Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8II04_LEIDO

TriTrypDb:

LdBPK_130790.1 , LdCL_130013300 , LDHU3_13.1000

Length:

631

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8II04

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8II04

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	439	443	PF00656	0.548
CLV_NRD_NRD_1	152	154	PF00675	0.444
CLV_NRD_NRD_1	166	168	PF00675	0.460
CLV_NRD_NRD_1	205	207	PF00675	0.437
CLV_NRD_NRD_1	209	211	PF00675	0.411
CLV_NRD_NRD_1	221	223	PF00675	0.438
CLV_NRD_NRD_1	260	262	PF00675	0.452
CLV_NRD_NRD_1	291	293	PF00675	0.548
CLV_NRD_NRD_1	33	35	PF00675	0.595
CLV_NRD_NRD_1	406	408	PF00675	0.618
CLV_NRD_NRD_1	52	54	PF00675	0.539
CLV_NRD_NRD_1	553	555	PF00675	0.655
CLV_NRD_NRD_1	578	580	PF00675	0.712
CLV_NRD_NRD_1	581	583	PF00675	0.804
CLV_NRD_NRD_1	624	626	PF00675	0.701
CLV_PCSK_FUR_1	579	583	PF00082	0.610
CLV_PCSK_KEX2_1	152	154	PF00082	0.444
CLV_PCSK_KEX2_1	166	168	PF00082	0.460
CLV_PCSK_KEX2_1	171	173	PF00082	0.457
CLV_PCSK_KEX2_1	209	211	PF00082	0.411
CLV_PCSK_KEX2_1	260	262	PF00082	0.452
CLV_PCSK_KEX2_1	286	288	PF00082	0.527
CLV_PCSK_KEX2_1	290	292	PF00082	0.566
CLV_PCSK_KEX2_1	301	303	PF00082	0.545
CLV_PCSK_KEX2_1	33	35	PF00082	0.533
CLV_PCSK_KEX2_1	51	53	PF00082	0.570
CLV_PCSK_KEX2_1	553	555	PF00082	0.655
CLV_PCSK_KEX2_1	577	579	PF00082	0.676
CLV_PCSK_KEX2_1	581	583	PF00082	0.772
CLV_PCSK_KEX2_1	68	70	PF00082	0.471
CLV_PCSK_KEX2_1	81	83	PF00082	0.486
CLV_PCSK_PC1ET2_1	171	173	PF00082	0.457
CLV_PCSK_PC1ET2_1	286	288	PF00082	0.466
CLV_PCSK_PC1ET2_1	301	303	PF00082	0.551
CLV_PCSK_PC1ET2_1	51	53	PF00082	0.570
CLV_PCSK_PC1ET2_1	68	70	PF00082	0.471
CLV_PCSK_PC1ET2_1	81	83	PF00082	0.486
CLV_PCSK_PC7_1	167	173	PF00082	0.454
CLV_PCSK_PC7_1	287	293	PF00082	0.473
CLV_PCSK_PC7_1	577	583	PF00082	0.621
CLV_PCSK_SKI1_1	210	214	PF00082	0.484
CLV_PCSK_SKI1_1	229	233	PF00082	0.479
CLV_PCSK_SKI1_1	265	269	PF00082	0.410
CLV_PCSK_SKI1_1	302	306	PF00082	0.497
CLV_PCSK_SKI1_1	461	465	PF00082	0.521
CLV_PCSK_SKI1_1	625	629	PF00082	0.711
DEG_Nend_UBRbox_1	1	4	PF02207	0.456
DEG_SPOP_SBC_1	107	111	PF00917	0.570
DEG_SPOP_SBC_1	369	373	PF00917	0.562
DOC_CKS1_1	516	521	PF01111	0.557
DOC_CYCLIN_RxL_1	298	308	PF00134	0.458
DOC_MAPK_gen_1	177	183	PF00069	0.483
DOC_MAPK_gen_1	206	217	PF00069	0.426
DOC_MAPK_gen_1	260	272	PF00069	0.445
DOC_MAPK_gen_1	286	297	PF00069	0.522
DOC_MAPK_gen_1	472	480	PF00069	0.496
