Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8II38_LEIDO

TriTrypDb:

LdBPK_302630.1 , LdCL_300031900 , LDHU3_30.3530

Length:

831

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8II38

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8II38

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	360	364	PF00656	0.461
CLV_MEL_PAP_1	47	53	PF00089	0.473
CLV_NRD_NRD_1	396	398	PF00675	0.452
CLV_NRD_NRD_1	440	442	PF00675	0.481
CLV_NRD_NRD_1	539	541	PF00675	0.632
CLV_NRD_NRD_1	626	628	PF00675	0.743
CLV_NRD_NRD_1	744	746	PF00675	0.856
CLV_NRD_NRD_1	819	821	PF00675	0.672
CLV_PCSK_KEX2_1	253	255	PF00082	0.504
CLV_PCSK_KEX2_1	295	297	PF00082	0.524
CLV_PCSK_KEX2_1	396	398	PF00082	0.452
CLV_PCSK_KEX2_1	413	415	PF00082	0.517
CLV_PCSK_KEX2_1	539	541	PF00082	0.632
CLV_PCSK_KEX2_1	626	628	PF00082	0.743
CLV_PCSK_KEX2_1	682	684	PF00082	0.849
CLV_PCSK_KEX2_1	744	746	PF00082	0.848
CLV_PCSK_KEX2_1	819	821	PF00082	0.672
CLV_PCSK_PC1ET2_1	253	255	PF00082	0.605
CLV_PCSK_PC1ET2_1	295	297	PF00082	0.524
CLV_PCSK_PC1ET2_1	413	415	PF00082	0.391
CLV_PCSK_PC1ET2_1	682	684	PF00082	0.849
CLV_PCSK_SKI1_1	253	257	PF00082	0.500
CLV_PCSK_SKI1_1	296	300	PF00082	0.482
CLV_PCSK_SKI1_1	381	385	PF00082	0.480
CLV_PCSK_SKI1_1	520	524	PF00082	0.738
CLV_PCSK_SKI1_1	539	543	PF00082	0.718
CLV_PCSK_SKI1_1	826	830	PF00082	0.733
DEG_APCC_DBOX_1	295	303	PF00400	0.478
DEG_APCC_DBOX_1	396	404	PF00400	0.404
DEG_APCC_DBOX_1	519	527	PF00400	0.739
DEG_Nend_UBRbox_2	1	3	PF02207	0.538
DEG_SPOP_SBC_1	283	287	PF00917	0.475
DOC_CDC14_PxL_1	96	104	PF14671	0.547
DOC_CYCLIN_RxL_1	376	388	PF00134	0.471
DOC_CYCLIN_yCln2_LP_2	424	430	PF00134	0.470
DOC_MAPK_DCC_7	313	321	PF00069	0.482
DOC_MAPK_gen_1	119	129	PF00069	0.524
DOC_MAPK_gen_1	253	262	PF00069	0.579
DOC_MAPK_gen_1	396	405	PF00069	0.421
DOC_MAPK_gen_1	413	424	PF00069	0.355
DOC_MAPK_HePTP_8	395	407	PF00069	0.410
DOC_MAPK_MEF2A_6	104	113	PF00069	0.627
DOC_MAPK_MEF2A_6	122	129	PF00069	0.437
DOC_MAPK_MEF2A_6	301	310	PF00069	0.543
DOC_MAPK_MEF2A_6	398	407	PF00069	0.403
DOC_PP2B_LxvP_1	761	764	PF13499	0.824
DOC_SPAK_OSR1_1	50	54	PF12202	0.569
DOC_USP7_MATH_1	138	142	PF00917	0.488
DOC_USP7_MATH_1	226	230	PF00917	0.527
DOC_USP7_MATH_1	239	243	PF00917	0.511
DOC_USP7_MATH_1	283	287	PF00917	0.461
DOC_USP7_MATH_1	357	361	PF00917	0.510
DOC_USP7_MATH_1	370	374	PF00917	0.403
DOC_USP7_MATH_1	446	450	PF00917	0.458
DOC_USP7_MATH_1	460	464	PF00917	0.632
DOC_USP7_MATH_1	569	573	PF00917	0.807
DOC_USP7_MATH_1	619	623	PF00917	0.827
DOC_USP7_MATH_1	706	710	PF00917	0.669
DOC_USP7_MATH_1	726	730	PF00917	0.700
DOC_USP7_MATH_1	768	772	PF00917	0.700
DOC_USP7_MATH_1	798	802	PF00917	0.725
DOC_USP7_UBL2_3	136	140	PF12436	0.624
DOC_WW_Pin1_4	222	227	PF00397	0.571
DOC_WW_Pin1_4	312	317	PF00397	0.457
DOC_WW_Pin1_4	435	440	PF00397	0.513
DOC_WW_Pin1_4	456	461	PF00397	0.608
DOC_WW_Pin1_4	593	598	PF00397	0.720
DOC_WW_Pin1_4	627	632	PF00397	0.762
DOC_WW_Pin1_4	633	638	PF00397	0.790
DOC_WW_Pin1_4	673	678	PF00397	0.829
DOC_WW_Pin1_4	686	691	PF00397	0.664
DOC_WW_Pin1_4	743	748	PF00397	0.845
DOC_WW_Pin1_4	794	799	PF00397	0.735
LIG_14-3-3_CanoR_1	122	126	PF00244	0.518
LIG_14-3-3_CanoR_1	254	264	PF00244	0.566
LIG_14-3-3_CanoR_1	326	336	PF00244	0.561
LIG_14-3-3_CanoR_1	445	451	PF00244	0.460
LIG_14-3-3_CanoR_1	50	54	PF00244	0.578
LIG_14-3-3_CanoR_1	511	515	PF00244	0.679
LIG_14-3-3_CanoR_1	626	630	PF00244	0.790
LIG_14-3-3_CanoR_1	697	706	PF00244	0.837
LIG_14-3-3_CanoR_1	813	819	PF00244	0.671
LIG_Actin_WH2_2	108	124	PF00022	0.509
LIG_Actin_WH2_2	240	258	PF00022	0.538
LIG_Actin_WH2_2	351	369	PF00022	0.476
LIG_AP2alpha_1	193	197	PF02296	0.751
LIG_CtBP_PxDLS_1	777	781	PF00389	0.733
LIG_FHA_1	122	128	PF00498	0.532
LIG_FHA_1	158	164	PF00498	0.591
LIG_FHA_1	250	256	PF00498	0.463
LIG_FHA_1	285	291	PF00498	0.447
LIG_FHA_1	582	588	PF00498	0.682
LIG_FHA_1	636	642	PF00498	0.644
LIG_FHA_1	646	652	PF00498	0.755
LIG_FHA_2	190	196	PF00498	0.747
LIG_FHA_2	206	212	PF00498	0.520
LIG_FHA_2	44	50	PF00498	0.513
LIG_GBD_Chelix_1	379	387	PF00786	0.470
LIG_LIR_Apic_2	602	608	PF02991	0.695
LIG_LIR_Gen_1	147	156	PF02991	0.504
LIG_LIR_Gen_1	187	197	PF02991	0.651
LIG_LIR_Gen_1	56	67	PF02991	0.582
LIG_LIR_Nem_3	147	151	PF02991	0.481
LIG_LIR_Nem_3	161	167	PF02991	0.501
LIG_LIR_Nem_3	187	193	PF02991	0.649
LIG_LIR_Nem_3	56	62	PF02991	0.563
LIG_LIR_Nem_3	789	795	PF02991	0.731
LIG_MAD2	452	460	PF02301	0.546
LIG_NRBOX	174	180	PF00104	0.548
LIG_NRBOX	420	426	PF00104	0.485
LIG_NRBOX	495	501	PF00104	0.493
LIG_PDZ_Class_2	826	831	PF00595	0.696
LIG_Pex14_2	193	197	PF04695	0.751
LIG_PTB_Apo_2	495	502	PF02174	0.521
LIG_SH2_CRK	605	609	PF00017	0.694
LIG_SH2_CRK	792	796	PF00017	0.711
LIG_SH2_PTP2	114	117	PF00017	0.486
LIG_SH2_PTP2	352	355	PF00017	0.519
LIG_SH2_STAP1	164	168	PF00017	0.605
LIG_SH2_STAP1	664	668	PF00017	0.782
LIG_SH2_STAT3	272	275	PF00017	0.503
LIG_SH2_STAT5	114	117	PF00017	0.486
LIG_SH2_STAT5	148	151	PF00017	0.473
LIG_SH2_STAT5	272	275	PF00017	0.485
LIG_SH2_STAT5	352	355	PF00017	0.519
LIG_SH2_STAT5	40	43	PF00017	0.458
LIG_SH2_STAT5	402	405	PF00017	0.424
LIG_SH2_STAT5	432	435	PF00017	0.511
LIG_SH3_1	18	24	PF00018	0.658
LIG_SH3_3	18	24	PF00018	0.570
LIG_SH3_3	450	456	PF00018	0.498
LIG_SH3_3	591	597	PF00018	0.656
LIG_SH3_3	613	619	PF00018	0.830
LIG_SH3_3	731	737	PF00018	0.714
