Cell division control protein 48, putative

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Cell division control protein 48, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8II41_LEIDO

TriTrypDb:

LdBPK_281580.1 , LdCL_280020500 , LDHU3_28.2030

Length:

770

Annotations

LeishMANIAdb annotations

A large and likely artifical grouping of protease domain carrying proteins related to proteasomal proteases. Only a tiny subgroup (the AFG3-related mitochondrail proteins) seem to have a TM segment.. Localization: Cytoplasmic (by homology) / Mitochondrial (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8II41

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8II41

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	2
GO:0051301	cell division	2	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016462	pyrophosphatase activity	5	11
GO:0016787	hydrolase activity	2	11
GO:0016817	hydrolase activity, acting on acid anhydrides	3	11
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	11
GO:0016887	ATP hydrolysis activity	7	11
GO:0017076	purine nucleotide binding	4	11
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	538	542	PF00656	0.623
CLV_NRD_NRD_1	113	115	PF00675	0.467
CLV_NRD_NRD_1	141	143	PF00675	0.477
CLV_NRD_NRD_1	145	147	PF00675	0.489
CLV_NRD_NRD_1	301	303	PF00675	0.526
CLV_NRD_NRD_1	400	402	PF00675	0.529
CLV_NRD_NRD_1	441	443	PF00675	0.485
CLV_NRD_NRD_1	494	496	PF00675	0.303
CLV_NRD_NRD_1	533	535	PF00675	0.729
CLV_NRD_NRD_1	616	618	PF00675	0.437
CLV_NRD_NRD_1	622	624	PF00675	0.424
CLV_NRD_NRD_1	674	676	PF00675	0.509
CLV_NRD_NRD_1	736	738	PF00675	0.525
CLV_PCSK_KEX2_1	113	115	PF00082	0.465
CLV_PCSK_KEX2_1	141	143	PF00082	0.477
CLV_PCSK_KEX2_1	145	147	PF00082	0.489
CLV_PCSK_KEX2_1	301	303	PF00082	0.526
CLV_PCSK_KEX2_1	400	402	PF00082	0.529
CLV_PCSK_KEX2_1	427	429	PF00082	0.485
CLV_PCSK_KEX2_1	441	443	PF00082	0.380
CLV_PCSK_KEX2_1	494	496	PF00082	0.321
CLV_PCSK_KEX2_1	532	534	PF00082	0.722
CLV_PCSK_KEX2_1	622	624	PF00082	0.417
CLV_PCSK_KEX2_1	674	676	PF00082	0.509
CLV_PCSK_KEX2_1	736	738	PF00082	0.533
CLV_PCSK_PC1ET2_1	427	429	PF00082	0.546
CLV_PCSK_PC7_1	141	147	PF00082	0.474
CLV_PCSK_PC7_1	437	443	PF00082	0.574
CLV_PCSK_SKI1_1	141	145	PF00082	0.535
CLV_PCSK_SKI1_1	301	305	PF00082	0.431
CLV_PCSK_SKI1_1	428	432	PF00082	0.417
CLV_PCSK_SKI1_1	461	465	PF00082	0.302
CLV_PCSK_SKI1_1	665	669	PF00082	0.487
