LeishMANIAdb
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Ubiquitin-conjugating_enzyme_E2_putative/GeneDB:L mjF.34.1555

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Ubiquitin-conjugating_enzyme_E2_putative/GeneDB:L mjF.34.1555
Gene product:
ubiquitin-conjugating enzyme E2, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8II37_LEIDO
TriTrypDb:
LdBPK_341660.1 , LdCL_340022900 , LDHU3_34.2500
Length:
166

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0005737 cytoplasm 2 1
GO:0031974 membrane-enclosed lumen 2 1
GO:0031981 nuclear lumen 5 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0043233 organelle lumen 3 1
GO:0070013 intracellular organelle lumen 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A0A3Q8II37
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8II37

Function

Biological processes
Term Name Level Count
GO:0000209 protein polyubiquitination 8 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0016567 protein ubiquitination 7 1
GO:0019538 protein metabolic process 3 1
GO:0032446 protein modification by small protein conjugation 6 1
GO:0036211 protein modification process 4 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043412 macromolecule modification 4 1
GO:0044238 primary metabolic process 2 1
GO:0070647 protein modification by small protein conjugation or removal 5 1
GO:0071704 organic substance metabolic process 2 1
GO:1901564 organonitrogen compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 3
GO:0004842 ubiquitin-protein transferase activity 4 1
GO:0016740 transferase activity 2 1
GO:0016874 ligase activity 2 3
GO:0019787 ubiquitin-like protein transferase activity 3 1
GO:0061631 ubiquitin conjugating enzyme activity 5 1
GO:0061650 ubiquitin-like protein conjugating enzyme activity 4 1
GO:0140096 catalytic activity, acting on a protein 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 7 9 PF00675 0.432
CLV_PCSK_KEX2_1 7 9 PF00082 0.397
CLV_PCSK_SKI1_1 124 128 PF00082 0.461
CLV_PCSK_SKI1_1 83 87 PF00082 0.354
DOC_CKS1_1 111 116 PF01111 0.483
DOC_MAPK_gen_1 4 13 PF00069 0.490
DOC_PP4_FxxP_1 77 80 PF00568 0.352
DOC_USP7_MATH_1 54 58 PF00917 0.358
DOC_USP7_MATH_1 91 95 PF00917 0.364
DOC_WW_Pin1_4 110 115 PF00397 0.483
DOC_WW_Pin1_4 145 150 PF00397 0.483
DOC_WW_Pin1_4 21 26 PF00397 0.462
LIG_BIR_II_1 1 5 PF00653 0.488
LIG_FHA_1 110 116 PF00498 0.460
LIG_FHA_1 130 136 PF00498 0.148
LIG_FHA_1 61 67 PF00498 0.407
LIG_FHA_2 146 152 PF00498 0.406
LIG_FHA_2 60 66 PF00498 0.483
LIG_LIR_Apic_2 74 80 PF02991 0.392
LIG_LIR_Gen_1 12 20 PF02991 0.483
LIG_LIR_Gen_1 132 141 PF02991 0.419
LIG_LIR_Gen_1 62 70 PF02991 0.411
LIG_LIR_Nem_3 12 16 PF02991 0.477
LIG_LIR_Nem_3 129 133 PF02991 0.354
LIG_LIR_Nem_3 62 67 PF02991 0.411
LIG_MAD2 83 91 PF02301 0.407
LIG_SH2_CRK 133 137 PF00017 0.483
LIG_SH2_CRK 64 68 PF00017 0.407
LIG_SH2_STAP1 64 68 PF00017 0.407
LIG_SH3_3 108 114 PF00018 0.407
LIG_SH3_3 48 54 PF00018 0.358
LIG_SH3_3 73 79 PF00018 0.338
LIG_TRAF2_1 148 151 PF00917 0.407
MOD_CK1_1 2 8 PF00069 0.575
MOD_CK2_1 145 151 PF00069 0.404
MOD_GlcNHglycan 21 24 PF01048 0.504
MOD_GlcNHglycan 27 30 PF01048 0.507
MOD_GSK3_1 159 166 PF00069 0.584
MOD_GSK3_1 19 26 PF00069 0.524
MOD_N-GLC_1 136 141 PF02516 0.381
MOD_NEK2_1 136 141 PF00069 0.352
MOD_NEK2_1 19 24 PF00069 0.483
MOD_NEK2_2 54 59 PF00069 0.407
MOD_PIKK_1 68 74 PF00454 0.264
MOD_PKA_2 159 165 PF00069 0.589
MOD_Plk_4 54 60 PF00069 0.407
MOD_ProDKin_1 110 116 PF00069 0.483
MOD_ProDKin_1 145 151 PF00069 0.483
MOD_ProDKin_1 21 27 PF00069 0.454
MOD_SUMO_rev_2 107 112 PF00179 0.414
TRG_ENDOCYTIC_2 133 136 PF00928 0.483
TRG_ENDOCYTIC_2 64 67 PF00928 0.407
TRG_ER_diArg_1 47 50 PF00400 0.483
TRG_ER_diArg_1 6 8 PF00400 0.446

