tRNA pseudouridine synthase D (TruD), putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tRNA pseudouridine synthase D (TruD), putative

Species:

Leishmania donovani

UniProt:

A0A3Q8II50_LEIDO

TriTrypDb:

LdBPK_281750.1 , LdCL_280022400 , LDHU3_28.2280

Length:

852

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8II50

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8II50

Function

Biological processes
Term	Name	Level	Count
GO:0001522	pseudouridine synthesis	6	10
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009451	RNA modification	5	10
GO:0009987	cellular process	1	10
GO:0016070	RNA metabolic process	5	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043412	macromolecule modification	4	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0046483	heterocycle metabolic process	3	10
GO:0071704	organic substance metabolic process	2	10
GO:0090304	nucleic acid metabolic process	4	10
GO:1901360	organic cyclic compound metabolic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0009982	pseudouridine synthase activity	4	12
GO:0016853	isomerase activity	2	12
GO:0016866	intramolecular transferase activity	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0004730	pseudouridylate synthase activity	5	2
GO:0016829	lyase activity	2	2
GO:0016835	carbon-oxygen lyase activity	3	2
GO:0016836	hydro-lyase activity	4	2
GO:0106029	tRNA pseudouridine synthase activity	5	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140101	catalytic activity, acting on a tRNA	4	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	108	112	PF00656	0.757
CLV_C14_Caspase3-7	461	465	PF00656	0.349
CLV_NRD_NRD_1	156	158	PF00675	0.635
CLV_NRD_NRD_1	164	166	PF00675	0.598
CLV_NRD_NRD_1	308	310	PF00675	0.414
CLV_NRD_NRD_1	311	313	PF00675	0.411
CLV_NRD_NRD_1	429	431	PF00675	0.334
CLV_NRD_NRD_1	433	435	PF00675	0.335
CLV_NRD_NRD_1	491	493	PF00675	0.327
CLV_NRD_NRD_1	540	542	PF00675	0.463
CLV_NRD_NRD_1	58	60	PF00675	0.502
CLV_NRD_NRD_1	616	618	PF00675	0.327
CLV_NRD_NRD_1	734	736	PF00675	0.625
CLV_NRD_NRD_1	751	753	PF00675	0.445
CLV_NRD_NRD_1	802	804	PF00675	0.582
CLV_NRD_NRD_1	805	807	PF00675	0.584
CLV_NRD_NRD_1	818	820	PF00675	0.608
CLV_NRD_NRD_1	95	97	PF00675	0.603
CLV_NRD_NRD_1	99	101	PF00675	0.598
CLV_PCSK_FUR_1	309	313	PF00082	0.446
CLV_PCSK_FUR_1	802	806	PF00082	0.597
CLV_PCSK_FUR_1	816	820	PF00082	0.622
CLV_PCSK_KEX2_1	156	158	PF00082	0.694
CLV_PCSK_KEX2_1	164	166	PF00082	0.771
CLV_PCSK_KEX2_1	308	310	PF00082	0.447
CLV_PCSK_KEX2_1	311	313	PF00082	0.449