CLV_PCSK_SKI1_1	685	689	PF00082	0.223
CLV_PCSK_SKI1_1	697	701	PF00082	0.428
CLV_PCSK_SKI1_1	737	741	PF00082	0.449
CLV_Separin_Metazoa	77	81	PF03568	0.554
DEG_APCC_DBOX_1	17	25	PF00400	0.608
DEG_COP1_1	95	104	PF00400	0.518
DEG_SPOP_SBC_1	170	174	PF00917	0.608
DEG_SPOP_SBC_1	207	211	PF00917	0.748
DOC_CDC14_PxL_1	478	486	PF14671	0.302
DOC_CKS1_1	293	298	PF01111	0.397
DOC_CYCLIN_yCln2_LP_2	592	598	PF00134	0.427
DOC_MAPK_gen_1	113	120	PF00069	0.455
DOC_MAPK_gen_1	400	408	PF00069	0.541
DOC_MAPK_gen_1	444	453	PF00069	0.475
DOC_MAPK_gen_1	504	512	PF00069	0.302
DOC_MAPK_gen_1	599	609	PF00069	0.302
DOC_MAPK_MEF2A_6	504	512	PF00069	0.302
DOC_PP2B_LxvP_1	321	324	PF13499	0.530
DOC_PP2B_LxvP_1	607	610	PF13499	0.437
DOC_PP4_FxxP_1	304	307	PF00568	0.505
DOC_SPAK_OSR1_1	442	446	PF12202	0.496
DOC_USP7_MATH_1	10	14	PF00917	0.736
DOC_USP7_MATH_1	354	358	PF00917	0.539
DOC_USP7_MATH_1	387	391	PF00917	0.516
DOC_USP7_MATH_1	535	539	PF00917	0.679
DOC_USP7_MATH_1	616	620	PF00917	0.410
DOC_USP7_MATH_1	709	713	PF00917	0.601
DOC_USP7_UBL2_3	423	427	PF12436	0.504
DOC_WW_Pin1_4	16	21	PF00397	0.542
DOC_WW_Pin1_4	172	177	PF00397	0.653
DOC_WW_Pin1_4	245	250	PF00397	0.585
DOC_WW_Pin1_4	292	297	PF00397	0.406
DOC_WW_Pin1_4	352	357	PF00397	0.543
DOC_WW_Pin1_4	359	364	PF00397	0.617
DOC_WW_Pin1_4	504	509	PF00397	0.302
LIG_14-3-3_CanoR_1	113	121	PF00244	0.462
LIG_14-3-3_CanoR_1	145	149	PF00244	0.498
LIG_14-3-3_CanoR_1	212	220	PF00244	0.679
LIG_14-3-3_CanoR_1	264	269	PF00244	0.420
LIG_14-3-3_CanoR_1	358	362	PF00244	0.701
LIG_14-3-3_CanoR_1	400	408	PF00244	0.488
LIG_14-3-3_CanoR_1	428	433	PF00244	0.472
LIG_14-3-3_CanoR_1	5	10	PF00244	0.527
LIG_14-3-3_CanoR_1	561	570	PF00244	0.297
LIG_14-3-3_CanoR_1	617	621	PF00244	0.408
LIG_14-3-3_CanoR_1	685	691	PF00244	0.431
LIG_Actin_WH2_2	509	525	PF00022	0.427
LIG_Actin_WH2_2	585	601	PF00022	0.304
LIG_APCC_ABBAyCdc20_2	622	628	PF00400	0.462
LIG_BIR_II_1	1	5	PF00653	0.734
LIG_BRCT_BRCA1_1	401	405	PF00533	0.588
LIG_BRCT_BRCA1_1	508	512	PF00533	0.302
LIG_BRCT_BRCA1_1	675	679	PF00533	0.474
LIG_Clathr_ClatBox_1	182	186	PF01394	0.441
LIG_Clathr_ClatBox_1	510	514	PF01394	0.427
LIG_deltaCOP1_diTrp_1	628	632	PF00928	0.397
LIG_FHA_1	103	109	PF00498	0.703
LIG_FHA_1	113	119	PF00498	0.446
LIG_FHA_1	135	141	PF00498	0.593
LIG_FHA_1	257	263	PF00498	0.521
LIG_FHA_1	270	276	PF00498	0.557
LIG_FHA_1	295	301	PF00498	0.529
LIG_FHA_1	331	337	PF00498	0.426
LIG_FHA_1	429	435	PF00498	0.520
