Serine/threonine-protein phosphatase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine/threonine protein phosphatase catalytic subunit, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IHY7_LEIDO

TriTrypDb:

LdBPK_280730.1 , LdCL_340013700 , LDHU3_34.1330

Length:

254

Annotations

LeishMANIAdb annotations

A large collection of various protein phosphatases. Very highly expanded in kinetoplastids.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 60

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 28

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 25
NetGPI	no	yes: 0, no: 25

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	4
GO:0005737	cytoplasm	2	4
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0043229	intracellular organelle	3	4
GO:0043231	intracellular membrane-bounded organelle	4	4
GO:0110165	cellular anatomical entity	1	4

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Expansion

Sequence features

A0A3Q8IHY7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHY7

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	26
GO:0004721	phosphoprotein phosphatase activity	3	26
GO:0004722	protein serine/threonine phosphatase activity	4	26
GO:0005488	binding	1	23
GO:0016787	hydrolase activity	2	26
GO:0016788	hydrolase activity, acting on ester bonds	3	26
GO:0016791	phosphatase activity	5	26
GO:0017018	myosin phosphatase activity	5	26
GO:0042578	phosphoric ester hydrolase activity	4	26
GO:0043167	ion binding	2	23

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	96	98	PF00675	0.292
CLV_PCSK_KEX2_1	95	97	PF00082	0.292
CLV_PCSK_PC1ET2_1	95	97	PF00082	0.292
CLV_PCSK_SKI1_1	101	105	PF00082	0.294
CLV_PCSK_SKI1_1	152	156	PF00082	0.305
CLV_PCSK_SKI1_1	168	172	PF00082	0.251
CLV_Separin_Metazoa	142	146	PF03568	0.238
DEG_APCC_DBOX_1	151	159	PF00400	0.403
DOC_MAPK_gen_1	95	102	PF00069	0.292
DOC_PP2B_LxvP_1	248	251	PF13499	0.550

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7S7	Leptomonas seymouri	64%	84%
A0A0N1HSR2	Leptomonas seymouri	45%	68%
A0A0N1IBK9	Leptomonas seymouri	43%	82%
A0A0N1P9X9	Leptomonas seymouri	43%	83%
A0A0N1PAV9	Leptomonas seymouri	62%	70%
A0A0N1PCC5	Leptomonas seymouri	41%	82%
A0A0N1PDK9	Leptomonas seymouri	45%	80%
A0A0S4ILF8	Bodo saltans	44%	84%
A0A0S4JJ52	Bodo saltans	64%	67%
A0A0S4JJ96	Bodo saltans	55%	81%

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