LeishMANIAdb
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Cytochrome P450 reductase, putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Cytochrome P450 reductase, putative
Gene product:
cytochrome P450 reductase, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8II21_LEIDO
TriTrypDb:
LdBPK_352600.1 * , LdCL_350030900 , LDHU3_35.3360
Length:
832

Annotations

LeishMANIAdb annotations

Homologous to other eukaryotic CYP450 reductases.. For some reason, these proteins duplicated in Kinetoplastids. Localization: ER (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 18
NetGPI no yes: 0, no: 18
Cellular components
Term Name Level Count
GO:0016020 membrane 2 2
GO:0110165 cellular anatomical entity 1 4
GO:0005829 cytosol 2 2

Expansion

Sequence features

A0A3Q8II21
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8II21

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 19
GO:0003824 catalytic activity 1 19
GO:0005488 binding 1 19
GO:0010181 FMN binding 4 19
GO:0016491 oxidoreductase activity 2 19
GO:0032553 ribonucleotide binding 3 19
GO:0036094 small molecule binding 2 19
GO:0043167 ion binding 2 19
GO:0043168 anion binding 3 19
GO:0097159 organic cyclic compound binding 2 19
GO:0097367 carbohydrate derivative binding 2 19
GO:1901265 nucleoside phosphate binding 3 19
GO:1901363 heterocyclic compound binding 2 19
GO:0003958 NADPH-hemoprotein reductase activity 5 6
GO:0016651 oxidoreductase activity, acting on NAD(P)H 3 6
GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 4 6
GO:0050660 flavin adenine dinucleotide binding 4 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 66 70 PF00656 0.761
CLV_NRD_NRD_1 150 152 PF00675 0.444
CLV_NRD_NRD_1 194 196 PF00675 0.321
CLV_NRD_NRD_1 33 35 PF00675 0.371
CLV_NRD_NRD_1 662 664 PF00675 0.269
CLV_NRD_NRD_1 668 670 PF00675 0.292
CLV_NRD_NRD_1 687 689 PF00675 0.292
CLV_NRD_NRD_1 725 727 PF00675 0.355
CLV_NRD_NRD_1 819 821 PF00675 0.322
CLV_PCSK_FUR_1 31 35 PF00082 0.345
CLV_PCSK_KEX2_1 127 129 PF00082 0.389
CLV_PCSK_KEX2_1 194 196 PF00082 0.321
CLV_PCSK_KEX2_1 33 35 PF00082 0.452
CLV_PCSK_KEX2_1 4 6 PF00082 0.600
CLV_PCSK_KEX2_1 642 644 PF00082 0.269
CLV_PCSK_KEX2_1 687 689 PF00082 0.336
CLV_PCSK_KEX2_1 725 727 PF00082 0.353
CLV_PCSK_KEX2_1 754 756 PF00082 0.289
CLV_PCSK_KEX2_1 819 821 PF00082 0.332
CLV_PCSK_PC1ET2_1 127 129 PF00082 0.389
CLV_PCSK_PC1ET2_1 4 6 PF00082 0.567
CLV_PCSK_PC1ET2_1 642 644 PF00082 0.269
CLV_PCSK_PC1ET2_1 754 756 PF00082 0.289
CLV_PCSK_PC7_1 638 644 PF00082 0.281
CLV_PCSK_SKI1_1 194 198 PF00082 0.331
CLV_PCSK_SKI1_1 243 247 PF00082 0.264
CLV_PCSK_SKI1_1 283 287 PF00082 0.386