CLV_PCSK_KEX2_1	428	430	PF00082	0.327
CLV_PCSK_KEX2_1	433	435	PF00082	0.327
CLV_PCSK_KEX2_1	491	493	PF00082	0.327
CLV_PCSK_KEX2_1	540	542	PF00082	0.489
CLV_PCSK_KEX2_1	58	60	PF00082	0.527
CLV_PCSK_KEX2_1	751	753	PF00082	0.552
CLV_PCSK_KEX2_1	760	762	PF00082	0.559
CLV_PCSK_KEX2_1	794	796	PF00082	0.557
CLV_PCSK_KEX2_1	802	804	PF00082	0.538
CLV_PCSK_KEX2_1	805	807	PF00082	0.547
CLV_PCSK_KEX2_1	818	820	PF00082	0.710
CLV_PCSK_KEX2_1	95	97	PF00082	0.760
CLV_PCSK_KEX2_1	99	101	PF00082	0.734
CLV_PCSK_PC1ET2_1	760	762	PF00082	0.677
CLV_PCSK_PC1ET2_1	794	796	PF00082	0.567
CLV_PCSK_PC1ET2_1	804	806	PF00082	0.549
CLV_PCSK_PC7_1	429	435	PF00082	0.327
CLV_PCSK_PC7_1	54	60	PF00082	0.518
CLV_PCSK_PC7_1	747	753	PF00082	0.563
CLV_PCSK_PC7_1	95	101	PF00082	0.581
CLV_PCSK_SKI1_1	340	344	PF00082	0.316
CLV_PCSK_SKI1_1	350	354	PF00082	0.345
CLV_PCSK_SKI1_1	410	414	PF00082	0.349
CLV_PCSK_SKI1_1	491	495	PF00082	0.355
CLV_PCSK_SKI1_1	636	640	PF00082	0.453
CLV_PCSK_SKI1_1	70	74	PF00082	0.691
CLV_PCSK_SKI1_1	760	764	PF00082	0.627
CLV_Separin_Metazoa	610	614	PF03568	0.327
DEG_APCC_DBOX_1	131	139	PF00400	0.396
DEG_APCC_DBOX_1	291	299	PF00400	0.343
DEG_APCC_DBOX_1	339	347	PF00400	0.364
DOC_CDC14_PxL_1	445	453	PF14671	0.339
DOC_CKS1_1	4	9	PF01111	0.684
DOC_CKS1_1	74	79	PF01111	0.559
DOC_CYCLIN_RxL_1	613	625	PF00134	0.412
DOC_CYCLIN_RxL_1	758	767	PF00134	0.643
DOC_MAPK_gen_1	308	319	PF00069	0.355
DOC_MAPK_gen_1	428	440	PF00069	0.405
DOC_PP1_RVXF_1	758	765	PF00149	0.701
DOC_PP2B_LxvP_1	667	670	PF13499	0.551
DOC_PP2B_LxvP_1	725	728	PF13499	0.589
DOC_PP4_FxxP_1	4	7	PF00568	0.613
DOC_PP4_FxxP_1	608	611	PF00568	0.327
DOC_PP4_FxxP_1	74	77	PF00568	0.652
DOC_USP7_MATH_1	122	126	PF00917	0.530
DOC_USP7_MATH_1	211	215	PF00917	0.770
DOC_USP7_MATH_1	236	240	PF00917	0.639
DOC_USP7_MATH_1	598	602	PF00917	0.448
DOC_USP7_MATH_1	711	715	PF00917	0.726
DOC_USP7_MATH_1	78	82	PF00917	0.713
DOC_USP7_MATH_1	789	793	PF00917	0.685
DOC_WW_Pin1_4	117	122	PF00397	0.705
DOC_WW_Pin1_4	296	301	PF00397	0.322
DOC_WW_Pin1_4	3	8	PF00397	0.596
DOC_WW_Pin1_4	73	78	PF00397	0.562
DOC_WW_Pin1_4	807	812	PF00397	0.669
DOC_WW_Pin1_4	819	824	PF00397	0.644
LIG_14-3-3_CanoR_1	275	280	PF00244	0.437
LIG_14-3-3_CanoR_1	316	324	PF00244	0.392
LIG_14-3-3_CanoR_1	373	377	PF00244	0.327
LIG_14-3-3_CanoR_1	491	498	PF00244	0.323
LIG_14-3-3_CanoR_1	818	823	PF00244	0.706
LIG_Actin_WH2_2	464	482	PF00022	0.448
LIG_AP2alpha_2	732	734	PF02296	0.656
LIG_BRCT_BRCA1_1	68	72	PF00533	0.727
LIG_BRCT_BRCA1_1	846	850	PF00533	0.564
LIG_CaM_IQ_9	124	139	PF13499	0.607