LIG_SH3_3	757	763	PF00018	0.835
LIG_SH3_3	806	812	PF00018	0.648
LIG_SUMO_SIM_anti_2	285	292	PF11976	0.454
LIG_SUMO_SIM_anti_2	305	310	PF11976	0.216
LIG_SUMO_SIM_anti_2	471	478	PF11976	0.636
LIG_TRAF2_1	754	757	PF00917	0.805
LIG_TYR_ITIM	400	405	PF00017	0.424
LIG_UBA3_1	30	38	PF00899	0.463
LIG_Vh1_VBS_1	273	291	PF01044	0.445
LIG_WRC_WIRS_1	148	153	PF05994	0.304
LIG_WRC_WIRS_1	227	232	PF05994	0.514
LIG_WW_3	762	766	PF00397	0.748
MOD_CDC14_SPxK_1	438	441	PF00782	0.506
MOD_CDC14_SPxK_1	689	692	PF00782	0.784
MOD_CDK_SPK_2	456	461	PF00069	0.650
MOD_CDK_SPxK_1	435	441	PF00069	0.512
MOD_CDK_SPxK_1	686	692	PF00069	0.791
MOD_CDK_SPxxK_3	435	442	PF00069	0.507
MOD_CK1_1	174	180	PF00069	0.649
MOD_CK1_1	184	190	PF00069	0.579
MOD_CK1_1	225	231	PF00069	0.631
MOD_CK1_1	242	248	PF00069	0.412
MOD_CK1_1	359	365	PF00069	0.562
MOD_CK1_1	43	49	PF00069	0.592
MOD_CK1_1	509	515	PF00069	0.658
MOD_CK1_1	518	524	PF00069	0.714
MOD_CK1_1	572	578	PF00069	0.737
MOD_CK1_1	579	585	PF00069	0.604
MOD_CK1_1	636	642	PF00069	0.761
MOD_CK1_1	696	702	PF00069	0.792
MOD_CK1_1	709	715	PF00069	0.720
MOD_CK1_1	799	805	PF00069	0.704
MOD_CK2_1	138	144	PF00069	0.486
MOD_CK2_1	43	49	PF00069	0.502
MOD_Cter_Amidation	537	540	PF01082	0.609
MOD_Cter_Amidation	624	627	PF01082	0.765
MOD_DYRK1A_RPxSP_1	627	631	PF00069	0.748
MOD_GlcNHglycan	296	299	PF01048	0.495
MOD_GlcNHglycan	336	339	PF01048	0.529
MOD_GlcNHglycan	359	362	PF01048	0.565
MOD_GlcNHglycan	387	390	PF01048	0.603
MOD_GlcNHglycan	514	517	PF01048	0.720
MOD_GlcNHglycan	621	624	PF01048	0.823
MOD_GlcNHglycan	631	634	PF01048	0.699
MOD_GlcNHglycan	678	681	PF01048	0.761
MOD_GlcNHglycan	699	702	PF01048	0.726
MOD_GlcNHglycan	708	711	PF01048	0.795
MOD_GlcNHglycan	728	731	PF01048	0.826
MOD_GlcNHglycan	740	743	PF01048	0.748
MOD_GlcNHglycan	801	804	PF01048	0.718
MOD_GSK3_1	134	141	PF00069	0.516
MOD_GSK3_1	182	189	PF00069	0.646
MOD_GSK3_1	193	200	PF00069	0.698
MOD_GSK3_1	218	225	PF00069	0.695
MOD_GSK3_1	239	246	PF00069	0.565
MOD_GSK3_1	328	335	PF00069	0.521
MOD_GSK3_1	338	345	PF00069	0.437
MOD_GSK3_1	456	463	PF00069	0.605
MOD_GSK3_1	502	509	PF00069	0.587
MOD_GSK3_1	518	525	PF00069	0.711
MOD_GSK3_1	569	576	PF00069	0.796
MOD_GSK3_1	595	602	PF00069	0.725
MOD_GSK3_1	625	632	PF00069	0.743
MOD_GSK3_1	63	70	PF00069	0.535
MOD_GSK3_1	645	652	PF00069	0.756
MOD_GSK3_1	686	693	PF00069	0.726
MOD_GSK3_1	721	728	PF00069	0.708
MOD_GSK3_1	794	801	PF00069	0.712
MOD_N-GLC_1	673	678	PF02516	0.744
MOD_N-GLC_1	697	702	PF02516	0.558
MOD_NEK2_1	121	126	PF00069	0.509
MOD_NEK2_1	13	18	PF00069	0.546
MOD_NEK2_1	186	191	PF00069	0.642
MOD_NEK2_1	193	198	PF00069	0.664
MOD_NEK2_1	255	260	PF00069	0.579
