A44l protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

a44l protein-like protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IHZ0_LEIDO

TriTrypDb:

LdBPK_366120.1 , LdCL_360068600 , LDHU3_36.8080

Length:

719

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A0A3Q8IHZ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHZ0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	18
GO:0003824	catalytic activity	1	18
GO:0005488	binding	1	18
GO:0005524	ATP binding	5	18
GO:0016462	pyrophosphatase activity	5	18
GO:0016787	hydrolase activity	2	18
GO:0016817	hydrolase activity, acting on acid anhydrides	3	18
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	18
GO:0016887	ATP hydrolysis activity	7	18
GO:0017076	purine nucleotide binding	4	18
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	18
GO:0030554	adenyl nucleotide binding	5	18
GO:0032553	ribonucleotide binding	3	18
GO:0032555	purine ribonucleotide binding	4	18
GO:0032559	adenyl ribonucleotide binding	5	18
GO:0035639	purine ribonucleoside triphosphate binding	4	18
GO:0036094	small molecule binding	2	18
GO:0043167	ion binding	2	18
GO:0043168	anion binding	3	18
GO:0097159	organic cyclic compound binding	2	18
GO:0097367	carbohydrate derivative binding	2	18
GO:1901265	nucleoside phosphate binding	3	18
GO:1901363	heterocyclic compound binding	2	18

