RNA-binding protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8II02_LEIDO

TriTrypDb:

LdBPK_302200.1 , LdCL_300027500 , LDHU3_30.2990

Length:

502

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A0A3Q8II02

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8II02

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0003723	RNA binding	4	8
GO:0005488	binding	1	8
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	439	443	PF00656	0.482
CLV_NRD_NRD_1	185	187	PF00675	0.527
CLV_NRD_NRD_1	65	67	PF00675	0.252
CLV_PCSK_FUR_1	182	186	PF00082	0.539
CLV_PCSK_KEX2_1	182	184	PF00082	0.541
CLV_PCSK_KEX2_1	185	187	PF00082	0.544
CLV_PCSK_SKI1_1	113	117	PF00082	0.220
CLV_PCSK_SKI1_1	149	153	PF00082	0.285
CLV_PCSK_SKI1_1	33	37	PF00082	0.285
CLV_PCSK_SKI1_1	414	418	PF00082	0.586
CLV_PCSK_SKI1_1	56	60	PF00082	0.325
CLV_PCSK_SKI1_1	88	92	PF00082	0.513
DOC_CKS1_1	289	294	PF01111	0.765
DOC_CKS1_1	304	309	PF01111	0.489
DOC_CKS1_1	384	389	PF01111	0.564
DOC_CYCLIN_RxL_1	411	421	PF00134	0.582
DOC_CYCLIN_yClb3_PxF_3	274	280	PF00134	0.523
DOC_MAPK_gen_1	42	51	PF00069	0.485
DOC_PP2B_LxvP_1	348	351	PF13499	0.586
DOC_PP4_FxxP_1	200	203	PF00568	0.589
DOC_PP4_FxxP_1	296	299	PF00568	0.625
DOC_PP4_FxxP_1	327	330	PF00568	0.562
DOC_PP4_FxxP_1	397	400	PF00568	0.619
DOC_PP4_MxPP_1	273	276	PF00568	0.489
DOC_USP7_MATH_1	250	254	PF00917	0.654
DOC_USP7_MATH_1	261	265	PF00917	0.642
DOC_USP7_MATH_1	323	327	PF00917	0.574
DOC_USP7_MATH_1	339	343	PF00917	0.698
DOC_USP7_MATH_1	481	485	PF00917	0.534
DOC_USP7_MATH_1	487	491	PF00917	0.513
DOC_USP7_UBL2_3	241	245	PF12436	0.646
DOC_WW_Pin1_4	263	268	PF00397	0.663
DOC_WW_Pin1_4	288	293	PF00397	0.767
DOC_WW_Pin1_4	303	308	PF00397	0.512
DOC_WW_Pin1_4	326	331	PF00397	0.582
DOC_WW_Pin1_4	383	388	PF00397	0.561
DOC_WW_Pin1_4	396	401	PF00397	0.642
LIG_14-3-3_CanoR_1	113	119	PF00244	0.467
LIG_APCC_ABBA_1	21	26	PF00400	0.485
LIG_APCC_ABBA_1	48	53	PF00400	0.485
LIG_BIR_II_1	1	5	PF00653	0.426
LIG_BRCT_BRCA1_1	42	46	PF00533	0.443
LIG_EVH1_2	276	280	PF00568	0.555
LIG_EVH1_2	332	336	PF00568	0.569
LIG_FHA_1	253	259	PF00498	0.649
LIG_FHA_1	371	377	PF00498	0.574
LIG_FHA_1	444	450	PF00498	0.570
LIG_FHA_1	75	81	PF00498	0.423
LIG_FHA_2	142	148	PF00498	0.492
LIG_FHA_2	310	316	PF00498	0.563
LIG_FHA_2	437	443	PF00498	0.523
LIG_IRF3_LxIS_1	413	420	PF10401	0.493
LIG_LIR_Apic_2	128	134	PF02991	0.467
LIG_LIR_Apic_2	293	299	PF02991	0.671
LIG_LIR_Apic_2	325	330	PF02991	0.558
LIG_LIR_Apic_2	395	400	PF02991	0.620
LIG_LIR_Apic_2	442	448	PF02991	0.614
LIG_LIR_Gen_1	141	148	PF02991	0.490
LIG_LIR_Gen_1	75	82	PF02991	0.538
LIG_LIR_Nem_3	117	121	PF02991	0.481
LIG_LIR_Nem_3	141	145	PF02991	0.518
LIG_LIR_Nem_3	43	49	PF02991	0.465
LIG_LIR_Nem_3	75	79	PF02991	0.526
LIG_PCNA_PIPBox_1	108	117	PF02747	0.485
LIG_PCNA_yPIPBox_3	108	116	PF02747	0.485
LIG_Pex14_2	114	118	PF04695	0.485
LIG_PTB_Apo_2	117	124	PF02174	0.485
LIG_PTB_Phospho_1	117	123	PF10480	0.485
LIG_SH2_CRK	131	135	PF00017	0.485
LIG_SH2_CRK	61	65	PF00017	0.482
LIG_SH2_GRB2like	426	429	PF00017	0.589
LIG_SH2_NCK_1	142	146	PF00017	0.485
LIG_SH2_STAT5	123	126	PF00017	0.443
LIG_SH2_STAT5	161	164	PF00017	0.499
LIG_SH2_STAT5	309	312	PF00017	0.570
LIG_SH2_STAT5	426	429	PF00017	0.639
LIG_SH2_STAT5	445	448	PF00017	0.614
LIG_SH2_STAT5	98	101	PF00017	0.443
LIG_SH3_3	268	274	PF00018	0.603