MOD_NEK2_1	385	390	PF00069	0.298
MOD_NEK2_1	506	511	PF00069	0.558
MOD_NEK2_1	522	527	PF00069	0.806
MOD_NEK2_1	590	595	PF00069	0.725
MOD_NEK2_1	63	68	PF00069	0.525
MOD_NEK2_1	650	655	PF00069	0.558
MOD_NEK2_2	40	45	PF00069	0.462
MOD_PIKK_1	255	261	PF00454	0.573
MOD_PIKK_1	338	344	PF00454	0.363
MOD_PIKK_1	515	521	PF00454	0.802
MOD_PIKK_1	812	818	PF00454	0.798
MOD_PK_1	659	665	PF00069	0.715
MOD_PKA_2	121	127	PF00069	0.514
MOD_PKA_2	325	331	PF00069	0.688
MOD_PKA_2	460	466	PF00069	0.641
MOD_PKA_2	49	55	PF00069	0.527
MOD_PKA_2	510	516	PF00069	0.670
MOD_PKA_2	556	562	PF00069	0.842
MOD_PKA_2	572	578	PF00069	0.724
MOD_PKA_2	625	631	PF00069	0.723
MOD_PKA_2	696	702	PF00069	0.847
MOD_PKA_2	812	818	PF00069	0.697
MOD_Plk_1	138	144	PF00069	0.486
MOD_Plk_1	182	188	PF00069	0.708
MOD_Plk_1	242	248	PF00069	0.656
MOD_Plk_2-3	49	55	PF00069	0.527
MOD_Plk_4	147	153	PF00069	0.392
MOD_Plk_4	174	180	PF00069	0.649
MOD_Plk_4	2	8	PF00069	0.529
MOD_Plk_4	226	232	PF00069	0.521
MOD_Plk_4	379	385	PF00069	0.514
MOD_Plk_4	446	452	PF00069	0.439
MOD_Plk_4	502	508	PF00069	0.586
MOD_Plk_4	54	60	PF00069	0.584
MOD_Plk_4	659	665	PF00069	0.702
MOD_ProDKin_1	222	228	PF00069	0.573
MOD_ProDKin_1	312	318	PF00069	0.466
MOD_ProDKin_1	435	441	PF00069	0.512
MOD_ProDKin_1	456	462	PF00069	0.605
MOD_ProDKin_1	593	599	PF00069	0.720
MOD_ProDKin_1	627	633	PF00069	0.763
MOD_ProDKin_1	673	679	PF00069	0.831
MOD_ProDKin_1	686	692	PF00069	0.665
MOD_ProDKin_1	743	749	PF00069	0.843
MOD_ProDKin_1	794	800	PF00069	0.735
MOD_SUMO_for_1	127	130	PF00179	0.561
MOD_SUMO_rev_2	130	138	PF00179	0.536
MOD_SUMO_rev_2	823	828	PF00179	0.654
TRG_DiLeu_BaEn_1	420	425	PF01217	0.491
TRG_DiLeu_BaEn_1	495	500	PF01217	0.531
TRG_DiLeu_BaEn_2	146	152	PF01217	0.493
TRG_DiLeu_BaEn_2	501	507	PF01217	0.566
TRG_DiLeu_BaEn_4	756	762	PF01217	0.720
TRG_DiLeu_BaLyEn_6	462	467	PF01217	0.611
TRG_DiLeu_BaLyEn_6	731	736	PF01217	0.697
TRG_ENDOCYTIC_2	114	117	PF00928	0.486
TRG_ENDOCYTIC_2	148	151	PF00928	0.491
TRG_ENDOCYTIC_2	352	355	PF00928	0.519
TRG_ENDOCYTIC_2	402	405	PF00928	0.424
TRG_ENDOCYTIC_2	792	795	PF00928	0.713
TRG_ER_diArg_1	395	397	PF00400	0.457
TRG_ER_diArg_1	526	529	PF00400	0.726
TRG_ER_diArg_1	818	820	PF00400	0.680
TRG_NES_CRM1_1	278	294	PF08389	0.464
TRG_NLS_Bipartite_1	235	257	PF00514	0.636
TRG_Pf-PMV_PEXEL_1	45	49	PF00026	0.516
TRG_Pf-PMV_PEXEL_1	540	544	PF00026	0.591
TRG_Pf-PMV_PEXEL_1	820	824	PF00026	0.652

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P525	Leptomonas seymouri	54%	96%
A4HIJ6	Leishmania braziliensis	74%	100%
A4I5U0	Leishmania infantum	99%	100%
E9B135	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q731	Leishmania major	93%	100%