BTB/POZ domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

btb/poz domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8II33_LEIDO

TriTrypDb:

LdBPK_352730.1 , LdCL_350032200 , LDHU3_35.3480

Length:

414

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8II33

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8II33

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0022607	cellular component assembly	4	11
GO:0043933	protein-containing complex organization	4	11
GO:0051259	protein complex oligomerization	6	11
GO:0051260	protein homooligomerization	7	11
GO:0065003	protein-containing complex assembly	5	11
GO:0071840	cellular component organization or biogenesis	2	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	41	45	PF00656	0.777
CLV_C14_Caspase3-7	70	74	PF00656	0.568
CLV_NRD_NRD_1	225	227	PF00675	0.427
CLV_NRD_NRD_1	336	338	PF00675	0.420
CLV_NRD_NRD_1	369	371	PF00675	0.424
CLV_NRD_NRD_1	379	381	PF00675	0.365
CLV_NRD_NRD_1	403	405	PF00675	0.423
CLV_PCSK_FUR_1	377	381	PF00082	0.525
CLV_PCSK_KEX2_1	225	227	PF00082	0.427
CLV_PCSK_KEX2_1	379	381	PF00082	0.517
CLV_PCSK_KEX2_1	402	404	PF00082	0.514
CLV_PCSK_SKI1_1	225	229	PF00082	0.384
CLV_PCSK_SKI1_1	382	386	PF00082	0.467
CLV_PCSK_SKI1_1	62	66	PF00082	0.636
DEG_APCC_DBOX_1	263	271	PF00400	0.573
DEG_APCC_DBOX_1	401	409	PF00400	0.517
DOC_CDC14_PxL_1	233	241	PF14671	0.427
DOC_CYCLIN_RxL_1	376	386	PF00134	0.501
DOC_MAPK_gen_1	266	275	PF00069	0.477
DOC_MAPK_gen_1	367	375	PF00069	0.473
DOC_MAPK_gen_1	379	389	PF00069	0.332
DOC_MAPK_MEF2A_6	141	150	PF00069	0.532
DOC_PP1_RVXF_1	377	384	PF00149	0.378
DOC_PP4_FxxP_1	155	158	PF00568	0.302
DOC_SPAK_OSR1_1	154	158	PF12202	0.420
DOC_USP7_MATH_1	17	21	PF00917	0.745
DOC_USP7_MATH_1	38	42	PF00917	0.763
DOC_USP7_MATH_1	94	98	PF00917	0.609
DOC_USP7_UBL2_3	367	371	PF12436	0.389
DOC_WW_Pin1_4	22	27	PF00397	0.710
DOC_WW_Pin1_4	252	257	PF00397	0.652
DOC_WW_Pin1_4	258	263	PF00397	0.612
DOC_WW_Pin1_4	403	408	PF00397	0.573
DOC_WW_Pin1_4	63	68	PF00397	0.782
LIG_14-3-3_CanoR_1	154	158	PF00244	0.420
LIG_14-3-3_CanoR_1	285	291	PF00244	0.348
LIG_14-3-3_CanoR_1	370	376	PF00244	0.544
LIG_14-3-3_CanoR_1	382	388	PF00244	0.429
LIG_14-3-3_CanoR_1	62	67	PF00244	0.660
LIG_Actin_WH2_2	368	384	PF00022	0.493
LIG_BIR_II_1	1	5	PF00653	0.621
LIG_BIR_III_4	73	77	PF00653	0.706
LIG_BRCT_BRCA1_1	325	329	PF00533	0.462
LIG_BRCT_BRCA1_1	65	69	PF00533	0.781
LIG_deltaCOP1_diTrp_1	178	187	PF00928	0.420
LIG_eIF4E_1	213	219	PF01652	0.380
LIG_eIF4E_1	234	240	PF01652	0.420
LIG_eIF4E_1	297	303	PF01652	0.323
LIG_FHA_1	154	160	PF00498	0.314
LIG_FHA_1	178	184	PF00498	0.420
LIG_FHA_1	191	197	PF00498	0.330
LIG_FHA_1	287	293	PF00498	0.338
LIG_FHA_1	350	356	PF00498	0.455
LIG_FHA_1	384	390	PF00498	0.473
LIG_FHA_2	112	118	PF00498	0.560
LIG_FHA_2	308	314	PF00498	0.421
LIG_FHA_2	77	83	PF00498	0.592
LIG_LIR_Apic_2	153	158	PF02991	0.305
LIG_LIR_Apic_2	179	185	PF02991	0.420
LIG_LIR_Gen_1	140	150	PF02991	0.453
LIG_LIR_Gen_1	311	322	PF02991	0.486
LIG_LIR_Gen_1	349	357	PF02991	0.348
LIG_LIR_Nem_3	140	145	PF02991	0.510
LIG_LIR_Nem_3	201	206	PF02991	0.295
LIG_LIR_Nem_3	230	236	PF02991	0.302
LIG_LIR_Nem_3	296	300	PF02991	0.360
LIG_LIR_Nem_3	311	317	PF02991	0.388
LIG_LIR_Nem_3	349	353	PF02991	0.365
LIG_LIR_Nem_3	358	364	PF02991	0.345
LIG_NRBOX	115	121	PF00104	0.556
LIG_PTB_Apo_2	329	336	PF02174	0.507
LIG_PTB_Apo_2	344	351	PF02174	0.509
LIG_PTB_Phospho_1	329	335	PF10480	0.502
LIG_RPA_C_Fungi	87	99	PF08784	0.597
LIG_SH2_CRK	234	238	PF00017	0.420
LIG_SH2_GRB2like	215	218	PF00017	0.427
LIG_SH2_GRB2like	330	333	PF00017	0.351
LIG_SH2_STAP1	290	294	PF00017	0.466
LIG_SH2_STAT5	170	173	PF00017	0.302
LIG_SH2_STAT5	205	208	PF00017	0.327
LIG_SH2_STAT5	209	212	PF00017	0.278
LIG_SH2_STAT5	215	218	PF00017	0.265
LIG_SH2_STAT5	297	300	PF00017	0.326
LIG_SH2_STAT5	330	333	PF00017	0.477
LIG_SH2_STAT5	361	364	PF00017	0.377
LIG_SH3_3	2	8	PF00018	0.679
LIG_SH3_3	29	35	PF00018	0.625
LIG_SUMO_SIM_anti_2	278	283	PF11976	0.512
LIG_TRAF2_1	310	313	PF00917	0.395
LIG_TRAF2_1	397	400	PF00917	0.408
LIG_TRAF2_1	411	414	PF00917	0.430
LIG_TRAF2_1	79	82	PF00917	0.588
MOD_CDC14_SPxK_1	261	264	PF00782	0.572
MOD_CDK_SPxK_1	258	264	PF00069	0.567
MOD_CDK_SPxxK_3	22	29	PF00069	0.753
MOD_CK1_1	104	110	PF00069	0.510
MOD_CK1_1	20	26	PF00069	0.713
MOD_CK1_1	280	286	PF00069	0.560
MOD_CK1_1	37	43	PF00069	0.651
MOD_CK1_1	55	61	PF00069	0.724
MOD_CK2_1	307	313	PF00069	0.405
MOD_CK2_1	408	414	PF00069	0.532
MOD_CK2_1	76	82	PF00069	0.676
MOD_GlcNHglycan	20	23	PF01048	0.659
MOD_GlcNHglycan	325	328	PF01048	0.467
MOD_GlcNHglycan	36	39	PF01048	0.542
MOD_GlcNHglycan	56	60	PF01048	0.457
MOD_GSK3_1	111	118	PF00069	0.560
MOD_GSK3_1	153	160	PF00069	0.412
MOD_GSK3_1	18	25	PF00069	0.685
MOD_GSK3_1	280	287	PF00069	0.491
MOD_GSK3_1	30	37	PF00069	0.607
MOD_GSK3_1	303	310	PF00069	0.452
MOD_GSK3_1	63	70	PF00069	0.711
MOD_GSK3_1	76	83	PF00069	0.565
MOD_NEK2_1	1	6	PF00069	0.669
MOD_NEK2_1	111	116	PF00069	0.434
MOD_NEK2_1	366	371	PF00069	0.379
MOD_NEK2_1	383	388	PF00069	0.355
MOD_NEK2_1	60	65	PF00069	0.729
MOD_NEK2_1	88	93	PF00069	0.627
MOD_PKA_2	153	159	PF00069	0.420
MOD_PKA_2	28	34	PF00069	0.750
MOD_PKA_2	284	290	PF00069	0.379
MOD_PKB_1	380	388	PF00069	0.485
MOD_Plk_1	220	226	PF00069	0.427
MOD_Plk_1	277	283	PF00069	0.513
MOD_Plk_4	115	121	PF00069	0.461
MOD_Plk_4	158	164	PF00069	0.352
MOD_Plk_4	190	196	PF00069	0.478
MOD_Plk_4	277	283	PF00069	0.551
MOD_ProDKin_1	22	28	PF00069	0.710
MOD_ProDKin_1	252	258	PF00069	0.654
MOD_ProDKin_1	403	409	PF00069	0.566
MOD_ProDKin_1	63	69	PF00069	0.783
MOD_SUMO_for_1	128	131	PF00179	0.609
MOD_SUMO_for_1	187	190	PF00179	0.427
MOD_SUMO_rev_2	122	128	PF00179	0.522
TRG_DiLeu_BaEn_2	345	351	PF01217	0.503
TRG_ENDOCYTIC_2	142	145	PF00928	0.522
TRG_ENDOCYTIC_2	170	173	PF00928	0.302
TRG_ENDOCYTIC_2	213	216	PF00928	0.321
TRG_ENDOCYTIC_2	233	236	PF00928	0.302
TRG_ENDOCYTIC_2	297	300	PF00928	0.326
TRG_ER_diArg_1	224	226	PF00400	0.427
TRG_ER_diArg_1	264	267	PF00400	0.476
TRG_ER_diArg_1	377	380	PF00400	0.523
TRG_ER_diArg_1	392	395	PF00400	0.402
TRG_ER_diArg_1	401	404	PF00400	0.480
TRG_Pf-PMV_PEXEL_1	225	230	PF00026	0.421
TRG_Pf-PMV_PEXEL_1	86	90	PF00026	0.631

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3C7	Leptomonas seymouri	68%	89%
A0A1X0P5J3	Trypanosomatidae	49%	80%
A0A422P2R6	Trypanosoma rangeli	47%	81%
A4HMT5	Leishmania braziliensis	94%	100%
A4IBD6	Leishmania infantum	100%	100%
C9ZZ82	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	80%
E9AF92	Leishmania major	97%	100%
E9B6E7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
V5DUU9	Trypanosoma cruzi	49%	81%