DUF2817 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2817), putative

Species:

Leishmania donovani

UniProt:

A0A3Q8II59_LEIDO

TriTrypDb:

LdBPK_303010.1 , LdCL_300035700 , LDHU3_30.4000

Length:

408

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 7
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A0A3Q8II59

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8II59

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	149	151	PF00675	0.516
CLV_NRD_NRD_1	291	293	PF00675	0.463
CLV_NRD_NRD_1	93	95	PF00675	0.482
CLV_PCSK_KEX2_1	149	151	PF00082	0.516
CLV_PCSK_KEX2_1	219	221	PF00082	0.473
CLV_PCSK_KEX2_1	385	387	PF00082	0.512
CLV_PCSK_KEX2_1	390	392	PF00082	0.563
CLV_PCSK_KEX2_1	77	79	PF00082	0.536
CLV_PCSK_KEX2_1	93	95	PF00082	0.430
CLV_PCSK_PC1ET2_1	219	221	PF00082	0.516
CLV_PCSK_PC1ET2_1	385	387	PF00082	0.512
CLV_PCSK_PC1ET2_1	390	392	PF00082	0.563
CLV_PCSK_PC1ET2_1	77	79	PF00082	0.530
CLV_PCSK_PC1ET2_1	93	95	PF00082	0.451
CLV_PCSK_PC7_1	386	392	PF00082	0.499
CLV_PCSK_SKI1_1	185	189	PF00082	0.562
CLV_PCSK_SKI1_1	199	203	PF00082	0.413
CLV_PCSK_SKI1_1	219	223	PF00082	0.362
CLV_PCSK_SKI1_1	248	252	PF00082	0.462
CLV_PCSK_SKI1_1	292	296	PF00082	0.473
CLV_PCSK_SKI1_1	374	378	PF00082	0.473
CLV_PCSK_SKI1_1	385	389	PF00082	0.473
DEG_APCC_DBOX_1	198	206	PF00400	0.248
DEG_MDM2_SWIB_1	396	403	PF02201	0.341
DOC_CKS1_1	190	195	PF01111	0.209
DOC_MAPK_gen_1	390	396	PF00069	0.294
DOC_MAPK_gen_1	93	100	PF00069	0.253
DOC_PP2B_LxvP_1	187	190	PF13499	0.274
DOC_USP7_MATH_1	317	321	PF00917	0.232
DOC_USP7_UBL2_3	93	97	PF12436	0.315
DOC_WW_Pin1_4	189	194	PF00397	0.273
LIG_14-3-3_CanoR_1	160	168	PF00244	0.273
LIG_14-3-3_CanoR_1	386	390	PF00244	0.312
LIG_BIR_II_1	1	5	PF00653	0.653
LIG_BRCT_BRCA1_1	132	136	PF00533	0.248
LIG_BRCT_BRCA1_1	3	7	PF00533	0.549
LIG_BRCT_BRCA1_1	392	396	PF00533	0.313
LIG_BRCT_BRCA1_2	392	398	PF00533	0.234
LIG_Clathr_ClatBox_1	19	23	PF01394	0.283
LIG_FHA_1	103	109	PF00498	0.304
LIG_FHA_1	15	21	PF00498	0.325
LIG_FHA_1	259	265	PF00498	0.310
LIG_FHA_1	329	335	PF00498	0.259
LIG_FHA_1	36	42	PF00498	0.361
LIG_FHA_2	273	279	PF00498	0.250
LIG_KLC1_Yacidic_2	262	267	PF13176	0.295
LIG_LIR_Apic_2	224	230	PF02991	0.273
LIG_LIR_Gen_1	10	20	PF02991	0.366
LIG_LIR_Gen_1	165	176	PF02991	0.372
LIG_LIR_Gen_1	198	207	PF02991	0.256
LIG_LIR_Gen_1	262	272	PF02991	0.274
LIG_LIR_Nem_3	10	15	PF02991	0.366
LIG_LIR_Nem_3	165	171	PF02991	0.252
LIG_LIR_Nem_3	198	203	PF02991	0.256
LIG_LIR_Nem_3	262	268	PF02991	0.274
LIG_LIR_Nem_3	335	341	PF02991	0.273
LIG_MYND_1	186	190	PF01753	0.248
LIG_PDZ_Class_1	403	408	PF00595	0.335
LIG_Pex14_2	396	400	PF04695	0.297
LIG_PTB_Apo_2	339	346	PF02174	0.362
LIG_PTB_Apo_2	351	358	PF02174	0.259
LIG_PTB_Phospho_1	351	357	PF10480	0.306
LIG_Rb_LxCxE_1	38	57	PF01857	0.311
LIG_REV1ctd_RIR_1	87	98	PF16727	0.209
LIG_SH2_GRB2like	37	40	PF00017	0.348
