Cyclic nucleotide-binding domain family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cyclic nucleotide-binding domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IHX4_LEIDO

TriTrypDb:

LdBPK_344250.1 , LdCL_340052600 , LDHU3_34.6640

Length:

801

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IHX4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHX4

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009116	nucleoside metabolic process	4	1
GO:0009987	cellular process	1	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044281	small molecule metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901657	glycosyl compound metabolic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	227	231	PF00656	0.774
CLV_NRD_NRD_1	143	145	PF00675	0.458
CLV_NRD_NRD_1	181	183	PF00675	0.525
CLV_NRD_NRD_1	261	263	PF00675	0.688
CLV_NRD_NRD_1	275	277	PF00675	0.491
CLV_NRD_NRD_1	325	327	PF00675	0.487
CLV_NRD_NRD_1	679	681	PF00675	0.558
CLV_NRD_NRD_1	746	748	PF00675	0.573
CLV_NRD_NRD_1	795	797	PF00675	0.517
CLV_PCSK_KEX2_1	137	139	PF00082	0.529
CLV_PCSK_KEX2_1	143	145	PF00082	0.458
CLV_PCSK_KEX2_1	275	277	PF00082	0.427
CLV_PCSK_KEX2_1	323	325	PF00082	0.516
CLV_PCSK_KEX2_1	605	607	PF00082	0.636
CLV_PCSK_KEX2_1	746	748	PF00082	0.605
CLV_PCSK_KEX2_1	780	782	PF00082	0.597
CLV_PCSK_PC1ET2_1	137	139	PF00082	0.553
CLV_PCSK_PC1ET2_1	323	325	PF00082	0.609
CLV_PCSK_PC1ET2_1	605	607	PF00082	0.636
CLV_PCSK_PC1ET2_1	780	782	PF00082	0.597
CLV_PCSK_PC7_1	271	277	PF00082	0.531
CLV_PCSK_SKI1_1	134	138	PF00082	0.547
CLV_PCSK_SKI1_1	218	222	PF00082	0.497
CLV_PCSK_SKI1_1	382	386	PF00082	0.608
CLV_PCSK_SKI1_1	463	467	PF00082	0.593
CLV_PCSK_SKI1_1	491	495	PF00082	0.482
CLV_PCSK_SKI1_1	625	629	PF00082	0.596
CLV_PCSK_SKI1_1	659	663	PF00082	0.481
CLV_PCSK_SKI1_1	681	685	PF00082	0.437
CLV_PCSK_SKI1_1	758	762	PF00082	0.516
CLV_PCSK_SKI1_1	792	796	PF00082	0.478
CLV_Separin_Metazoa	379	383	PF03568	0.639
DEG_APCC_DBOX_1	365	373	PF00400	0.513
DEG_APCC_DBOX_1	40	48	PF00400	0.630
DEG_APCC_DBOX_1	791	799	PF00400	0.490
DEG_Nend_UBRbox_3	1	3	PF02207	0.733
DOC_CDC14_PxL_1	79	87	PF14671	0.504
DOC_CYCLIN_RxL_1	491	501	PF00134	0.446
DOC_CYCLIN_RxL_1	622	633	PF00134	0.477
DOC_CYCLIN_RxL_1	655	666	PF00134	0.525
DOC_CYCLIN_RxL_1	752	765	PF00134	0.545
DOC_CYCLIN_yClb1_LxF_4	657	662	PF00134	0.507
