MRB1-associated protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

guide RNA associated protein 1, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8II17_LEIDO

TriTrypDb:

LdBPK_332870.1 , LdCL_330035800 , LDHU3_33.4020

Length:

502

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 22
NetGPI	no	yes: 0, no: 22

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	3
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2

Expansion

Sequence features

A0A3Q8II17

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8II17

Function

Biological processes
Term	Name	Level	Count
GO:0000959	mitochondrial RNA metabolic process	6	2
GO:0000963	mitochondrial RNA processing	6	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006396	RNA processing	6	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009451	RNA modification	5	1
GO:0009987	cellular process	1	2
GO:0010467	gene expression	4	2
GO:0016070	RNA metabolic process	5	2
GO:0016071	mRNA metabolic process	6	1
GO:0016556	mRNA modification	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:0140053	mitochondrial gene expression	5	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0003729	mRNA binding	5	2
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	329	333	PF00656	0.505
CLV_C14_Caspase3-7	390	394	PF00656	0.471
CLV_NRD_NRD_1	160	162	PF00675	0.595
CLV_NRD_NRD_1	17	19	PF00675	0.715
CLV_NRD_NRD_1	232	234	PF00675	0.467
CLV_NRD_NRD_1	325	327	PF00675	0.437
CLV_NRD_NRD_1	414	416	PF00675	0.330
CLV_NRD_NRD_1	433	435	PF00675	0.489
CLV_PCSK_KEX2_1	160	162	PF00082	0.580
CLV_PCSK_KEX2_1	17	19	PF00082	0.708
CLV_PCSK_KEX2_1	232	234	PF00082	0.467
CLV_PCSK_KEX2_1	325	327	PF00082	0.448
CLV_PCSK_KEX2_1	376	378	PF00082	0.358
CLV_PCSK_KEX2_1	433	435	PF00082	0.390
CLV_PCSK_PC1ET2_1	376	378	PF00082	0.406
CLV_PCSK_SKI1_1	257	261	PF00082	0.453
DOC_MAPK_gen_1	160	168	PF00069	0.559
DOC_MAPK_gen_1	266	274	PF00069	0.455
DOC_MAPK_gen_1	433	439	PF00069	0.401
DOC_MAPK_MEF2A_6	358	366	PF00069	0.358
DOC_MAPK_MEF2A_6	420	429	PF00069	0.402
DOC_PP1_RVXF_1	231	238	PF00149	0.407
DOC_PP1_RVXF_1	255	261	PF00149	0.472
DOC_SPAK_OSR1_1	350	354	PF12202	0.375
DOC_SPAK_OSR1_1	365	369	PF12202	0.351
DOC_USP7_MATH_1	100	104	PF00917	0.399
DOC_USP7_MATH_1	207	211	PF00917	0.511
DOC_USP7_MATH_1	291	295	PF00917	0.372
DOC_USP7_MATH_1	316	320	PF00917	0.398
DOC_USP7_MATH_1	498	502	PF00917	0.664
DOC_USP7_MATH_1	88	92	PF00917	0.594
DOC_WW_Pin1_4	23	28	PF00397	0.630
DOC_WW_Pin1_4	397	402	PF00397	0.406
DOC_WW_Pin1_4	432	437	PF00397	0.389
DOC_WW_Pin1_4	44	49	PF00397	0.578
LIG_14-3-3_CanoR_1	11	15	PF00244	0.694
LIG_14-3-3_CanoR_1	17	23	PF00244	0.671