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	180	184	PF00656	0.604
CLV_C14_Caspase3-7	460	464	PF00656	0.738
CLV_C14_Caspase3-7	628	632	PF00656	0.632
CLV_C14_Caspase3-7	695	699	PF00656	0.478
CLV_NRD_NRD_1	115	117	PF00675	0.336
CLV_NRD_NRD_1	204	206	PF00675	0.459
CLV_NRD_NRD_1	211	213	PF00675	0.420
CLV_NRD_NRD_1	228	230	PF00675	0.348
CLV_NRD_NRD_1	402	404	PF00675	0.504
CLV_NRD_NRD_1	467	469	PF00675	0.519
CLV_NRD_NRD_1	643	645	PF00675	0.355
CLV_PCSK_FUR_1	400	404	PF00082	0.538
CLV_PCSK_KEX2_1	204	206	PF00082	0.452
CLV_PCSK_KEX2_1	228	230	PF00082	0.359
CLV_PCSK_KEX2_1	322	324	PF00082	0.291
CLV_PCSK_KEX2_1	402	404	PF00082	0.508
CLV_PCSK_PC1ET2_1	322	324	PF00082	0.319
CLV_PCSK_PC7_1	318	324	PF00082	0.338
CLV_PCSK_SKI1_1	122	126	PF00082	0.466
CLV_PCSK_SKI1_1	205	209	PF00082	0.402
CLV_PCSK_SKI1_1	288	292	PF00082	0.372
CLV_PCSK_SKI1_1	375	379	PF00082	0.338
CLV_PCSK_SKI1_1	446	450	PF00082	0.537
CLV_PCSK_SKI1_1	469	473	PF00082	0.528
DEG_APCC_DBOX_1	479	487	PF00400	0.553
DEG_Nend_Nbox_1	1	3	PF02207	0.801
DEG_SCF_SKP2-CKS1_1	557	564	PF00560	0.646
DEG_SPOP_SBC_1	360	364	PF00917	0.456
DOC_CKS1_1	677	682	PF01111	0.635
DOC_CKS1_1	96	101	PF01111	0.564
DOC_CYCLIN_yClb1_LxF_4	307	312	PF00134	0.539
DOC_CYCLIN_yCln2_LP_2	165	171	PF00134	0.640
DOC_MAPK_gen_1	130	138	PF00069	0.598
DOC_MAPK_gen_1	162	171	PF00069	0.649
DOC_MAPK_gen_1	204	211	PF00069	0.656
DOC_MAPK_gen_1	517	527	PF00069	0.577
DOC_MAPK_MEF2A_6	162	171	PF00069	0.627
DOC_MAPK_MEF2A_6	204	211	PF00069	0.637
DOC_MAPK_MEF2A_6	335	342	PF00069	0.504
DOC_PP1_RVXF_1	307	313	PF00149	0.538
DOC_PP1_RVXF_1	372	379	PF00149	0.538
DOC_PP1_RVXF_1	615	621	PF00149	0.621
DOC_PP2B_LxvP_1	165	168	PF13499	0.661
DOC_PP2B_LxvP_1	2	5	PF13499	0.602
DOC_USP7_MATH_1	13	17	PF00917	0.651
DOC_USP7_MATH_1	203	207	PF00917	0.570
DOC_USP7_MATH_1	341	345	PF00917	0.584
DOC_USP7_MATH_1	392	396	PF00917	0.672
DOC_USP7_MATH_1	464	468	PF00917	0.750
DOC_USP7_MATH_1	605	609	PF00917	0.727
DOC_USP7_MATH_1	91	95	PF00917	0.557
DOC_WW_Pin1_4	213	218	PF00397	0.597
DOC_WW_Pin1_4	45	50	PF00397	0.466
DOC_WW_Pin1_4	558	563	PF00397	0.779
DOC_WW_Pin1_4	676	681	PF00397	0.562
DOC_WW_Pin1_4	71	76	PF00397	0.531
DOC_WW_Pin1_4	95	100	PF00397	0.568
LIG_14-3-3_CanoR_1	130	135	PF00244	0.607
LIG_14-3-3_CanoR_1	15	19	PF00244	0.624
LIG_14-3-3_CanoR_1	204	208	PF00244	0.660
LIG_14-3-3_CanoR_1	391	401	PF00244	0.647
LIG_14-3-3_CanoR_1	468	472	PF00244	0.781
LIG_14-3-3_CanoR_1	480	490	PF00244	0.627
LIG_14-3-3_CanoR_1	520	529	PF00244	0.569
LIG_14-3-3_CanoR_1	669	675	PF00244	0.665
LIG_14-3-3_CanoR_1	705	714	PF00244	0.599
LIG_Actin_WH2_2	2	17	PF00022	0.715
LIG_APCC_ABBA_1	158	163	PF00400	0.593
LIG_BIR_III_4	463	467	PF00653	0.670
LIG_BRCT_BRCA1_1	672	676	PF00533	0.620
LIG_FHA_1	106	112	PF00498	0.627
LIG_FHA_1	442	448	PF00498	0.663
LIG_FHA_1	520	526	PF00498	0.649
LIG_FHA_1	53	59	PF00498	0.330
LIG_FHA_1	96	102	PF00498	0.611
LIG_FHA_2	123	129	PF00498	0.647
LIG_FHA_2	178	184	PF00498	0.529
LIG_FHA_2	344	350	PF00498	0.468