DOC_CYCLIN_yCln2_LP_2	240	246	PF00134	0.498
DOC_MAPK_gen_1	182	188	PF00069	0.518
DOC_MAPK_gen_1	275	283	PF00069	0.491
DOC_MAPK_gen_1	463	471	PF00069	0.549
DOC_MAPK_gen_1	602	612	PF00069	0.629
DOC_MAPK_HePTP_8	98	110	PF00069	0.453
DOC_MAPK_MEF2A_6	101	110	PF00069	0.453
DOC_MAPK_MEF2A_6	235	244	PF00069	0.507
DOC_MAPK_MEF2A_6	275	283	PF00069	0.491
DOC_PP1_RVXF_1	656	663	PF00149	0.506
DOC_PP2B_LxvP_1	178	181	PF13499	0.484
DOC_PP2B_LxvP_1	240	243	PF13499	0.535
DOC_PP2B_LxvP_1	654	657	PF13499	0.371
DOC_PP4_FxxP_1	50	53	PF00568	0.642
DOC_USP7_MATH_1	550	554	PF00917	0.638
DOC_USP7_MATH_1	595	599	PF00917	0.687
DOC_USP7_MATH_1	71	75	PF00917	0.713
DOC_USP7_UBL2_3	133	137	PF12436	0.547
DOC_USP7_UBL2_3	65	69	PF12436	0.614
DOC_WW_Pin1_4	189	194	PF00397	0.577
DOC_WW_Pin1_4	310	315	PF00397	0.657
DOC_WW_Pin1_4	371	376	PF00397	0.569
DOC_WW_Pin1_4	485	490	PF00397	0.540
DOC_WW_Pin1_4	579	584	PF00397	0.617
DOC_WW_Pin1_4	63	68	PF00397	0.815
DOC_WW_Pin1_4	686	691	PF00397	0.588
LIG_14-3-3_CanoR_1	247	256	PF00244	0.597
LIG_14-3-3_CanoR_1	326	332	PF00244	0.535
LIG_14-3-3_CanoR_1	468	478	PF00244	0.627
LIG_14-3-3_CanoR_1	634	639	PF00244	0.535
LIG_14-3-3_CanoR_1	680	684	PF00244	0.695
LIG_Actin_WH2_2	123	139	PF00022	0.547
LIG_Actin_WH2_2	40	57	PF00022	0.760
LIG_Actin_WH2_2	780	798	PF00022	0.569
LIG_AP2alpha_1	185	189	PF02296	0.534
LIG_APCC_ABBA_1	210	215	PF00400	0.511
LIG_APCC_ABBA_1	430	435	PF00400	0.497
LIG_BIR_III_4	230	234	PF00653	0.635
LIG_BRCT_BRCA1_1	191	195	PF00533	0.530
LIG_BRCT_BRCA1_1	297	301	PF00533	0.647
LIG_BRCT_BRCA1_1	403	407	PF00533	0.626
LIG_BRCT_BRCA1_1	445	449	PF00533	0.598
LIG_BRCT_BRCA1_1	556	560	PF00533	0.623
LIG_eIF4E_1	535	541	PF01652	0.542
LIG_FHA_1	124	130	PF00498	0.448
LIG_FHA_1	173	179	PF00498	0.459
LIG_FHA_1	27	33	PF00498	0.722
LIG_FHA_1	272	278	PF00498	0.526
LIG_FHA_1	282	288	PF00498	0.482
LIG_FHA_1	311	317	PF00498	0.692
LIG_FHA_1	335	341	PF00498	0.498
LIG_FHA_1	344	350	PF00498	0.455
LIG_FHA_1	536	542	PF00498	0.552
LIG_FHA_1	670	676	PF00498	0.624
LIG_FHA_1	687	693	PF00498	0.432
LIG_FHA_1	85	91	PF00498	0.554
LIG_FHA_2	559	565	PF00498	0.525
LIG_FHA_2	664	670	PF00498	0.602
LIG_FHA_2	727	733	PF00498	0.562
LIG_FHA_2	87	93	PF00498	0.535
LIG_GBD_Chelix_1	461	469	PF00786	0.394
LIG_HCF-1_HBM_1	117	120	PF13415	0.547
LIG_IBAR_NPY_1	452	454	PF08397	0.527
LIG_Integrin_RGD_1	41	43	PF01839	0.625
