Serine_incorporator_(Serinc)_putative/Pfam:PF0334 8

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Serine incorporator (Serinc), putative

Species:

Leishmania donovani

UniProt:

A0A3Q8II09_LEIDO

TriTrypDb:

LdBPK_281080.1 , LdCL_280015400 , LDHU3_28.1310

Length:

416

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	13
GO:0110165	cellular anatomical entity	1	13

Expansion

Sequence features

A0A3Q8II09

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8II09

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	179	183	PF00656	0.494
CLV_MEL_PAP_1	83	89	PF00089	0.278
CLV_NRD_NRD_1	12	14	PF00675	0.512
CLV_PCSK_KEX2_1	11	13	PF00082	0.496
CLV_PCSK_SKI1_1	119	123	PF00082	0.251
CLV_PCSK_SKI1_1	125	129	PF00082	0.296
CLV_PCSK_SKI1_1	276	280	PF00082	0.553
DEG_SPOP_SBC_1	281	285	PF00917	0.326
DOC_CDC14_PxL_1	55	63	PF14671	0.328
DOC_MAPK_gen_1	11	19	PF00069	0.732
DOC_MAPK_gen_1	30	39	PF00069	0.388
DOC_MAPK_HePTP_8	27	39	PF00069	0.498
DOC_MAPK_MEF2A_6	125	134	PF00069	0.300
DOC_MAPK_MEF2A_6	30	39	PF00069	0.377
DOC_MAPK_NFAT4_5	32	40	PF00069	0.411
DOC_PP1_RVXF_1	84	90	PF00149	0.265
DOC_PP2B_LxvP_1	395	398	PF13499	0.265
DOC_PP4_FxxP_1	137	140	PF00568	0.300
DOC_USP7_MATH_1	195	199	PF00917	0.378
DOC_USP7_MATH_1	244	248	PF00917	0.441
DOC_USP7_MATH_1	309	313	PF00917	0.471
DOC_USP7_MATH_1	66	70	PF00917	0.319
DOC_WW_Pin1_4	21	26	PF00397	0.528
LIG_14-3-3_CanoR_1	119	129	PF00244	0.507
LIG_14-3-3_CanoR_1	280	289	PF00244	0.317
LIG_14-3-3_CanoR_1	380	385	PF00244	0.313
LIG_14-3-3_CanoR_1	48	58	PF00244	0.365
LIG_14-3-3_CanoR_1	86	90	PF00244	0.265
LIG_Actin_WH2_2	16	34	PF00022	0.621
LIG_APCC_ABBA_1	213	218	PF00400	0.317
LIG_BIR_II_1	1	5	PF00653	0.599
LIG_BRCT_BRCA1_1	251	255	PF00533	0.349
LIG_eIF4E_1	147	153	PF01652	0.313
LIG_eIF4E_1	257	263	PF01652	0.411
LIG_eIF4E_1	36	42	PF01652	0.296
LIG_FHA_1	104	110	PF00498	0.435
LIG_FHA_1	124	130	PF00498	0.369
LIG_FHA_1	134	140	PF00498	0.259
LIG_FHA_1	256	262	PF00498	0.270
LIG_FHA_1	283	289	PF00498	0.254
LIG_FHA_1	292	298	PF00498	0.306
LIG_FHA_1	330	336	PF00498	0.513
LIG_FHA_1	341	347	PF00498	0.300
LIG_FHA_2	267	273	PF00498	0.277
LIG_LIR_Apic_2	136	140	PF02991	0.275
LIG_LIR_Gen_1	145	153	PF02991	0.259
LIG_LIR_Gen_1	155	166	PF02991	0.236
LIG_LIR_Gen_1	209	215	PF02991	0.298
LIG_LIR_Gen_1	283	293	PF02991	0.319
LIG_LIR_Gen_1	298	308	PF02991	0.294
LIG_LIR_Gen_1	336	346	PF02991	0.436
LIG_LIR_Gen_1	349	355	PF02991	0.229
LIG_LIR_Gen_1	382	392	PF02991	0.295
LIG_LIR_LC3C_4	126	131	PF02991	0.397
LIG_LIR_Nem_3	145	150	PF02991	0.269
LIG_LIR_Nem_3	209	213	PF02991	0.285
LIG_LIR_Nem_3	283	289	PF02991	0.306
LIG_LIR_Nem_3	291	296	PF02991	0.325
LIG_LIR_Nem_3	298	303	PF02991	0.251
LIG_LIR_Nem_3	336	341	PF02991	0.445
LIG_LIR_Nem_3	382	388	PF02991	0.269
LIG_LIR_Nem_3	92	97	PF02991	0.376
LIG_PDZ_Class_3	411	416	PF00595	0.647
LIG_PDZ_Wminus1_1	414	416	PF00595	0.658
LIG_Pex14_1	385	389	PF04695	0.397
LIG_Pex14_2	165	169	PF04695	0.310
LIG_Pex14_2	389	393	PF04695	0.366
LIG_PTB_Apo_2	138	145	PF02174	0.265
LIG_PTB_Apo_2	159	166	PF02174	0.294
LIG_REV1ctd_RIR_1	119	129	PF16727	0.433
LIG_SH2_CRK	147	151	PF00017	0.274
LIG_SH2_CRK	286	290	PF00017	0.311
LIG_SH2_CRK	304	308	PF00017	0.151
LIG_SH2_NCK_1	304	308	PF00017	0.258
