Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8II07_LEIDO

TriTrypDb:

LdBPK_341180.1 , LdCL_340017700 , LDHU3_34.1900

Length:

387

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8II07

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8II07

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.545
CLV_C14_Caspase3-7	283	287	PF00656	0.513
CLV_NRD_NRD_1	236	238	PF00675	0.497
CLV_NRD_NRD_1	298	300	PF00675	0.432
CLV_NRD_NRD_1	314	316	PF00675	0.490
CLV_NRD_NRD_1	39	41	PF00675	0.500
CLV_PCSK_KEX2_1	236	238	PF00082	0.497
CLV_PCSK_KEX2_1	298	300	PF00082	0.435
CLV_PCSK_KEX2_1	314	316	PF00082	0.490
CLV_PCSK_KEX2_1	39	41	PF00082	0.500
CLV_PCSK_SKI1_1	314	318	PF00082	0.525
CLV_PCSK_SKI1_1	319	323	PF00082	0.492
CLV_PCSK_SKI1_1	334	338	PF00082	0.416
CLV_PCSK_SKI1_1	366	370	PF00082	0.374
CLV_PCSK_SKI1_1	39	43	PF00082	0.501
DEG_APCC_DBOX_1	298	306	PF00400	0.496
DEG_APCC_DBOX_1	365	373	PF00400	0.441
DEG_APCC_DBOX_1	38	46	PF00400	0.513
DOC_CKS1_1	328	333	PF01111	0.403
DOC_CKS1_1	53	58	PF01111	0.585
DOC_CYCLIN_RxL_1	331	338	PF00134	0.468
DOC_CYCLIN_RxL_1	37	46	PF00134	0.519
DOC_MAPK_gen_1	298	304	PF00069	0.492
DOC_MAPK_gen_1	314	322	PF00069	0.388
DOC_MAPK_gen_1	362	369	PF00069	0.429
DOC_MAPK_gen_1	39	45	PF00069	0.501
DOC_MAPK_HePTP_8	316	328	PF00069	0.487
DOC_MAPK_MEF2A_6	203	210	PF00069	0.428
DOC_MAPK_MEF2A_6	319	328	PF00069	0.543
DOC_MAPK_MEF2A_6	378	386	PF00069	0.428
DOC_MAPK_MEF2A_6	78	85	PF00069	0.590
DOC_PP2B_LxvP_1	29	32	PF13499	0.542
DOC_USP7_MATH_1	124	128	PF00917	0.556
DOC_USP7_MATH_1	252	256	PF00917	0.549
DOC_USP7_MATH_1	261	265	PF00917	0.563
DOC_USP7_MATH_1	49	53	PF00917	0.625
DOC_USP7_MATH_1	60	64	PF00917	0.567
DOC_WW_Pin1_4	106	111	PF00397	0.630
DOC_WW_Pin1_4	248	253	PF00397	0.605
DOC_WW_Pin1_4	327	332	PF00397	0.423
DOC_WW_Pin1_4	52	57	PF00397	0.608
LIG_14-3-3_CanoR_1	203	209	PF00244	0.499
LIG_14-3-3_CanoR_1	314	322	PF00244	0.566
LIG_14-3-3_CanoR_1	40	46	PF00244	0.503
LIG_BRCT_BRCA1_1	101	105	PF00533	0.541
LIG_BRCT_BRCA1_1	206	210	PF00533	0.460
LIG_BRCT_BRCA1_1	382	386	PF00533	0.396
LIG_deltaCOP1_diTrp_1	5	11	PF00928	0.488
LIG_FHA_1	199	205	PF00498	0.589
LIG_FHA_1	315	321	PF00498	0.449
LIG_FHA_1	328	334	PF00498	0.472
LIG_FHA_2	209	215	PF00498	0.526
LIG_FHA_2	242	248	PF00498	0.685
LIG_FHA_2	342	348	PF00498	0.467
LIG_FHA_2	7	13	PF00498	0.480
LIG_GBD_Chelix_1	332	340	PF00786	0.469
LIG_LIR_Nem_3	335	340	PF02991	0.405
LIG_LIR_Nem_3	35	41	PF02991	0.497
LIG_LIR_Nem_3	375	380	PF02991	0.416
LIG_LIR_Nem_3	5	10	PF02991	0.495
LIG_MAD2	40	48	PF02301	0.516
LIG_NRBOX	167	173	PF00104	0.451
LIG_PCNA_yPIPBox_3	366	380	PF02747	0.465
LIG_Pex14_2	337	341	PF04695	0.393
LIG_Pex14_2	355	359	PF04695	0.349
LIG_SH2_CRK	38	42	PF00017	0.522
LIG_SH2_STAP1	175	179	PF00017	0.392
LIG_SH2_STAT5	135	138	PF00017	0.607
LIG_SH3_1	307	313	PF00018	0.536
LIG_SH3_2	310	315	PF14604	0.543
