Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8II43_LEIDO

TriTrypDb:

LdBPK_131300.1 , LdCL_130018500 , LDHU3_13.1580

Length:

658

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8II43

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8II43

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	453	457	PF00656	0.437
CLV_NRD_NRD_1	448	450	PF00675	0.490
CLV_NRD_NRD_1	533	535	PF00675	0.514
CLV_NRD_NRD_1	62	64	PF00675	0.587
CLV_PCSK_KEX2_1	29	31	PF00082	0.543
CLV_PCSK_KEX2_1	448	450	PF00082	0.402
CLV_PCSK_KEX2_1	533	535	PF00082	0.514
CLV_PCSK_KEX2_1	62	64	PF00082	0.588
CLV_PCSK_PC1ET2_1	29	31	PF00082	0.543
CLV_PCSK_SKI1_1	363	367	PF00082	0.513
CLV_PCSK_SKI1_1	449	453	PF00082	0.345
CLV_PCSK_SKI1_1	534	538	PF00082	0.601
CLV_PCSK_SKI1_1	62	66	PF00082	0.600
CLV_Separin_Metazoa	628	632	PF03568	0.622
DEG_APCC_DBOX_1	414	422	PF00400	0.456
DEG_APCC_DBOX_1	486	494	PF00400	0.423
DEG_APCC_DBOX_1	53	61	PF00400	0.689
DOC_ANK_TNKS_1	46	53	PF00023	0.593
DOC_CKS1_1	431	436	PF01111	0.475
DOC_CKS1_1	500	505	PF01111	0.532
DOC_CYCLIN_yCln2_LP_2	3	6	PF00134	0.553
DOC_MAPK_DCC_7	395	405	PF00069	0.435
DOC_MAPK_gen_1	564	572	PF00069	0.524
DOC_MAPK_gen_1	67	76	PF00069	0.580
DOC_MAPK_MEF2A_6	411	418	PF00069	0.543
DOC_PP2B_LxvP_1	3	6	PF13499	0.518
DOC_PP2B_LxvP_1	414	417	PF13499	0.464
DOC_USP7_MATH_1	111	115	PF00917	0.484
DOC_USP7_MATH_1	129	133	PF00917	0.695
DOC_USP7_MATH_1	305	309	PF00917	0.629
DOC_USP7_MATH_1	383	387	PF00917	0.657
DOC_USP7_MATH_1	539	543	PF00917	0.585
DOC_USP7_MATH_1	558	562	PF00917	0.515
DOC_USP7_MATH_1	611	615	PF00917	0.610
DOC_USP7_MATH_1	87	91	PF00917	0.530
DOC_USP7_UBL2_3	560	564	PF12436	0.495
DOC_WW_Pin1_4	127	132	PF00397	0.514
DOC_WW_Pin1_4	200	205	PF00397	0.422
DOC_WW_Pin1_4	258	263	PF00397	0.572
DOC_WW_Pin1_4	430	435	PF00397	0.466
DOC_WW_Pin1_4	499	504	PF00397	0.440
LIG_14-3-3_CanoR_1	184	189	PF00244	0.464
LIG_14-3-3_CanoR_1	346	354	PF00244	0.621
LIG_14-3-3_CanoR_1	395	403	PF00244	0.484
LIG_14-3-3_CanoR_1	415	425	PF00244	0.503
LIG_14-3-3_CanoR_1	449	459	PF00244	0.478
LIG_14-3-3_CanoR_1	642	648	PF00244	0.594
LIG_FHA_1	169	175	PF00498	0.388
LIG_FHA_1	197	203	PF00498	0.513
LIG_FHA_1	375	381	PF00498	0.555
LIG_FHA_1	395	401	PF00498	0.514
LIG_FHA_1	500	506	PF00498	0.507
LIG_FHA_1	565	571	PF00498	0.757
LIG_FHA_1	616	622	PF00498	0.527
LIG_FHA_1	638	644	PF00498	0.534
LIG_FHA_2	165	171	PF00498	0.324
LIG_FHA_2	18	24	PF00498	0.578
LIG_FHA_2	389	395	PF00498	0.464
LIG_FHA_2	484	490	PF00498	0.606
LIG_FHA_2	73	79	PF00498	0.558
LIG_Integrin_RGD_1	40	42	PF01839	0.526
LIG_LIR_Gen_1	649	657	PF02991	0.632
LIG_LIR_Nem_3	518	522	PF02991	0.400
LIG_LIR_Nem_3	649	655	PF02991	0.614
LIG_LIR_Nem_3	98	103	PF02991	0.519
LIG_MYND_1	2	6	PF01753	0.619
LIG_Pex14_2	603	607	PF04695	0.461
LIG_SH2_NCK_1	522	526	PF00017	0.483
LIG_SH2_SRC	511	514	PF00017	0.466
LIG_SH2_SRC	522	525	PF00017	0.431
LIG_SH2_STAP1	290	294	PF00017	0.515
LIG_SH2_STAT3	186	189	PF00017	0.462
LIG_SH2_STAT3	478	481	PF00017	0.539
LIG_SH2_STAT5	164	167	PF00017	0.334
LIG_SH2_STAT5	186	189	PF00017	0.375
LIG_SH2_STAT5	247	250	PF00017	0.455
LIG_SH2_STAT5	478	481	PF00017	0.427
LIG_SH2_STAT5	633	636	PF00017	0.533
LIG_SH3_3	201	207	PF00018	0.526
LIG_SH3_3	256	262	PF00018	0.368
LIG_SH3_3	421	427	PF00018	0.372
LIG_SH3_3	638	644	PF00018	0.576
LIG_SH3_3	96	102	PF00018	0.406
