Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IHZ9_LEIDO

TriTrypDb:

LdBPK_352170.1 , LdCL_350026600 , LDHU3_35.2770

Length:

504

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IHZ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHZ9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	153	157	PF00656	0.682
CLV_MEL_PAP_1	36	42	PF00089	0.756
CLV_NRD_NRD_1	218	220	PF00675	0.741
CLV_NRD_NRD_1	36	38	PF00675	0.646
CLV_NRD_NRD_1	95	97	PF00675	0.661
CLV_PCSK_FUR_1	93	97	PF00082	0.631
CLV_PCSK_KEX2_1	218	220	PF00082	0.741
CLV_PCSK_KEX2_1	234	236	PF00082	0.478
CLV_PCSK_KEX2_1	38	40	PF00082	0.656
CLV_PCSK_KEX2_1	95	97	PF00082	0.632
CLV_PCSK_PC1ET2_1	234	236	PF00082	0.675
CLV_PCSK_PC1ET2_1	38	40	PF00082	0.639
CLV_PCSK_SKI1_1	275	279	PF00082	0.751
DEG_COP1_1	295	304	PF00400	0.558
DOC_CYCLIN_yCln2_LP_2	464	470	PF00134	0.510
DOC_MAPK_gen_1	376	384	PF00069	0.557
DOC_PP1_RVXF_1	26	32	PF00149	0.598
DOC_PP4_FxxP_1	135	138	PF00568	0.674
DOC_USP7_MATH_1	106	110	PF00917	0.758
DOC_USP7_MATH_1	138	142	PF00917	0.775
DOC_USP7_MATH_1	190	194	PF00917	0.688
DOC_USP7_MATH_1	199	203	PF00917	0.674
DOC_USP7_MATH_1	269	273	PF00917	0.668
DOC_USP7_MATH_1	347	351	PF00917	0.705
DOC_USP7_MATH_1	476	480	PF00917	0.678
DOC_USP7_MATH_1	493	497	PF00917	0.676
DOC_WW_Pin1_4	141	146	PF00397	0.675
DOC_WW_Pin1_4	17	22	PF00397	0.551
DOC_WW_Pin1_4	2	7	PF00397	0.852
DOC_WW_Pin1_4	204	209	PF00397	0.608
DOC_WW_Pin1_4	341	346	PF00397	0.677
LIG_14-3-3_CanoR_1	270	274	PF00244	0.687
LIG_14-3-3_CanoR_1	37	45	PF00244	0.666
LIG_14-3-3_CanoR_1	378	383	PF00244	0.570
LIG_14-3-3_CanoR_1	95	102	PF00244	0.730
LIG_BRCT_BRCA1_1	325	329	PF00533	0.731
LIG_CAP-Gly_1	497	504	PF01302	0.589
LIG_Clathr_ClatBox_1	305	309	PF01394	0.611
LIG_deltaCOP1_diTrp_1	121	127	PF00928	0.641
LIG_deltaCOP1_diTrp_1	334	340	PF00928	0.627
LIG_FHA_1	276	282	PF00498	0.586
LIG_FHA_1	31	37	PF00498	0.660
LIG_FHA_1	379	385	PF00498	0.572
LIG_FHA_1	97	103	PF00498	0.777
LIG_FHA_2	111	117	PF00498	0.687
LIG_FHA_2	168	174	PF00498	0.771
LIG_FHA_2	184	190	PF00498	0.507
LIG_FHA_2	467	473	PF00498	0.546
LIG_LIR_Gen_1	144	155	PF02991	0.628
LIG_LIR_Gen_1	227	236	PF02991	0.644
LIG_LIR_Gen_1	334	342	PF02991	0.623
LIG_LIR_Nem_3	144	150	PF02991	0.630
LIG_LIR_Nem_3	227	232	PF02991	0.680
LIG_LIR_Nem_3	334	339	PF02991	0.625
LIG_LIR_Nem_3	350	356	PF02991	0.643
LIG_LIR_Nem_3	447	453	PF02991	0.639
LIG_LYPXL_yS_3	353	356	PF13949	0.612
LIG_MYND_1	9	13	PF01753	0.854
LIG_NRBOX	417	423	PF00104	0.603
LIG_NRBOX	51	57	PF00104	0.645
LIG_PCNA_yPIPBox_3	174	183	PF02747	0.696
LIG_Pex14_2	336	340	PF04695	0.620
LIG_Pex14_2	458	462	PF04695	0.571
LIG_PTAP_UEV_1	5	10	PF05743	0.704
LIG_SH2_CRK	229	233	PF00017	0.683
LIG_SH2_NCK_1	229	233	PF00017	0.725
LIG_SH2_STAP1	229	233	PF00017	0.625
LIG_SH3_3	15	21	PF00018	0.776
LIG_SH3_3	3	9	PF00018	0.767
LIG_SH3_3	339	345	PF00018	0.594
LIG_SH3_3	482	488	PF00018	0.623
LIG_SUMO_SIM_anti_2	47	54	PF11976	0.691
LIG_SUMO_SIM_par_1	303	309	PF11976	0.751
LIG_SUMO_SIM_par_1	47	54	PF11976	0.721
LIG_TRAF2_1	240	243	PF00917	0.683
LIG_TRAF2_1	32	35	PF00917	0.619
MOD_CK1_1	107	113	PF00069	0.716
MOD_CK1_1	115	121	PF00069	0.715