DOC_MAPK_gen_1	560	567	PF00069	0.615
DOC_MAPK_MEF2A_6	209	217	PF00069	0.423
DOC_MAPK_MEF2A_6	290	299	PF00069	0.477
DOC_MAPK_NFAT4_5	210	218	PF00069	0.429
DOC_PP1_RVXF_1	238	244	PF00149	0.466
DOC_PP1_RVXF_1	299	306	PF00149	0.452
DOC_PP2B_LxvP_1	334	337	PF13499	0.478
DOC_PP4_FxxP_1	146	149	PF00568	0.439
DOC_USP7_MATH_1	107	111	PF00917	0.570
DOC_USP7_MATH_1	117	121	PF00917	0.571
DOC_USP7_MATH_1	135	139	PF00917	0.454
DOC_USP7_MATH_1	279	283	PF00917	0.473
DOC_USP7_MATH_1	368	372	PF00917	0.586
DOC_USP7_MATH_1	416	420	PF00917	0.597
DOC_USP7_MATH_1	549	553	PF00917	0.592
DOC_USP7_MATH_1	588	592	PF00917	0.626
DOC_USP7_UBL2_3	262	266	PF12436	0.438
DOC_WW_Pin1_4	109	114	PF00397	0.555
DOC_WW_Pin1_4	145	150	PF00397	0.443
DOC_WW_Pin1_4	424	429	PF00397	0.769
DOC_WW_Pin1_4	515	520	PF00397	0.720
DOC_WW_Pin1_4	523	528	PF00397	0.574
DOC_WW_Pin1_4	584	589	PF00397	0.557
DOC_WW_Pin1_4	598	603	PF00397	0.608
DOC_WW_Pin1_4	611	616	PF00397	0.538
LIG_14-3-3_CanoR_1	209	213	PF00244	0.401
LIG_14-3-3_CanoR_1	461	467	PF00244	0.609
LIG_14-3-3_CanoR_1	474	480	PF00244	0.440
LIG_14-3-3_CanoR_1	9	18	PF00244	0.467
LIG_Actin_WH2_2	71	86	PF00022	0.480
LIG_APCC_ABBAyCdc20_2	301	307	PF00400	0.443
LIG_BIR_III_2	504	508	PF00653	0.593
LIG_BIR_III_2	585	589	PF00653	0.532
LIG_BRCT_BRCA1_1	142	146	PF00533	0.499
LIG_BRCT_BRCA1_1	227	231	PF00533	0.477
LIG_deltaCOP1_diTrp_1	64	74	PF00928	0.462
LIG_DLG_GKlike_1	291	299	PF00625	0.515
LIG_FHA_1	320	326	PF00498	0.496
LIG_FHA_1	333	339	PF00498	0.457
LIG_FHA_1	462	468	PF00498	0.701
LIG_FHA_1	473	479	PF00498	0.493
LIG_FHA_1	485	491	PF00498	0.474
LIG_FHA_1	611	617	PF00498	0.580
LIG_FHA_1	85	91	PF00498	0.504
LIG_FHA_2	203	209	PF00498	0.490
LIG_FHA_2	214	220	PF00498	0.399
LIG_FHA_2	308	314	PF00498	0.641
LIG_Integrin_RGD_1	400	402	PF01839	0.586
LIG_LIR_Apic_2	143	149	PF02991	0.471
LIG_LIR_Gen_1	141	150	PF02991	0.473
LIG_LIR_Gen_1	211	220	PF02991	0.441
LIG_LIR_Gen_1	70	78	PF02991	0.468
LIG_LIR_Nem_3	141	145	PF02991	0.485
LIG_LIR_Nem_3	211	215	PF02991	0.493
LIG_LIR_Nem_3	70	74	PF02991	0.465
LIG_MYND_1	498	502	PF01753	0.569
LIG_Pex14_2	142	146	PF04695	0.482
LIG_SH2_CRK	274	278	PF00017	0.545
LIG_SH2_CRK	56	60	PF00017	0.559
LIG_SH2_GRB2like	20	23	PF00017	0.487
LIG_SH2_STAP1	56	60	PF00017	0.597
LIG_SH2_STAT5	144	147	PF00017	0.469
LIG_SH2_STAT5	20	23	PF00017	0.465
LIG_SH2_STAT5	276	279	PF00017	0.472
LIG_SH2_STAT5	6	9	PF00017	0.457
LIG_SH3_2	612	617	PF14604	0.543
