Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IHY4_LEIDO

TriTrypDb:

LdBPK_130430.1 , LdCL_130009700 , LDHU3_13.0600

Length:

198

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	7
GO:0016020	membrane	2	6

Expansion

Sequence features

A0A3Q8IHY4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHY4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	70	74	PF00656	0.566
CLV_NRD_NRD_1	180	182	PF00675	0.558
CLV_NRD_NRD_1	54	56	PF00675	0.385
CLV_PCSK_FUR_1	45	49	PF00082	0.403
CLV_PCSK_KEX2_1	178	180	PF00082	0.433
CLV_PCSK_KEX2_1	47	49	PF00082	0.381
CLV_PCSK_KEX2_1	53	55	PF00082	0.376
CLV_PCSK_PC1ET2_1	178	180	PF00082	0.440
CLV_PCSK_PC1ET2_1	47	49	PF00082	0.379
CLV_PCSK_SKI1_1	128	132	PF00082	0.433
CLV_PCSK_SKI1_1	33	37	PF00082	0.399
CLV_PCSK_SKI1_1	86	90	PF00082	0.421
DEG_APCC_DBOX_1	127	135	PF00400	0.336
DEG_CRL4_CDT2_1	38	49	PF00400	0.621
DEG_CRL4_CDT2_2	38	49	PF00400	0.621
DEG_Nend_UBRbox_3	1	3	PF02207	0.651
DOC_CKS1_1	1	6	PF01111	0.750
DOC_CYCLIN_yCln2_LP_2	129	135	PF00134	0.431
DOC_MAPK_DCC_7	128	136	PF00069	0.336
DOC_MAPK_gen_1	45	52	PF00069	0.657
DOC_MAPK_MEF2A_6	128	136	PF00069	0.336
DOC_PP2B_LxvP_1	129	132	PF13499	0.431
DOC_USP7_MATH_1	35	39	PF00917	0.629
DOC_USP7_MATH_1	67	71	PF00917	0.743
DOC_USP7_MATH_1	7	11	PF00917	0.674
DOC_USP7_MATH_1	82	86	PF00917	0.612
DOC_USP7_UBL2_3	178	182	PF12436	0.747
DOC_WW_Pin1_4	188	193	PF00397	0.668
DOC_WW_Pin1_4	73	78	PF00397	0.724
DOC_WW_Pin1_4	9	14	PF00397	0.631
LIG_14-3-3_CanoR_1	24	29	PF00244	0.594
LIG_14-3-3_CanoR_1	81	88	PF00244	0.662
LIG_FHA_1	139	145	PF00498	0.303
LIG_FHA_1	82	88	PF00498	0.601
LIG_FHA_2	184	190	PF00498	0.660
LIG_LIR_Gen_1	25	35	PF02991	0.546
LIG_LIR_Gen_1	46	57	PF02991	0.645
LIG_LIR_Nem_3	25	31	PF02991	0.550
LIG_LIR_Nem_3	46	52	PF02991	0.638
LIG_SH2_GRB2like	125	128	PF00017	0.350
LIG_SH2_NCK_1	28	32	PF00017	0.626
LIG_SH2_SRC	28	31	PF00017	0.551
LIG_SH2_STAP1	28	32	PF00017	0.606
LIG_SH2_STAT5	121	124	PF00017	0.431
LIG_SH2_STAT5	157	160	PF00017	0.576
LIG_SH2_STAT5	49	52	PF00017	0.573
LIG_SH3_3	129	135	PF00018	0.269
LIG_TRAF2_1	27	30	PF00917	0.533
LIG_TYR_ITIM	26	31	PF00017	0.541
MOD_CK1_1	113	119	PF00069	0.271
MOD_CK1_1	38	44	PF00069	0.619
MOD_CK2_1	183	189	PF00069	0.673
MOD_CK2_1	24	30	PF00069	0.551
MOD_CMANNOS	142	145	PF00535	0.284
MOD_GlcNHglycan	102	105	PF01048	0.317
MOD_GlcNHglycan	69	72	PF01048	0.461
MOD_GlcNHglycan	9	12	PF01048	0.440
MOD_GlcNHglycan	92	95	PF01048	0.390
MOD_GlcNHglycan	96	99	PF01048	0.381
MOD_GSK3_1	106	113	PF00069	0.231
MOD_GSK3_1	18	25	PF00069	0.658
MOD_GSK3_1	90	97	PF00069	0.597
MOD_N-GLC_1	18	23	PF02516	0.372
MOD_N-GLC_1	7	12	PF02516	0.458
MOD_NEK2_1	100	105	PF00069	0.535
MOD_NEK2_1	183	188	PF00069	0.623
MOD_NEK2_2	96	101	PF00069	0.570
MOD_PKA_2	80	86	PF00069	0.663
MOD_Plk_4	35	41	PF00069	0.592
MOD_Plk_4	96	102	PF00069	0.633
MOD_ProDKin_1	188	194	PF00069	0.667
MOD_ProDKin_1	73	79	PF00069	0.724
MOD_ProDKin_1	9	15	PF00069	0.631
TRG_DiLeu_BaEn_1	61	66	PF01217	0.610
TRG_DiLeu_BaLyEn_6	83	88	PF01217	0.591
TRG_ENDOCYTIC_2	121	124	PF00928	0.389
TRG_ENDOCYTIC_2	28	31	PF00928	0.541
TRG_ENDOCYTIC_2	49	52	PF00928	0.541
TRG_ER_diArg_1	179	181	PF00400	0.727
TRG_ER_diArg_1	52	55	PF00400	0.584
TRG_NLS_MonoCore_2	177	182	PF00514	0.722
TRG_NLS_MonoExtC_3	177	182	PF00514	0.727
TRG_Pf-PMV_PEXEL_1	54	58	PF00026	0.409
TRG_Pf-PMV_PEXEL_1	86	90	PF00026	0.396

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE47	Leptomonas seymouri	76%	100%
A0A0S4J5J9	Bodo saltans	39%	100%
A0A1X0NNT8	Trypanosomatidae	43%	96%
A0A3R7MTA4	Trypanosoma rangeli	47%	100%
A4H743	Leishmania braziliensis	85%	100%
A4HVI3	Leishmania infantum	100%	100%
D0A6S6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9AP78	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QGA0	Leishmania major	96%	100%
V5DBH6	Trypanosoma cruzi	48%	100%