LIG_CtBP_PxDLS_1	619	623	PF00389	0.343
LIG_deltaCOP1_diTrp_1	542	547	PF00928	0.448
LIG_EH1_1	22	30	PF00400	0.596
LIG_eIF4E_1	324	330	PF01652	0.362
LIG_FHA_1	197	203	PF00498	0.760
LIG_FHA_1	24	30	PF00498	0.621
LIG_FHA_1	324	330	PF00498	0.339
LIG_FHA_1	506	512	PF00498	0.343
LIG_FHA_1	661	667	PF00498	0.651
LIG_FHA_1	74	80	PF00498	0.753
LIG_FHA_1	832	838	PF00498	0.740
LIG_FHA_2	173	179	PF00498	0.798
LIG_FHA_2	238	244	PF00498	0.345
LIG_FHA_2	37	43	PF00498	0.781
LIG_FHA_2	401	407	PF00498	0.347
LIG_FHA_2	421	427	PF00498	0.491
LIG_FHA_2	441	447	PF00498	0.283
LIG_FHA_2	459	465	PF00498	0.204
LIG_FHA_2	533	539	PF00498	0.384
LIG_FHA_2	544	550	PF00498	0.390
LIG_FHA_2	558	564	PF00498	0.369
LIG_FHA_2	685	691	PF00498	0.609
LIG_LIR_Apic_2	607	611	PF02991	0.328
LIG_LIR_Apic_2	71	77	PF02991	0.598
LIG_LIR_Gen_1	382	393	PF02991	0.327
LIG_LIR_Gen_1	542	551	PF02991	0.448
LIG_LIR_Gen_1	839	844	PF02991	0.609
LIG_LIR_Nem_3	123	129	PF02991	0.578
LIG_LIR_Nem_3	362	368	PF02991	0.363
LIG_LIR_Nem_3	382	388	PF02991	0.145
LIG_LIR_Nem_3	481	486	PF02991	0.381
LIG_LIR_Nem_3	542	547	PF02991	0.448
LIG_LIR_Nem_3	570	574	PF02991	0.349
LIG_LIR_Nem_3	671	677	PF02991	0.661
LIG_LIR_Nem_3	690	695	PF02991	0.363
LIG_LIR_Nem_3	839	843	PF02991	0.655
LIG_LIR_Nem_3	9	15	PF02991	0.634
LIG_NRBOX	408	414	PF00104	0.327
LIG_PCNA_PIPBox_1	578	587	PF02747	0.362
LIG_PCNA_yPIPBox_3	578	591	PF02747	0.454
LIG_PCNA_yPIPBox_3	641	653	PF02747	0.327
LIG_Pex14_1	543	547	PF04695	0.448
LIG_Pex14_2	12	16	PF04695	0.596
LIG_Pex14_2	335	339	PF04695	0.327
LIG_Pex14_2	395	399	PF04695	0.343
LIG_SH2_CRK	585	589	PF00017	0.437
LIG_SH2_CRK	644	648	PF00017	0.327
LIG_SH2_CRK	797	801	PF00017	0.672
LIG_SH2_GRB2like	644	647	PF00017	0.327
LIG_SH2_NCK_1	626	630	PF00017	0.393
LIG_SH2_NCK_1	644	648	PF00017	0.259
LIG_SH2_SRC	644	647	PF00017	0.246
LIG_SH2_SRC	695	698	PF00017	0.680
LIG_SH2_STAP1	644	648	PF00017	0.260
LIG_SH2_STAP1	797	801	PF00017	0.672
LIG_SH2_STAT3	369	372	PF00017	0.353
LIG_SH2_STAT3	584	587	PF00017	0.343
LIG_SH2_STAT5	247	250	PF00017	0.328
LIG_SH2_STAT5	285	288	PF00017	0.343
LIG_SH2_STAT5	402	405	PF00017	0.332
LIG_SH2_STAT5	483	486	PF00017	0.403
LIG_SH2_STAT5	559	562	PF00017	0.412
LIG_SH2_STAT5	684	687	PF00017	0.540
LIG_SH3_3	325	331	PF00018	0.329
LIG_SH3_3	343	349	PF00018	0.362
LIG_SH3_3	561	567	PF00018	0.327
LIG_SH3_3	608	614	PF00018	0.327
LIG_SH3_3	74	80	PF00018	0.574
LIG_SH3_3	782	788	PF00018	0.603
LIG_SUMO_SIM_anti_2	662	668	PF11976	0.557
LIG_SUMO_SIM_par_1	26	37	PF11976	0.713
LIG_SUMO_SIM_par_1	618	623	PF11976	0.470
LIG_WRC_WIRS_1	498	503	PF05994	0.448