LIG_FHA_2	383	389	PF00498	0.544
LIG_FHA_2	474	480	PF00498	0.692
LIG_FHA_2	609	615	PF00498	0.645
LIG_Integrin_RGD_1	347	349	PF01839	0.256
LIG_LIR_Apic_2	140	145	PF02991	0.659
LIG_LIR_Apic_2	93	99	PF02991	0.572
LIG_LIR_Gen_1	206	214	PF02991	0.559
LIG_LIR_Gen_1	365	376	PF02991	0.512
LIG_LIR_Gen_1	528	536	PF02991	0.549
LIG_LIR_Gen_1	673	680	PF02991	0.623
LIG_LIR_Nem_3	149	154	PF02991	0.774
LIG_LIR_Nem_3	206	211	PF02991	0.543
LIG_LIR_Nem_3	349	355	PF02991	0.442
LIG_LIR_Nem_3	365	371	PF02991	0.445
LIG_LIR_Nem_3	45	50	PF02991	0.498
LIG_LIR_Nem_3	528	532	PF02991	0.496
LIG_LIR_Nem_3	673	677	PF02991	0.601
LIG_LIR_Nem_3	94	100	PF02991	0.627
LIG_NRBOX	309	315	PF00104	0.443
LIG_NRBOX	482	488	PF00104	0.582
LIG_PCNA_PIPBox_1	135	144	PF02747	0.538
LIG_PTB_Apo_2	128	135	PF02174	0.633
LIG_RPA_C_Fungi	17	29	PF08784	0.484
LIG_SH2_CRK	142	146	PF00017	0.598
LIG_SH2_CRK	674	678	PF00017	0.524
LIG_SH2_NCK_1	142	146	PF00017	0.591
LIG_SH2_PTP2	529	532	PF00017	0.363
LIG_SH2_SRC	100	103	PF00017	0.549
LIG_SH2_STAT5	238	241	PF00017	0.417
LIG_SH2_STAT5	243	246	PF00017	0.433
LIG_SH2_STAT5	254	257	PF00017	0.364
LIG_SH2_STAT5	356	359	PF00017	0.384
LIG_SH2_STAT5	529	532	PF00017	0.346
LIG_SH2_STAT5	703	706	PF00017	0.402
LIG_SH2_STAT5	83	86	PF00017	0.563
LIG_SH2_STAT5	97	100	PF00017	0.518
LIG_SH3_1	96	102	PF00018	0.439
LIG_SH3_2	75	80	PF14604	0.401
LIG_SH3_3	151	157	PF00018	0.562
LIG_SH3_3	166	172	PF00018	0.457
LIG_SH3_3	265	271	PF00018	0.542
LIG_SH3_3	276	282	PF00018	0.469
LIG_SH3_3	335	341	PF00018	0.471
LIG_SH3_3	398	404	PF00018	0.522
LIG_SH3_3	559	565	PF00018	0.706
LIG_SH3_3	72	78	PF00018	0.546
LIG_SH3_3	96	102	PF00018	0.484
LIG_SH3_4	429	436	PF00018	0.570
LIG_SUMO_SIM_anti_2	495	504	PF11976	0.400
LIG_SUMO_SIM_anti_2	53	58	PF11976	0.346
LIG_SUMO_SIM_par_1	137	143	PF11976	0.469
LIG_SUMO_SIM_par_1	500	506	PF11976	0.438
LIG_SUMO_SIM_par_1	587	594	PF11976	0.526
LIG_TRAF2_1	364	367	PF00917	0.475
LIG_TRAF2_1	440	443	PF00917	0.763
LIG_TRAF2_1	656	659	PF00917	0.452
LIG_UBA3_1	110	117	PF00899	0.397
LIG_UBA3_1	135	144	PF00899	0.451
LIG_WRC_WIRS_1	342	347	PF05994	0.405
MOD_CDK_SPxK_1	558	564	PF00069	0.574
MOD_CK1_1	140	146	PF00069	0.584
MOD_CK1_1	343	349	PF00069	0.314
MOD_CK1_1	359	365	PF00069	0.202
MOD_CK1_1	419	425	PF00069	0.608
MOD_CK1_1	437	443	PF00069	0.652
MOD_CK1_1	45	51	PF00069	0.527
MOD_CK1_1	467	473	PF00069	0.773
MOD_CK1_1	482	488	PF00069	0.447
MOD_CK1_1	577	583	PF00069	0.711
MOD_CK1_1	608	614	PF00069	0.531
MOD_CK2_1	122	128	PF00069	0.545
MOD_CK2_1	13	19	PF00069	0.655
MOD_CK2_1	143	149	PF00069	0.533
MOD_CK2_1	360	366	PF00069	0.446
MOD_CK2_1	437	443	PF00069	0.744
MOD_Cter_Amidation	320	323	PF01082	0.405
MOD_GlcNHglycan	10	13	PF01048	0.639
MOD_GlcNHglycan	200	203	PF01048	0.672
MOD_GlcNHglycan	418	421	PF01048	0.695
MOD_GlcNHglycan	575	579	PF01048	0.725
MOD_GlcNHglycan	625	628	PF01048	0.623
MOD_GlcNHglycan	700	703	PF01048	0.456
MOD_GlcNHglycan	709	712	PF01048	0.580
MOD_GlcNHglycan	93	96	PF01048	0.602