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I707 Leptomonas seymouri 28% 100%
A0A0N1IA94 Leptomonas seymouri 57% 100%
A0A0S4IWQ9 Bodo saltans 34% 86%
A0A0S4JGV6 Bodo saltans 25% 100%
A0A0S4JK56 Bodo saltans 26% 100%
A0A0S4JS17 Bodo saltans 26% 100%
A0A0S4KIJ1 Bodo saltans 27% 92%
A0A0S4KJ33 Bodo saltans 25% 100%
A0A1X0NH68 Trypanosomatidae 28% 100%
A0A1X0NT81 Trypanosomatidae 30% 79%
A0A1X0P9M3 Trypanosomatidae 29% 100%
A0A422MVJ2 Trypanosoma rangeli 26% 100%
A0A422MW82 Trypanosoma rangeli 31% 100%
A0A422NDI3 Trypanosoma rangeli 31% 78%
A0A422NWQ7 Trypanosoma rangeli 28% 100%
A3KN22 Bos taurus 28% 91%
A4HAM6 Leishmania braziliensis 83% 100%
A4I9W7 Leishmania infantum 100% 100%
A5PKP9 Xenopus laevis 25% 100%
C9ZMR5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
C9ZNM0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 100%
C9ZW85 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 100%
E9B4Y0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
O14933 Homo sapiens 23% 100%
O74196 Colletotrichum gloeosporioides 32% 100%
O74201 Candida albicans (strain SC5314 / ATCC MYA-2876) 27% 93%
P06104 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 31% 97%
P0CS16 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) 27% 98%
P0CS17 Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) 27% 98%
P23566 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 27% 100%
P25153 Drosophila melanogaster 27% 100%
P25865 Arabidopsis thaliana 29% 100%
P25866 Triticum aestivum 28% 100%
P25868 Triticum aestivum 24% 99%
P35130 Medicago sativa 29% 100%
P35131 Arabidopsis thaliana 30% 100%
P35132 Arabidopsis thaliana 28% 100%
P35133 Arabidopsis thaliana 29% 100%
P35135 Solanum lycopersicum 28% 100%
P42745 Arabidopsis thaliana 29% 100%
P42746 Arabidopsis thaliana 27% 100%
P49459 Homo sapiens 26% 100%
P52478 Caenorhabditis elegans 26% 86%
P52493 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 27% 100%
P61081 Homo sapiens 28% 91%
P61082 Mus musculus 28% 91%
P62253 Homo sapiens 25% 98%
P62254 Mus musculus 25% 98%
P62255 Rattus norvegicus 25% 98%
P63146 Homo sapiens 28% 100%
P63147 Mus musculus 28% 100%
P63148 Oryctolagus cuniculus 28% 100%
P63149 Rattus norvegicus 28% 100%
P78717 Fusarium solani 27% 100%
Q32P99 Bos taurus 28% 100%
Q42540 Arabidopsis thaliana 28% 100%
Q42541 Arabidopsis thaliana 28% 100%
Q4PFA5 Ustilago maydis (strain 521 / FGSC 9021) 28% 90%
Q4Q346 Leishmania major 92% 100%
Q4WLA7 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 26% 100%
Q54TI6 Dictyostelium discoideum 26% 72%
Q553F3 Dictyostelium discoideum 30% 100%
Q58FS2 Trichoderma harzianum 27% 100%
Q6BU36 Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) 27% 99%
Q6C093 Yarrowia lipolytica (strain CLIB 122 / E 150) 28% 100%
Q6C9W0 Yarrowia lipolytica (strain CLIB 122 / E 150) 32% 93%
Q6CUD9 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 31% 100%
Q6DCZ9 Xenopus laevis 27% 91%
Q6FR76 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 31% 99%
Q6P8D9 Xenopus tropicalis 27% 91%
Q75EB8 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 31% 98%
Q8L7T3 Arabidopsis thaliana 28% 92%
Q8S919 Oryza sativa subsp. japonica 28% 100%
Q94F47 Arabidopsis thaliana 29% 100%
Q96UP5 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 26% 100%
Q9QZU9 Mus musculus 28% 100%
Q9SLE4 Arabidopsis thaliana 32% 100%
Q9VSF3 Drosophila melanogaster 26% 92%
Q9VTY6 Drosophila melanogaster 30% 93%
Q9Z255 Mus musculus 26% 100%
V5BVS1 Trypanosoma cruzi 31% 74%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS