Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8II27_LEIDO

TriTrypDb:

LdBPK_131160.1 , LdCL_130017000 , LDHU3_13.1420

Length:

192

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A0A3Q8II27

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8II27

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	138	142	PF00656	0.755
CLV_NRD_NRD_1	135	137	PF00675	0.490
CLV_PCSK_KEX2_1	135	137	PF00082	0.487
CLV_PCSK_KEX2_1	6	8	PF00082	0.518
CLV_PCSK_PC1ET2_1	135	137	PF00082	0.507
CLV_PCSK_PC1ET2_1	6	8	PF00082	0.436
CLV_PCSK_SKI1_1	61	65	PF00082	0.356
DEG_APCC_DBOX_1	60	68	PF00400	0.272
DOC_MAPK_gen_1	95	105	PF00069	0.303
DOC_MAPK_MEF2A_6	98	106	PF00069	0.346
DOC_PP2B_LxvP_1	29	32	PF13499	0.665
DOC_USP7_MATH_1	165	169	PF00917	0.655
DOC_USP7_MATH_1	19	23	PF00917	0.673
DOC_USP7_MATH_1	33	37	PF00917	0.618
DOC_USP7_UBL2_3	133	137	PF12436	0.679
LIG_deltaCOP1_diTrp_1	91	99	PF00928	0.452
LIG_LIR_LC3C_4	26	31	PF02991	0.631
LIG_PDZ_Class_3	187	192	PF00595	0.713
LIG_Pex14_1	93	97	PF04695	0.451
LIG_SH2_CRK	65	69	PF00017	0.356
LIG_SH2_STAT3	57	60	PF00017	0.614
LIG_SH3_3	11	17	PF00018	0.695
LIG_SH3_3	27	33	PF00018	0.568
LIG_SUMO_SIM_anti_2	26	32	PF11976	0.694
LIG_SUMO_SIM_anti_2	47	53	PF11976	0.633
LIG_SUMO_SIM_par_1	101	108	PF11976	0.401
LIG_TRAF2_1	164	167	PF00917	0.716
LIG_Vh1_VBS_1	103	121	PF01044	0.296
MOD_CK1_1	168	174	PF00069	0.728
MOD_CK1_1	186	192	PF00069	0.618
MOD_CK2_1	145	151	PF00069	0.729
MOD_CK2_1	185	191	PF00069	0.713
MOD_GlcNHglycan	23	26	PF01048	0.476
MOD_GSK3_1	131	138	PF00069	0.706
MOD_GSK3_1	165	172	PF00069	0.707
MOD_N-GLC_1	186	191	PF02516	0.469
MOD_N-GLC_1	89	94	PF02516	0.636
MOD_NEK2_1	82	87	PF00069	0.528
MOD_NEK2_1	89	94	PF00069	0.483
MOD_PKA_1	135	141	PF00069	0.694
MOD_PKA_2	135	141	PF00069	0.798
MOD_Plk_1	168	174	PF00069	0.745
MOD_Plk_1	46	52	PF00069	0.636
MOD_Plk_1	89	95	PF00069	0.426
MOD_Plk_2-3	169	175	PF00069	0.719
MOD_Plk_4	105	111	PF00069	0.344
MOD_Plk_4	46	52	PF00069	0.700
TRG_NLS_MonoExtN_4	133	139	PF00514	0.700
TRG_Pf-PMV_PEXEL_1	155	159	PF00026	0.479
TRG_Pf-PMV_PEXEL_1	76	81	PF00026	0.740

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H7A9	Leishmania braziliensis	52%	100%
A4HVQ4	Leishmania infantum	99%	100%
E9APF0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4QG28	Leishmania major	83%	100%