LIG_Integrin_RGD_1	651	653	PF01839	0.497
LIG_LIR_Gen_1	102	110	PF02991	0.453
LIG_LIR_Gen_1	209	216	PF02991	0.489
LIG_LIR_Gen_1	282	293	PF02991	0.467
LIG_LIR_Gen_1	557	568	PF02991	0.527
LIG_LIR_Nem_3	209	213	PF02991	0.473
LIG_LIR_Nem_3	282	288	PF02991	0.457
LIG_LIR_Nem_3	531	537	PF02991	0.504
LIG_LIR_Nem_3	757	762	PF02991	0.482
LIG_NRBOX	536	542	PF00104	0.550
LIG_NRBOX	623	629	PF00104	0.486
LIG_Pex14_1	234	238	PF04695	0.404
LIG_Pex14_2	185	189	PF04695	0.435
LIG_Rb_LxCxE_1	353	374	PF01857	0.591
LIG_SH2_CRK	428	432	PF00017	0.502
LIG_SH2_CRK	722	726	PF00017	0.532
LIG_SH2_GRB2like	454	457	PF00017	0.557
LIG_SH2_PTP2	285	288	PF00017	0.585
LIG_SH2_SRC	115	118	PF00017	0.531
LIG_SH2_SRC	285	288	PF00017	0.585
LIG_SH2_STAP1	454	458	PF00017	0.576
LIG_SH2_STAT3	437	440	PF00017	0.453
LIG_SH2_STAT5	115	118	PF00017	0.507
LIG_SH2_STAT5	120	123	PF00017	0.521
LIG_SH2_STAT5	238	241	PF00017	0.553
LIG_SH2_STAT5	272	275	PF00017	0.514
LIG_SH2_STAT5	285	288	PF00017	0.463
LIG_SH2_STAT5	296	299	PF00017	0.607
LIG_SH2_STAT5	437	440	PF00017	0.534
LIG_SH2_STAT5	535	538	PF00017	0.512
LIG_SH2_STAT5	737	740	PF00017	0.485
LIG_SH2_STAT5	759	762	PF00017	0.509
LIG_SH3_1	65	71	PF00018	0.702
LIG_SH3_3	65	71	PF00018	0.762
LIG_SH3_3	772	778	PF00018	0.790
LIG_SUMO_SIM_anti_2	126	132	PF11976	0.458
LIG_SUMO_SIM_anti_2	175	181	PF11976	0.461
LIG_SUMO_SIM_anti_2	284	290	PF11976	0.547
LIG_SUMO_SIM_anti_2	337	343	PF11976	0.560
LIG_SUMO_SIM_anti_2	94	100	PF11976	0.624
LIG_SUMO_SIM_par_1	284	290	PF11976	0.497
LIG_SUMO_SIM_par_1	571	577	PF11976	0.582
LIG_SUMO_SIM_par_1	86	92	PF11976	0.595
LIG_TRAF2_1	89	92	PF00917	0.638
LIG_TYR_ITIM	283	288	PF00017	0.397
LIG_UBA3_1	177	183	PF00899	0.440
LIG_UBA3_1	357	364	PF00899	0.565
LIG_UBA3_1	496	505	PF00899	0.610
LIG_WRC_WIRS_1	207	212	PF05994	0.537
LIG_WRC_WIRS_1	628	633	PF05994	0.532
LIG_WRC_WIRS_1	75	80	PF05994	0.580
MOD_CDC14_SPxK_1	488	491	PF00782	0.573
MOD_CDC14_SPxK_1	66	69	PF00782	0.643
MOD_CDK_SPK_2	67	72	PF00069	0.774
MOD_CDK_SPxK_1	485	491	PF00069	0.562
MOD_CDK_SPxK_1	63	69	PF00069	0.660
MOD_CK1_1	172	178	PF00069	0.440
MOD_CK1_1	224	230	PF00069	0.682
MOD_CK1_1	251	257	PF00069	0.542
MOD_CK1_1	26	32	PF00069	0.798
MOD_CK1_1	443	449	PF00069	0.635
MOD_CK1_1	512	518	PF00069	0.696
MOD_CK1_1	579	585	PF00069	0.591
MOD_CK1_1	598	604	PF00069	0.581