LIG_SH3_5	629	633	PF00018	0.436
LIG_SUMO_SIM_anti_2	71	78	PF11976	0.589
LIG_SUMO_SIM_par_1	71	78	PF11976	0.581
LIG_TRAF2_1	136	139	PF00917	0.681
LIG_TRAF2_1	486	489	PF00917	0.644
LIG_TRAF2_1	69	72	PF00917	0.642
LIG_TRFH_1	535	539	PF08558	0.608
LIG_WW_3	628	632	PF00397	0.622
MOD_CDK_SPxK_1	127	133	PF00069	0.560
MOD_CDK_SPxxK_3	203	210	PF00069	0.548
MOD_CK1_1	125	131	PF00069	0.634
MOD_CK1_1	140	146	PF00069	0.612
MOD_CK1_1	203	209	PF00069	0.510
MOD_CK1_1	309	315	PF00069	0.592
MOD_CK1_1	542	548	PF00069	0.586
MOD_CK1_1	86	92	PF00069	0.441
MOD_CK2_1	17	23	PF00069	0.628
MOD_CK2_1	483	489	PF00069	0.607
MOD_CK2_1	617	623	PF00069	0.568
MOD_CK2_1	643	649	PF00069	0.602
MOD_Cter_Amidation	60	63	PF01082	0.652
MOD_GlcNHglycan	113	116	PF01048	0.544
MOD_GlcNHglycan	123	127	PF01048	0.406
MOD_GlcNHglycan	194	197	PF01048	0.462
MOD_GlcNHglycan	262	265	PF01048	0.557
MOD_GlcNHglycan	308	311	PF01048	0.491
MOD_GlcNHglycan	349	352	PF01048	0.726
MOD_GlcNHglycan	385	388	PF01048	0.664
MOD_GlcNHglycan	578	583	PF01048	0.760
MOD_GlcNHglycan	85	88	PF01048	0.428
MOD_GlcNHglycan	89	92	PF01048	0.511
MOD_GSK3_1	111	118	PF00069	0.552
MOD_GSK3_1	125	132	PF00069	0.540
MOD_GSK3_1	164	171	PF00069	0.376
MOD_GSK3_1	192	199	PF00069	0.513
MOD_GSK3_1	295	302	PF00069	0.648
MOD_GSK3_1	305	312	PF00069	0.586
MOD_GSK3_1	331	338	PF00069	0.510
MOD_GSK3_1	374	381	PF00069	0.563
MOD_GSK3_1	574	581	PF00069	0.745
MOD_GSK3_1	611	618	PF00069	0.535
MOD_GSK3_1	79	86	PF00069	0.500
MOD_GSK3_1	87	94	PF00069	0.492
MOD_LATS_1	361	367	PF00433	0.429
MOD_N-GLC_1	196	201	PF02516	0.549
MOD_NEK2_1	192	197	PF00069	0.416
MOD_NEK2_1	396	401	PF00069	0.446
MOD_NEK2_1	450	455	PF00069	0.468
MOD_NEK2_1	482	487	PF00069	0.511
MOD_NEK2_1	83	88	PF00069	0.453
MOD_NEK2_2	290	295	PF00069	0.478
MOD_NEK2_2	460	465	PF00069	0.399
MOD_NEK2_2	558	563	PF00069	0.518
MOD_NEK2_2	637	642	PF00069	0.516
MOD_PKA_1	29	35	PF00069	0.544
MOD_PKA_2	116	122	PF00069	0.436
MOD_PKA_2	29	35	PF00069	0.544
MOD_PKA_2	318	324	PF00069	0.502
MOD_PKA_2	394	400	PF00069	0.459
MOD_Plk_1	140	146	PF00069	0.644
MOD_Plk_1	158	164	PF00069	0.261
MOD_Plk_1	17	23	PF00069	0.619
MOD_Plk_1	290	296	PF00069	0.615
MOD_Plk_1	91	97	PF00069	0.528
MOD_Plk_2-3	72	78	PF00069	0.556
MOD_Plk_4	299	305	PF00069	0.581
MOD_Plk_4	331	337	PF00069	0.450
MOD_Plk_4	396	402	PF00069	0.408
MOD_Plk_4	474	480	PF00069	0.556
MOD_Plk_4	611	617	PF00069	0.649
MOD_Plk_4	72	78	PF00069	0.571
MOD_Plk_4	79	85	PF00069	0.499
MOD_Plk_4	95	101	PF00069	0.318
MOD_ProDKin_1	127	133	PF00069	0.529
MOD_ProDKin_1	200	206	PF00069	0.423
MOD_ProDKin_1	258	264	PF00069	0.566
MOD_ProDKin_1	430	436	PF00069	0.474
MOD_ProDKin_1	499	505	PF00069	0.435
TRG_DiLeu_BaEn_1	524	529	PF01217	0.522
TRG_DiLeu_BaLyEn_6	60	65	PF01217	0.624
TRG_ENDOCYTIC_2	600	603	PF00928	0.549
TRG_ENDOCYTIC_2	652	655	PF00928	0.584
TRG_ER_diArg_1	448	450	PF00400	0.489
TRG_ER_diArg_1	533	535	PF00400	0.514
TRG_ER_diArg_1	62	64	PF00400	0.590
TRG_Pf-PMV_PEXEL_1	47	51	PF00026	0.715

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM77	Leptomonas seymouri	57%	80%
A0A1X0NK49	Trypanosomatidae	35%	93%
A4H7C2	Leishmania braziliensis	81%	100%
A4HVR8	Leishmania infantum	100%	100%
D0A6H1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	90%
E9APG4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QG14	Leishmania major	94%	100%
V5BHJ9	Trypanosoma cruzi	38%	98%