Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8II15_LEIDO

TriTrypDb:

LdBPK_341310.1 , LdCL_340019100 , LDHU3_34.2050

Length:

475

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8II15

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8II15

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	426	430	PF00656	0.655
CLV_MEL_PAP_1	61	67	PF00089	0.554
CLV_NRD_NRD_1	102	104	PF00675	0.413
CLV_NRD_NRD_1	292	294	PF00675	0.530
CLV_NRD_NRD_1	325	327	PF00675	0.589
CLV_NRD_NRD_1	460	462	PF00675	0.605
CLV_NRD_NRD_1	88	90	PF00675	0.510
CLV_PCSK_FUR_1	169	173	PF00082	0.447
CLV_PCSK_KEX2_1	171	173	PF00082	0.495
CLV_PCSK_KEX2_1	213	215	PF00082	0.537
CLV_PCSK_KEX2_1	292	294	PF00082	0.530
CLV_PCSK_KEX2_1	325	327	PF00082	0.572
CLV_PCSK_KEX2_1	342	344	PF00082	0.602
CLV_PCSK_KEX2_1	387	389	PF00082	0.567
CLV_PCSK_KEX2_1	460	462	PF00082	0.605
CLV_PCSK_KEX2_1	87	89	PF00082	0.497
CLV_PCSK_PC1ET2_1	171	173	PF00082	0.437
CLV_PCSK_PC1ET2_1	213	215	PF00082	0.537
CLV_PCSK_PC1ET2_1	342	344	PF00082	0.576
CLV_PCSK_PC1ET2_1	387	389	PF00082	0.534
CLV_PCSK_PC7_1	383	389	PF00082	0.632
CLV_PCSK_SKI1_1	103	107	PF00082	0.534
CLV_PCSK_SKI1_1	147	151	PF00082	0.434
CLV_PCSK_SKI1_1	296	300	PF00082	0.550
CLV_PCSK_SKI1_1	339	343	PF00082	0.688
CLV_PCSK_SKI1_1	406	410	PF00082	0.678
CLV_PCSK_SKI1_1	5	9	PF00082	0.673
DEG_SPOP_SBC_1	302	306	PF00917	0.698
DOC_CYCLIN_yClb5_NLxxxL_5	219	226	PF00134	0.556
DOC_MAPK_gen_1	292	299	PF00069	0.539
DOC_MAPK_HePTP_8	322	338	PF00069	0.670
DOC_MAPK_HePTP_8	61	73	PF00069	0.542
DOC_MAPK_MEF2A_6	41	48	PF00069	0.485
DOC_MAPK_MEF2A_6	64	73	PF00069	0.548
DOC_PP2B_LxvP_1	240	243	PF13499	0.639
DOC_PP2B_LxvP_1	40	43	PF13499	0.458
DOC_PP2B_PxIxI_1	16	22	PF00149	0.606
DOC_USP7_MATH_1	249	253	PF00917	0.679
DOC_USP7_MATH_1	261	265	PF00917	0.750
DOC_USP7_MATH_1	274	278	PF00917	0.675
DOC_USP7_MATH_1	315	319	PF00917	0.592
DOC_USP7_MATH_1	411	415	PF00917	0.658
DOC_WW_Pin1_4	245	250	PF00397	0.644
DOC_WW_Pin1_4	311	316	PF00397	0.606
DOC_WW_Pin1_4	429	434	PF00397	0.820
DOC_WW_Pin1_4	442	447	PF00397	0.702
LIG_14-3-3_CanoR_1	130	138	PF00244	0.544
LIG_14-3-3_CanoR_1	169	175	PF00244	0.594
LIG_14-3-3_CanoR_1	235	241	PF00244	0.605
LIG_14-3-3_CanoR_1	64	68	PF00244	0.597
LIG_BIR_II_1	1	5	PF00653	0.546
LIG_eIF4E_1	402	408	PF01652	0.659
LIG_FHA_1	16	22	PF00498	0.760
LIG_FHA_1	345	351	PF00498	0.676
LIG_FHA_1	419	425	PF00498	0.659
LIG_FHA_1	447	453	PF00498	0.707
LIG_FHA_1	56	62	PF00498	0.508
LIG_FHA_2	202	208	PF00498	0.596
LIG_FHA_2	265	271	PF00498	0.631
LIG_FHA_2	369	375	PF00498	0.596
LIG_FHA_2	424	430	PF00498	0.673
LIG_LIR_Nem_3	329	334	PF02991	0.632
LIG_SH2_GRB2like	402	405	PF00017	0.495