LIG_WRC_WIRS_1	544	549	PF05994	0.441
LIG_WRC_WIRS_1	837	842	PF05994	0.714
LIG_WW_2	77	80	PF00397	0.713
LIG_WW_3	610	614	PF00397	0.327
MOD_CDK_SPK_2	807	812	PF00069	0.673
MOD_CK1_1	187	193	PF00069	0.783
MOD_CK1_1	320	326	PF00069	0.339
MOD_CK1_1	36	42	PF00069	0.757
MOD_CK1_1	767	773	PF00069	0.605
MOD_CK1_1	825	831	PF00069	0.734
MOD_CK1_1	833	839	PF00069	0.667
MOD_CK2_1	117	123	PF00069	0.713
MOD_CK2_1	172	178	PF00069	0.644
MOD_CK2_1	211	217	PF00069	0.752
MOD_CK2_1	237	243	PF00069	0.443
MOD_CK2_1	36	42	PF00069	0.760
MOD_CK2_1	405	411	PF00069	0.334
MOD_CK2_1	420	426	PF00069	0.362
MOD_CK2_1	532	538	PF00069	0.437
MOD_CK2_1	709	715	PF00069	0.687
MOD_Cter_Amidation	93	96	PF01082	0.537
MOD_DYRK1A_RPxSP_1	819	823	PF00069	0.715
MOD_GlcNHglycan	186	189	PF01048	0.783
MOD_GlcNHglycan	199	202	PF01048	0.626
MOD_GlcNHglycan	213	216	PF01048	0.682
MOD_GlcNHglycan	224	227	PF01048	0.702
MOD_GlcNHglycan	456	459	PF01048	0.398
MOD_GlcNHglycan	602	605	PF01048	0.412
MOD_GlcNHglycan	654	657	PF01048	0.468
MOD_GlcNHglycan	711	714	PF01048	0.684
MOD_GlcNHglycan	791	794	PF01048	0.676
MOD_GlcNHglycan	830	833	PF01048	0.767
MOD_GSK3_1	117	124	PF00069	0.703
MOD_GSK3_1	183	190	PF00069	0.793
MOD_GSK3_1	211	218	PF00069	0.713
MOD_GSK3_1	224	231	PF00069	0.681
MOD_GSK3_1	32	39	PF00069	0.644
MOD_GSK3_1	454	461	PF00069	0.406
MOD_GSK3_1	487	494	PF00069	0.362
MOD_GSK3_1	709	716	PF00069	0.742
MOD_GSK3_1	763	770	PF00069	0.698
MOD_GSK3_1	817	824	PF00069	0.781
MOD_GSK3_1	827	834	PF00069	0.705
MOD_GSK3_1	839	846	PF00069	0.517
MOD_LATS_1	273	279	PF00433	0.448
MOD_N-GLC_1	296	301	PF02516	0.320
MOD_N-GLC_1	400	405	PF02516	0.412
MOD_N-GLC_1	789	794	PF02516	0.690
MOD_NEK2_1	248	253	PF00069	0.461
MOD_NEK2_1	400	405	PF00069	0.298
MOD_NEK2_1	474	479	PF00069	0.339
MOD_NEK2_1	652	657	PF00069	0.540
MOD_NEK2_1	72	77	PF00069	0.677
MOD_NEK2_1	763	768	PF00069	0.567
MOD_NEK2_1	817	822	PF00069	0.728
MOD_NEK2_1	843	848	PF00069	0.435
MOD_NEK2_2	122	127	PF00069	0.506
MOD_NEK2_2	631	636	PF00069	0.470
MOD_OFUCOSY	223	228	PF10250	0.593
MOD_PIKK_1	420	426	PF00454	0.470
MOD_PIKK_1	474	480	PF00454	0.329
MOD_PIKK_1	6	12	PF00454	0.631
MOD_PIKK_1	739	745	PF00454	0.686
MOD_PIKK_1	767	773	PF00454	0.668
MOD_PK_1	275	281	PF00069	0.448
MOD_PK_1	344	350	PF00069	0.470
MOD_PKA_1	491	497	PF00069	0.327
MOD_PKA_1	818	824	PF00069	0.737
MOD_PKA_2	197	203	PF00069	0.685
MOD_PKA_2	237	243	PF00069	0.474
MOD_PKA_2	372	378	PF00069	0.327
MOD_PKA_2	491	497	PF00069	0.327
MOD_PKA_2	549	555	PF00069	0.467
MOD_PKA_2	557	563	PF00069	0.145
MOD_PKA_2	746	752	PF00069	0.634