LIG_SH2_PTP2	149	152	PF00017	0.349
LIG_SH2_SRC	147	150	PF00017	0.281
LIG_SH2_SRC	242	245	PF00017	0.369
LIG_SH2_STAP1	257	261	PF00017	0.294
LIG_SH2_STAP1	304	308	PF00017	0.411
LIG_SH2_STAP1	33	37	PF00017	0.278
LIG_SH2_STAP1	342	346	PF00017	0.338
LIG_SH2_STAT5	149	152	PF00017	0.292
LIG_SH2_STAT5	158	161	PF00017	0.296
LIG_SH2_STAT5	190	193	PF00017	0.277
LIG_SH2_STAT5	236	239	PF00017	0.313
LIG_SH2_STAT5	242	245	PF00017	0.299
LIG_SH2_STAT5	257	260	PF00017	0.193
LIG_SH2_STAT5	342	345	PF00017	0.303
LIG_SH2_STAT5	351	354	PF00017	0.271
LIG_SH2_STAT5	36	39	PF00017	0.278
LIG_SH2_STAT5	391	394	PF00017	0.265
LIG_SH2_STAT5	399	402	PF00017	0.423
LIG_SUMO_SIM_anti_2	126	132	PF11976	0.294
LIG_SUMO_SIM_par_1	192	198	PF11976	0.313
LIG_SUMO_SIM_par_1	98	104	PF11976	0.290
LIG_TYR_ITIM	302	307	PF00017	0.292
LIG_UBA3_1	27	32	PF00899	0.528
LIG_UBA3_1	50	57	PF00899	0.294
LIG_WRC_WIRS_1	134	139	PF05994	0.291
LIG_WRC_WIRS_1	196	201	PF05994	0.394
LIG_WRC_WIRS_1	207	212	PF05994	0.269
MOD_CK1_1	103	109	PF00069	0.433
MOD_CK1_1	120	126	PF00069	0.278
MOD_CK1_1	282	288	PF00069	0.292
MOD_CK1_1	312	318	PF00069	0.514
MOD_CK2_1	266	272	PF00069	0.328
MOD_GlcNHglycan	154	157	PF01048	0.280
MOD_GlcNHglycan	311	314	PF01048	0.259
MOD_GlcNHglycan	361	364	PF01048	0.431
MOD_GSK3_1	167	174	PF00069	0.430
MOD_GSK3_1	214	221	PF00069	0.226
MOD_GSK3_1	244	251	PF00069	0.458
MOD_GSK3_1	262	269	PF00069	0.265
MOD_GSK3_1	276	283	PF00069	0.196
MOD_GSK3_1	284	291	PF00069	0.228
MOD_GSK3_1	298	305	PF00069	0.276
MOD_GSK3_1	329	336	PF00069	0.498
MOD_GSK3_1	355	362	PF00069	0.318
MOD_GSK3_1	85	92	PF00069	0.406
MOD_N-GLC_2	222	224	PF02516	0.528
MOD_NEK2_1	117	122	PF00069	0.470
MOD_NEK2_1	152	157	PF00069	0.287
MOD_NEK2_1	237	242	PF00069	0.355
MOD_NEK2_1	255	260	PF00069	0.146
MOD_NEK2_1	262	267	PF00069	0.265
MOD_NEK2_1	295	300	PF00069	0.305
MOD_NEK2_1	302	307	PF00069	0.250
MOD_NEK2_1	340	345	PF00069	0.284
MOD_NEK2_1	354	359	PF00069	0.224
MOD_NEK2_1	369	374	PF00069	0.233
MOD_NEK2_1	41	46	PF00069	0.303
MOD_NEK2_1	50	55	PF00069	0.242
MOD_NEK2_1	89	94	PF00069	0.372
MOD_NEK2_2	133	138	PF00069	0.420
MOD_NEK2_2	142	147	PF00069	0.314
MOD_PKA_2	266	272	PF00069	0.328
MOD_PKA_2	279	285	PF00069	0.328
MOD_PKA_2	379	385	PF00069	0.369
MOD_PKA_2	85	91	PF00069	0.265
MOD_Plk_1	167	173	PF00069	0.416
MOD_Plk_4	123	129	PF00069	0.276
MOD_Plk_4	133	139	PF00069	0.283
MOD_Plk_4	195	201	PF00069	0.284
MOD_Plk_4	206	212	PF00069	0.296
MOD_Plk_4	237	243	PF00069	0.324
MOD_Plk_4	244	250	PF00069	0.524
MOD_Plk_4	284	290	PF00069	0.248
MOD_Plk_4	302	308	PF00069	0.176
MOD_Plk_4	340	346	PF00069	0.295
MOD_Plk_4	380	386	PF00069	0.278
MOD_Plk_4	50	56	PF00069	0.279
MOD_ProDKin_1	21	27	PF00069	0.528
TRG_DiLeu_BaEn_4	330	336	PF01217	0.506
TRG_ENDOCYTIC_2	147	150	PF00928	0.267
TRG_ENDOCYTIC_2	158	161	PF00928	0.259
TRG_ENDOCYTIC_2	190	193	PF00928	0.250
TRG_ENDOCYTIC_2	236	239	PF00928	0.349
TRG_ENDOCYTIC_2	286	289	PF00928	0.311
TRG_ENDOCYTIC_2	304	307	PF00928	0.151
TRG_ENDOCYTIC_2	338	341	PF00928	0.273
TRG_ENDOCYTIC_2	342	345	PF00928	0.268
TRG_ENDOCYTIC_2	351	354	PF00928	0.245
TRG_ENDOCYTIC_2	36	39	PF00928	0.278
TRG_ER_diArg_1	109	112	PF00400	0.520
TRG_ER_diArg_1	11	13	PF00400	0.717
TRG_ER_FFAT_2	116	126	PF00635	0.434
TRG_Pf-PMV_PEXEL_1	112	116	PF00026	0.255

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HS92	Leptomonas seymouri	75%	100%
A0A0S4JS67	Bodo saltans	40%	90%
A0A0S4KHE1	Bodo saltans	31%	100%
A0A1X0NWP2	Trypanosomatidae	54%	100%
A0A3R7M259	Trypanosoma rangeli	54%	100%
A4FUZ5	Bos taurus	22%	88%
A4HGE3	Leishmania braziliensis	84%	100%
A4I3H6	Leishmania infantum	100%	100%
A7S4N4	Nematostella vectensis	25%	91%
D0A7F8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9AZR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q12116	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	21%	88%
Q13530	Homo sapiens	24%	88%
Q3MHV9	Bos taurus	25%	92%
Q4Q8G8	Leishmania major	93%	100%
Q4R6L9	Macaca fascicularis	23%	98%
Q54UF8	Dictyostelium discoideum	25%	100%
Q58CW5	Bos taurus	23%	92%
Q5R419	Pongo abelii	25%	92%
Q5R533	Pongo abelii	24%	88%
Q63175	Rattus norvegicus	22%	90%
Q7TNK0	Rattus norvegicus	25%	92%
Q803X0	Danio rerio	22%	90%
Q86VE9	Homo sapiens	23%	98%
Q8BHJ6	Mus musculus	22%	90%
Q8K0E7	Mus musculus	23%	92%
Q96SA4	Homo sapiens	24%	91%
Q9HDY3	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	94%
Q9NRX5	Homo sapiens	25%	92%
Q9QZI8	Mus musculus	25%	92%
Q9QZI9	Mus musculus	24%	88%
V5BWF9	Trypanosoma cruzi	53%	100%