Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IHZ3_LEIDO

TriTrypDb:

LdBPK_350350.1 , LdCL_350008500 , LDHU3_35.0450

Length:

703

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IHZ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHZ3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	457	461	PF00656	0.764
CLV_NRD_NRD_1	258	260	PF00675	0.650
CLV_NRD_NRD_1	335	337	PF00675	0.403
CLV_NRD_NRD_1	650	652	PF00675	0.572
CLV_NRD_NRD_1	669	671	PF00675	0.468
CLV_PCSK_FUR_1	648	652	PF00082	0.593
CLV_PCSK_KEX2_1	149	151	PF00082	0.509
CLV_PCSK_KEX2_1	258	260	PF00082	0.617
CLV_PCSK_KEX2_1	335	337	PF00082	0.422
CLV_PCSK_KEX2_1	650	652	PF00082	0.501
CLV_PCSK_KEX2_1	669	671	PF00082	0.467
CLV_PCSK_PC1ET2_1	149	151	PF00082	0.496
CLV_PCSK_PC1ET2_1	669	671	PF00082	0.467
CLV_PCSK_SKI1_1	240	244	PF00082	0.374
CLV_PCSK_SKI1_1	296	300	PF00082	0.529
CLV_PCSK_SKI1_1	413	417	PF00082	0.496
CLV_PCSK_SKI1_1	558	562	PF00082	0.421
CLV_PCSK_SKI1_1	586	590	PF00082	0.559
CLV_Separin_Metazoa	53	57	PF03568	0.316
DEG_APCC_DBOX_1	239	247	PF00400	0.383
DEG_APCC_DBOX_1	262	270	PF00400	0.396
DEG_MDM2_SWIB_1	627	635	PF02201	0.478
DOC_ANK_TNKS_1	155	162	PF00023	0.548
DOC_ANK_TNKS_1	287	294	PF00023	0.503
DOC_ANK_TNKS_1	604	611	PF00023	0.359
DOC_ANK_TNKS_1	649	656	PF00023	0.569
DOC_CYCLIN_yCln2_LP_2	98	104	PF00134	0.592
DOC_MAPK_FxFP_2	551	554	PF00069	0.371
DOC_MAPK_gen_1	258	266	PF00069	0.445
DOC_MAPK_gen_1	479	488	PF00069	0.610
DOC_MAPK_gen_1	669	681	PF00069	0.405
DOC_MAPK_MEF2A_6	258	266	PF00069	0.445
DOC_MAPK_MEF2A_6	629	637	PF00069	0.365
DOC_MAPK_MEF2A_6	674	681	PF00069	0.379
DOC_MAPK_NFAT4_5	259	267	PF00069	0.425
DOC_PP2B_LxvP_1	74	77	PF13499	0.621
DOC_PP2B_LxvP_1	98	101	PF13499	0.579
DOC_PP4_FxxP_1	235	238	PF00568	0.555
DOC_PP4_FxxP_1	551	554	PF00568	0.371
DOC_USP7_MATH_1	10	14	PF00917	0.459
DOC_USP7_MATH_1	109	113	PF00917	0.522
DOC_USP7_MATH_1	126	130	PF00917	0.651
DOC_USP7_MATH_1	138	142	PF00917	0.502
DOC_USP7_MATH_1	188	192	PF00917	0.608
DOC_USP7_MATH_1	358	362	PF00917	0.571
DOC_USP7_MATH_1	516	520	PF00917	0.740
DOC_USP7_MATH_1	653	657	PF00917	0.472
DOC_USP7_UBL2_3	45	49	PF12436	0.185
DOC_WW_Pin1_4	105	110	PF00397	0.447
DOC_WW_Pin1_4	113	118	PF00397	0.504
DOC_WW_Pin1_4	179	184	PF00397	0.657
DOC_WW_Pin1_4	563	568	PF00397	0.377
LIG_14-3-3_CanoR_1	261	267	PF00244	0.503
LIG_14-3-3_CanoR_1	9	17	PF00244	0.423
LIG_Actin_WH2_2	250	265	PF00022	0.459
LIG_Actin_WH2_2	674	689	PF00022	0.522
LIG_AP2alpha_1	588	592	PF02296	0.421
LIG_APCC_ABBA_1	677	682	PF00400	0.361
LIG_BIR_II_1	1	5	PF00653	0.445
LIG_BRCT_BRCA1_1	111	115	PF00533	0.519
LIG_BRCT_BRCA1_1	140	144	PF00533	0.514
LIG_BRCT_BRCA1_1	194	198	PF00533	0.352
LIG_BRCT_BRCA1_1	309	313	PF00533	0.442