MOD_CK1_1	663	669	PF00069	0.527
MOD_CK1_1	70	76	PF00069	0.643
MOD_CK2_1	1	7	PF00069	0.750
MOD_CK2_1	373	379	PF00069	0.628
MOD_CK2_1	405	411	PF00069	0.528
MOD_CK2_1	469	475	PF00069	0.654
MOD_CK2_1	558	564	PF00069	0.563
MOD_CK2_1	579	585	PF00069	0.633
MOD_CK2_1	663	669	PF00069	0.543
MOD_CK2_1	86	92	PF00069	0.543
MOD_Cter_Amidation	321	324	PF01082	0.624
MOD_Cter_Amidation	603	606	PF01082	0.652
MOD_GlcNHglycan	123	126	PF01048	0.458
MOD_GlcNHglycan	226	229	PF01048	0.729
MOD_GlcNHglycan	235	238	PF01048	0.586
MOD_GlcNHglycan	25	28	PF01048	0.635
MOD_GlcNHglycan	251	254	PF01048	0.468
MOD_GlcNHglycan	3	6	PF01048	0.773
MOD_GlcNHglycan	375	378	PF01048	0.617
MOD_GlcNHglycan	392	395	PF01048	0.735
MOD_GlcNHglycan	500	503	PF01048	0.547
MOD_GlcNHglycan	513	517	PF01048	0.679
MOD_GlcNHglycan	568	571	PF01048	0.519
MOD_GlcNHglycan	640	643	PF01048	0.548
MOD_GlcNHglycan	696	699	PF01048	0.597
MOD_GlcNHglycan	7	11	PF01048	0.740
MOD_GSK3_1	165	172	PF00069	0.442
MOD_GSK3_1	222	229	PF00069	0.661
MOD_GSK3_1	401	408	PF00069	0.587
MOD_GSK3_1	443	450	PF00069	0.614
MOD_GSK3_1	485	492	PF00069	0.467
MOD_GSK3_1	550	557	PF00069	0.602
MOD_GSK3_1	579	586	PF00069	0.601
MOD_GSK3_1	623	630	PF00069	0.474
MOD_GSK3_1	63	70	PF00069	0.756
MOD_GSK3_1	634	641	PF00069	0.471
MOD_GSK3_1	74	81	PF00069	0.558
MOD_GSK3_1	783	790	PF00069	0.503
MOD_LATS_1	142	148	PF00433	0.458
MOD_N-GLC_1	1	6	PF02516	0.691
MOD_N-GLC_1	173	178	PF02516	0.541
MOD_N-GLC_1	197	202	PF02516	0.597
MOD_N-GLC_1	279	284	PF02516	0.480
MOD_N-GLC_1	390	395	PF02516	0.669
MOD_N-GLC_1	489	494	PF02516	0.499
MOD_N-GLC_1	509	514	PF02516	0.676
MOD_N-GLC_1	579	584	PF02516	0.562
MOD_N-GLC_1	638	643	PF02516	0.494
MOD_N-GLC_2	354	356	PF02516	0.477
MOD_NEK2_1	1	6	PF00069	0.787
MOD_NEK2_1	221	226	PF00069	0.639
MOD_NEK2_1	248	253	PF00069	0.559
MOD_NEK2_1	627	632	PF00069	0.511
MOD_NEK2_1	660	665	PF00069	0.499
MOD_NEK2_1	692	697	PF00069	0.631
MOD_NEK2_1	712	717	PF00069	0.502
MOD_NEK2_1	721	726	PF00069	0.502
MOD_NEK2_1	733	738	PF00069	0.434
MOD_NEK2_1	751	756	PF00069	0.528
MOD_NEK2_1	78	83	PF00069	0.515
MOD_NEK2_2	208	213	PF00069	0.595
MOD_NEK2_2	489	494	PF00069	0.588
MOD_PIKK_1	198	204	PF00454	0.611
MOD_PIKK_1	287	293	PF00454	0.562
MOD_PIKK_1	712	718	PF00454	0.573
MOD_PK_1	634	640	PF00069	0.530
MOD_PKA_1	16	22	PF00069	0.773
MOD_PKA_2	249	255	PF00069	0.527
MOD_PKA_2	679	685	PF00069	0.679