LIG_SH3_3	276	282	PF00018	0.592
LIG_SH3_3	327	333	PF00018	0.586
LIG_SH3_3	448	454	PF00018	0.616
LIG_SH3_3	465	471	PF00018	0.588
LIG_SH3_3	76	82	PF00018	0.369
LIG_SUMO_SIM_anti_2	373	378	PF11976	0.581
LIG_SUMO_SIM_par_1	372	378	PF11976	0.586
LIG_TRAF2_2	351	356	PF00917	0.593
LIG_TRFH_1	383	387	PF08558	0.616
LIG_WRC_WIRS_1	115	120	PF05994	0.478
LIG_WRC_WIRS_1	434	439	PF05994	0.570
LIG_WW_3	452	456	PF00397	0.499
MOD_CK1_1	212	218	PF00069	0.658
MOD_CK1_1	234	240	PF00069	0.641
MOD_CK1_1	243	249	PF00069	0.653
MOD_CK1_1	325	331	PF00069	0.627
MOD_CK1_1	399	405	PF00069	0.626
MOD_CK1_1	430	436	PF00069	0.616
MOD_CK1_1	490	496	PF00069	0.594
MOD_CK2_1	202	208	PF00069	0.712
MOD_CK2_1	309	315	PF00069	0.593
MOD_GlcNHglycan	164	167	PF01048	0.462
MOD_GlcNHglycan	195	198	PF01048	0.676
MOD_GlcNHglycan	208	212	PF01048	0.619
MOD_GlcNHglycan	252	255	PF01048	0.629
MOD_GlcNHglycan	268	271	PF01048	0.625
MOD_GlcNHglycan	30	33	PF01048	0.285
MOD_GlcNHglycan	315	318	PF01048	0.594
MOD_GlcNHglycan	341	344	PF01048	0.621
MOD_GlcNHglycan	429	432	PF01048	0.687
MOD_GlcNHglycan	483	486	PF01048	0.543
MOD_GSK3_1	209	216	PF00069	0.604
MOD_GSK3_1	226	233	PF00069	0.590
MOD_GSK3_1	237	244	PF00069	0.698
MOD_GSK3_1	290	297	PF00069	0.738
MOD_GSK3_1	309	316	PF00069	0.593
MOD_GSK3_1	322	329	PF00069	0.626
MOD_GSK3_1	366	373	PF00069	0.627
MOD_GSK3_1	395	402	PF00069	0.636
MOD_GSK3_1	408	415	PF00069	0.610
MOD_GSK3_1	483	490	PF00069	0.628
MOD_N-GLC_1	157	162	PF02516	0.393
MOD_N-GLC_1	361	366	PF02516	0.610
MOD_N-GLC_1	370	375	PF02516	0.603
MOD_N-GLC_1	427	432	PF02516	0.616
MOD_NEK2_1	114	119	PF00069	0.478
MOD_NEK2_1	162	167	PF00069	0.509
MOD_NEK2_1	213	218	PF00069	0.610
MOD_NEK2_1	313	318	PF00069	0.563
MOD_NEK2_1	408	413	PF00069	0.660
MOD_NEK2_1	417	422	PF00069	0.540
MOD_PIKK_1	285	291	PF00454	0.585
MOD_PIKK_1	337	343	PF00454	0.592
MOD_PIKK_1	408	414	PF00454	0.616
MOD_PKA_2	250	256	PF00069	0.648
MOD_Plk_1	157	163	PF00069	0.603
MOD_Plk_1	361	367	PF00069	0.607
MOD_Plk_1	370	376	PF00069	0.563
MOD_Plk_1	464	470	PF00069	0.653
MOD_Plk_2-3	141	147	PF00069	0.492
MOD_Plk_4	157	163	PF00069	0.603
MOD_Plk_4	370	376	PF00069	0.563
MOD_Plk_4	412	418	PF00069	0.612
MOD_Plk_4	487	493	PF00069	0.593
MOD_ProDKin_1	263	269	PF00069	0.666
MOD_ProDKin_1	288	294	PF00069	0.770
MOD_ProDKin_1	303	309	PF00069	0.508
MOD_ProDKin_1	326	332	PF00069	0.583
MOD_ProDKin_1	383	389	PF00069	0.561
MOD_ProDKin_1	396	402	PF00069	0.642
MOD_SUMO_for_1	170	173	PF00179	0.398
MOD_SUMO_for_1	178	181	PF00179	0.480
MOD_SUMO_rev_2	141	151	PF00179	0.485
MOD_SUMO_rev_2	233	243	PF00179	0.691
MOD_SUMO_rev_2	52	58	PF00179	0.500
TRG_DiLeu_BaEn_4	92	98	PF01217	0.435
TRG_DiLeu_BaLyEn_6	341	346	PF01217	0.617
TRG_ENDOCYTIC_2	123	126	PF00928	0.443
TRG_ENDOCYTIC_2	142	145	PF00928	0.443
TRG_ENDOCYTIC_2	61	64	PF00928	0.443
TRG_ER_diArg_1	182	185	PF00400	0.529
TRG_Pf-PMV_PEXEL_1	13	17	PF00026	0.285

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1Q0	Leptomonas seymouri	63%	100%
A4H9C3	Leishmania braziliensis	26%	100%
A4HIF1	Leishmania braziliensis	70%	98%
A4I5P8	Leishmania infantum	99%	100%
C9ZR15	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9B0Z2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
P42731	Arabidopsis thaliana	22%	80%
Q4Q774	Leishmania major	88%	99%
Q9FXA2	Arabidopsis thaliana	26%	75%