LIG_FHA_1	447	453	PF00498	0.275
LIG_FHA_1	525	531	PF00498	0.393
LIG_FHA_1	585	591	PF00498	0.344
LIG_FHA_1	698	704	PF00498	0.491
LIG_FHA_1	738	744	PF00498	0.463
LIG_FHA_2	145	151	PF00498	0.505
LIG_FHA_2	173	179	PF00498	0.550
LIG_FHA_2	293	299	PF00498	0.403
LIG_FHA_2	393	399	PF00498	0.514
LIG_FHA_2	409	415	PF00498	0.413
LIG_FHA_2	554	560	PF00498	0.420
LIG_FHA_2	603	609	PF00498	0.302
LIG_FHA_2	657	663	PF00498	0.481
LIG_FHA_2	71	77	PF00498	0.493
LIG_GBD_Chelix_1	562	570	PF00786	0.346
LIG_LIR_Gen_1	240	250	PF02991	0.414
LIG_LIR_Gen_1	402	410	PF02991	0.482
LIG_LIR_Gen_1	411	420	PF02991	0.389
LIG_LIR_Gen_1	475	485	PF02991	0.302
LIG_LIR_Gen_1	577	586	PF02991	0.302
LIG_LIR_Nem_3	232	237	PF02991	0.488
LIG_LIR_Nem_3	240	245	PF02991	0.362
LIG_LIR_Nem_3	337	341	PF02991	0.422
LIG_LIR_Nem_3	402	408	PF02991	0.471
LIG_LIR_Nem_3	411	416	PF02991	0.401
LIG_LIR_Nem_3	438	443	PF02991	0.512
LIG_LIR_Nem_3	475	481	PF02991	0.302
LIG_LIR_Nem_3	498	502	PF02991	0.427
LIG_LIR_Nem_3	577	583	PF02991	0.303
LIG_LYPXL_S_1	233	237	PF13949	0.560
LIG_LYPXL_yS_3	234	237	PF13949	0.548
LIG_NRBOX	139	145	PF00104	0.545
LIG_NRBOX	27	33	PF00104	0.515
LIG_NRBOX	565	571	PF00104	0.346
LIG_NRBOX	602	608	PF00104	0.420
LIG_Pex14_2	687	691	PF04695	0.368
LIG_RPA_C_Fungi	556	568	PF08784	0.356
LIG_SH2_CRK	242	246	PF00017	0.402
LIG_SH2_CRK	338	342	PF00017	0.362
LIG_SH2_GRB2like	524	527	PF00017	0.420
LIG_SH2_SRC	289	292	PF00017	0.522
LIG_SH2_SRC	37	40	PF00017	0.484
LIG_SH2_STAP1	149	153	PF00017	0.491
LIG_SH2_STAP1	289	293	PF00017	0.547
LIG_SH2_STAP1	524	528	PF00017	0.411
LIG_SH2_STAT5	191	194	PF00017	0.613
LIG_SH2_STAT5	242	245	PF00017	0.527
LIG_SH2_STAT5	286	289	PF00017	0.513
LIG_SH2_STAT5	351	354	PF00017	0.543
LIG_SH2_STAT5	388	391	PF00017	0.461
LIG_SH2_STAT5	499	502	PF00017	0.427
LIG_SH3_1	33	39	PF00018	0.502
LIG_SH3_3	117	123	PF00018	0.531
LIG_SH3_3	214	220	PF00018	0.743
LIG_SH3_3	316	322	PF00018	0.584
LIG_SH3_3	33	39	PF00018	0.557
LIG_SH3_3	427	433	PF00018	0.389
LIG_SH3_3	606	612	PF00018	0.320
LIG_Sin3_3	757	764	PF02671	0.488
LIG_SUMO_SIM_anti_2	177	183	PF11976	0.468
LIG_SUMO_SIM_anti_2	756	763	PF11976	0.501
LIG_SUMO_SIM_par_1	180	186	PF11976	0.368
LIG_SxIP_EBH_1	113	127	PF03271	0.550
LIG_TYR_ITIM	336	341	PF00017	0.360
LIG_WW_2	319	322	PF00397	0.367
MOD_CDC14_SPxK_1	355	358	PF00782	0.528
MOD_CDK_SPxK_1	352	358	PF00069	0.497
MOD_CK1_1	14	20	PF00069	0.588
MOD_CK1_1	203	209	PF00069	0.753