LIG_BRCT_BRCA1_1	535	539	PF00533	0.357
LIG_CaM_IQ_9	148	164	PF13499	0.516
LIG_Clathr_ClatBox_1	33	37	PF01394	0.352
LIG_deltaCOP1_diTrp_1	363	368	PF00928	0.544
LIG_FHA_1	114	120	PF00498	0.645
LIG_FHA_1	354	360	PF00498	0.552
LIG_FHA_1	368	374	PF00498	0.318
LIG_FHA_1	409	415	PF00498	0.554
LIG_FHA_1	526	532	PF00498	0.389
LIG_FHA_1	545	551	PF00498	0.306
LIG_FHA_1	567	573	PF00498	0.416
LIG_FHA_1	695	701	PF00498	0.441
LIG_FHA_2	378	384	PF00498	0.691
LIG_FHA_2	385	391	PF00498	0.583
LIG_FHA_2	623	629	PF00498	0.376
LIG_FHA_2	82	88	PF00498	0.772
LIG_IBAR_NPY_1	612	614	PF08397	0.485
LIG_LIR_Apic_2	549	554	PF02991	0.369
LIG_LIR_Gen_1	133	139	PF02991	0.489
LIG_LIR_Gen_1	200	209	PF02991	0.475
LIG_LIR_Gen_1	363	373	PF02991	0.510
LIG_LIR_Gen_1	484	491	PF02991	0.529
LIG_LIR_Gen_1	587	595	PF02991	0.473
LIG_LIR_Nem_3	14	20	PF02991	0.330
LIG_LIR_Nem_3	200	205	PF02991	0.467
LIG_LIR_Nem_3	363	368	PF02991	0.442
LIG_LIR_Nem_3	484	488	PF02991	0.590
LIG_LIR_Nem_3	555	560	PF02991	0.486
LIG_LIR_Nem_3	587	592	PF02991	0.473
LIG_LIR_Nem_3	97	102	PF02991	0.586
LIG_LYPXL_yS_3	553	556	PF13949	0.406
LIG_MLH1_MIPbox_1	194	198	PF16413	0.352
LIG_MYND_1	207	211	PF01753	0.436
LIG_PCNA_yPIPBox_3	685	698	PF02747	0.502
LIG_Pex14_1	193	197	PF04695	0.496
LIG_Pex14_1	231	235	PF04695	0.570
LIG_Pex14_2	198	202	PF04695	0.533
LIG_Pex14_2	588	592	PF04695	0.421
LIG_Pex14_2	627	631	PF04695	0.371
LIG_Pex14_2	692	696	PF04695	0.367
LIG_PTB_Apo_2	424	431	PF02174	0.381
LIG_PTB_Phospho_1	424	430	PF10480	0.381
LIG_REV1ctd_RIR_1	152	160	PF16727	0.501
LIG_SH2_NCK_1	431	435	PF00017	0.572
LIG_SH2_PTP2	614	617	PF00017	0.511
LIG_SH2_SRC	51	54	PF00017	0.297
LIG_SH2_STAP1	431	435	PF00017	0.572
LIG_SH2_STAT3	58	61	PF00017	0.543
LIG_SH2_STAT5	197	200	PF00017	0.470
LIG_SH2_STAT5	485	488	PF00017	0.522
LIG_SH2_STAT5	51	54	PF00017	0.385
LIG_SH2_STAT5	579	582	PF00017	0.266
LIG_SH2_STAT5	603	606	PF00017	0.356
LIG_SH2_STAT5	614	617	PF00017	0.367
LIG_SH2_STAT5	65	68	PF00017	0.478
LIG_SH3_3	116	122	PF00018	0.412
LIG_SH3_3	180	186	PF00018	0.747
LIG_SH3_3	397	403	PF00018	0.418
LIG_SH3_3	493	499	PF00018	0.765
LIG_SH3_3	660	666	PF00018	0.442
LIG_SH3_3	74	80	PF00018	0.677
LIG_SH3_3	98	104	PF00018	0.592
LIG_SUMO_SIM_anti_2	484	490	PF11976	0.592
LIG_SUMO_SIM_par_1	31	37	PF11976	0.371
LIG_TRFH_1	134	138	PF08558	0.385
LIG_UBA3_1	208	216	PF00899	0.585
LIG_WRC_WIRS_1	624	629	PF05994	0.471
LIG_WW_3	237	241	PF00397	0.501
MOD_CDK_SPK_2	113	118	PF00069	0.571
MOD_CK1_1	120	126	PF00069	0.670
MOD_CK1_1	191	197	PF00069	0.559
MOD_CK1_1	454	460	PF00069	0.713
MOD_CK1_1	519	525	PF00069	0.638
MOD_CK1_1	542	548	PF00069	0.501
MOD_CK1_1	563	569	PF00069	0.546
MOD_CK1_1	622	628	PF00069	0.378
MOD_CK1_1	656	662	PF00069	0.526
MOD_CK1_1	90	96	PF00069	0.694
