RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8II25_LEIDO

TriTrypDb:

LdBPK_333120.1 , LdCL_330038500 , LDHU3_33.4530

Length:

622

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8II25

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8II25

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	153	157	PF00656	0.581
CLV_C14_Caspase3-7	274	278	PF00656	0.705
CLV_NRD_NRD_1	160	162	PF00675	0.559
CLV_NRD_NRD_1	369	371	PF00675	0.594
CLV_NRD_NRD_1	475	477	PF00675	0.570
CLV_PCSK_KEX2_1	160	162	PF00082	0.602
CLV_PCSK_KEX2_1	369	371	PF00082	0.594
CLV_PCSK_KEX2_1	563	565	PF00082	0.513
CLV_PCSK_KEX2_1	597	599	PF00082	0.436
CLV_PCSK_PC1ET2_1	563	565	PF00082	0.566
CLV_PCSK_PC1ET2_1	597	599	PF00082	0.410
CLV_PCSK_SKI1_1	189	193	PF00082	0.644
CLV_PCSK_SKI1_1	208	212	PF00082	0.622
CLV_PCSK_SKI1_1	223	227	PF00082	0.611
CLV_PCSK_SKI1_1	232	236	PF00082	0.709
CLV_PCSK_SKI1_1	307	311	PF00082	0.485
CLV_PCSK_SKI1_1	411	415	PF00082	0.408
CLV_PCSK_SKI1_1	422	426	PF00082	0.311
DEG_Nend_UBRbox_1	1	4	PF02207	0.483
DEG_SPOP_SBC_1	580	584	PF00917	0.522
DOC_CYCLIN_RxL_1	294	305	PF00134	0.371
DOC_MAPK_gen_1	304	313	PF00069	0.385
DOC_MAPK_gen_1	324	334	PF00069	0.394
DOC_MAPK_gen_1	369	376	PF00069	0.440
DOC_MAPK_gen_1	476	484	PF00069	0.364
DOC_MAPK_gen_1	597	603	PF00069	0.404
DOC_MAPK_MEF2A_6	477	486	PF00069	0.543
DOC_PP4_FxxP_1	493	496	PF00568	0.305
DOC_USP7_MATH_1	177	181	PF00917	0.656
DOC_USP7_MATH_1	424	428	PF00917	0.513
DOC_USP7_MATH_1	434	438	PF00917	0.311
DOC_USP7_MATH_1	62	66	PF00917	0.692
DOC_USP7_UBL2_3	198	202	PF12436	0.652
DOC_USP7_UBL2_3	216	220	PF12436	0.623
DOC_USP7_UBL2_3	223	227	PF12436	0.578
DOC_USP7_UBL2_3	250	254	PF12436	0.804
DOC_USP7_UBL2_3	261	265	PF12436	0.718
DOC_USP7_UBL2_3	310	314	PF12436	0.514
DOC_USP7_UBL2_3	473	477	PF12436	0.439
DOC_USP7_UBL2_3	571	575	PF12436	0.481
DOC_WW_Pin1_4	190	195	PF00397	0.663
DOC_WW_Pin1_4	425	430	PF00397	0.418
LIG_14-3-3_CanoR_1	160	165	PF00244	0.635
LIG_14-3-3_CanoR_1	295	300	PF00244	0.445
LIG_14-3-3_CanoR_1	369	377	PF00244	0.376
LIG_14-3-3_CanoR_1	476	485	PF00244	0.411
LIG_14-3-3_CanoR_1	517	521	PF00244	0.475
LIG_FHA_1	358	364	PF00498	0.354
LIG_FHA_1	369	375	PF00498	0.317
LIG_FHA_1	383	389	PF00498	0.544
LIG_FHA_1	438	444	PF00498	0.446
LIG_FHA_1	524	530	PF00498	0.346
LIG_FHA_2	228	234	PF00498	0.535
LIG_FHA_2	324	330	PF00498	0.452
LIG_FHA_2	400	406	PF00498	0.518
LIG_FHA_2	437	443	PF00498	0.568
LIG_FHA_2	567	573	PF00498	0.527
LIG_FHA_2	581	587	PF00498	0.627
