RAP domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IHX9_LEIDO

TriTrypDb:

LdBPK_365980.1 , LdCL_360067200 , LDHU3_36.7900

Length:

672

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IHX9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHX9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	658	662	PF00656	0.359
CLV_NRD_NRD_1	23	25	PF00675	0.451
CLV_NRD_NRD_1	240	242	PF00675	0.499
CLV_NRD_NRD_1	360	362	PF00675	0.718
CLV_NRD_NRD_1	394	396	PF00675	0.526
CLV_NRD_NRD_1	439	441	PF00675	0.426
CLV_PCSK_FUR_1	392	396	PF00082	0.523
CLV_PCSK_KEX2_1	23	25	PF00082	0.446
CLV_PCSK_KEX2_1	360	362	PF00082	0.640
CLV_PCSK_KEX2_1	394	396	PF00082	0.505
CLV_PCSK_KEX2_1	439	441	PF00082	0.426
CLV_PCSK_SKI1_1	234	238	PF00082	0.349
CLV_PCSK_SKI1_1	394	398	PF00082	0.543
CLV_PCSK_SKI1_1	431	435	PF00082	0.456
CLV_PCSK_SKI1_1	608	612	PF00082	0.469
CLV_PCSK_SKI1_1	628	632	PF00082	0.422
DEG_APCC_DBOX_1	233	241	PF00400	0.331
DEG_APCC_DBOX_1	38	46	PF00400	0.473
DEG_APCC_DBOX_1	627	635	PF00400	0.417
DEG_SPOP_SBC_1	366	370	PF00917	0.592
DOC_CDC14_PxL_1	514	522	PF14671	0.605
DOC_CYCLIN_RxL_1	538	547	PF00134	0.507
DOC_CYCLIN_RxL_1	622	633	PF00134	0.310
DOC_CYCLIN_RxL_1	661	671	PF00134	0.381
DOC_MAPK_DCC_7	39	47	PF00069	0.535
DOC_MAPK_FxFP_2	202	205	PF00069	0.543
DOC_MAPK_gen_1	179	187	PF00069	0.412
DOC_MAPK_gen_1	23	30	PF00069	0.508
DOC_MAPK_JIP1_4	181	187	PF00069	0.420
DOC_MAPK_MEF2A_6	322	330	PF00069	0.344
DOC_MAPK_MEF2A_6	39	47	PF00069	0.529
DOC_PP1_RVXF_1	662	669	PF00149	0.427
DOC_PP2B_LxvP_1	350	353	PF13499	0.490
DOC_PP4_FxxP_1	202	205	PF00568	0.567
DOC_USP7_MATH_1	134	138	PF00917	0.674
DOC_USP7_MATH_1	144	148	PF00917	0.684
DOC_USP7_MATH_1	153	157	PF00917	0.437
DOC_USP7_MATH_1	366	370	PF00917	0.718
DOC_USP7_MATH_1	371	375	PF00917	0.699
DOC_WW_Pin1_4	362	367	PF00397	0.604
DOC_WW_Pin1_4	387	392	PF00397	0.630
LIG_14-3-3_CanoR_1	143	153	PF00244	0.593
LIG_14-3-3_CanoR_1	181	186	PF00244	0.382
LIG_14-3-3_CanoR_1	234	243	PF00244	0.513
LIG_14-3-3_CanoR_1	360	366	PF00244	0.630
LIG_14-3-3_CanoR_1	439	443	PF00244	0.498
LIG_14-3-3_CanoR_1	444	453	PF00244	0.481
LIG_14-3-3_CanoR_1	470	474	PF00244	0.475
LIG_14-3-3_CanoR_1	532	538	PF00244	0.471
LIG_14-3-3_CanoR_1	54	58	PF00244	0.398
LIG_14-3-3_CanoR_1	555	559	PF00244	0.661
LIG_14-3-3_CanoR_1	64	70	PF00244	0.299
LIG_Actin_WH2_2	542	557	PF00022	0.577
LIG_Actin_WH2_2	56	73	PF00022	0.456
LIG_CtBP_PxDLS_1	466	470	PF00389	0.539
LIG_DLG_GKlike_1	159	167	PF00625	0.326
LIG_EH1_1	497	505	PF00400	0.400
