Putative GTPase activating protein for Arf family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative GTPase activating protein for Arf, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IHZ4_LEIDO

TriTrypDb:

LdBPK_130600.1 , LdCL_130011400 , LDHU3_13.0790

Length:

442

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0000139	Golgi membrane	5	1
GO:0016020	membrane	2	1
GO:0031090	organelle membrane	3	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IHZ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHZ4

Function

Biological processes
Term	Name	Level	Count
GO:0006901	vesicle coating	6	1
GO:0006996	organelle organization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0016050	vesicle organization	5	1
GO:0048200	Golgi transport vesicle coating	7	1
GO:0048205	COPI coating of Golgi vesicle	8	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0005096	GTPase activator activity	4	8
GO:0008047	enzyme activator activity	3	8
GO:0030234	enzyme regulator activity	2	8
GO:0030695	GTPase regulator activity	4	8
GO:0060589	nucleoside-triphosphatase regulator activity	3	8
GO:0098772	molecular function regulator activity	1	8
GO:0140677	molecular function activator activity	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	405	409	PF00656	0.680
CLV_NRD_NRD_1	252	254	PF00675	0.592
CLV_PCSK_KEX2_1	118	120	PF00082	0.446
CLV_PCSK_PC1ET2_1	118	120	PF00082	0.446
CLV_PCSK_SKI1_1	352	356	PF00082	0.655
CLV_PCSK_SKI1_1	436	440	PF00082	0.507
CLV_PCSK_SKI1_1	84	88	PF00082	0.384
CLV_PCSK_SKI1_1	94	98	PF00082	0.282
DEG_SCF_FBW7_1	170	177	PF00400	0.663
DOC_MAPK_gen_1	58	66	PF00069	0.349
DOC_MAPK_MEF2A_6	58	66	PF00069	0.349
DOC_MAPK_MEF2A_6	78	87	PF00069	0.144
DOC_MAPK_RevD_3	190	206	PF00069	0.631
DOC_PP1_RVXF_1	28	34	PF00149	0.349
DOC_PP2B_LxvP_1	7	10	PF13499	0.613
DOC_PP4_FxxP_1	33	36	PF00568	0.349
DOC_USP7_MATH_1	165	169	PF00917	0.705
DOC_USP7_MATH_1	172	176	PF00917	0.640
DOC_USP7_MATH_1	194	198	PF00917	0.607
DOC_USP7_MATH_1	393	397	PF00917	0.675
DOC_USP7_MATH_1	416	420	PF00917	0.541
DOC_USP7_UBL2_3	217	221	PF12436	0.689
DOC_USP7_UBL2_3	94	98	PF12436	0.403
DOC_WW_Pin1_4	108	113	PF00397	0.494
DOC_WW_Pin1_4	135	140	PF00397	0.624
DOC_WW_Pin1_4	145	150	PF00397	0.574
DOC_WW_Pin1_4	153	158	PF00397	0.587
DOC_WW_Pin1_4	168	173	PF00397	0.595
DOC_WW_Pin1_4	174	179	PF00397	0.655
DOC_WW_Pin1_4	182	187	PF00397	0.631
DOC_WW_Pin1_4	352	357	PF00397	0.737
LIG_BIR_II_1	1	5	PF00653	0.603
LIG_BRCT_BRCA1_1	155	159	PF00533	0.668
LIG_FHA_1	2	8	PF00498	0.704
LIG_FHA_1	202	208	PF00498	0.668
LIG_FHA_1	235	241	PF00498	0.646
LIG_FHA_1	299	305	PF00498	0.698
LIG_FHA_1	353	359	PF00498	0.659
LIG_FHA_1	426	432	PF00498	0.608
LIG_FHA_1	44	50	PF00498	0.326
LIG_FHA_2	10	16	PF00498	0.513
LIG_FHA_2	403	409	PF00498	0.678
LIG_LIR_Apic_2	107	112	PF02991	0.503
LIG_LIR_Gen_1	41	50	PF02991	0.349
LIG_LIR_Nem_3	156	162	PF02991	0.534
LIG_LIR_Nem_3	372	376	PF02991	0.603
LIG_LIR_Nem_3	41	45	PF02991	0.349
LIG_LIR_Nem_3	46	50	PF02991	0.349
LIG_MYND_1	356	360	PF01753	0.555
LIG_PDZ_Class_3	437	442	PF00595	0.520
LIG_PTB_Apo_2	375	382	PF02174	0.662