CLV_PCSK_SKI1_1 355 359 PF00082 0.432
CLV_PCSK_SKI1_1 360 364 PF00082 0.410
CLV_PCSK_SKI1_1 39 43 PF00082 0.505
CLV_PCSK_SKI1_1 400 404 PF00082 0.318
CLV_PCSK_SKI1_1 451 455 PF00082 0.232
CLV_PCSK_SKI1_1 476 480 PF00082 0.287
CLV_PCSK_SKI1_1 490 494 PF00082 0.180
CLV_PCSK_SKI1_1 603 607 PF00082 0.331
CLV_PCSK_SKI1_1 643 647 PF00082 0.301
CLV_PCSK_SKI1_1 664 668 PF00082 0.257
CLV_PCSK_SKI1_1 755 759 PF00082 0.431
CLV_PCSK_SKI1_1 826 830 PF00082 0.276
CLV_Separin_Metazoa 526 530 PF03568 0.474
DEG_APCC_DBOX_1 160 168 PF00400 0.595
DEG_APCC_DBOX_1 485 493 PF00400 0.425
DEG_SPOP_SBC_1 321 325 PF00917 0.643
DEG_SPOP_SBC_1 341 345 PF00917 0.561
DEG_SPOP_SBC_1 370 374 PF00917 0.639
DOC_CKS1_1 463 468 PF01111 0.467
DOC_CYCLIN_yCln2_LP_2 132 138 PF00134 0.657
DOC_CYCLIN_yCln2_LP_2 463 469 PF00134 0.477
DOC_MAPK_gen_1 253 260 PF00069 0.427
DOC_MAPK_gen_1 502 510 PF00069 0.427
DOC_MAPK_gen_1 642 648 PF00069 0.573
DOC_MAPK_MEF2A_6 161 169 PF00069 0.512
DOC_MAPK_MEF2A_6 301 310 PF00069 0.643
DOC_MAPK_MEF2A_6 486 493 PF00069 0.405
DOC_MAPK_MEF2A_6 597 604 PF00069 0.521
DOC_PP1_RVXF_1 260 266 PF00149 0.521
DOC_PP2B_LxvP_1 407 410 PF13499 0.394
DOC_PP2B_LxvP_1 456 459 PF13499 0.483
DOC_PP2B_LxvP_1 528 531 PF13499 0.580
DOC_PP4_FxxP_1 382 385 PF00568 0.721
DOC_PP4_FxxP_1 633 636 PF00568 0.482
DOC_USP7_MATH_1 202 206 PF00917 0.525
DOC_USP7_MATH_1 212 216 PF00917 0.547
DOC_USP7_MATH_1 322 326 PF00917 0.741
DOC_USP7_MATH_1 340 344 PF00917 0.774
DOC_USP7_MATH_1 353 357 PF00917 0.699
DOC_USP7_MATH_1 362 366 PF00917 0.767
DOC_USP7_MATH_1 369 373 PF00917 0.682
DOC_USP7_MATH_1 410 414 PF00917 0.539
DOC_USP7_MATH_1 503 507 PF00917 0.441
DOC_USP7_MATH_1 540 544 PF00917 0.544
DOC_USP7_MATH_1 724 728 PF00917 0.622
DOC_USP7_UBL2_3 148 152 PF12436 0.662
DOC_WW_Pin1_4 156 161 PF00397 0.652
DOC_WW_Pin1_4 360 365 PF00397 0.791
DOC_WW_Pin1_4 405 410 PF00397 0.490
DOC_WW_Pin1_4 441 446 PF00397 0.389
DOC_WW_Pin1_4 462 467 PF00397 0.448
DOC_WW_Pin1_4 58 63 PF00397 0.766
LIG_14-3-3_CanoR_1 194 202 PF00244 0.427
LIG_14-3-3_CanoR_1 243 252 PF00244 0.512
LIG_14-3-3_CanoR_1 502 511 PF00244 0.451
LIG_14-3-3_CanoR_1 591 598 PF00244 0.526
LIG_14-3-3_CanoR_1 629 634 PF00244 0.530
LIG_14-3-3_CanoR_1 687 694 PF00244 0.473
LIG_14-3-3_CanoR_1 725 735 PF00244 0.530
LIG_14-3-3_CanoR_1 755 761 PF00244 0.458
LIG_Actin_WH2_2 475 492 PF00022 0.534
LIG_Actin_WH2_2 814 831 PF00022 0.519
LIG_APCC_ABBA_1 183 188 PF00400 0.458
LIG_BIR_II_1 1 5 PF00653 0.492
LIG_BRCT_BRCA1_1 378 382 PF00533 0.656
LIG_CtBP_PxDLS_1 445 449 PF00389 0.521
LIG_eIF4E_1 662 668 PF01652 0.448
LIG_EVH1_1 380 384 PF00568 0.692