MOD_CK1_1	226	232	PF00069	0.664
MOD_CK1_1	357	363	PF00069	0.645
MOD_CK1_1	364	370	PF00069	0.659
MOD_CK1_1	390	396	PF00069	0.485
MOD_CK1_1	550	556	PF00069	0.368
MOD_CK1_1	638	644	PF00069	0.582
MOD_CK1_1	746	752	PF00069	0.597
MOD_CK2_1	16	22	PF00069	0.620
MOD_CK2_1	172	178	PF00069	0.682
MOD_CK2_1	250	256	PF00069	0.543
MOD_CK2_1	292	298	PF00069	0.405
MOD_CK2_1	392	398	PF00069	0.533
MOD_CK2_1	5	11	PF00069	0.583
MOD_CK2_1	602	608	PF00069	0.302
MOD_CK2_1	656	662	PF00069	0.482
MOD_CK2_1	677	683	PF00069	0.469
MOD_CK2_1	79	85	PF00069	0.636
MOD_CMANNOS	629	632	PF00535	0.395
MOD_GlcNHglycan	105	108	PF01048	0.505
MOD_GlcNHglycan	13	16	PF01048	0.737
MOD_GlcNHglycan	164	167	PF01048	0.650
MOD_GlcNHglycan	203	206	PF01048	0.761
MOD_GlcNHglycan	225	228	PF01048	0.649
MOD_GlcNHglycan	364	367	PF01048	0.661
MOD_GlcNHglycan	390	393	PF01048	0.435
MOD_GlcNHglycan	401	404	PF01048	0.490
MOD_GlcNHglycan	537	540	PF01048	0.712
MOD_GlcNHglycan	643	646	PF01048	0.739
MOD_GlcNHglycan	679	682	PF01048	0.421
MOD_GlcNHglycan	745	748	PF01048	0.567
MOD_GlcNHglycan	93	97	PF01048	0.637
MOD_GSK3_1	10	17	PF00069	0.656
MOD_GSK3_1	112	119	PF00069	0.509
MOD_GSK3_1	156	163	PF00069	0.599
MOD_GSK3_1	168	175	PF00069	0.677
MOD_GSK3_1	199	206	PF00069	0.672
MOD_GSK3_1	207	214	PF00069	0.623
MOD_GSK3_1	218	225	PF00069	0.652
MOD_GSK3_1	240	247	PF00069	0.529
MOD_GSK3_1	330	337	PF00069	0.453
MOD_GSK3_1	357	364	PF00069	0.655
MOD_GSK3_1	388	395	PF00069	0.491
MOD_GSK3_1	50	57	PF00069	0.541
MOD_GSK3_1	547	554	PF00069	0.682
MOD_GSK3_1	673	680	PF00069	0.378
MOD_GSK3_1	699	706	PF00069	0.388
MOD_GSK3_1	742	749	PF00069	0.525
MOD_GSK3_1	92	99	PF00069	0.642
MOD_LATS_1	40	46	PF00433	0.400
MOD_N-GLC_1	472	477	PF02516	0.302
MOD_N-GLC_1	685	690	PF02516	0.491
MOD_N-GLC_2	68	70	PF02516	0.516
MOD_NEK2_1	144	149	PF00069	0.595
MOD_NEK2_1	27	32	PF00069	0.507
MOD_NEK2_1	472	477	PF00069	0.302
MOD_NEK2_1	742	747	PF00069	0.543
MOD_PIKK_1	218	224	PF00454	0.553
MOD_PIKK_1	250	256	PF00454	0.536
MOD_PIKK_1	656	662	PF00454	0.617
MOD_PIKK_1	703	709	PF00454	0.497
MOD_PK_1	264	270	PF00069	0.474
MOD_PK_1	42	48	PF00069	0.388
MOD_PKA_2	112	118	PF00069	0.462
MOD_PKA_2	144	150	PF00069	0.494
MOD_PKA_2	156	162	PF00069	0.599
MOD_PKA_2	211	217	PF00069	0.767
MOD_PKA_2	357	363	PF00069	0.671
MOD_PKA_2	399	405	PF00069	0.454
MOD_PKA_2	4	10	PF00069	0.559
MOD_PKA_2	436	442	PF00069	0.519
MOD_PKA_2	445	451	PF00069	0.402
