Serine/threonine-protein phosphatase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine/threonine protein phosphatase catalytic subunit, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IHY7_LEIDO

TriTrypDb:

LdBPK_280730.1 , LdCL_340013700 , LDHU3_34.1330

Length:

254

Annotations

LeishMANIAdb annotations

A large collection of various protein phosphatases. Very highly expanded in kinetoplastids.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 60

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 28

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 25
NetGPI	no	yes: 0, no: 25

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	4
GO:0005737	cytoplasm	2	4
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0043229	intracellular organelle	3	4
GO:0043231	intracellular membrane-bounded organelle	4	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A0A3Q8IHY7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHY7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	26
GO:0004721	phosphoprotein phosphatase activity	3	26
GO:0004722	protein serine/threonine phosphatase activity	4	26
GO:0016787	hydrolase activity	2	26
GO:0016788	hydrolase activity, acting on ester bonds	3	26
GO:0016791	phosphatase activity	5	26
GO:0017018	myosin phosphatase activity	5	26
GO:0042578	phosphoric ester hydrolase activity	4	26
GO:0140096	catalytic activity, acting on a protein	2	26
GO:0005488	binding	1	23
GO:0043167	ion binding	2	23
GO:0043169	cation binding	3	23
GO:0046872	metal ion binding	4	23

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	96	98	PF00675	0.292
CLV_PCSK_KEX2_1	95	97	PF00082	0.292
CLV_PCSK_PC1ET2_1	95	97	PF00082	0.292
CLV_PCSK_SKI1_1	101	105	PF00082	0.294
CLV_PCSK_SKI1_1	152	156	PF00082	0.305
CLV_PCSK_SKI1_1	168	172	PF00082	0.251
CLV_Separin_Metazoa	142	146	PF03568	0.238
DEG_APCC_DBOX_1	151	159	PF00400	0.403
DOC_MAPK_gen_1	95	102	PF00069	0.292
DOC_PP2B_LxvP_1	248	251	PF13499	0.550
DOC_PP4_FxxP_1	221	224	PF00568	0.518
DOC_WW_Pin1_4	128	133	PF00397	0.312
LIG_14-3-3_CanoR_1	175	180	PF00244	0.291
LIG_14-3-3_CanoR_1	215	221	PF00244	0.614
LIG_14-3-3_CanoR_1	50	56	PF00244	0.282
LIG_AP2alpha_1	106	110	PF02296	0.292
LIG_BIR_II_1	1	5	PF00653	0.392
LIG_BRCT_BRCA1_1	177	181	PF00533	0.291
LIG_FHA_1	110	116	PF00498	0.292
LIG_FHA_1	55	61	PF00498	0.290
LIG_FHA_2	236	242	PF00498	0.444
LIG_LIR_Apic_2	157	163	PF02991	0.292
LIG_LIR_Apic_2	219	224	PF02991	0.517
LIG_LIR_Gen_1	107	118	PF02991	0.292
LIG_LIR_Gen_1	188	197	PF02991	0.293
LIG_LIR_Gen_1	246	253	PF02991	0.528
LIG_LIR_Gen_1	39	48	PF02991	0.296
LIG_LIR_Nem_3	246	250	PF02991	0.528
LIG_LIR_Nem_3	39	44	PF02991	0.296
LIG_LIR_Nem_3	70	75	PF02991	0.292
LIG_NRBOX	154	160	PF00104	0.292
LIG_Pex14_2	106	110	PF04695	0.292
LIG_PTB_Apo_2	37	44	PF02174	0.308
LIG_REV1ctd_RIR_1	209	219	PF16727	0.506
LIG_REV1ctd_RIR_1	70	80	PF16727	0.292
LIG_SH2_CRK	24	28	PF00017	0.328
LIG_SH2_CRK	64	68	PF00017	0.292
LIG_SH2_GRB2like	38	41	PF00017	0.308
LIG_SH2_STAP1	209	213	PF00017	0.430
LIG_SH2_STAP1	38	42	PF00017	0.308
LIG_SH2_STAT5	179	182	PF00017	0.291
LIG_SH2_STAT5	226	229	PF00017	0.514
LIG_SH2_STAT5	41	44	PF00017	0.292
LIG_SH2_STAT5	47	50	PF00017	0.297
LIG_SUMO_SIM_anti_2	194	199	PF11976	0.155
LIG_SUMO_SIM_par_1	191	196	PF11976	0.148
LIG_SUMO_SIM_par_1	216	222	PF11976	0.506
LIG_UBA3_1	26	32	PF00899	0.328
MOD_CK1_1	54	60	PF00069	0.297
MOD_GlcNHglycan	221	224	PF01048	0.519
MOD_GSK3_1	128	135	PF00069	0.291
MOD_N-GLC_2	225	227	PF02516	0.520
MOD_NEK2_1	211	216	PF00069	0.571
MOD_NEK2_1	243	248	PF00069	0.509
MOD_Plk_1	135	141	PF00069	0.298
MOD_Plk_4	175	181	PF00069	0.291
MOD_Plk_4	216	222	PF00069	0.506
MOD_Plk_4	243	249	PF00069	0.524
MOD_Plk_4	54	60	PF00069	0.419
MOD_ProDKin_1	128	134	PF00069	0.312
TRG_DiLeu_BaEn_1	70	75	PF01217	0.382
TRG_DiLeu_BaEn_2	165	171	PF01217	0.226
TRG_ENDOCYTIC_2	209	212	PF00928	0.508
TRG_ENDOCYTIC_2	23	26	PF00928	0.308
TRG_ENDOCYTIC_2	41	44	PF00928	0.292
TRG_ENDOCYTIC_2	64	67	PF00928	0.312
TRG_ENDOCYTIC_2	88	91	PF00928	0.292
TRG_ER_diArg_1	96	98	PF00400	0.292
TRG_NES_CRM1_1	183	196	PF08389	0.291