LIG_FHA_1 16 22 PF00498 0.309
LIG_FHA_1 196 202 PF00498 0.515
LIG_FHA_1 246 252 PF00498 0.470
LIG_FHA_1 322 328 PF00498 0.626
LIG_FHA_1 342 348 PF00498 0.562
LIG_FHA_1 505 511 PF00498 0.565
LIG_FHA_1 514 520 PF00498 0.496
LIG_FHA_1 604 610 PF00498 0.523
LIG_FHA_1 630 636 PF00498 0.508
LIG_FHA_1 677 683 PF00498 0.517
LIG_FHA_1 756 762 PF00498 0.479
LIG_FHA_2 151 157 PF00498 0.763
LIG_FHA_2 170 176 PF00498 0.414
LIG_FHA_2 216 222 PF00498 0.340
LIG_FHA_2 463 469 PF00498 0.472
LIG_FHA_2 552 558 PF00498 0.427
LIG_FHA_2 594 600 PF00498 0.445
LIG_FHA_2 739 745 PF00498 0.505
LIG_FHA_2 98 104 PF00498 0.482
LIG_GBD_Chelix_1 601 609 PF00786 0.321
LIG_HCF-1_HBM_1 824 827 PF13415 0.571
LIG_LIR_Apic_2 379 385 PF02991 0.688
LIG_LIR_Apic_2 631 636 PF02991 0.492
LIG_LIR_Gen_1 114 124 PF02991 0.561
LIG_LIR_Gen_1 179 189 PF02991 0.484
LIG_LIR_Gen_1 522 532 PF02991 0.482
LIG_LIR_Gen_1 622 633 PF02991 0.476
LIG_LIR_Gen_1 766 776 PF02991 0.570
LIG_LIR_Nem_3 179 185 PF02991 0.481
LIG_LIR_Nem_3 220 226 PF02991 0.435
LIG_LIR_Nem_3 235 241 PF02991 0.446
LIG_LIR_Nem_3 307 313 PF02991 0.608
LIG_LIR_Nem_3 522 527 PF02991 0.477
LIG_LIR_Nem_3 622 628 PF02991 0.559
LIG_LIR_Nem_3 729 735 PF02991 0.500
LIG_LIR_Nem_3 766 772 PF02991 0.509
LIG_NRBOX 798 804 PF00104 0.499
LIG_Pex14_2 182 186 PF04695 0.458
LIG_PTB_Apo_2 222 229 PF02174 0.500
LIG_PTB_Phospho_1 222 228 PF10480 0.500
LIG_SH2_GRB2like 124 127 PF00017 0.584
LIG_SH2_NCK_1 585 589 PF00017 0.443
LIG_SH2_PTP2 166 169 PF00017 0.521
LIG_SH2_PTP2 496 499 PF00017 0.483
LIG_SH2_PTP2 6 9 PF00017 0.421
LIG_SH2_PTP2 627 630 PF00017 0.577
LIG_SH2_SRC 122 125 PF00017 0.570
LIG_SH2_STAP1 40 44 PF00017 0.571
LIG_SH2_STAT3 270 273 PF00017 0.378
LIG_SH2_STAT3 40 43 PF00017 0.673
LIG_SH2_STAT5 122 125 PF00017 0.598
LIG_SH2_STAT5 166 169 PF00017 0.514
LIG_SH2_STAT5 241 244 PF00017 0.451
LIG_SH2_STAT5 496 499 PF00017 0.441
LIG_SH2_STAT5 514 517 PF00017 0.437
LIG_SH2_STAT5 558 561 PF00017 0.450
LIG_SH2_STAT5 6 9 PF00017 0.446
LIG_SH2_STAT5 613 616 PF00017 0.482
LIG_SH2_STAT5 627 630 PF00017 0.496
LIG_SH2_STAT5 692 695 PF00017 0.495
LIG_SH2_STAT5 756 759 PF00017 0.504
LIG_SH2_STAT5 827 830 PF00017 0.502
LIG_SH3_3 157 163 PF00018 0.736
LIG_SH3_3 300 306 PF00018 0.568
LIG_SH3_3 378 384 PF00018 0.662
LIG_SH3_3 439 445 PF00018 0.462
LIG_SH3_4 305 312 PF00018 0.641
LIG_SUMO_SIM_anti_2 18 25 PF11976 0.267
LIG_SUMO_SIM_anti_2 596 602 PF11976 0.491
LIG_SUMO_SIM_par_1 284 290 PF11976 0.492
LIG_SUMO_SIM_par_1 385 390 PF11976 0.683
LIG_SUMO_SIM_par_1 464 471 PF11976 0.417
LIG_TRAF2_1 153 156 PF00917 0.627
LIG_TRAF2_1 217 220 PF00917 0.543
LIG_TRAF2_1 287 290 PF00917 0.561