LIG_14-3-3_CanoR_1	269	273	PF00244	0.437
LIG_14-3-3_CanoR_1	325	331	PF00244	0.557
LIG_14-3-3_CanoR_1	41	48	PF00244	0.662
LIG_Actin_WH2_2	159	174	PF00022	0.534
LIG_Actin_WH2_2	376	391	PF00022	0.510
LIG_BIR_II_1	1	5	PF00653	0.556
LIG_BRCT_BRCA1_1	90	94	PF00533	0.481
LIG_deltaCOP1_diTrp_1	150	157	PF00928	0.592
LIG_deltaCOP1_diTrp_1	236	243	PF00928	0.384
LIG_deltaCOP1_diTrp_1	58	64	PF00928	0.453
LIG_FHA_1	269	275	PF00498	0.575
LIG_FHA_1	31	37	PF00498	0.712
LIG_FHA_1	352	358	PF00498	0.481
LIG_FHA_1	383	389	PF00498	0.353
LIG_FHA_1	424	430	PF00498	0.355
LIG_FHA_1	433	439	PF00498	0.384
LIG_FHA_1	54	60	PF00498	0.577
LIG_FHA_1	72	78	PF00498	0.549
LIG_FHA_1	91	97	PF00498	0.605
LIG_FHA_2	131	137	PF00498	0.610
LIG_FHA_2	139	145	PF00498	0.622
LIG_FHA_2	197	203	PF00498	0.461
LIG_GBD_Chelix_1	304	312	PF00786	0.422
LIG_LIR_Gen_1	164	173	PF02991	0.542
LIG_LIR_Gen_1	450	461	PF02991	0.344
LIG_LIR_Gen_1	51	60	PF02991	0.427
LIG_LIR_Nem_3	164	168	PF02991	0.556
LIG_LIR_Nem_3	175	180	PF02991	0.497
LIG_LIR_Nem_3	450	456	PF02991	0.348
LIG_LIR_Nem_3	475	479	PF02991	0.463
LIG_LIR_Nem_3	51	55	PF02991	0.443
LIG_SH2_CRK	185	189	PF00017	0.418
LIG_SH2_CRK	261	265	PF00017	0.467
LIG_SH2_CRK	476	480	PF00017	0.462
LIG_SH2_SRC	282	285	PF00017	0.420
LIG_SH2_STAP1	451	455	PF00017	0.296
LIG_SH2_STAT3	79	82	PF00017	0.399
LIG_SH2_STAT5	216	219	PF00017	0.476
LIG_SH2_STAT5	287	290	PF00017	0.459
LIG_SH2_STAT5	356	359	PF00017	0.356
LIG_SH2_STAT5	382	385	PF00017	0.523
LIG_SH2_STAT5	408	411	PF00017	0.342
LIG_SH2_STAT5	80	83	PF00017	0.398
LIG_SH3_1	176	182	PF00018	0.467
LIG_SH3_3	176	182	PF00018	0.467
LIG_SH3_3	21	27	PF00018	0.709
LIG_SH3_3	395	401	PF00018	0.437
LIG_SH3_3	452	458	PF00018	0.347
LIG_SH3_3	92	98	PF00018	0.494
LIG_SUMO_SIM_anti_2	452	458	PF11976	0.477
LIG_SUMO_SIM_par_1	435	440	PF11976	0.424
LIG_TYR_ITIM	259	264	PF00017	0.442
LIG_TYR_ITIM	449	454	PF00017	0.358
MOD_CDK_SPxK_1	44	50	PF00069	0.451
MOD_CK1_1	190	196	PF00069	0.448
MOD_CK1_1	28	34	PF00069	0.650
MOD_CK1_1	394	400	PF00069	0.404
MOD_CK1_1	44	50	PF00069	0.502
MOD_CK1_1	53	59	PF00069	0.484
MOD_CK1_1	71	77	PF00069	0.381
MOD_CK2_1	138	144	PF00069	0.694
MOD_CK2_1	293	299	PF00069	0.399
MOD_CK2_1	70	76	PF00069	0.406
MOD_CMANNOS	61	64	PF00535	0.397
MOD_DYRK1A_RPxSP_1	23	27	PF00069	0.500
MOD_GlcNHglycan	1	4	PF01048	0.749
MOD_GlcNHglycan	113	116	PF01048	0.511
MOD_GlcNHglycan	191	195	PF01048	0.550
MOD_GlcNHglycan	293	296	PF01048	0.488
MOD_GlcNHglycan	30	33	PF01048	0.678
MOD_GlcNHglycan	44	47	PF01048	0.648
MOD_GlcNHglycan	469	472	PF01048	0.398
MOD_GSK3_1	126	133	PF00069	0.732
MOD_GSK3_1	28	35	PF00069	0.701
MOD_GSK3_1	316	323	PF00069	0.330
MOD_GSK3_1	387	394	PF00069	0.414