LIG_SH3_3	324	330	PF00018	0.433
LIG_SH3_3	445	451	PF00018	0.574
LIG_SH3_3	492	498	PF00018	0.553
LIG_SH3_3	609	615	PF00018	0.572
LIG_SH3_CIN85_PxpxPR_1	602	607	PF14604	0.599
LIG_Sin3_3	361	368	PF02671	0.551
LIG_SUMO_SIM_anti_2	179	185	PF11976	0.443
LIG_SUMO_SIM_anti_2	452	458	PF11976	0.585
LIG_SUMO_SIM_par_1	179	185	PF11976	0.443
LIG_SUMO_SIM_par_1	452	458	PF11976	0.585
LIG_TRAF2_1	383	386	PF00917	0.595
LIG_TYR_ITIM	272	277	PF00017	0.473
LIG_UBA3_1	295	301	PF00899	0.475
MOD_CDC14_SPxK_1	427	430	PF00782	0.575
MOD_CDC14_SPxK_1	614	617	PF00782	0.538
MOD_CDK_SPK_2	525	530	PF00069	0.570
MOD_CDK_SPK_2	600	605	PF00069	0.600
MOD_CDK_SPxK_1	424	430	PF00069	0.576
MOD_CDK_SPxK_1	611	617	PF00069	0.537
MOD_CDK_SPxxK_3	145	152	PF00069	0.436
MOD_CDK_SPxxK_3	523	530	PF00069	0.597
MOD_CDK_SPxxK_3	598	605	PF00069	0.619
MOD_CK1_1	109	115	PF00069	0.555
MOD_CK1_1	11	17	PF00069	0.464
MOD_CK1_1	138	144	PF00069	0.521
MOD_CK1_1	182	188	PF00069	0.446
MOD_CK1_1	38	44	PF00069	0.556
MOD_CK1_1	412	418	PF00069	0.588
MOD_CK1_1	424	430	PF00069	0.544
MOD_CK1_1	552	558	PF00069	0.588
MOD_CK1_1	596	602	PF00069	0.639
MOD_CK1_1	73	79	PF00069	0.453
MOD_CK2_1	145	151	PF00069	0.456
MOD_CK2_1	202	208	PF00069	0.502
MOD_CK2_1	213	219	PF00069	0.389
MOD_CK2_1	584	590	PF00069	0.642
MOD_Cter_Amidation	299	302	PF01082	0.478
MOD_Cter_Amidation	49	52	PF01082	0.582
MOD_GlcNHglycan	119	122	PF01048	0.636
MOD_GlcNHglycan	349	352	PF01048	0.579
MOD_GlcNHglycan	353	356	PF01048	0.566
MOD_GlcNHglycan	372	375	PF01048	0.556
MOD_GlcNHglycan	411	414	PF01048	0.705
MOD_GlcNHglycan	418	421	PF01048	0.583
MOD_GlcNHglycan	42	45	PF01048	0.591
MOD_GlcNHglycan	424	427	PF01048	0.525
MOD_GlcNHglycan	432	435	PF01048	0.536
MOD_GlcNHglycan	491	494	PF01048	0.568
MOD_GlcNHglycan	539	542	PF01048	0.656
MOD_GlcNHglycan	555	558	PF01048	0.535
MOD_GlcNHglycan	75	78	PF01048	0.473
MOD_GlcNHglycan	87	90	PF01048	0.500
MOD_GlcNHglycan	94	97	PF01048	0.496
MOD_GSK3_1	10	17	PF00069	0.462
MOD_GSK3_1	140	147	PF00069	0.512
MOD_GSK3_1	18	25	PF00069	0.481
MOD_GSK3_1	303	310	PF00069	0.508
MOD_GSK3_1	315	322	PF00069	0.512
MOD_GSK3_1	332	339	PF00069	0.428
MOD_GSK3_1	347	354	PF00069	0.501
MOD_GSK3_1	35	42	PF00069	0.549
MOD_GSK3_1	411	418	PF00069	0.580
MOD_GSK3_1	457	464	PF00069	0.524
MOD_GSK3_1	484	491	PF00069	0.523
MOD_GSK3_1	525	532	PF00069	0.700
MOD_GSK3_1	548	555	PF00069	0.598
MOD_GSK3_1	584	591	PF00069	0.632
MOD_GSK3_1	593	600	PF00069	0.604
