Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IHX7_LEIDO

TriTrypDb:

LdBPK_340650.1 , LdCL_340012100 , LDHU3_34.1080

Length:

786

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IHX7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHX7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	630	634	PF00656	0.581
CLV_NRD_NRD_1	191	193	PF00675	0.568
CLV_NRD_NRD_1	273	275	PF00675	0.795
CLV_NRD_NRD_1	285	287	PF00675	0.710
CLV_NRD_NRD_1	392	394	PF00675	0.641
CLV_NRD_NRD_1	463	465	PF00675	0.755
CLV_NRD_NRD_1	531	533	PF00675	0.523
CLV_NRD_NRD_1	585	587	PF00675	0.720
CLV_NRD_NRD_1	759	761	PF00675	0.567
CLV_NRD_NRD_1	83	85	PF00675	0.580
CLV_PCSK_FUR_1	364	368	PF00082	0.659
CLV_PCSK_FUR_1	529	533	PF00082	0.589
CLV_PCSK_KEX2_1	190	192	PF00082	0.552
CLV_PCSK_KEX2_1	273	275	PF00082	0.734
CLV_PCSK_KEX2_1	284	286	PF00082	0.712
CLV_PCSK_KEX2_1	366	368	PF00082	0.630
CLV_PCSK_KEX2_1	463	465	PF00082	0.755
CLV_PCSK_KEX2_1	531	533	PF00082	0.520
CLV_PCSK_KEX2_1	587	589	PF00082	0.659
CLV_PCSK_KEX2_1	759	761	PF00082	0.613
CLV_PCSK_KEX2_1	77	79	PF00082	0.621
CLV_PCSK_KEX2_1	83	85	PF00082	0.602
CLV_PCSK_PC1ET2_1	366	368	PF00082	0.654
CLV_PCSK_PC1ET2_1	587	589	PF00082	0.659
CLV_PCSK_PC1ET2_1	77	79	PF00082	0.595
CLV_PCSK_SKI1_1	131	135	PF00082	0.590
CLV_PCSK_SKI1_1	201	205	PF00082	0.636
CLV_PCSK_SKI1_1	366	370	PF00082	0.647
CLV_PCSK_SKI1_1	387	391	PF00082	0.706
CLV_PCSK_SKI1_1	464	468	PF00082	0.748
CLV_PCSK_SKI1_1	60	64	PF00082	0.539
CLV_PCSK_SKI1_1	709	713	PF00082	0.665
CLV_PCSK_SKI1_1	760	764	PF00082	0.535
CLV_Separin_Metazoa	552	556	PF03568	0.604
CLV_Separin_Metazoa	563	567	PF03568	0.357
DEG_APCC_DBOX_1	366	374	PF00400	0.655
DEG_APCC_DBOX_1	613	621	PF00400	0.525
DEG_Nend_UBRbox_3	1	3	PF02207	0.738
DOC_CDC14_PxL_1	228	236	PF14671	0.582
DOC_CYCLIN_RxL_1	175	188	PF00134	0.614
DOC_CYCLIN_RxL_1	198	208	PF00134	0.632
DOC_CYCLIN_RxL_1	218	230	PF00134	0.316
DOC_CYCLIN_RxL_1	364	375	PF00134	0.657
DOC_MAPK_gen_1	223	233	PF00069	0.470
DOC_MAPK_gen_1	364	373	PF00069	0.610
DOC_MAPK_gen_1	438	447	PF00069	0.594
DOC_MAPK_gen_1	529	538	PF00069	0.594
DOC_MAPK_gen_1	57	65	PF00069	0.526
DOC_MAPK_MEF2A_6	529	538	PF00069	0.644
DOC_MAPK_MEF2A_6	57	65	PF00069	0.582
DOC_MIT_MIM_1	702	711	PF04212	0.633
DOC_PP4_FxxP_1	298	301	PF00568	0.778
DOC_USP7_MATH_1	301	305	PF00917	0.726
DOC_USP7_MATH_1	421	425	PF00917	0.618
DOC_USP7_MATH_1	462	466	PF00917	0.749
DOC_USP7_MATH_1	589	593	PF00917	0.656
DOC_USP7_MATH_1	738	742	PF00917	0.661
DOC_USP7_MATH_1	79	83	PF00917	0.665
DOC_USP7_MATH_2	506	512	PF00917	0.678
DOC_USP7_UBL2_3	159	163	PF12436	0.576
DOC_USP7_UBL2_3	411	415	PF12436	0.609
DOC_WW_Pin1_4	267	272	PF00397	0.757
DOC_WW_Pin1_4	278	283	PF00397	0.734
DOC_WW_Pin1_4	424	429	PF00397	0.597
LIG_14-3-3_CanoR_1	119	125	PF00244	0.556
LIG_14-3-3_CanoR_1	152	158	PF00244	0.589
LIG_14-3-3_CanoR_1	190	198	PF00244	0.575
LIG_14-3-3_CanoR_1	218	222	PF00244	0.560
LIG_14-3-3_CanoR_1	226	234	PF00244	0.527
LIG_14-3-3_CanoR_1	264	270	PF00244	0.759
LIG_14-3-3_CanoR_1	463	472	PF00244	0.637
LIG_14-3-3_CanoR_1	493	500	PF00244	0.648
LIG_14-3-3_CanoR_1	535	544	PF00244	0.593
LIG_14-3-3_CanoR_1	588	597	PF00244	0.625
LIG_14-3-3_CanoR_1	638	643	PF00244	0.609
LIG_14-3-3_CanoR_1	693	699	PF00244	0.635
LIG_14-3-3_CanoR_1	83	90	PF00244	0.549
LIG_Actin_WH2_2	755	772	PF00022	0.617
LIG_APCC_ABBA_1	547	552	PF00400	0.607
LIG_BRCT_BRCA1_1	243	247	PF00533	0.626
LIG_CaM_IQ_9	147	162	PF13499	0.611
LIG_CaM_IQ_9	701	717	PF13499	0.643
LIG_CaM_NSCaTE_8	690	697	PF13499	0.598
LIG_Clathr_ClatBox_1	182	186	PF01394	0.568
LIG_Clathr_ClatBox_1	370	374	PF01394	0.654
LIG_Clathr_ClatBox_1	62	66	PF01394	0.580
LIG_FAT_LD_1	65	73	PF03623	0.578
LIG_FHA_1	264	270	PF00498	0.724
LIG_FHA_1	699	705	PF00498	0.713
LIG_FHA_1	764	770	PF00498	0.613
LIG_FHA_2	203	209	PF00498	0.548
LIG_FHA_2	322	328	PF00498	0.631
LIG_FHA_2	558	564	PF00498	0.590
LIG_FHA_2	83	89	PF00498	0.640
LIG_HCF-1_HBM_1	396	399	PF13415	0.702
LIG_Integrin_isoDGR_2	345	347	PF01839	0.646
LIG_LIR_Apic_2	295	301	PF02991	0.779
LIG_LIR_Apic_2	396	402	PF02991	0.556
LIG_LIR_Gen_1	244	253	PF02991	0.649
LIG_LIR_Gen_1	359	370	PF02991	0.633
LIG_LIR_Gen_1	641	650	PF02991	0.606
LIG_LIR_LC3C_4	24	28	PF02991	0.637
LIG_LIR_Nem_3	244	250	PF02991	0.570
LIG_LIR_Nem_3	328	334	PF02991	0.705
LIG_LIR_Nem_3	359	365	PF02991	0.627
LIG_LIR_Nem_3	424	429	PF02991	0.531
LIG_LIR_Nem_3	641	646	PF02991	0.608
LIG_LYPXL_yS_3	417	420	PF13949	0.595
LIG_NRBOX	707	713	PF00104	0.636
LIG_PTB_Apo_2	411	418	PF02174	0.537
LIG_PTB_Phospho_1	411	417	PF10480	0.616
LIG_Rb_pABgroove_1	544	552	PF01858	0.610
LIG_SH2_CRK	331	335	PF00017	0.691
LIG_SH2_CRK	453	457	PF00017	0.705
LIG_SH2_NCK_1	453	457	PF00017	0.705
LIG_SH2_STAP1	143	147	PF00017	0.509
LIG_SH2_STAP1	403	407	PF00017	0.570
LIG_SH2_STAP1	550	554	PF00017	0.469
LIG_SH2_STAP1	572	576	PF00017	0.567
LIG_SH2_STAT5	237	240	PF00017	0.506
LIG_SH2_STAT5	256	259	PF00017	0.612
LIG_SH3_1	415	421	PF00018	0.635
LIG_SH3_1	453	459	PF00018	0.611
LIG_SH3_3	415	421	PF00018	0.635
LIG_SH3_3	453	459	PF00018	0.611
LIG_SUMO_SIM_anti_2	351	357	PF11976	0.685
LIG_SUMO_SIM_par_1	181	186	PF11976	0.627
LIG_SUMO_SIM_par_1	351	357	PF11976	0.610
LIG_SUMO_SIM_par_1	369	375	PF11976	0.655
LIG_TRAF2_1	124	127	PF00917	0.540
LIG_TRAF2_1	514	517	PF00917	0.654
LIG_TRAF2_1	700	703	PF00917	0.647
LIG_TRAF2_1	85	88	PF00917	0.598
LIG_UBA3_1	114	123	PF00899	0.567
LIG_UBA3_1	32	37	PF00899	0.615
LIG_UBA3_1	430	435	PF00899	0.644
LIG_UBA3_1	68	77	PF00899	0.519
MOD_CDC14_SPxK_1	270	273	PF00782	0.734
MOD_CDC14_SPxK_1	281	284	PF00782	0.730
MOD_CDK_SPxK_1	267	273	PF00069	0.733
MOD_CDK_SPxK_1	278	284	PF00069	0.742
MOD_CDK_SPxxK_3	267	274	PF00069	0.757
MOD_CDK_SPxxK_3	278	285	PF00069	0.736
MOD_CK1_1	194	200	PF00069	0.566
MOD_CK1_1	267	273	PF00069	0.770
MOD_CK1_1	304	310	PF00069	0.784
MOD_CK1_1	317	323	PF00069	0.484
MOD_CK1_1	354	360	PF00069	0.700
MOD_CK1_1	424	430	PF00069	0.552
MOD_CK1_1	489	495	PF00069	0.728
MOD_CK1_1	634	640	PF00069	0.524
MOD_CK1_1	641	647	PF00069	0.535
MOD_CK1_1	674	680	PF00069	0.758
MOD_CK1_1	681	687	PF00069	0.758
MOD_CK1_1	82	88	PF00069	0.554
MOD_CK1_1	96	102	PF00069	0.368
MOD_CK2_1	163	169	PF00069	0.512
MOD_CK2_1	202	208	PF00069	0.549
MOD_CK2_1	321	327	PF00069	0.715
MOD_CK2_1	557	563	PF00069	0.622
MOD_CK2_1	578	584	PF00069	0.679
MOD_CK2_1	697	703	PF00069	0.738
MOD_CK2_1	82	88	PF00069	0.640
MOD_Cter_Amidation	188	191	PF01082	0.559
MOD_GlcNHglycan	186	190	PF01048	0.577
MOD_GlcNHglycan	307	310	PF01048	0.760
MOD_GlcNHglycan	316	319	PF01048	0.772
MOD_GlcNHglycan	356	359	PF01048	0.611
MOD_GlcNHglycan	384	387	PF01048	0.671
MOD_GlcNHglycan	464	467	PF01048	0.747
MOD_GlcNHglycan	488	491	PF01048	0.716
MOD_GlcNHglycan	573	576	PF01048	0.617
MOD_GlcNHglycan	591	594	PF01048	0.668
MOD_GlcNHglycan	603	606	PF01048	0.545
MOD_GlcNHglycan	678	681	PF01048	0.762
MOD_GlcNHglycan	690	693	PF01048	0.739
MOD_GSK3_1	263	270	PF00069	0.723
MOD_GSK3_1	274	281	PF00069	0.752
MOD_GSK3_1	301	308	PF00069	0.785
MOD_GSK3_1	317	324	PF00069	0.724
MOD_GSK3_1	467	474	PF00069	0.683
MOD_GSK3_1	485	492	PF00069	0.710
MOD_GSK3_1	634	641	PF00069	0.600
MOD_GSK3_1	661	668	PF00069	0.693
MOD_GSK3_1	670	677	PF00069	0.751
MOD_GSK3_1	678	685	PF00069	0.813
MOD_GSK3_1	688	695	PF00069	0.760
MOD_N-GLC_1	314	319	PF02516	0.730
MOD_N-GLC_1	360	365	PF02516	0.633
MOD_NEK2_1	136	141	PF00069	0.606