LIG_eIF4E_1	498	504	PF01652	0.452
LIG_FHA_1	115	121	PF00498	0.315
LIG_FHA_1	182	188	PF00498	0.340
LIG_FHA_1	192	198	PF00498	0.317
LIG_FHA_1	478	484	PF00498	0.376
LIG_FHA_1	544	550	PF00498	0.455
LIG_FHA_2	444	450	PF00498	0.508
LIG_FHA_2	473	479	PF00498	0.342
LIG_FHA_2	573	579	PF00498	0.421
LIG_FHA_2	600	606	PF00498	0.460
LIG_LIR_Apic_2	403	409	PF02991	0.573
LIG_LIR_Gen_1	533	542	PF02991	0.504
LIG_LIR_Nem_3	533	537	PF02991	0.523
LIG_NRBOX	109	115	PF00104	0.375
LIG_NRBOX	609	615	PF00104	0.437
LIG_Pex14_1	635	639	PF04695	0.454
LIG_PTB_Apo_2	340	347	PF02174	0.502
LIG_RPA_C_Fungi	10	22	PF08784	0.396
LIG_SH2_CRK	406	410	PF00017	0.425
LIG_SH2_CRK	505	509	PF00017	0.506
LIG_SH2_NCK_1	406	410	PF00017	0.425
LIG_SH2_PTP2	413	416	PF00017	0.434
LIG_SH2_SRC	413	416	PF00017	0.440
LIG_SH2_SRC	95	98	PF00017	0.397
LIG_SH2_STAP1	263	267	PF00017	0.345
LIG_SH2_STAP1	639	643	PF00017	0.418
LIG_SH2_STAT5	293	296	PF00017	0.502
LIG_SH2_STAT5	406	409	PF00017	0.510
LIG_SH2_STAT5	413	416	PF00017	0.380
LIG_SH2_STAT5	498	501	PF00017	0.516
LIG_SH2_STAT5	505	508	PF00017	0.464
LIG_SH3_3	509	515	PF00018	0.478
LIG_SH3_3	556	562	PF00018	0.591
LIG_SUMO_SIM_anti_2	183	189	PF11976	0.355
LIG_SUMO_SIM_par_1	183	189	PF11976	0.480
LIG_SUMO_SIM_par_1	478	486	PF11976	0.394
LIG_SUMO_SIM_par_1	540	547	PF11976	0.484
LIG_TRAF2_1	580	583	PF00917	0.524
LIG_TRFH_1	406	410	PF08558	0.537
LIG_TYR_ITIM	503	508	PF00017	0.493
LIG_UBA3_1	236	242	PF00899	0.358
LIG_UBA3_1	606	611	PF00899	0.427
LIG_WRC_WIRS_1	160	165	PF05994	0.360
MOD_CDK_SPK_2	387	392	PF00069	0.537
MOD_CDK_SPxxK_3	387	394	PF00069	0.508
MOD_CK1_1	142	148	PF00069	0.694
MOD_CK1_1	186	192	PF00069	0.377
MOD_CK1_1	362	368	PF00069	0.623
MOD_CK1_1	369	375	PF00069	0.582
MOD_CK1_1	404	410	PF00069	0.449
MOD_CK1_1	482	488	PF00069	0.316
MOD_CK1_1	50	56	PF00069	0.416
MOD_CK1_1	65	71	PF00069	0.294
MOD_CK2_1	186	192	PF00069	0.383
MOD_CK2_1	306	312	PF00069	0.424
MOD_CK2_1	443	449	PF00069	0.461
MOD_CK2_1	472	478	PF00069	0.507
MOD_CK2_1	572	578	PF00069	0.619
MOD_GlcNHglycan	117	120	PF01048	0.365
MOD_GlcNHglycan	155	158	PF01048	0.585
MOD_GlcNHglycan	562	565	PF01048	0.558
MOD_GSK3_1	109	116	PF00069	0.380
MOD_GSK3_1	142	149	PF00069	0.680
MOD_GSK3_1	159	166	PF00069	0.455
MOD_GSK3_1	186	193	PF00069	0.347
MOD_GSK3_1	253	260	PF00069	0.453
MOD_GSK3_1	360	367	PF00069	0.751
MOD_GSK3_1	431	438	PF00069	0.420
MOD_GSK3_1	46	53	PF00069	0.515
MOD_GSK3_1	577	584	PF00069	0.494
MOD_GSK3_1	595	602	PF00069	0.397
MOD_LATS_1	303	309	PF00433	0.363
MOD_N-GLC_1	245	250	PF02516	0.444
MOD_N-GLC_1	268	273	PF02516	0.447
MOD_N-GLC_1	401	406	PF02516	0.638
MOD_NEK2_1	113	118	PF00069	0.422
MOD_NEK2_1	139	144	PF00069	0.761
MOD_NEK2_1	163	168	PF00069	0.365
MOD_NEK2_1	190	195	PF00069	0.373
MOD_NEK2_1	236	241	PF00069	0.439
MOD_NEK2_1	257	262	PF00069	0.461
MOD_NEK2_1	306	311	PF00069	0.368
MOD_NEK2_1	469	474	PF00069	0.436
MOD_NEK2_1	530	535	PF00069	0.494
MOD_NEK2_1	554	559	PF00069	0.617
MOD_NEK2_1	606	611	PF00069	0.579
MOD_NEK2_1	616	621	PF00069	0.354
MOD_NEK2_1	62	67	PF00069	0.330
MOD_NEK2_1	630	635	PF00069	0.262
MOD_PIKK_1	274	280	PF00454	0.421
MOD_PIKK_1	281	287	PF00454	0.331
MOD_PIKK_1	369	375	PF00454	0.554
MOD_PK_1	479	485	PF00069	0.383
MOD_PKA_1	360	366	PF00069	0.532
MOD_PKA_2	114	120	PF00069	0.332
MOD_PKA_2	142	148	PF00069	0.641
MOD_PKA_2	180	186	PF00069	0.454
MOD_PKA_2	359	365	PF00069	0.583
MOD_PKA_2	435	441	PF00069	0.448
MOD_PKA_2	443	449	PF00069	0.443
MOD_PKA_2	469	475	PF00069	0.474
MOD_PKA_2	53	59	PF00069	0.404
MOD_PKA_2	554	560	PF00069	0.589
MOD_PKB_1	179	187	PF00069	0.412
MOD_Plk_1	11	17	PF00069	0.407
MOD_Plk_1	404	410	PF00069	0.542
MOD_Plk_1	477	483	PF00069	0.421
MOD_Plk_2-3	595	601	PF00069	0.409
MOD_Plk_4	109	115	PF00069	0.405
MOD_Plk_4	159	165	PF00069	0.466
MOD_Plk_4	183	189	PF00069	0.352
MOD_Plk_4	306	312	PF00069	0.353
MOD_Plk_4	630	636	PF00069	0.373
MOD_Plk_4	65	71	PF00069	0.325
MOD_ProDKin_1	362	368	PF00069	0.605
MOD_ProDKin_1	387	393	PF00069	0.622
TRG_DiLeu_BaEn_1	109	114	PF01217	0.419
TRG_DiLeu_BaEn_1	33	38	PF01217	0.398
TRG_DiLeu_BaEn_1	449	454	PF01217	0.410
TRG_DiLeu_BaEn_1	642	647	PF01217	0.616
TRG_DiLeu_BaEn_4	582	588	PF01217	0.479
TRG_DiLeu_BaLyEn_6	123	128	PF01217	0.474
TRG_DiLeu_BaLyEn_6	24	29	PF01217	0.438
TRG_DiLeu_BaLyEn_6	661	666	PF01217	0.435
TRG_ENDOCYTIC_2	413	416	PF00928	0.425
TRG_ENDOCYTIC_2	430	433	PF00928	0.345
TRG_ENDOCYTIC_2	505	508	PF00928	0.497
TRG_ER_diArg_1	391	394	PF00400	0.520
TRG_NES_CRM1_1	319	333	PF08389	0.322
TRG_Pf-PMV_PEXEL_1	300	304	PF00026	0.345
TRG_Pf-PMV_PEXEL_1	395	399	PF00026	0.652

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMS6	Leptomonas seymouri	65%	99%
A0A0S4IXA8	Bodo saltans	28%	95%
A0A1X0NNB6	Trypanosomatidae	42%	100%
A4HQ89	Leishmania braziliensis	80%	100%
A4IDY7	Leishmania infantum	100%	100%
D0A422	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AU07	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q0I8	Leishmania major	94%	100%
V5B3L6	Trypanosoma cruzi	43%	100%