MOD_GSK3_1	611	618	PF00069	0.520
MOD_GSK3_1	69	76	PF00069	0.467
MOD_N-GLC_1	483	488	PF02516	0.507
MOD_NEK2_1	16	21	PF00069	0.492
MOD_NEK2_1	213	218	PF00069	0.430
MOD_NEK2_1	305	310	PF00069	0.416
MOD_NEK2_1	466	471	PF00069	0.520
MOD_NEK2_1	489	494	PF00069	0.551
MOD_PIKK_1	588	594	PF00454	0.617
MOD_PKA_1	291	297	PF00069	0.549
MOD_PKA_1	553	559	PF00069	0.590
MOD_PKA_2	208	214	PF00069	0.408
MOD_PKA_2	291	297	PF00069	0.618
MOD_PKA_2	38	44	PF00069	0.607
MOD_PKA_2	473	479	PF00069	0.493
MOD_PKA_2	484	490	PF00069	0.522
MOD_PKA_2	552	558	PF00069	0.588
MOD_PKA_2	8	14	PF00069	0.456
MOD_PKB_1	159	167	PF00069	0.408
MOD_PKB_1	37	45	PF00069	0.584
MOD_PKB_1	82	90	PF00069	0.496
MOD_Plk_1	315	321	PF00069	0.591
MOD_Plk_1	69	75	PF00069	0.465
MOD_Plk_4	179	185	PF00069	0.439
MOD_Plk_4	279	285	PF00069	0.475
MOD_Plk_4	291	297	PF00069	0.473
MOD_Plk_4	462	468	PF00069	0.521
MOD_Plk_4	70	76	PF00069	0.451
MOD_ProDKin_1	109	115	PF00069	0.559
MOD_ProDKin_1	145	151	PF00069	0.441
MOD_ProDKin_1	424	430	PF00069	0.772
MOD_ProDKin_1	515	521	PF00069	0.724
MOD_ProDKin_1	523	529	PF00069	0.569
MOD_ProDKin_1	584	590	PF00069	0.560
MOD_ProDKin_1	598	604	PF00069	0.606
MOD_ProDKin_1	611	617	PF00069	0.542
MOD_SUMO_rev_2	225	233	PF00179	0.520
MOD_SUMO_rev_2	235	242	PF00179	0.412
MOD_SUMO_rev_2	373	383	PF00179	0.570
TRG_DiLeu_BaEn_1	340	345	PF01217	0.463
TRG_DiLeu_BaEn_2	207	213	PF01217	0.454
TRG_DiLeu_BaEn_2	69	75	PF01217	0.465
TRG_DiLeu_BaLyEn_6	299	304	PF01217	0.483
TRG_DiLeu_LyEn_5	340	345	PF01217	0.463
TRG_ENDOCYTIC_2	274	277	PF00928	0.477
TRG_ENDOCYTIC_2	56	59	PF00928	0.565
TRG_ER_diArg_1	259	261	PF00400	0.465
TRG_ER_diArg_1	290	292	PF00400	0.515
TRG_ER_diArg_1	33	35	PF00400	0.608
TRG_ER_diArg_1	36	39	PF00400	0.611
TRG_ER_diArg_1	52	55	PF00400	0.475
TRG_ER_diArg_1	564	567	PF00400	0.617
TRG_ER_diArg_1	577	579	PF00400	0.576
TRG_ER_diArg_1	604	607	PF00400	0.602
TRG_ER_diLys_1	626	631	PF00400	0.563
TRG_NLS_Bipartite_1	33	55	PF00514	0.526
TRG_NLS_Bipartite_1	577	598	PF00514	0.565
TRG_NLS_MonoExtC_3	50	55	PF00514	0.522
TRG_NLS_MonoExtC_3	624	629	PF00514	0.532
TRG_Pf-PMV_PEXEL_1	197	202	PF00026	0.485
TRG_Pf-PMV_PEXEL_1	343	347	PF00026	0.478

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I995	Leptomonas seymouri	57%	100%
A4H778	Leishmania braziliensis	70%	100%
A4HVL8	Leishmania infantum	99%	100%
E9APB4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	99%
Q4QG64	Leishmania major	90%	100%