LIG_SH2_SRC	137	140	PF00017	0.396
LIG_SH2_SRC	402	405	PF00017	0.495
LIG_SH2_STAP1	120	124	PF00017	0.500
LIG_SH2_STAP1	139	143	PF00017	0.650
LIG_SH2_STAT5	137	140	PF00017	0.453
LIG_SH3_3	26	32	PF00018	0.639
LIG_SH3_3	414	420	PF00018	0.712
LIG_SUMO_SIM_anti_2	277	283	PF11976	0.497
LIG_SUMO_SIM_anti_2	333	338	PF11976	0.600
LIG_SUMO_SIM_par_1	17	22	PF11976	0.655
LIG_SUMO_SIM_par_1	277	283	PF11976	0.608
LIG_SxIP_EBH_1	23	33	PF03271	0.540
LIG_TRAF2_1	208	211	PF00917	0.527
LIG_TRAF2_1	98	101	PF00917	0.596
LIG_WW_3	27	31	PF00397	0.592
MOD_CDK_SPK_2	245	250	PF00069	0.495
MOD_CDK_SPK_2	442	447	PF00069	0.700
MOD_CK1_1	12	18	PF00069	0.762
MOD_CK1_1	184	190	PF00069	0.632
MOD_CK1_1	248	254	PF00069	0.662
MOD_CK1_1	264	270	PF00069	0.651
MOD_CK1_1	304	310	PF00069	0.678
MOD_CK2_1	201	207	PF00069	0.600
MOD_CK2_1	264	270	PF00069	0.731
MOD_CK2_1	311	317	PF00069	0.686
MOD_CK2_1	368	374	PF00069	0.597
MOD_GlcNHglycan	11	14	PF01048	0.758
MOD_GlcNHglycan	131	134	PF01048	0.559
MOD_GlcNHglycan	183	186	PF01048	0.527
MOD_GlcNHglycan	194	197	PF01048	0.524
MOD_GlcNHglycan	256	259	PF01048	0.681
MOD_GlcNHglycan	270	273	PF01048	0.659
MOD_GlcNHglycan	282	285	PF01048	0.537
MOD_GlcNHglycan	306	309	PF01048	0.691
MOD_GlcNHglycan	94	97	PF01048	0.481
MOD_GSK3_1	11	18	PF00069	0.745
MOD_GSK3_1	244	251	PF00069	0.723
MOD_GSK3_1	264	271	PF00069	0.725
MOD_GSK3_1	302	309	PF00069	0.693
MOD_GSK3_1	311	318	PF00069	0.714
MOD_GSK3_1	425	432	PF00069	0.763
MOD_GSK3_1	442	449	PF00069	0.533
MOD_N-GLC_1	268	273	PF02516	0.638
MOD_NEK2_1	280	285	PF00069	0.715
MOD_NEK2_2	63	68	PF00069	0.540
MOD_PIKK_1	190	196	PF00454	0.607
MOD_PKA_2	129	135	PF00069	0.538
MOD_PKA_2	15	21	PF00069	0.670
MOD_PKA_2	354	360	PF00069	0.589
MOD_PKA_2	453	459	PF00069	0.646
MOD_PKA_2	63	69	PF00069	0.542
MOD_Plk_1	145	151	PF00069	0.589
MOD_Plk_1	316	322	PF00069	0.651
MOD_Plk_2-3	374	380	PF00069	0.586
MOD_Plk_4	15	21	PF00069	0.672
MOD_Plk_4	236	242	PF00069	0.617
MOD_Plk_4	275	281	PF00069	0.583
MOD_ProDKin_1	245	251	PF00069	0.646
MOD_ProDKin_1	311	317	PF00069	0.606
MOD_ProDKin_1	429	435	PF00069	0.821
MOD_ProDKin_1	442	448	PF00069	0.700
MOD_SUMO_rev_2	205	215	PF00179	0.528
TRG_ER_diArg_1	292	294	PF00400	0.530
TRG_ER_diArg_1	324	326	PF00400	0.593
TRG_ER_diArg_1	459	461	PF00400	0.593
TRG_ER_diArg_1	87	89	PF00400	0.503

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HY58	Leptomonas seymouri	46%	85%
A0A422MPI6	Trypanosoma rangeli	24%	100%
A4HBJ3	Leishmania braziliensis	65%	100%
A4I9T3	Leishmania infantum	99%	100%
C9ZMU6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9B4U4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q382	Leishmania major	89%	100%