MOD_NEK2_1	150	155	PF00069	0.543
MOD_NEK2_1	185	190	PF00069	0.580
MOD_NEK2_1	257	262	PF00069	0.737
MOD_NEK2_1	536	541	PF00069	0.601
MOD_NEK2_1	571	576	PF00069	0.611
MOD_NEK2_1	747	752	PF00069	0.597
MOD_OFUCOSY	619	625	PF10250	0.568
MOD_PIKK_1	161	167	PF00454	0.607
MOD_PIKK_1	457	463	PF00454	0.753
MOD_PIKK_1	537	543	PF00454	0.557
MOD_PKA_1	191	197	PF00069	0.552
MOD_PKA_2	118	124	PF00069	0.605
MOD_PKA_2	191	197	PF00069	0.566
MOD_PKA_2	217	223	PF00069	0.570
MOD_PKA_2	263	269	PF00069	0.725
MOD_PKA_2	272	278	PF00069	0.689
MOD_PKA_2	462	468	PF00069	0.765
MOD_PKA_2	492	498	PF00069	0.719
MOD_PKA_2	578	584	PF00069	0.664
MOD_PKA_2	692	698	PF00069	0.641
MOD_PKA_2	82	88	PF00069	0.612
MOD_PKA_2	93	99	PF00069	0.571
MOD_PKB_1	190	198	PF00069	0.625
MOD_PKB_1	262	270	PF00069	0.795
MOD_PKB_1	586	594	PF00069	0.667
MOD_PKB_1	663	671	PF00069	0.659
MOD_Plk_1	294	300	PF00069	0.783
MOD_Plk_1	360	366	PF00069	0.644
MOD_Plk_2-3	202	208	PF00069	0.506
MOD_Plk_2-3	294	300	PF00069	0.783
MOD_Plk_4	638	644	PF00069	0.607
MOD_Plk_4	694	700	PF00069	0.745
MOD_Plk_4	747	753	PF00069	0.560
MOD_ProDKin_1	267	273	PF00069	0.757
MOD_ProDKin_1	278	284	PF00069	0.734
MOD_ProDKin_1	424	430	PF00069	0.591
MOD_SUMO_for_1	36	39	PF00179	0.621
MOD_SUMO_rev_2	138	148	PF00179	0.557
MOD_SUMO_rev_2	5	12	PF00179	0.559
MOD_SUMO_rev_2	53	62	PF00179	0.582
MOD_SUMO_rev_2	581	589	PF00179	0.671
MOD_SUMO_rev_2	71	79	PF00179	0.430
TRG_DiLeu_BaEn_1	58	63	PF01217	0.582
TRG_DiLeu_BaEn_4	374	380	PF01217	0.662
TRG_DiLeu_BaEn_4	38	44	PF01217	0.627
TRG_DiLeu_BaEn_4	58	64	PF01217	0.583
TRG_DiLeu_BaLyEn_6	220	225	PF01217	0.499
TRG_DiLeu_BaLyEn_6	613	618	PF01217	0.577
TRG_ENDOCYTIC_2	331	334	PF00928	0.697
TRG_ENDOCYTIC_2	403	406	PF00928	0.541
TRG_ENDOCYTIC_2	417	420	PF00928	0.572
TRG_ENDOCYTIC_2	550	553	PF00928	0.478
TRG_ENDOCYTIC_2	643	646	PF00928	0.611
TRG_ER_diArg_1	190	192	PF00400	0.580
TRG_ER_diArg_1	284	286	PF00400	0.712
TRG_ER_diArg_1	444	447	PF00400	0.575
TRG_ER_diArg_1	529	532	PF00400	0.521
TRG_ER_diArg_1	758	760	PF00400	0.613
TRG_NLS_MonoExtN_4	364	370	PF00514	0.661
TRG_Pf-PMV_PEXEL_1	123	127	PF00026	0.576

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3M8	Leptomonas seymouri	57%	76%
A0A422N4B9	Trypanosoma rangeli	28%	89%
A4HAH3	Leishmania braziliensis	84%	99%
A4I9N3	Leishmania infantum	100%	100%
E9B4N2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q3E4	Leishmania major	93%	99%
V5DIQ2	Trypanosoma cruzi	28%	92%