LIG_TYR_ITIM 164 169 PF00017 0.511
LIG_TYR_ITIM 767 772 PF00017 0.466
LIG_UBA3_1 132 137 PF00899 0.609
LIG_UBA3_1 285 291 PF00899 0.501
LIG_UBA3_1 527 534 PF00899 0.399
LIG_WRC_WIRS_1 630 635 PF05994 0.565
LIG_WW_3 408 412 PF00397 0.394
MOD_CDC14_SPxK_1 408 411 PF00782 0.498
MOD_CDK_SPK_2 156 161 PF00069 0.583
MOD_CDK_SPxK_1 405 411 PF00069 0.498
MOD_CK1_1 140 146 PF00069 0.738
MOD_CK1_1 150 156 PF00069 0.726
MOD_CK1_1 206 212 PF00069 0.576
MOD_CK1_1 215 221 PF00069 0.517
MOD_CK1_1 343 349 PF00069 0.741
MOD_CK1_1 413 419 PF00069 0.491
MOD_CK1_1 586 592 PF00069 0.441
MOD_CK1_1 593 599 PF00069 0.440
MOD_CK1_1 61 67 PF00069 0.694
MOD_CK1_1 738 744 PF00069 0.551
MOD_CK2_1 141 147 PF00069 0.728
MOD_CK2_1 150 156 PF00069 0.763
MOD_CK2_1 169 175 PF00069 0.422
MOD_CK2_1 213 219 PF00069 0.405
MOD_CK2_1 441 447 PF00069 0.494
MOD_CK2_1 462 468 PF00069 0.495
MOD_CK2_1 593 599 PF00069 0.441
MOD_GlcNHglycan 144 147 PF01048 0.492
MOD_GlcNHglycan 18 21 PF01048 0.261
MOD_GlcNHglycan 190 193 PF01048 0.268
MOD_GlcNHglycan 205 208 PF01048 0.213
MOD_GlcNHglycan 215 218 PF01048 0.283
MOD_GlcNHglycan 243 246 PF01048 0.227
MOD_GlcNHglycan 373 376 PF01048 0.529
MOD_GlcNHglycan 58 61 PF01048 0.529
MOD_GlcNHglycan 63 66 PF01048 0.547
MOD_GlcNHglycan 784 787 PF01048 0.286
MOD_GlcNHglycan 86 89 PF01048 0.298
MOD_GSK3_1 137 144 PF00069 0.714
MOD_GSK3_1 202 209 PF00069 0.567
MOD_GSK3_1 241 248 PF00069 0.490
MOD_GSK3_1 312 319 PF00069 0.652
MOD_GSK3_1 336 343 PF00069 0.762
MOD_GSK3_1 358 365 PF00069 0.650
MOD_GSK3_1 410 417 PF00069 0.473
MOD_GSK3_1 586 593 PF00069 0.429
MOD_GSK3_1 61 68 PF00069 0.683
MOD_GSK3_1 724 731 PF00069 0.659
MOD_GSK3_1 735 742 PF00069 0.546
MOD_GSK3_1 782 789 PF00069 0.483
MOD_N-GLC_1 141 146 PF02516 0.387
MOD_N-GLC_1 353 358 PF02516 0.426
MOD_NEK2_1 15 20 PF00069 0.287
MOD_NEK2_1 233 238 PF00069 0.435
MOD_NEK2_1 294 299 PF00069 0.652
MOD_NEK2_1 312 317 PF00069 0.676
MOD_NEK2_1 358 363 PF00069 0.654
MOD_NEK2_1 609 614 PF00069 0.534
MOD_NEK2_1 771 776 PF00069 0.517
MOD_NEK2_1 97 102 PF00069 0.554
MOD_PIKK_1 402 408 PF00454 0.499
MOD_PIKK_1 577 583 PF00454 0.427
MOD_PK_1 454 460 PF00069 0.427
MOD_PK_1 583 589 PF00069 0.444
MOD_PKA_1 194 200 PF00069 0.427
MOD_PKA_1 504 510 PF00069 0.491
MOD_PKA_1 687 693 PF00069 0.498
MOD_PKA_2 150 156 PF00069 0.607
MOD_PKA_2 194 200 PF00069 0.427
MOD_PKA_2 410 416 PF00069 0.472
MOD_PKA_2 590 596 PF00069 0.521
MOD_PKA_2 628 634 PF00069 0.500
MOD_PKA_2 687 693 PF00069 0.483
MOD_PKA_2 724 730 PF00069 0.544
MOD_PKB_1 398 406 PF00069 0.503
MOD_Plk_1 234 240 PF00069 0.433
MOD_Plk_1 353 359 PF00069 0.627
MOD_Plk_1 786 792 PF00069 0.499
