Protein kinase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8II10_LEIDO

TriTrypDb:

LdBPK_352370.1 , LdCL_350028600 , LDHU3_35.3010

Length:

1128

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8II10

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8II10

Function

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Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0007165	signal transduction	2	1
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016310	phosphorylation	5	7
GO:0019538	protein metabolic process	3	7
GO:0035556	intracellular signal transduction	3	1

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0004672	protein kinase activity	3	7
GO:0004674	protein serine/threonine kinase activity	4	2
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0016301	kinase activity	4	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	7

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	19	23	PF00656	0.732
CLV_C14_Caspase3-7	314	318	PF00656	0.513
CLV_C14_Caspase3-7	379	383	PF00656	0.476
CLV_C14_Caspase3-7	42	46	PF00656	0.807
CLV_C14_Caspase3-7	480	484	PF00656	0.450
CLV_C14_Caspase3-7	625	629	PF00656	0.796
CLV_C14_Caspase3-7	847	851	PF00656	0.643
CLV_NRD_NRD_1	1126	1128	PF00675	0.783
CLV_NRD_NRD_1	150	152	PF00675	0.740
CLV_NRD_NRD_1	153	155	PF00675	0.670

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMG5	Leptomonas seymouri	50%	100%
A4HMQ6	Leishmania braziliensis	62%	99%
A4IBC4	Leishmania infantum	99%	100%
E9AF56	Leishmania major	88%	100%
E9B6B2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	99%

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