CS domain family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CS domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8II57_LEIDO

TriTrypDb:

LdBPK_340230.1 , LdCL_340007400 , LDHU3_34.0360

Length:

209

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8II57

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8II57

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0043933	protein-containing complex organization	4	1
GO:0051131	chaperone-mediated protein complex assembly	6	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0005515	protein binding	2	10
GO:0031072	heat shock protein binding	3	10
GO:0051879	Hsp90 protein binding	4	10
GO:0051087	protein-folding chaperone binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	140	144	PF00656	0.702
CLV_NRD_NRD_1	83	85	PF00675	0.308
DOC_CYCLIN_yCln2_LP_2	7	10	PF00134	0.454
DOC_MAPK_gen_1	108	116	PF00069	0.410
DOC_MAPK_gen_1	75	83	PF00069	0.508
DOC_MAPK_MEF2A_6	108	116	PF00069	0.500
DOC_MAPK_MEF2A_6	16	24	PF00069	0.426
DOC_MAPK_MEF2A_6	75	83	PF00069	0.508
DOC_PIKK_1	126	134	PF02985	0.553
DOC_PP1_RVXF_1	39	46	PF00149	0.426
DOC_PP2B_LxvP_1	7	10	PF13499	0.479
DOC_PP2B_PxIxI_1	111	117	PF00149	0.476
DOC_USP7_MATH_1	165	169	PF00917	0.555
DOC_USP7_UBL2_3	106	110	PF12436	0.555
DOC_USP7_UBL2_3	82	86	PF12436	0.443
DOC_WW_Pin1_4	46	51	PF00397	0.560
LIG_BIR_II_1	1	5	PF00653	0.529
LIG_deltaCOP1_diTrp_1	117	121	PF00928	0.419
LIG_FHA_1	21	27	PF00498	0.489
LIG_LIR_Gen_1	146	157	PF02991	0.557
LIG_LIR_Gen_1	18	26	PF02991	0.450
LIG_LIR_Nem_3	18	22	PF02991	0.473
LIG_LIR_Nem_3	58	64	PF02991	0.430
LIG_LIR_Nem_3	98	104	PF02991	0.468
LIG_LYPXL_yS_3	111	114	PF13949	0.478
LIG_MYND_3	202	206	PF01753	0.547
LIG_SH2_CRK	62	66	PF00017	0.460
LIG_SH2_PTP2	19	22	PF00017	0.469
LIG_SH2_STAP1	149	153	PF00017	0.578
LIG_SH2_STAP1	55	59	PF00017	0.508
LIG_SH2_STAT5	19	22	PF00017	0.469
LIG_SH3_3	3	9	PF00018	0.432
LIG_SH3_3	70	76	PF00018	0.454
LIG_SH3_3	96	102	PF00018	0.521
LIG_TRAF2_1	204	207	PF00917	0.593
LIG_TRAF2_1	66	69	PF00917	0.443
MOD_CDK_SPxxK_3	46	53	PF00069	0.452
MOD_CK1_1	67	73	PF00069	0.457
MOD_CK2_1	45	51	PF00069	0.485
MOD_CK2_1	63	69	PF00069	0.397
MOD_CMANNOS	118	121	PF00535	0.434
MOD_GlcNHglycan	139	142	PF01048	0.635
MOD_GlcNHglycan	166	170	PF01048	0.684
MOD_GlcNHglycan	180	183	PF01048	0.530
MOD_GlcNHglycan	3	6	PF01048	0.493
MOD_GSK3_1	112	119	PF00069	0.559
MOD_GSK3_1	147	154	PF00069	0.580
MOD_GSK3_1	26	33	PF00069	0.535
MOD_GSK3_1	63	70	PF00069	0.448
MOD_N-GLC_1	112	117	PF02516	0.503
MOD_NEK2_1	1	6	PF00069	0.618
MOD_NEK2_1	137	142	PF00069	0.550
MOD_NEK2_1	26	31	PF00069	0.506
MOD_NEK2_1	45	50	PF00069	0.391
MOD_NEK2_2	55	60	PF00069	0.508
MOD_PIKK_1	151	157	PF00454	0.563
MOD_PIKK_1	67	73	PF00454	0.508
MOD_PKA_1	85	91	PF00069	0.503
MOD_PKA_2	102	108	PF00069	0.417
MOD_Plk_1	112	118	PF00069	0.406
MOD_ProDKin_1	46	52	PF00069	0.560
MOD_SUMO_for_1	36	39	PF00179	0.508
TRG_DiLeu_BaEn_4	166	172	PF01217	0.609
TRG_ENDOCYTIC_2	111	114	PF00928	0.478
TRG_ENDOCYTIC_2	149	152	PF00928	0.494
TRG_ENDOCYTIC_2	19	22	PF00928	0.469
TRG_ENDOCYTIC_2	62	65	PF00928	0.460
TRG_ER_diArg_1	74	77	PF00400	0.514
TRG_NLS_MonoExtN_4	82	88	PF00514	0.443

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6I2	Leptomonas seymouri	65%	100%
A0A0S4JQC8	Bodo saltans	29%	100%
A0A1X0P8I0	Trypanosomatidae	36%	100%
A0A3S5H807	Leishmania donovani	29%	100%
A0A422N770	Trypanosoma rangeli	44%	100%
A4HAD9	Leishmania braziliensis	86%	100%
A4HNB5	Leishmania braziliensis	28%	100%
A4I9J1	Leishmania infantum	100%	100%
A4IBY7	Leishmania infantum	29%	100%
D0A1U8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AFS4	Leishmania major	26%	100%
E9B4I9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9B6X6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
G1TGF1	Oryctolagus cuniculus	30%	100%
P28707	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	38%	97%
P83868	Rattus norvegicus	30%	100%
Q11118	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	100%
Q15185	Homo sapiens	30%	100%
Q3ZBF7	Bos taurus	30%	100%
Q4Q3I7	Leishmania major	95%	100%
Q5NVM4	Pongo abelii	30%	100%
Q6PWL5	Macaca fascicularis	30%	100%
Q9FR62	Brassica napus	28%	100%
Q9R0Q7	Mus musculus	30%	100%
V5B2A2	Trypanosoma cruzi	41%	100%