MOD_CK2_1	212	218	PF00069	0.550
MOD_CK2_1	384	390	PF00069	0.578
MOD_CK2_1	622	628	PF00069	0.378
MOD_GlcNHglycan	1	4	PF01048	0.459
MOD_GlcNHglycan	109	112	PF01048	0.495
MOD_GlcNHglycan	127	131	PF01048	0.623
MOD_GlcNHglycan	336	339	PF01048	0.529
MOD_GlcNHglycan	360	363	PF01048	0.545
MOD_GlcNHglycan	455	459	PF01048	0.691
MOD_GlcNHglycan	544	547	PF01048	0.501
MOD_GSK3_1	105	112	PF00069	0.463
MOD_GSK3_1	113	120	PF00069	0.530
MOD_GSK3_1	126	133	PF00069	0.359
MOD_GSK3_1	184	191	PF00069	0.724
MOD_GSK3_1	303	310	PF00069	0.489
MOD_GSK3_1	330	337	PF00069	0.493
MOD_GSK3_1	363	370	PF00069	0.493
MOD_GSK3_1	521	528	PF00069	0.429
MOD_GSK3_1	535	542	PF00069	0.379
MOD_GSK3_1	619	626	PF00069	0.440
MOD_GSK3_1	65	72	PF00069	0.586
MOD_N-GLC_2	374	376	PF02516	0.596
MOD_NEK2_1	1	6	PF00069	0.497
MOD_NEK2_1	132	137	PF00069	0.487
MOD_NEK2_1	16	21	PF00069	0.268
MOD_NEK2_1	212	217	PF00069	0.571
MOD_NEK2_1	262	267	PF00069	0.494
MOD_NEK2_1	425	430	PF00069	0.425
MOD_NEK2_1	539	544	PF00069	0.381
MOD_PIKK_1	280	286	PF00454	0.541
MOD_PIKK_1	539	545	PF00454	0.497
MOD_PKA_1	558	564	PF00069	0.495
MOD_PKA_2	262	268	PF00069	0.501
MOD_PKA_2	334	340	PF00069	0.517
MOD_PKA_2	408	414	PF00069	0.527
MOD_PKA_2	87	93	PF00069	0.730
MOD_PKB_1	446	454	PF00069	0.673
MOD_Plk_1	177	183	PF00069	0.643
MOD_Plk_1	539	545	PF00069	0.497
MOD_Plk_1	622	628	PF00069	0.378
MOD_Plk_2-3	384	390	PF00069	0.545
MOD_Plk_2-3	460	466	PF00069	0.781
MOD_Plk_2-3	623	629	PF00069	0.470
MOD_Plk_4	11	17	PF00069	0.371
MOD_Plk_4	132	138	PF00069	0.427
MOD_Plk_4	188	194	PF00069	0.661
MOD_Plk_4	262	268	PF00069	0.501
MOD_Plk_4	575	581	PF00069	0.355
MOD_Plk_4	69	75	PF00069	0.683
MOD_ProDKin_1	105	111	PF00069	0.444
MOD_ProDKin_1	113	119	PF00069	0.515
MOD_ProDKin_1	179	185	PF00069	0.656
MOD_ProDKin_1	563	569	PF00069	0.371
MOD_SUMO_for_1	198	201	PF00179	0.460
TRG_AP2beta_CARGO_1	587	596	PF09066	0.255
TRG_DiLeu_BaEn_4	200	206	PF01217	0.515
TRG_DiLeu_BaLyEn_6	204	209	PF01217	0.449
TRG_DiLeu_BaLyEn_6	400	405	PF01217	0.558
TRG_ENDOCYTIC_2	134	137	PF00928	0.390
TRG_ENDOCYTIC_2	485	488	PF00928	0.522
TRG_ENDOCYTIC_2	51	54	PF00928	0.477
TRG_ENDOCYTIC_2	553	556	PF00928	0.390
TRG_ER_diArg_1	257	259	PF00400	0.503
TRG_ER_diArg_1	260	263	PF00400	0.421
TRG_ER_diArg_1	334	336	PF00400	0.495
TRG_NLS_MonoExtN_4	666	673	PF00514	0.435

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HV24	Leptomonas seymouri	63%	95%
A0A1X0NJK7	Trypanosomatidae	40%	91%
A0A3R7L3P1	Trypanosoma rangeli	47%	100%
A4HM73	Leishmania braziliensis	81%	100%
A4IAT6	Leishmania infantum	99%	100%
D0A2C2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AEL2	Leishmania major	92%	100%
E9B5S3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BSU8	Trypanosoma cruzi	46%	100%