MOD_PKA_2	751	757	PF00069	0.625
MOD_PKB_1	552	560	PF00069	0.615
MOD_Plk_1	165	171	PF00069	0.433
MOD_Plk_1	173	179	PF00069	0.413
MOD_Plk_1	279	285	PF00069	0.559
MOD_Plk_1	420	426	PF00069	0.608
MOD_Plk_1	489	495	PF00069	0.534
MOD_Plk_1	6	12	PF00069	0.781
MOD_Plk_1	612	618	PF00069	0.495
MOD_Plk_1	91	97	PF00069	0.595
MOD_Plk_2-3	295	301	PF00069	0.673
MOD_Plk_2-3	509	515	PF00069	0.747
MOD_Plk_2-3	669	675	PF00069	0.571
MOD_Plk_2-3	92	98	PF00069	0.614
MOD_Plk_4	144	150	PF00069	0.522
MOD_Plk_4	173	179	PF00069	0.442
MOD_Plk_4	251	257	PF00069	0.496
MOD_Plk_4	281	287	PF00069	0.450
MOD_Plk_4	334	340	PF00069	0.545
MOD_Plk_4	457	463	PF00069	0.553
MOD_Plk_4	679	685	PF00069	0.674
MOD_Plk_4	733	739	PF00069	0.534
MOD_Plk_4	74	80	PF00069	0.653
MOD_Plk_4	783	789	PF00069	0.583
MOD_ProDKin_1	189	195	PF00069	0.568
MOD_ProDKin_1	310	316	PF00069	0.645
MOD_ProDKin_1	371	377	PF00069	0.560
MOD_ProDKin_1	485	491	PF00069	0.547
MOD_ProDKin_1	579	585	PF00069	0.617
MOD_ProDKin_1	63	69	PF00069	0.807
MOD_ProDKin_1	686	692	PF00069	0.585
MOD_SUMO_rev_2	501	507	PF00179	0.605
TRG_DiLeu_BaEn_1	56	61	PF01217	0.831
TRG_DiLeu_BaEn_4	111	117	PF01217	0.510
TRG_DiLeu_BaEn_4	91	97	PF01217	0.625
TRG_DiLeu_BaLyEn_6	687	692	PF01217	0.636
TRG_ENDOCYTIC_2	103	106	PF00928	0.437
TRG_ENDOCYTIC_2	285	288	PF00928	0.536
TRG_ENDOCYTIC_2	428	431	PF00928	0.482
TRG_ENDOCYTIC_2	533	536	PF00928	0.570
TRG_ENDOCYTIC_2	722	725	PF00928	0.493
TRG_ER_diArg_1	143	145	PF00400	0.458
TRG_ER_diArg_1	275	277	PF00400	0.577
TRG_ER_diArg_1	324	326	PF00400	0.483
TRG_ER_diArg_1	365	368	PF00400	0.478
TRG_ER_diArg_1	551	554	PF00400	0.622
TRG_NES_CRM1_1	347	361	PF08389	0.445
TRG_NLS_MonoCore_2	322	327	PF00514	0.620
TRG_Pf-PMV_PEXEL_1	505	509	PF00026	0.533
TRG_Pf-PMV_PEXEL_1	740	744	PF00026	0.503
TRG_Pf-PMV_PEXEL_1	796	800	PF00026	0.544

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ14	Leptomonas seymouri	76%	100%
A0A0S4JKK7	Bodo saltans	34%	100%
A0A1X0NTY5	Trypanosomatidae	30%	82%
A0A1X0PB50	Trypanosomatidae	48%	100%
A0A3R7L5E3	Trypanosoma rangeli	31%	82%
A0A3R7MMZ6	Trypanosoma rangeli	46%	100%
A4H882	Leishmania braziliensis	28%	76%
A4HBG8	Leishmania braziliensis	82%	100%
A4IAJ9	Leishmania infantum	100%	100%
E9B5N9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q279	Leishmania major	92%	100%
V5BRC6	Trypanosoma cruzi	46%	100%