LIG_SH3_3	111	117	PF00018	0.520
LIG_SH3_3	307	313	PF00018	0.581
LIG_SH3_3	325	331	PF00018	0.320
LIG_SH3_3	42	48	PF00018	0.514
LIG_SH3_3	92	98	PF00018	0.615
LIG_SUMO_SIM_par_1	41	46	PF11976	0.503
LIG_TRAF2_1	271	274	PF00917	0.636
LIG_TRAF2_1	292	295	PF00917	0.528
MOD_CDC14_SPxK_1	251	254	PF00782	0.580
MOD_CDK_SPxK_1	248	254	PF00069	0.580
MOD_CDK_SPxxK_3	327	334	PF00069	0.488
MOD_CK1_1	103	109	PF00069	0.613
MOD_CK1_1	125	131	PF00069	0.586
MOD_CK1_1	134	140	PF00069	0.506
MOD_CK1_1	190	196	PF00069	0.632
MOD_CK1_1	198	204	PF00069	0.545
MOD_CK1_1	335	341	PF00069	0.467
MOD_CK1_1	52	58	PF00069	0.632
MOD_CK1_1	62	68	PF00069	0.599
MOD_CK2_1	208	214	PF00069	0.467
MOD_CK2_1	241	247	PF00069	0.560
MOD_CK2_1	341	347	PF00069	0.460
MOD_CK2_1	6	12	PF00069	0.479
MOD_GlcNHglycan	141	144	PF01048	0.588
MOD_GlcNHglycan	146	149	PF01048	0.564
MOD_GlcNHglycan	189	193	PF01048	0.742
MOD_GlcNHglycan	45	48	PF01048	0.503
MOD_GlcNHglycan	62	65	PF01048	0.550
MOD_GlcNHglycan	68	71	PF01048	0.609
MOD_GSK3_1	108	115	PF00069	0.576
MOD_GSK3_1	118	125	PF00069	0.574
MOD_GSK3_1	127	134	PF00069	0.566
MOD_GSK3_1	184	191	PF00069	0.488
MOD_GSK3_1	204	211	PF00069	0.363
MOD_GSK3_1	239	246	PF00069	0.531
MOD_GSK3_1	248	255	PF00069	0.580
MOD_GSK3_1	261	268	PF00069	0.689
MOD_GSK3_1	380	387	PF00069	0.483
MOD_GSK3_1	51	58	PF00069	0.658
MOD_GSK3_1	59	66	PF00069	0.593
MOD_GSK3_1	81	88	PF00069	0.638
MOD_GSK3_1	99	106	PF00069	0.484
MOD_NEK2_1	100	105	PF00069	0.615
MOD_NEK2_1	272	277	PF00069	0.554
MOD_NEK2_1	332	337	PF00069	0.529
MOD_NEK2_1	340	345	PF00069	0.380
MOD_NEK2_1	372	377	PF00069	0.382
MOD_NEK2_1	380	385	PF00069	0.393
MOD_NEK2_1	43	48	PF00069	0.521
MOD_PIKK_1	236	242	PF00454	0.531
MOD_PKA_1	236	242	PF00069	0.531
MOD_PKA_1	314	320	PF00069	0.570
MOD_PKA_2	139	145	PF00069	0.561
MOD_PKA_2	187	193	PF00069	0.616
MOD_PKA_2	236	242	PF00069	0.531
MOD_PKA_2	314	320	PF00069	0.586
MOD_Plk_1	122	128	PF00069	0.675
MOD_Plk_1	341	347	PF00069	0.460
MOD_Plk_2-3	224	230	PF00069	0.467
MOD_Plk_4	100	106	PF00069	0.471
MOD_Plk_4	108	114	PF00069	0.559
MOD_Plk_4	159	165	PF00069	0.487
MOD_Plk_4	332	338	PF00069	0.487
MOD_Plk_4	372	378	PF00069	0.468
MOD_Plk_4	380	386	PF00069	0.400
MOD_Plk_4	6	12	PF00069	0.517
MOD_Plk_4	81	87	PF00069	0.584
MOD_ProDKin_1	106	112	PF00069	0.631
MOD_ProDKin_1	248	254	PF00069	0.605
MOD_ProDKin_1	327	333	PF00069	0.414
MOD_ProDKin_1	52	58	PF00069	0.609
MOD_SUMO_rev_2	88	96	PF00179	0.662
TRG_ENDOCYTIC_2	38	41	PF00928	0.521
TRG_ER_diArg_1	235	237	PF00400	0.489
TRG_ER_diArg_1	298	301	PF00400	0.451
TRG_ER_diArg_1	313	315	PF00400	0.466
TRG_ER_diArg_1	38	40	PF00400	0.532

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P9L5	Trypanosomatidae	24%	94%
A4HAM8	Leishmania braziliensis	68%	100%
A4I9S0	Leishmania infantum	99%	100%
E9B4T1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q395	Leishmania major	89%	99%