MOD_GSK3_1	490	497	PF00069	0.566
MOD_GSK3_1	71	78	PF00069	0.504
MOD_LATS_1	16	22	PF00433	0.542
MOD_NEK2_1	242	247	PF00069	0.417
MOD_NEK2_1	260	265	PF00069	0.563
MOD_NEK2_1	339	344	PF00069	0.389
MOD_NEK2_1	351	356	PF00069	0.337
MOD_NEK2_1	36	41	PF00069	0.744
MOD_NEK2_1	429	434	PF00069	0.360
MOD_NEK2_1	437	442	PF00069	0.466
MOD_NEK2_1	492	497	PF00069	0.519
MOD_NEK2_1	70	75	PF00069	0.362
MOD_NEK2_2	320	325	PF00069	0.307
MOD_PIKK_1	356	362	PF00454	0.344
MOD_PIKK_1	418	424	PF00454	0.508
MOD_PKA_1	101	107	PF00069	0.573
MOD_PKA_1	17	23	PF00069	0.697
MOD_PKA_1	325	331	PF00069	0.535
MOD_PKA_2	10	16	PF00069	0.768
MOD_PKA_2	17	23	PF00069	0.783
MOD_PKA_2	268	274	PF00069	0.580
MOD_PKA_2	324	330	PF00069	0.544
MOD_PKA_2	388	394	PF00069	0.484
MOD_Plk_1	138	144	PF00069	0.690
MOD_Plk_1	50	56	PF00069	0.476
MOD_Plk_1	75	81	PF00069	0.518
MOD_Plk_4	101	107	PF00069	0.445
MOD_Plk_4	32	38	PF00069	0.647
MOD_Plk_4	394	400	PF00069	0.404
MOD_Plk_4	75	81	PF00069	0.462
MOD_Plk_4	90	96	PF00069	0.696
MOD_ProDKin_1	23	29	PF00069	0.630
MOD_ProDKin_1	397	403	PF00069	0.400
MOD_ProDKin_1	432	438	PF00069	0.393
MOD_ProDKin_1	44	50	PF00069	0.569
TRG_DiLeu_BaLyEn_6	433	438	PF01217	0.395
TRG_ENDOCYTIC_2	165	168	PF00928	0.608
TRG_ENDOCYTIC_2	177	180	PF00928	0.397
TRG_ENDOCYTIC_2	185	188	PF00928	0.213
TRG_ENDOCYTIC_2	261	264	PF00928	0.444
TRG_ENDOCYTIC_2	287	290	PF00928	0.398
TRG_ENDOCYTIC_2	451	454	PF00928	0.328
TRG_ENDOCYTIC_2	476	479	PF00928	0.464
TRG_ER_diArg_1	231	233	PF00400	0.376
TRG_ER_diArg_1	324	326	PF00400	0.414
TRG_ER_diArg_1	368	371	PF00400	0.362
TRG_NES_CRM1_1	186	202	PF08389	0.478
TRG_NES_CRM1_1	299	314	PF08389	0.518
TRG_NLS_MonoExtC_3	374	380	PF00514	0.391
TRG_NLS_MonoExtN_4	373	379	PF00514	0.437

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK37	Leptomonas seymouri	29%	100%
A0A0N1IKX3	Leptomonas seymouri	77%	92%
A0A0S4IN88	Bodo saltans	29%	94%
A0A0S4JQR1	Bodo saltans	55%	93%
A0A1X0NRA1	Trypanosomatidae	70%	98%
A0A1X0NTQ0	Trypanosomatidae	29%	100%
A0A3S7WX47	Leishmania donovani	28%	100%
A0A422NDT8	Trypanosoma rangeli	29%	100%
A0A422NKD3	Trypanosoma rangeli	68%	100%
A4HCA9	Leishmania braziliensis	27%	100%
A4HLY4	Leishmania braziliensis	87%	100%
A4HZU2	Leishmania infantum	28%	100%
A4I9B3	Leishmania infantum	100%	100%
C9ZJB1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	100%
C9ZRN1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AVP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9B4B3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q3R2	Leishmania major	95%	100%
Q4QBT2	Leishmania major	28%	100%
V5BAI0	Trypanosoma cruzi	67%	100%
V5BVS4	Trypanosoma cruzi	29%	100%