MOD_Plk_4 247 253 PF00069 0.483
MOD_Plk_4 389 395 PF00069 0.573
MOD_Plk_4 414 420 PF00069 0.457
MOD_Plk_4 609 615 PF00069 0.502
MOD_Plk_4 676 682 PF00069 0.552
MOD_Plk_4 735 741 PF00069 0.473
MOD_Plk_4 756 762 PF00069 0.613
MOD_Plk_4 786 792 PF00069 0.526
MOD_ProDKin_1 156 162 PF00069 0.644
MOD_ProDKin_1 360 366 PF00069 0.791
MOD_ProDKin_1 405 411 PF00069 0.490
MOD_ProDKin_1 441 447 PF00069 0.389
MOD_ProDKin_1 462 468 PF00069 0.448
MOD_ProDKin_1 58 64 PF00069 0.765
MOD_SUMO_for_1 304 307 PF00179 0.621
TRG_DiLeu_BaEn_4 289 295 PF01217 0.529
TRG_ENDOCYTIC_2 166 169 PF00928 0.481
TRG_ENDOCYTIC_2 227 230 PF00928 0.442
TRG_ENDOCYTIC_2 496 499 PF00928 0.441
TRG_ENDOCYTIC_2 584 587 PF00928 0.470
TRG_ENDOCYTIC_2 6 9 PF00928 0.434
TRG_ENDOCYTIC_2 627 630 PF00928 0.577
TRG_ENDOCYTIC_2 769 772 PF00928 0.562
TRG_ER_diArg_1 193 195 PF00400 0.521
TRG_ER_diArg_1 398 401 PF00400 0.503
TRG_ER_diArg_1 818 820 PF00400 0.533
TRG_NLS_MonoExtN_4 548 554 PF00514 0.521
TRG_Pf-PMV_PEXEL_1 603 607 PF00026 0.241
TRG_Pf-PMV_PEXEL_1 826 830 PF00026 0.299

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P7X2 Leptomonas seymouri 30% 100%
A0A0N1IBR8 Leptomonas seymouri 67% 100%
A0A1X0P5U2 Trypanosomatidae 42% 100%
A0A2U1KZS6 Artemisia annua 25% 100%
A0A3R7K908 Trypanosoma rangeli 43% 100%
A0A3S7X1H9 Leishmania donovani 30% 100%
A0A422N1R6 Trypanosoma rangeli 29% 100%
A2AI05 Mus musculus 23% 100%
A4HGH1 Leishmania braziliensis 29% 100%
A4HMS7 Leishmania braziliensis 85% 100%
A4I3K3 Leishmania infantum 30% 100%
A4IBG5 Leishmania infantum 100% 100%
C9ZZA0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 40% 100%
D0A835 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 100%
E9AF79 Leishmania major 96% 100%
E9AZU3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 86%
E9B6D5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
O62699 Canis lupus familiaris 24% 72%
P04175 Sus scrofa 24% 100%
P35228 Homo sapiens 23% 72%
P37116 Vigna radiata var. radiata 23% 100%
Q05001 Catharanthus roseus 26% 100%
Q0J705 Oryza sativa subsp. japonica 25% 100%
Q17574 Caenorhabditis elegans 21% 100%
Q1JPJ0 Bos taurus 24% 100%
Q27995 Bos taurus 23% 72%
Q3SYT8 Bos taurus 23% 100%
Q4JIJ2 Bos taurus 25% 100%
Q4Q8E2 Leishmania major 38% 100%
Q6NRG5 Xenopus laevis 22% 100%
Q6PFP6 Danio rerio 23% 100%
Q7X7K8 Oryza sativa subsp. japonica 25% 100%
Q90703 Gallus gallus 22% 73%
Q9SB48 Arabidopsis thaliana 22% 100%
Q9UBK8 Homo sapiens 23% 100%
Q9UHB4 Homo sapiens 24% 100%
Q9US28 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 21% 100%
V5DK85 Trypanosoma cruzi 40% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS