60S ribosomal protein L18a

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60S ribosomal protein L18a, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8II03_LEIDO

TriTrypDb:

LdBPK_350600.1 , LdCL_350010900 , LDHU3_35.0740

Length:

179

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 21

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 15

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	13
GO:0032991	protein-containing complex	1	14
GO:0043226	organelle	2	14
GO:0043228	non-membrane-bounded organelle	3	14
GO:0043229	intracellular organelle	3	14
GO:0043232	intracellular non-membrane-bounded organelle	4	14
GO:0110165	cellular anatomical entity	1	14
GO:1990904	ribonucleoprotein complex	2	14
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0015934	large ribosomal subunit	4	1
GO:0022625	cytosolic large ribosomal subunit	5	1
GO:0044391	ribosomal subunit	3	1

Expansion

Sequence features

A0A3Q8II03

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8II03

PDB structure(s): 6az3_R

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	14
GO:0006518	peptide metabolic process	4	14
GO:0006807	nitrogen compound metabolic process	2	14
GO:0008152	metabolic process	1	14
GO:0009058	biosynthetic process	2	14
GO:0009059	macromolecule biosynthetic process	4	14
GO:0009987	cellular process	1	14
GO:0019538	protein metabolic process	3	14
GO:0034641	cellular nitrogen compound metabolic process	3	14
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	14
GO:0043043	peptide biosynthetic process	5	14
GO:0043170	macromolecule metabolic process	3	14
GO:0043603	amide metabolic process	3	14
GO:0043604	amide biosynthetic process	4	14
GO:0044237	cellular metabolic process	2	14
GO:0044238	primary metabolic process	2	14
GO:0044249	cellular biosynthetic process	3	14
GO:0044260	obsolete cellular macromolecule metabolic process	3	14
GO:0044271	cellular nitrogen compound biosynthetic process	4	14
GO:0071704	organic substance metabolic process	2	14
GO:1901564	organonitrogen compound metabolic process	3	14
GO:1901566	organonitrogen compound biosynthetic process	4	14
GO:1901576	organic substance biosynthetic process	3	14

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	14
GO:0005198	structural molecule activity	1	14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	156	158	PF00675	0.516
CLV_NRD_NRD_1	161	163	PF00675	0.501
CLV_PCSK_KEX2_1	156	158	PF00082	0.538
CLV_PCSK_KEX2_1	174	176	PF00082	0.518
CLV_PCSK_PC1ET2_1	174	176	PF00082	0.506
CLV_PCSK_SKI1_1	156	160	PF00082	0.461
CLV_PCSK_SKI1_1	165	169	PF00082	0.512
CLV_PCSK_SKI1_1	64	68	PF00082	0.375
CLV_PCSK_SKI1_1	91	95	PF00082	0.465
DEG_APCC_DBOX_1	73	81	PF00400	0.465
DOC_MAPK_gen_1	117	125	PF00069	0.364
DOC_MAPK_gen_1	159	169	PF00069	0.501
DOC_MAPK_gen_1	40	49	PF00069	0.489
DOC_USP7_UBL2_3	159	163	PF12436	0.486
DOC_USP7_UBL2_3	170	174	PF12436	0.510
DOC_USP7_UBL2_3	50	54	PF12436	0.363
DOC_WW_Pin1_4	13	18	PF00397	0.393
LIG_FHA_1	100	106	PF00498	0.465
LIG_FHA_1	88	94	PF00498	0.412
LIG_FHA_2	54	60	PF00498	0.364
LIG_LIR_Gen_1	106	113	PF02991	0.374
LIG_LIR_Nem_3	106	112	PF02991	0.359
LIG_LIR_Nem_3	150	154	PF02991	0.485
LIG_LIR_Nem_3	95	99	PF02991	0.405
LIG_PDZ_Class_2	174	179	PF00595	0.512
LIG_Pex14_2	32	36	PF04695	0.380
LIG_SH2_CRK	144	148	PF00017	0.560
LIG_SH2_CRK	9	13	PF00017	0.380
LIG_SH2_GRB2like	120	123	PF00017	0.400
LIG_SH2_STAP1	89	93	PF00017	0.454
LIG_SH2_STAT3	82	85	PF00017	0.364
LIG_SH2_STAT5	76	79	PF00017	0.483
LIG_SH2_STAT5	89	92	PF00017	0.315
LIG_SH3_3	28	34	PF00018	0.389
MOD_CDK_SPxxK_3	13	20	PF00069	0.425
MOD_CK2_1	13	19	PF00069	0.429
MOD_GSK3_1	99	106	PF00069	0.457
MOD_N-GLC_1	147	152	PF02516	0.558
MOD_PIKK_1	103	109	PF00454	0.364
MOD_PIKK_1	81	87	PF00454	0.364
MOD_PK_1	137	143	PF00069	0.525
MOD_PKA_1	170	176	PF00069	0.505
MOD_Plk_1	147	153	PF00069	0.534
MOD_Plk_4	22	28	PF00069	0.380
MOD_ProDKin_1	13	19	PF00069	0.393
MOD_SUMO_rev_2	130	139	PF00179	0.595
MOD_SUMO_rev_2	62	72	PF00179	0.384
TRG_DiLeu_BaLyEn_6	149	154	PF01217	0.511
TRG_ENDOCYTIC_2	109	112	PF00928	0.401
TRG_ENDOCYTIC_2	120	123	PF00928	0.368
TRG_ENDOCYTIC_2	89	92	PF00928	0.409
TRG_ENDOCYTIC_2	9	12	PF00928	0.380
TRG_ER_diArg_1	117	120	PF00400	0.364
TRG_ER_diArg_1	156	158	PF00400	0.474

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4J901	Bodo saltans	77%	100%
A0A0S4KR94	Bodo saltans	77%	100%
A0A1D8PLC9	Candida albicans (strain SC5314 / ATCC MYA-2876)	39%	100%
A0A1X0NUM1	Trypanosomatidae	87%	100%
A0A3Q8IT55	Leishmania donovani	99%	100%
A0A3R7KWM8	Trypanosoma rangeli	86%	100%
A0A422N9H1	Trypanosoma rangeli	87%	100%
A4HK69	Leishmania braziliensis	98%	100%
A4I7Q4	Leishmania infantum	99%	100%
D0A297	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	85%	100%
E9B2L2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
E9B5U1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
O44480	Caenorhabditis elegans	38%	99%
O57561	Salmo salar	39%	100%
P0CT68	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	42%	100%
P0CT69	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	42%	100%
P0CX23	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	39%	100%
P0CX24	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	39%	100%
P0DJ18	Tetrahymena thermophila	32%	95%
P41093	Drosophila melanogaster	41%	100%
P51418	Arabidopsis thaliana	37%	100%
P62717	Mus musculus	38%	100%
P62718	Rattus norvegicus	38%	100%
Q02543	Homo sapiens	38%	100%
Q3T003	Bos taurus	38%	100%
Q4Q5J4	Leishmania major	99%	100%
Q54MK8	Dictyostelium discoideum	35%	100%
Q7ZWJ4	Danio rerio	40%	100%
Q8L7K0	Arabidopsis thaliana	37%	100%
Q8WQI7	Spodoptera frugiperda	39%	100%
Q90YU9	Ictalurus punctatus	41%	100%
Q943F3	Oryza sativa subsp. japonica	35%	100%
Q9ATF5	Castanea sativa	38%	100%
Q9LUD4	Arabidopsis thaliana	36%	100%