MOD_PKA_2	817	823	PF00069	0.696
MOD_PKA_2	98	104	PF00069	0.713
MOD_PKB_1	816	824	PF00069	0.762
MOD_Plk_1	122	128	PF00069	0.672
MOD_Plk_1	139	145	PF00069	0.554
MOD_Plk_1	191	197	PF00069	0.679
MOD_Plk_1	320	326	PF00069	0.343
MOD_Plk_1	344	350	PF00069	0.429
MOD_Plk_1	405	411	PF00069	0.362
MOD_Plk_1	620	626	PF00069	0.438
MOD_Plk_1	764	770	PF00069	0.658
MOD_Plk_1	843	849	PF00069	0.437
MOD_Plk_2-3	237	243	PF00069	0.345
MOD_Plk_4	122	128	PF00069	0.617
MOD_Plk_4	497	503	PF00069	0.337
MOD_Plk_4	662	668	PF00069	0.591
MOD_Plk_4	78	84	PF00069	0.640
MOD_ProDKin_1	117	123	PF00069	0.704
MOD_ProDKin_1	296	302	PF00069	0.322
MOD_ProDKin_1	3	9	PF00069	0.594
MOD_ProDKin_1	73	79	PF00069	0.561
MOD_ProDKin_1	807	813	PF00069	0.673
MOD_ProDKin_1	819	825	PF00069	0.643
MOD_SUMO_for_1	229	232	PF00179	0.705
MOD_SUMO_for_1	84	87	PF00179	0.579
MOD_SUMO_rev_2	69	75	PF00179	0.774
MOD_SUMO_rev_2	709	718	PF00179	0.678
MOD_SUMO_rev_2	753	762	PF00179	0.615
TRG_DiLeu_BaEn_1	720	725	PF01217	0.531
TRG_DiLeu_BaLyEn_6	758	763	PF01217	0.703
TRG_ENDOCYTIC_2	483	486	PF00928	0.412
TRG_ENDOCYTIC_2	585	588	PF00928	0.362
TRG_ENDOCYTIC_2	644	647	PF00928	0.341
TRG_ENDOCYTIC_2	797	800	PF00928	0.677
TRG_ER_diArg_1	131	134	PF00400	0.670
TRG_ER_diArg_1	155	157	PF00400	0.639
TRG_ER_diArg_1	163	165	PF00400	0.690
TRG_ER_diArg_1	292	295	PF00400	0.327
TRG_ER_diArg_1	308	310	PF00400	0.327
TRG_ER_diArg_1	427	430	PF00400	0.327
TRG_ER_diArg_1	432	434	PF00400	0.327
TRG_ER_diArg_1	491	493	PF00400	0.327
TRG_ER_diArg_1	556	559	PF00400	0.470
TRG_ER_diArg_1	57	59	PF00400	0.497
TRG_ER_diArg_1	801	803	PF00400	0.550
TRG_ER_diArg_1	805	807	PF00400	0.572
TRG_ER_diArg_1	815	818	PF00400	0.659
TRG_NES_CRM1_1	284	296	PF08389	0.384
TRG_NLS_Bipartite_1	794	808	PF00514	0.633
TRG_NLS_MonoCore_2	802	807	PF00514	0.684
TRG_NLS_MonoExtN_4	802	808	PF00514	0.654
TRG_Pf-PMV_PEXEL_1	407	411	PF00026	0.356
TRG_Pf-PMV_PEXEL_1	491	496	PF00026	0.343
TRG_Pf-PMV_PEXEL_1	518	523	PF00026	0.477
TRG_Pf-PMV_PEXEL_1	657	662	PF00026	0.627
TRG_Pf-PMV_PEXEL_1	66	71	PF00026	0.683
TRG_Pf-PMV_PEXEL_1	761	765	PF00026	0.628

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P820	Leptomonas seymouri	66%	86%
A0A0S4K0L8	Bodo saltans	45%	84%
A0A1X0NQX7	Trypanosomatidae	57%	93%
A0A3S5ISD4	Trypanosoma rangeli	59%	97%
A4HGL5	Leishmania braziliensis	84%	100%
A4I3P1	Leishmania infantum	99%	100%
D0A8C3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	92%
E9AZY2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q8A3	Leishmania major	93%	100%
V5BFB8	Trypanosoma cruzi	60%	92%