LIG_LIR_Apic_2	492	496	PF02991	0.301
LIG_LIR_Gen_1	150	158	PF02991	0.573
LIG_LIR_Gen_1	396	404	PF02991	0.303
LIG_LIR_Gen_1	591	599	PF02991	0.380
LIG_LIR_Nem_3	150	154	PF02991	0.633
LIG_LIR_Nem_3	391	397	PF02991	0.555
LIG_LIR_Nem_3	468	472	PF02991	0.328
LIG_SH2_CRK	151	155	PF00017	0.519
LIG_SH2_STAP1	592	596	PF00017	0.491
LIG_SH2_STAT5	380	383	PF00017	0.347
LIG_SH2_STAT5	394	397	PF00017	0.212
LIG_SH2_STAT5	398	401	PF00017	0.302
LIG_SH2_STAT5	469	472	PF00017	0.524
LIG_SH2_STAT5	485	488	PF00017	0.218
LIG_SH2_STAT5	568	571	PF00017	0.596
LIG_SH3_1	216	222	PF00018	0.556
LIG_SH3_2	509	514	PF14604	0.393
LIG_SH3_3	216	222	PF00018	0.632
LIG_SH3_3	427	433	PF00018	0.499
LIG_SH3_3	506	512	PF00018	0.391
LIG_SH3_4	250	257	PF00018	0.547
LIG_SUMO_SIM_anti_2	298	303	PF11976	0.437
LIG_SUMO_SIM_par_1	359	366	PF11976	0.356
LIG_TRAF2_1	583	586	PF00917	0.579
LIG_UBA3_1	501	508	PF00899	0.352
LIG_UBA3_1	595	604	PF00899	0.407
MOD_CDK_SPxxK_3	190	197	PF00069	0.559
MOD_CK1_1	150	156	PF00069	0.689
MOD_CK1_1	365	371	PF00069	0.401
MOD_CK1_1	43	49	PF00069	0.617
MOD_CK1_1	437	443	PF00069	0.334
MOD_CK1_1	581	587	PF00069	0.480
MOD_CK2_1	227	233	PF00069	0.711
MOD_CK2_1	399	405	PF00069	0.355
MOD_CK2_1	436	442	PF00069	0.500
MOD_CK2_1	530	536	PF00069	0.432
MOD_CK2_1	566	572	PF00069	0.526
MOD_CK2_1	579	585	PF00069	0.466
MOD_GlcNHglycan	14	17	PF01048	0.614
MOD_GlcNHglycan	185	188	PF01048	0.703
MOD_GlcNHglycan	239	242	PF01048	0.780
MOD_GlcNHglycan	28	31	PF01048	0.626
MOD_GlcNHglycan	291	294	PF01048	0.546
MOD_GlcNHglycan	304	307	PF01048	0.315
MOD_GlcNHglycan	390	393	PF01048	0.541
MOD_GlcNHglycan	478	481	PF01048	0.408
MOD_GlcNHglycan	534	540	PF01048	0.385
MOD_GlcNHglycan	558	561	PF01048	0.486
MOD_GSK3_1	156	163	PF00069	0.635
MOD_GSK3_1	179	186	PF00069	0.744
MOD_GSK3_1	26	33	PF00069	0.612
MOD_GSK3_1	291	298	PF00069	0.415
MOD_GSK3_1	393	400	PF00069	0.361
MOD_GSK3_1	485	492	PF00069	0.421
MOD_GSK3_1	552	559	PF00069	0.417
MOD_GSK3_1	580	587	PF00069	0.549
MOD_N-GLC_1	357	362	PF02516	0.433
MOD_N-GLC_1	489	494	PF02516	0.345
MOD_N-GLC_2	183	185	PF02516	0.577
MOD_NEK2_1	289	294	PF00069	0.472
MOD_NEK2_1	465	470	PF00069	0.301
MOD_NEK2_1	489	494	PF00069	0.326
MOD_NEK2_2	107	112	PF00069	0.581
MOD_NEK2_2	116	121	PF00069	0.682
MOD_NEK2_2	125	130	PF00069	0.578
MOD_NEK2_2	134	139	PF00069	0.573
MOD_NEK2_2	142	147	PF00069	0.583
MOD_NEK2_2	309	314	PF00069	0.374
MOD_NEK2_2	62	67	PF00069	0.608
MOD_NEK2_2	71	76	PF00069	0.524
MOD_NEK2_2	80	85	PF00069	0.466
MOD_NEK2_2	89	94	PF00069	0.561
MOD_NEK2_2	98	103	PF00069	0.634
MOD_OFUCOSY	378	384	PF10250	0.291
MOD_PIKK_1	368	374	PF00454	0.528
MOD_PK_1	243	249	PF00069	0.595
MOD_PKA_1	160	166	PF00069	0.558
MOD_PKA_1	202	208	PF00069	0.618
MOD_PKA_1	237	243	PF00069	0.699
MOD_PKA_1	254	260	PF00069	0.825
MOD_PKA_1	476	482	PF00069	0.436
MOD_PKA_2	160	166	PF00069	0.599
MOD_PKA_2	315	321	PF00069	0.368
MOD_PKA_2	368	374	PF00069	0.593
MOD_PKA_2	475	481	PF00069	0.483
MOD_PKA_2	516	522	PF00069	0.368
MOD_Plk_1	232	238	PF00069	0.596
MOD_Plk_1	357	363	PF00069	0.408
MOD_Plk_1	489	495	PF00069	0.453
MOD_Plk_4	107	113	PF00069	0.562
MOD_Plk_4	116	122	PF00069	0.594
MOD_Plk_4	125	131	PF00069	0.578
MOD_Plk_4	134	140	PF00069	0.493
MOD_Plk_4	142	148	PF00069	0.525
MOD_Plk_4	150	156	PF00069	0.588
MOD_Plk_4	160	166	PF00069	0.538
MOD_Plk_4	315	321	PF00069	0.562
MOD_Plk_4	357	363	PF00069	0.393
MOD_Plk_4	465	471	PF00069	0.412
MOD_Plk_4	489	495	PF00069	0.327
MOD_Plk_4	591	597	PF00069	0.581
MOD_Plk_4	62	68	PF00069	0.605
MOD_Plk_4	71	77	PF00069	0.655
MOD_Plk_4	80	86	PF00069	0.730
MOD_Plk_4	89	95	PF00069	0.524
MOD_Plk_4	98	104	PF00069	0.557
MOD_ProDKin_1	190	196	PF00069	0.664
MOD_ProDKin_1	425	431	PF00069	0.418
MOD_SUMO_for_1	210	213	PF00179	0.644
MOD_SUMO_for_1	225	228	PF00179	0.576
MOD_SUMO_rev_2	186	194	PF00179	0.615
MOD_SUMO_rev_2	195	205	PF00179	0.602
MOD_SUMO_rev_2	213	222	PF00179	0.589
MOD_SUMO_rev_2	239	246	PF00179	0.778
MOD_SUMO_rev_2	248	257	PF00179	0.731
MOD_SUMO_rev_2	262	271	PF00179	0.668
MOD_SUMO_rev_2	317	326	PF00179	0.584
MOD_SUMO_rev_2	581	590	PF00179	0.587
MOD_SUMO_rev_2	607	616	PF00179	0.568
TRG_DiLeu_BaEn_4	510	516	PF01217	0.379
TRG_ENDOCYTIC_2	151	154	PF00928	0.664
TRG_ENDOCYTIC_2	17	20	PF00928	0.665
TRG_ENDOCYTIC_2	394	397	PF00928	0.331
TRG_ENDOCYTIC_2	398	401	PF00928	0.302
TRG_ENDOCYTIC_2	44	47	PF00928	0.692
TRG_ENDOCYTIC_2	469	472	PF00928	0.328
TRG_ENDOCYTIC_2	592	595	PF00928	0.510
TRG_Pf-PMV_PEXEL_1	411	416	PF00026	0.379

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHP8	Leptomonas seymouri	23%	76%
A0A1X0NRB5	Trypanosomatidae	34%	73%
A0A1X0NST4	Trypanosomatidae	30%	75%
A0A1X0NU85	Trypanosomatidae	25%	81%
A0A3S7X791	Leishmania donovani	34%	95%
A4HM05	Leishmania braziliensis	34%	99%
A4HM06	Leishmania braziliensis	76%	100%
A4I9D6	Leishmania infantum	33%	95%
A4I9D8	Leishmania infantum	99%	79%
E9B4D6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	96%
E9B4D7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q3P0	Leishmania major	90%	100%
Q4Q3P1	Leishmania major	33%	95%