LIG_PTB_Phospho_1	375	381	PF10480	0.665
LIG_SH2_CRK	109	113	PF00017	0.447
LIG_SH2_NCK_1	109	113	PF00017	0.447
LIG_SH2_STAP1	246	250	PF00017	0.613
LIG_SH2_STAT5	109	112	PF00017	0.503
LIG_SH2_STAT5	381	384	PF00017	0.624
LIG_SH2_STAT5	387	390	PF00017	0.649
LIG_SH3_1	283	289	PF00018	0.777
LIG_SH3_2	326	331	PF14604	0.670
LIG_SH3_3	159	165	PF00018	0.575
LIG_SH3_3	283	289	PF00018	0.777
LIG_SH3_3	323	329	PF00018	0.734
LIG_SH3_3	353	359	PF00018	0.723
LIG_SUMO_SIM_anti_2	18	24	PF11976	0.397
LIG_SUMO_SIM_par_1	191	197	PF11976	0.594
LIG_TRAF2_1	12	15	PF00917	0.521
MOD_CK1_1	107	113	PF00069	0.479
MOD_CK1_1	148	154	PF00069	0.675
MOD_CK1_1	168	174	PF00069	0.648
MOD_CK1_1	185	191	PF00069	0.598
MOD_CK1_1	197	203	PF00069	0.571
MOD_CK1_1	347	353	PF00069	0.602
MOD_CK1_1	41	47	PF00069	0.349
MOD_CK2_1	9	15	PF00069	0.504
MOD_Cter_Amidation	217	220	PF01082	0.745
MOD_DYRK1A_RPxSP_1	352	356	PF00069	0.704
MOD_GlcNHglycan	135	138	PF01048	0.604
MOD_GlcNHglycan	174	177	PF01048	0.783
MOD_GlcNHglycan	209	212	PF01048	0.687
MOD_GlcNHglycan	344	347	PF01048	0.639
MOD_GlcNHglycan	352	355	PF01048	0.648
MOD_GlcNHglycan	363	366	PF01048	0.562
MOD_GlcNHglycan	389	392	PF01048	0.685
MOD_GlcNHglycan	396	399	PF01048	0.738
MOD_GlcNHglycan	422	425	PF01048	0.580
MOD_GlcNHglycan	70	73	PF01048	0.403
MOD_GSK3_1	104	111	PF00069	0.506
MOD_GSK3_1	166	173	PF00069	0.637
MOD_GSK3_1	174	181	PF00069	0.624
MOD_GSK3_1	193	200	PF00069	0.418
MOD_GSK3_1	350	357	PF00069	0.716
MOD_GSK3_1	383	390	PF00069	0.682
MOD_GSK3_1	416	423	PF00069	0.492
MOD_GSK3_1	64	71	PF00069	0.349
MOD_N-GLC_1	339	344	PF02516	0.679
MOD_NEK2_1	1	6	PF00069	0.748
MOD_NEK2_1	207	212	PF00069	0.738
MOD_NEK2_1	316	321	PF00069	0.699
MOD_NEK2_1	361	366	PF00069	0.678
MOD_NEK2_1	420	425	PF00069	0.579
MOD_PIKK_1	292	298	PF00454	0.572
MOD_PKA_2	298	304	PF00069	0.761
MOD_PKA_2	393	399	PF00069	0.670
MOD_Plk_1	126	132	PF00069	0.394
MOD_Plk_1	383	389	PF00069	0.779
MOD_Plk_4	104	110	PF00069	0.403
MOD_Plk_4	155	161	PF00069	0.655
MOD_Plk_4	276	282	PF00069	0.695
MOD_ProDKin_1	108	114	PF00069	0.487
MOD_ProDKin_1	135	141	PF00069	0.628
MOD_ProDKin_1	145	151	PF00069	0.573
MOD_ProDKin_1	153	159	PF00069	0.591
MOD_ProDKin_1	168	174	PF00069	0.592
MOD_ProDKin_1	182	188	PF00069	0.630
MOD_ProDKin_1	352	358	PF00069	0.738
MOD_SUMO_rev_2	11	19	PF00179	0.462
TRG_DiLeu_BaEn_1	15	20	PF01217	0.493
TRG_ENDOCYTIC_2	117	120	PF00928	0.447
TRG_ENDOCYTIC_2	47	50	PF00928	0.349
TRG_NLS_Bipartite_1	205	223	PF00514	0.639
TRG_NLS_MonoExtN_4	217	223	PF00514	0.628
TRG_Pf-PMV_PEXEL_1	24	28	PF00026	0.474
TRG_Pf-PMV_PEXEL_1	374	379	PF00026	0.761
TRG_Pf-PMV_PEXEL_1	418	422	PF00026	0.574

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I148	Leptomonas seymouri	61%	99%
A0A0S4JHE6	Bodo saltans	38%	100%
A1L520	Bos taurus	28%	85%
A4H760	Leishmania braziliensis	77%	100%
A4HVJ9	Leishmania infantum	100%	100%
E9AP95	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	99%
Q28CM8	Xenopus tropicalis	28%	84%
Q3MID3	Rattus norvegicus	27%	85%
Q4QG83	Leishmania major	91%	98%
Q5RAT7	Pongo abelii	27%	85%
Q8N6H7	Homo sapiens	27%	85%
Q99K28	Mus musculus	27%	85%