MOD_PKA_2	535	541	PF00069	0.727
MOD_PKA_2	616	622	PF00069	0.407
MOD_PKA_2	673	679	PF00069	0.467
MOD_PKA_2	79	85	PF00069	0.602
MOD_PKB_1	444	452	PF00069	0.480
MOD_PKB_1	504	512	PF00069	0.302
MOD_PKB_1	532	540	PF00069	0.774
MOD_Plk_1	472	478	PF00069	0.307
MOD_Plk_1	656	662	PF00069	0.454
MOD_Plk_1	685	691	PF00069	0.485
MOD_Plk_4	116	122	PF00069	0.601
MOD_Plk_4	229	235	PF00069	0.612
MOD_Plk_4	240	246	PF00069	0.456
MOD_Plk_4	27	33	PF00069	0.455
MOD_Plk_4	42	48	PF00069	0.326
MOD_Plk_4	459	465	PF00069	0.309
MOD_Plk_4	472	478	PF00069	0.302
MOD_Plk_4	506	512	PF00069	0.316
MOD_Plk_4	602	608	PF00069	0.302
MOD_Plk_4	616	622	PF00069	0.388
MOD_Plk_4	638	644	PF00069	0.677
MOD_Plk_4	686	692	PF00069	0.483
MOD_Plk_4	96	102	PF00069	0.516
MOD_ProDKin_1	16	22	PF00069	0.535
MOD_ProDKin_1	172	178	PF00069	0.635
MOD_ProDKin_1	245	251	PF00069	0.578
MOD_ProDKin_1	292	298	PF00069	0.405
MOD_ProDKin_1	352	358	PF00069	0.555
MOD_ProDKin_1	359	365	PF00069	0.622
MOD_ProDKin_1	504	510	PF00069	0.302
TRG_DiLeu_BaEn_1	178	183	PF01217	0.502
TRG_DiLeu_BaEn_1	22	27	PF01217	0.493
TRG_DiLeu_BaLyEn_6	139	144	PF01217	0.545
TRG_DiLeu_BaLyEn_6	565	570	PF01217	0.411
TRG_DiLeu_BaLyEn_6	592	597	PF01217	0.427
TRG_ENDOCYTIC_2	234	237	PF00928	0.472
TRG_ENDOCYTIC_2	242	245	PF00928	0.366
TRG_ENDOCYTIC_2	338	341	PF00928	0.396
TRG_ENDOCYTIC_2	440	443	PF00928	0.483
TRG_ENDOCYTIC_2	478	481	PF00928	0.302
TRG_ENDOCYTIC_2	499	502	PF00928	0.427
TRG_ER_diArg_1	140	142	PF00400	0.473
TRG_ER_diArg_1	144	146	PF00400	0.453
TRG_ER_diArg_1	282	285	PF00400	0.559
TRG_ER_diArg_1	300	302	PF00400	0.511
TRG_ER_diArg_1	399	401	PF00400	0.509
TRG_ER_diArg_1	434	437	PF00400	0.504
TRG_ER_diArg_1	440	442	PF00400	0.452
TRG_ER_diArg_1	443	446	PF00400	0.454
TRG_ER_diArg_1	494	496	PF00400	0.321
TRG_ER_diArg_1	532	534	PF00400	0.722
TRG_ER_diArg_1	621	623	PF00400	0.523
TRG_ER_diArg_1	673	675	PF00400	0.510
TRG_ER_diArg_1	735	737	PF00400	0.570
TRG_ER_diLys_1	766	770	PF00400	0.563
TRG_Pf-PMV_PEXEL_1	494	498	PF00026	0.346

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9Q8	Leptomonas seymouri	53%	100%
A0A1X0NZ99	Trypanosomatidae	42%	100%
A0A422MTD5	Trypanosoma rangeli	40%	100%
A4HGJ8	Leishmania braziliensis	77%	100%
A4I3M5	Leishmania infantum	100%	100%
D0A856	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AZW6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q8C0	Leishmania major	93%	100%
V5BCT3	Trypanosoma cruzi	39%	100%