Cyclic nucleotide-binding domain family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cyclic nucleotide-binding domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IHX4_LEIDO

TriTrypDb:

LdBPK_344250.1 , LdCL_340052600 , LDHU3_34.6640

Length:

801

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IHX4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHX4

Function

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Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009116	nucleoside metabolic process	4	1
GO:0009987	cellular process	1	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044281	small molecule metabolic process	2	1

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	227	231	PF00656	0.774
CLV_NRD_NRD_1	143	145	PF00675	0.458
CLV_NRD_NRD_1	181	183	PF00675	0.525
CLV_NRD_NRD_1	261	263	PF00675	0.688
CLV_NRD_NRD_1	275	277	PF00675	0.491
CLV_NRD_NRD_1	325	327	PF00675	0.487
CLV_NRD_NRD_1	679	681	PF00675	0.558
CLV_NRD_NRD_1	746	748	PF00675	0.573
CLV_NRD_NRD_1	795	797	PF00675	0.517
CLV_PCSK_KEX2_1	137	139	PF00082	0.529

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ14	Leptomonas seymouri	76%	100%
A0A0S4JKK7	Bodo saltans	34%	100%
A0A1X0NTY5	Trypanosomatidae	30%	82%
A0A1X0PB50	Trypanosomatidae	48%	100%
A0A3R7L5E3	Trypanosoma rangeli	31%	82%
A0A3R7MMZ6	Trypanosoma rangeli	46%	100%
A4H882	Leishmania braziliensis	28%	76%
A4HBG8	Leishmania braziliensis	82%	100%
A4IAJ9	Leishmania infantum	100%	100%
E9B5N9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%

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