LIG_SH2_NCK_1	314	318	PF00017	0.295
LIG_SH2_PTP2	200	203	PF00017	0.279
LIG_SH2_SRC	265	268	PF00017	0.357
LIG_SH2_SRC	364	367	PF00017	0.264
LIG_SH2_STAP1	37	41	PF00017	0.455
LIG_SH2_STAP1	48	52	PF00017	0.305
LIG_SH2_STAT5	162	165	PF00017	0.315
LIG_SH2_STAT5	200	203	PF00017	0.271
LIG_SH2_STAT5	204	207	PF00017	0.274
LIG_SH2_STAT5	265	268	PF00017	0.295
LIG_SH2_STAT5	364	367	PF00017	0.248
LIG_SH2_STAT5	37	40	PF00017	0.390
LIG_SH2_STAT5	402	405	PF00017	0.310
LIG_SH3_2	190	195	PF14604	0.315
LIG_SH3_3	187	193	PF00018	0.283
LIG_SH3_3	373	379	PF00018	0.264
LIG_SUMO_SIM_anti_2	243	249	PF11976	0.273
LIG_SUMO_SIM_par_1	12	17	PF11976	0.317
LIG_SUMO_SIM_par_1	330	337	PF11976	0.308
LIG_TRAF2_1	164	167	PF00917	0.295
LIG_TRAF2_1	26	29	PF00917	0.356
LIG_TRAF2_1	284	287	PF00917	0.264
LIG_WW_3	192	196	PF00397	0.315
MOD_CDK_SPxK_1	189	195	PF00069	0.209
MOD_CK1_1	130	136	PF00069	0.308
MOD_CK1_1	308	314	PF00069	0.313
MOD_CK2_1	161	167	PF00069	0.344
MOD_CK2_1	281	287	PF00069	0.281
MOD_CMANNOS	397	400	PF00535	0.523
MOD_Cter_Amidation	91	94	PF01082	0.516
MOD_GlcNHglycan	102	105	PF01048	0.479
MOD_GlcNHglycan	113	116	PF01048	0.470
MOD_GlcNHglycan	129	132	PF01048	0.448
MOD_GlcNHglycan	307	310	PF01048	0.501
MOD_GlcNHglycan	9	12	PF01048	0.392
MOD_GSK3_1	272	279	PF00069	0.259
MOD_GSK3_1	300	307	PF00069	0.330
MOD_GSK3_1	328	335	PF00069	0.248
MOD_N-GLC_1	124	129	PF02516	0.448
MOD_N-GLC_1	35	40	PF02516	0.546
MOD_NEK2_1	111	116	PF00069	0.259
MOD_NEK2_1	27	32	PF00069	0.404
MOD_NEK2_1	281	286	PF00069	0.268
MOD_NEK2_1	403	408	PF00069	0.335
MOD_NEK2_1	7	12	PF00069	0.423
MOD_NEK2_1	99	104	PF00069	0.362
MOD_NEK2_2	317	322	PF00069	0.232
MOD_PIKK_1	282	288	PF00454	0.266
MOD_PIKK_1	300	306	PF00454	0.203
MOD_PK_1	242	248	PF00069	0.295
MOD_PK_1	390	396	PF00069	0.294
MOD_PKA_1	385	391	PF00069	0.312
MOD_PKA_2	360	366	PF00069	0.315
MOD_PKA_2	385	391	PF00069	0.312
MOD_Plk_1	124	130	PF00069	0.315
MOD_Plk_1	380	386	PF00069	0.308
MOD_Plk_4	130	136	PF00069	0.248
MOD_Plk_4	27	33	PF00069	0.362
MOD_Plk_4	276	282	PF00069	0.295
MOD_Plk_4	360	366	PF00069	0.270
MOD_Plk_4	368	374	PF00069	0.253
MOD_ProDKin_1	189	195	PF00069	0.273
MOD_SUMO_rev_2	164	173	PF00179	0.252
MOD_SUMO_rev_2	238	244	PF00179	0.295
TRG_DiLeu_BaEn_4	153	159	PF01217	0.297
TRG_DiLeu_BaLyEn_6	183	188	PF01217	0.248
TRG_ENDOCYTIC_2	181	184	PF00928	0.248
TRG_ENDOCYTIC_2	200	203	PF00928	0.248
TRG_ENDOCYTIC_2	265	268	PF00928	0.295
TRG_ER_diArg_1	148	150	PF00400	0.315
TRG_Pf-PMV_PEXEL_1	119	123	PF00026	0.476

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKP4	Leptomonas seymouri	69%	100%
A0A1X0P1D9	Trypanosomatidae	50%	100%
A4HIN1	Leishmania braziliensis	82%	100%
A4I5X8	Leishmania infantum	100%	100%
C9ZRA5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9B171	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q6Z3	Leishmania major	96%	100%