	PF00928	0.289
TRG_ENDOCYTIC_2	89	92	PF00928	0.326
TRG_ER_diArg_1	115	118	PF00400	0.530
TRG_ER_diArg_1	172	174	PF00400	0.538
TRG_ER_diArg_1	52	54	PF00400	0.518
TRG_NLS_Bipartite_1	280	300	PF00514	0.679
TRG_NLS_MonoExtC_3	294	299	PF00514	0.679
TRG_NLS_MonoExtN_4	295	300	PF00514	0.640
TRG_Pf-PMV_PEXEL_1	208	212	PF00026	0.388

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8X7	Leptomonas seymouri	86%	100%
A0A0S4J844	Bodo saltans	53%	96%
A0A1X0P9K7	Trypanosomatidae	64%	100%
A4HAS3	Leishmania braziliensis	89%	100%
A4IAM4	Leishmania infantum	100%	100%
C9ZMP7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	100%
E9B4Z7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q2Y9	Leishmania major	98%	100%
V5BQ04	Trypanosoma cruzi	68%	100%