MOD_GSK3_1	14	21	PF00069	0.695
MOD_GSK3_1	189	196	PF00069	0.551
MOD_GSK3_1	317	324	PF00069	0.272
MOD_GSK3_1	356	363	PF00069	0.310
MOD_GSK3_1	405	412	PF00069	0.639
MOD_GSK3_1	437	444	PF00069	0.757
MOD_GSK3_1	550	557	PF00069	0.734
MOD_GSK3_1	563	570	PF00069	0.670
MOD_GSK3_1	91	98	PF00069	0.535
MOD_N-GLC_1	130	135	PF02516	0.511
MOD_N-GLC_1	705	710	PF02516	0.545
MOD_NEK2_1	176	181	PF00069	0.388
MOD_NEK2_1	18	23	PF00069	0.573
MOD_NEK2_1	264	269	PF00069	0.416
MOD_NEK2_1	370	375	PF00069	0.506
MOD_NEK2_1	481	486	PF00069	0.510
MOD_NEK2_1	52	57	PF00069	0.538
MOD_NEK2_1	574	579	PF00069	0.723
MOD_NEK2_1	625	630	PF00069	0.681
MOD_NEK2_2	203	208	PF00069	0.447
MOD_PIKK_1	409	415	PF00454	0.762
MOD_PIKK_1	429	435	PF00454	0.709
MOD_PIKK_1	660	666	PF00454	0.471
MOD_PKA_2	14	20	PF00069	0.521
MOD_PKA_2	203	209	PF00069	0.542
MOD_PKA_2	317	323	PF00069	0.387
MOD_PKA_2	392	398	PF00069	0.644
MOD_PKA_2	467	473	PF00069	0.703
MOD_PKA_2	479	485	PF00069	0.504
MOD_PKA_2	519	525	PF00069	0.472
MOD_PKA_2	605	611	PF00069	0.751
MOD_PKA_2	670	676	PF00069	0.559
MOD_Plk_1	130	136	PF00069	0.516
MOD_Plk_1	52	58	PF00069	0.384
MOD_Plk_4	130	136	PF00069	0.479
MOD_Plk_4	137	143	PF00069	0.469
MOD_Plk_4	275	281	PF00069	0.438
MOD_Plk_4	286	292	PF00069	0.420
MOD_Plk_4	356	362	PF00069	0.268
MOD_Plk_4	467	473	PF00069	0.572
MOD_Plk_4	482	488	PF00069	0.404
MOD_Plk_4	52	58	PF00069	0.401
MOD_ProDKin_1	213	219	PF00069	0.485
MOD_ProDKin_1	45	51	PF00069	0.585
MOD_ProDKin_1	558	564	PF00069	0.742
MOD_ProDKin_1	676	682	PF00069	0.440
MOD_ProDKin_1	71	77	PF00069	0.394
MOD_ProDKin_1	95	101	PF00069	0.443
TRG_DiLeu_BaEn_1	19	24	PF01217	0.489
TRG_DiLeu_BaEn_1	366	371	PF01217	0.413
TRG_DiLeu_BaEn_1	531	536	PF01217	0.530
TRG_DiLeu_BaEn_2	154	160	PF01217	0.486
TRG_DiLeu_BaEn_4	366	372	PF01217	0.290
TRG_DiLeu_LyEn_5	19	24	PF01217	0.489
TRG_ENDOCYTIC_2	151	154	PF00928	0.551
TRG_ENDOCYTIC_2	47	50	PF00928	0.588
TRG_ENDOCYTIC_2	529	532	PF00928	0.427
TRG_ENDOCYTIC_2	571	574	PF00928	0.610
TRG_ENDOCYTIC_2	674	677	PF00928	0.536
TRG_ENDOCYTIC_2	85	88	PF00928	0.579
TRG_ER_diArg_1	209	212	PF00400	0.544
TRG_ER_diArg_1	227	229	PF00400	0.441
TRG_ER_diArg_1	390	393	PF00400	0.494
TRG_ER_diArg_1	399	402	PF00400	0.638
TRG_Pf-PMV_PEXEL_1	116	120	PF00026	0.465

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P906	Leptomonas seymouri	46%	98%
A0A1X0NTT2	Trypanosomatidae	33%	100%
A0A3Q8IC80	Leishmania donovani	28%	97%
A0A3Q8IC95	Leishmania donovani	28%	100%
A0A422NUH1	Trypanosoma rangeli	30%	100%
A4HCE5	Leishmania braziliensis	28%	96%
A4HZW7	Leishmania infantum	28%	100%
A4IDZ9	Leishmania infantum	100%	100%
C9ZSJ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AU21	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
E9AVS5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AVS6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	98%
Q4Q0H4	Leishmania major	90%	100%
Q4QBQ3	Leishmania major	29%	100%
Q4QBQ4	Leishmania major	29%	100%
V5DMJ8	Trypanosoma cruzi	30%	100%