MOD_CK1_1	141	147	PF00069	0.758
MOD_CK1_1	17	23	PF00069	0.619
MOD_CK1_1	325	331	PF00069	0.699
MOD_CK1_1	393	399	PF00069	0.671
MOD_CK1_1	4	10	PF00069	0.810
MOD_CK1_1	41	47	PF00069	0.650
MOD_CK2_1	110	116	PF00069	0.708
MOD_CK2_1	183	189	PF00069	0.635
MOD_CK2_1	294	300	PF00069	0.724
MOD_CK2_1	317	323	PF00069	0.807
MOD_CK2_1	466	472	PF00069	0.532
MOD_CMANNOS	335	338	PF00535	0.623
MOD_CMANNOS	459	462	PF00535	0.581
MOD_GlcNHglycan	106	109	PF01048	0.717
MOD_GlcNHglycan	201	204	PF01048	0.736
MOD_GlcNHglycan	295	299	PF01048	0.675
MOD_GlcNHglycan	319	322	PF01048	0.816
MOD_GlcNHglycan	325	328	PF01048	0.657
MOD_GlcNHglycan	397	402	PF01048	0.697
MOD_GlcNHglycan	403	406	PF01048	0.706
MOD_GlcNHglycan	459	462	PF01048	0.539
MOD_GlcNHglycan	464	467	PF01048	0.515
MOD_GlcNHglycan	6	9	PF01048	0.816
MOD_GSK3_1	104	111	PF00069	0.696
MOD_GSK3_1	112	119	PF00069	0.715
MOD_GSK3_1	146	153	PF00069	0.712
MOD_GSK3_1	258	265	PF00069	0.758
MOD_GSK3_1	310	317	PF00069	0.684
MOD_GSK3_1	321	328	PF00069	0.646
MOD_GSK3_1	393	400	PF00069	0.658
MOD_GSK3_1	453	460	PF00069	0.685
MOD_GSK3_1	462	469	PF00069	0.570
MOD_GSK3_1	50	57	PF00069	0.740
MOD_N-GLC_1	184	189	PF02516	0.742
MOD_N-GLC_1	96	101	PF02516	0.842
MOD_NEK2_1	183	188	PF00069	0.644
MOD_NEK2_1	310	315	PF00069	0.638
MOD_NEK2_1	322	327	PF00069	0.641
MOD_NEK2_1	457	462	PF00069	0.535
MOD_NEK2_2	269	274	PF00069	0.633
MOD_NEK2_2	453	458	PF00069	0.613
MOD_PIKK_1	212	218	PF00454	0.629
MOD_PKA_1	38	44	PF00069	0.755
MOD_PKA_1	95	101	PF00069	0.653
MOD_PKA_2	11	17	PF00069	0.788
MOD_PKA_2	269	275	PF00069	0.655
MOD_PKA_2	317	323	PF00069	0.790
MOD_PKA_2	38	44	PF00069	0.755
MOD_PKA_2	95	101	PF00069	0.748
MOD_PKB_1	376	384	PF00069	0.557
MOD_PKB_1	93	101	PF00069	0.628
MOD_Plk_1	166	172	PF00069	0.550
MOD_Plk_1	183	189	PF00069	0.704
MOD_Plk_1	257	263	PF00069	0.678
MOD_Plk_1	41	47	PF00069	0.681
MOD_Plk_1	444	450	PF00069	0.608
MOD_Plk_2-3	167	173	PF00069	0.713
MOD_Plk_2-3	184	190	PF00069	0.481
MOD_Plk_4	146	152	PF00069	0.709
MOD_Plk_4	167	173	PF00069	0.615
MOD_Plk_4	263	269	PF00069	0.812
MOD_Plk_4	325	331	PF00069	0.719
MOD_Plk_4	417	423	PF00069	0.603
MOD_Plk_4	453	459	PF00069	0.566
MOD_Plk_4	51	57	PF00069	0.679
MOD_ProDKin_1	141	147	PF00069	0.674
MOD_ProDKin_1	17	23	PF00069	0.547
MOD_ProDKin_1	2	8	PF00069	0.850
MOD_ProDKin_1	204	210	PF00069	0.606
MOD_ProDKin_1	341	347	PF00069	0.682
MOD_SUMO_rev_2	20	29	PF00179	0.702
TRG_DiLeu_BaEn_1	300	305	PF01217	0.569
TRG_DiLeu_BaLyEn_6	482	487	PF01217	0.619
TRG_ENDOCYTIC_2	229	232	PF00928	0.607
TRG_ENDOCYTIC_2	233	236	PF00928	0.605
TRG_ENDOCYTIC_2	353	356	PF00928	0.612
TRG_ER_diArg_1	217	219	PF00400	0.740
TRG_ER_diArg_1	36	39	PF00400	0.650
TRG_ER_diArg_1	375	378	PF00400	0.567
TRG_ER_diArg_1	59	62	PF00400	0.603
TRG_ER_diArg_1	93	96	PF00400	0.632
TRG_NLS_MonoExtC_3	36	42	PF00514	0.691
TRG_Pf-PMV_PEXEL_1	218	222	PF00026	0.577

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSZ3	Leptomonas seymouri	49%	99%
A4HMN5	Leishmania braziliensis	70%	99%
E9AF37	Leishmania major	87%	100%
E9AHV4	Leishmania infantum	99%	100%
E9B692	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%