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7S7	Leptomonas seymouri	64%	84%
A0A0N1HSR2	Leptomonas seymouri	45%	68%
A0A0N1IBK9	Leptomonas seymouri	43%	82%
A0A0N1P9X9	Leptomonas seymouri	43%	83%
A0A0N1PAV9	Leptomonas seymouri	62%	70%
A0A0N1PCC5	Leptomonas seymouri	41%	82%
A0A0N1PDK9	Leptomonas seymouri	45%	80%
A0A0S4ILF8	Bodo saltans	44%	84%
A0A0S4JJ52	Bodo saltans	64%	67%
A0A0S4JJ96	Bodo saltans	55%	81%
A0A0S4JJH3	Bodo saltans	89%	81%
A0A0S4KGD7	Bodo saltans	46%	86%
A0A0S4KKU2	Bodo saltans	44%	83%
A0A1X0NK88	Trypanosomatidae	64%	74%
A0A1X0NNN6	Trypanosomatidae	45%	76%
A0A1X0NS37	Trypanosomatidae	42%	92%
A0A1X0NS65	Trypanosomatidae	44%	84%
A0A1X0NYR5	Trypanosomatidae	64%	84%
A0A1X0P6J3	Trypanosomatidae	38%	67%
A0A1X0P982	Trypanosomatidae	57%	77%
A0A1X0PA67	Trypanosomatidae	88%	86%
A0A1X0PAK9	Trypanosomatidae	91%	86%
A0A1X0PBJ2	Trypanosomatidae	37%	83%
A0A3Q8IFB2	Leishmania donovani	92%	100%
A0A3Q8IH18	Leishmania donovani	44%	100%
A0A3R7KQR6	Trypanosoma rangeli	46%	75%
A0A3R7MFZ7	Trypanosoma rangeli	56%	77%
A0A3R7N275	Trypanosoma rangeli	64%	84%
A0A3R7NP99	Trypanosoma rangeli	38%	83%
A0A3S5H6T9	Leishmania donovani	45%	68%
A0A3S5H7Q6	Leishmania donovani	63%	100%
A0A3S7WZ39	Leishmania donovani	44%	80%
A0A3S7X190	Leishmania donovani	64%	84%
A0A3S7X1Y0	Leishmania donovani	43%	83%
A0A3S7X7I6	Leishmania donovani	93%	84%
A0A3S7X7J8	Leishmania donovani	57%	86%
A0A3S7X7K2	Leishmania donovani	99%	84%
A0A3S7X8K6	Leishmania donovani	41%	82%
A0A422N8P1	Trypanosoma rangeli	88%	89%
A0A422NKG0	Trypanosoma rangeli	41%	83%
A0A422NPG1	Trypanosoma rangeli	65%	73%
A0A422NYN7	Trypanosoma rangeli	44%	84%
A0C1E4	Paramecium tetraurelia	46%	83%
A0CCD2	Paramecium tetraurelia	46%	83%
A0CNL9	Paramecium tetraurelia	44%	81%
A0DJ90	Paramecium tetraurelia	42%	84%
A2X2G3	Oryza sativa subsp. indica	45%	83%
A2XN40	Oryza sativa subsp. indica	42%	83%
A2YEB4	Oryza sativa subsp. indica	44%	83%
A3C4N5	Oryza sativa subsp. japonica	41%	81%
A4H7Z3	Leishmania braziliensis	45%	100%
A4HAI7	Leishmania braziliensis	92%	100%
A4HAI8	Leishmania braziliensis	96%	100%
A4HAI9	Leishmania braziliensis	91%	100%
A4HAJ8	Leishmania braziliensis	56%	100%
A4HBE2	Leishmania braziliensis	41%	100%
A4HE75	Leishmania braziliensis	41%	100%
A4HGA9	Leishmania braziliensis	64%	100%
A4HGX0	Leishmania braziliensis	43%	100%
A4HJQ1	Leishmania braziliensis	63%	100%
A4HKU9	Leishmania braziliensis	44%	100%
A4HWC1	Leishmania infantum	45%	100%
A4I1H6	Leishmania infantum	44%	100%
A4I3E3	Leishmania infantum	64%	100%
A4I400	Leishmania infantum	43%	100%
A4I768	Leishmania infantum	63%	100%
A4I8C8	Leishmania infantum	44%	100%
A4I9P2	Leishmania infantum	57%	100%
A4IAJ0	Leishmania infantum	41%	100%
A6H772	Bos taurus	46%	83%
A8WGP3	Danio rerio	46%	82%
A8XE00	Caenorhabditis briggsae	46%	76%
A9JRC7	Danio rerio	46%	83%
C9ZJZ6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	79%
C9ZMF3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	73%
C9ZN02	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	78%
C9ZN04	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
C9ZN06	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	86%	86%
C9ZWN3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	73%
D0A805	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	84%
D0A970	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	83%
D0AAU4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	84%
E9AHS8	Leishmania infantum	98%	100%
E9AHS9	Leishmania infantum	98%	100%
E9AHT0	Leishmania infantum	92%	100%
E9AHT1	Leishmania infantum	93%	100%
E9AQ21	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E9AXL1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9AZN0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	100%
E9B090	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9B262	Leishmania mexicana (strain MHOM/GT/2001/U1103)	63%	100%
E9B387	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9B4P8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9B4P9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
E9B4Q0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9B4Q1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9B4Q6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	57%	100%
E9B5L4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
G5EGK8	Caenorhabditis elegans	48%	80%
O00743	Homo sapiens	44%	83%
O02658	Caenorhabditis elegans	59%	83%
O04856	Nicotiana tabacum	66%	80%
O04857	Nicotiana tabacum	66%	82%
O04858	Nicotiana tabacum	63%	84%
O04860	Nicotiana tabacum	44%	81%
O04951	Arabidopsis thaliana	45%	83%
O15757	Dictyostelium discoideum	66%	79%
O74789	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	73%
O76932	Drosophila melanogaster	45%	83%
O82733	Arabidopsis thaliana	64%	77%
O82734	Arabidopsis thaliana	62%	78%
P0C5D7	Oryza sativa subsp. indica	41%	81%
P11084	Oryctolagus cuniculus	46%	83%
P11493	Sus scrofa	48%	87%
P11611	Oryctolagus cuniculus	48%	82%
P11612	Drosophila melanogaster	63%	81%
P12982	Drosophila melanogaster	66%	84%
P13681	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	65%	78%
P20604	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	42%	82%
P20654	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	65%	79%
P22198	Zea mays	65%	80%
P23594	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	44%	69%
P23595	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	45%	67%
P23635	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	46%	82%
P23636	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	44%	79%
P23696	Drosophila melanogaster	47%	82%
P23733	Trypanosoma brucei brucei	62%	73%
P23734	Trypanosoma brucei brucei	64%	73%
P23777	Brassica napus	61%	100%
P23778	Brassica napus	43%	82%
P23880	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	67%	79%
P30366	Arabidopsis thaliana	64%	80%
P32345	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	45%	82%
P32598	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	65%	81%
P32838	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	41%	69%
P34350	Caenorhabditis elegans	32%	67%
P34430	Caenorhabditis elegans	33%	100%
P36614	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	44%	83%
P36873	Homo sapiens	67%	79%
P36874	Xenopus laevis	67%	79%
P48458	Caenorhabditis elegans	50%	70%
P48461	Drosophila melanogaster	66%	78%
P48462	Drosophila melanogaster	66%	77%
P48463	Gallus gallus	48%	82%
P48480	Acetabularia peniculus	67%	80%
P48481	Acetabularia peniculus	67%	80%
P48482	Arabidopsis thaliana	66%	81%
P48483	Arabidopsis thaliana	65%	79%
P48484	Arabidopsis thaliana	64%	79%
P48485	Arabidopsis thaliana	67%	81%
P48486	Arabidopsis thaliana	65%	79%
P48487	Brassica oleracea	64%	80%
P48488	Medicago sativa subsp. varia	65%	79%
P48489	Oryza sativa subsp. japonica	66%	79%
P48490	Phaseolus vulgaris	63%	81%
P48528	Arabidopsis thaliana	45%	83%
P48529	Arabidopsis thaliana	45%	83%
P48577	Acetabularia peniculus	45%	83%
P48578	Arabidopsis thaliana	42%	81%
P48579	Helianthus annuus	46%	83%
P48580	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	47%	78%
P48726	Paramecium tetraurelia	44%	81%
P48727	Caenorhabditis elegans	68%	76%
P49576	Paramecium tetraurelia	42%	84%
P60510	Homo sapiens	46%	83%
P61287	Bos taurus	67%	79%
P61292	Sus scrofa	65%	78%
P62136	Homo sapiens	67%	77%
P62137	Mus musculus	67%	77%
P62138	Rattus norvegicus	67%	77%
P62139	Oryctolagus cuniculus	67%	77%
P62140	Homo sapiens	65%	78%
P62141	Mus musculus	65%	78%
P62142	Rattus norvegicus	65%	78%
P62143	Oryctolagus cuniculus	65%	78%
P62207	Gallus gallus	65%	78%
P62714	Homo sapiens	48%	82%
P62715	Mus musculus	48%	82%
P62716	Rattus norvegicus	48%	82%
P63087	Mus musculus	67%	79%
P63088	Rattus norvegicus	67%	79%
P63330	Mus musculus	47%	82%
P63331	Rattus norvegicus	47%	82%
P67774	Bos taurus	47%	82%
P67775	Homo sapiens	47%	82%
P67776	Sus scrofa	47%	82%
P67777	Oryctolagus cuniculus	47%	82%
P91420	Caenorhabditis elegans	59%	83%
P97470	Mus musculus	46%	83%
Q05547	Drosophila melanogaster	66%	84%
Q06009	Medicago sativa	43%	81%
Q07098	Arabidopsis thaliana	45%	83%
Q07099	Arabidopsis thaliana	46%	83%
Q07100	Arabidopsis thaliana	43%	81%
Q09496	Caenorhabditis elegans	42%	77%
Q0DBD3	Oryza sativa subsp. japonica	44%	83%
Q0E2S4	Oryza sativa subsp. japonica	45%	83%
Q0P594	Bos taurus	48%	82%
Q10298	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	43%	83%
Q10BT5	Oryza sativa subsp. japonica	42%	83%
Q27497	Caenorhabditis elegans	65%	77%
Q27884	Drosophila melanogaster	41%	84%
Q3SWW9	Bos taurus	65%	78%
Q3T0E7	Bos taurus	67%	77%
Q4Q2C2	Leishmania major	41%	100%
Q4Q3C0	Leishmania major	57%	100%
Q4Q3C5	Leishmania major	91%	100%
Q4Q3C6	Leishmania major	93%	100%
Q4Q3C7	Leishmania major	99%	100%
Q4Q3C8	Leishmania major	92%	100%
Q4Q4W8	Leishmania major	44%	100%
Q4Q5Z8	Leishmania major	63%	100%
Q4Q7Z5	Leishmania major	43%	100%
Q4Q8K1	Leishmania major	64%	100%
Q4Q9W1	Leishmania major	44%	100%
Q4QFG0	Leishmania major	45%	100%
Q54RD6	Dictyostelium discoideum	45%	81%
Q59KY8	Candida albicans (strain SC5314 / ATCC MYA-2876)	40%	81%
Q5BJ92	Rattus norvegicus	46%	83%
Q5I085	Xenopus tropicalis	65%	78%
Q5R6K8	Pongo abelii	46%	83%
Q5R740	Pongo abelii	65%	78%
Q61JR3	Caenorhabditis briggsae	65%	77%
Q627N3	Caenorhabditis briggsae	68%	76%
Q64620	Rattus norvegicus	44%	83%
Q6BFF6	Paramecium tetraurelia	44%	81%
Q6CNT6	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	44%	82%
Q6FM81	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	45%	82%
Q6GQL2	Xenopus laevis	65%	78%
Q6IP91	Xenopus laevis	46%	83%
Q6NVU2	Xenopus tropicalis	67%	79%
Q6P861	Xenopus tropicalis	46%	83%
Q74ZR2	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	44%	82%
Q7SZ10	Xenopus laevis	67%	79%
Q8LSN3	Pisum sativum	41%	84%
Q8MJ46	Canis lupus familiaris	67%	79%
Q8MJ47	Canis lupus familiaris	65%	78%
Q8WMS6	Canis lupus familiaris	67%	77%
Q8X178	Blumeria hordei	46%	77%
Q9CQR6	Mus musculus	44%	83%
Q9HFQ2	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	47%	77%
Q9LHE7	Arabidopsis thaliana	42%	84%
Q9M9W3	Arabidopsis thaliana	62%	80%
Q9SX52	Arabidopsis thaliana	41%	84%
Q9U9A3	Dictyostelium discoideum	42%	83%
Q9UW86	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	65%	82%
Q9XGH7	Nicotiana tabacum	42%	81%
Q9XTT8	Caenorhabditis elegans	46%	79%
Q9XW79	Caenorhabditis elegans	46%	76%
Q9XZE5	Dictyostelium discoideum	46%	83%
Q9Y0B7	Dictyostelium discoideum	43%	83%
Q9ZSE4	Hevea brasiliensis	46%	83%
V5AUW3	Trypanosoma cruzi	55%	77%
V5B3V2	Trypanosoma cruzi	39%	66%
V5B5K9	Trypanosoma cruzi	43%	76%
V5B8G5	Trypanosoma cruzi	46%	75%
V5BKU4	Trypanosoma cruzi	65%	84%
V5D2G9	Trypanosoma cruzi	65%	72%
V5DAX7	Trypanosoma cruzi	88%	100%
V5DCW3	Trypanosoma cruzi	42%	83%
V5DMS5	Trypanosoma cruzi	39%	83%