Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IHX1_LEIDO

TriTrypDb:

LdBPK_301690.1 , LdCL_300022200 , LDHU3_30.2370

Length:

352

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IHX1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHX1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	213	217	PF00656	0.593
CLV_C14_Caspase3-7	229	233	PF00656	0.611
CLV_NRD_NRD_1	151	153	PF00675	0.701
CLV_NRD_NRD_1	273	275	PF00675	0.566
CLV_NRD_NRD_1	291	293	PF00675	0.348
CLV_NRD_NRD_1	8	10	PF00675	0.556
CLV_PCSK_KEX2_1	150	152	PF00082	0.719
CLV_PCSK_KEX2_1	273	275	PF00082	0.566
CLV_PCSK_KEX2_1	291	293	PF00082	0.348
CLV_PCSK_KEX2_1	70	72	PF00082	0.465
CLV_PCSK_KEX2_1	8	10	PF00082	0.556
CLV_PCSK_KEX2_1	97	99	PF00082	0.637
CLV_PCSK_PC1ET2_1	150	152	PF00082	0.719
CLV_PCSK_PC1ET2_1	70	72	PF00082	0.508
CLV_PCSK_PC1ET2_1	97	99	PF00082	0.576
CLV_PCSK_PC7_1	66	72	PF00082	0.491
CLV_PCSK_SKI1_1	12	16	PF00082	0.478
DEG_SCF_SKP2-CKS1_1	143	150	PF00560	0.704
DOC_CKS1_1	266	271	PF01111	0.531
DOC_CYCLIN_RxL_1	8	16	PF00134	0.483
DOC_CYCLIN_yClb5_NLxxxL_5	291	299	PF00134	0.523
DOC_MAPK_DCC_7	273	283	PF00069	0.457
DOC_MAPK_MEF2A_6	274	283	PF00069	0.594
DOC_MAPK_RevD_3	279	292	PF00069	0.556
DOC_PP4_FxxP_1	203	206	PF00568	0.565
DOC_USP7_MATH_1	140	144	PF00917	0.744
DOC_USP7_MATH_1	160	164	PF00917	0.474
DOC_USP7_MATH_1	176	180	PF00917	0.606
DOC_USP7_MATH_1	193	197	PF00917	0.400
DOC_USP7_MATH_1	198	202	PF00917	0.470
DOC_USP7_MATH_1	208	212	PF00917	0.618
DOC_USP7_MATH_1	242	246	PF00917	0.697
DOC_USP7_MATH_1	259	263	PF00917	0.755
DOC_USP7_MATH_1	53	57	PF00917	0.541
DOC_USP7_UBL2_3	30	34	PF12436	0.639
DOC_WW_Pin1_4	132	137	PF00397	0.677
DOC_WW_Pin1_4	144	149	PF00397	0.656
DOC_WW_Pin1_4	156	161	PF00397	0.677
DOC_WW_Pin1_4	185	190	PF00397	0.639
DOC_WW_Pin1_4	265	270	PF00397	0.605
DOC_WW_Pin1_4	56	61	PF00397	0.580
LIG_14-3-3_CanoR_1	125	131	PF00244	0.515
LIG_14-3-3_CanoR_1	142	148	PF00244	0.707
LIG_14-3-3_CanoR_1	192	202	PF00244	0.473
LIG_14-3-3_CanoR_1	64	69	PF00244	0.497
LIG_14-3-3_CanoR_1	9	15	PF00244	0.526
LIG_FHA_1	47	53	PF00498	0.579
LIG_FHA_1	88	94	PF00498	0.610
LIG_FHA_2	227	233	PF00498	0.646
LIG_GBD_Chelix_1	10	18	PF00786	0.414
LIG_LIR_Apic_2	201	207	PF02991	0.588
LIG_LIR_Gen_1	13	22	PF02991	0.420
LIG_LIR_Nem_3	13	18	PF02991	0.451
LIG_OCRL_FandH_1	14	26	PF00620	0.425
LIG_SH2_CRK	204	208	PF00017	0.654
LIG_SH2_NCK_1	105	109	PF00017	0.504
LIG_SH2_NCK_1	204	208	PF00017	0.558
LIG_SH2_SRC	204	207	PF00017	0.586
LIG_SH2_STAP1	105	109	PF00017	0.411
LIG_SH2_STAP1	89	93	PF00017	0.404
LIG_SH2_STAT5	105	108	PF00017	0.480
LIG_SH2_STAT5	89	92	PF00017	0.425
LIG_SH3_1	204	210	PF00018	0.549
LIG_SH3_2	239	244	PF14604	0.600
LIG_SH3_3	204	210	PF00018	0.549
LIG_SH3_3	236	242	PF00018	0.647
LIG_SH3_3	263	269	PF00018	0.559
LIG_SH3_3	345	351	PF00018	0.695
LIG_SH3_3	38	44	PF00018	0.780
LIG_SH3_4	30	37	PF00018	0.674
LIG_SUMO_SIM_par_1	89	95	PF11976	0.567
LIG_TRAF2_2	119	124	PF00917	0.607
LIG_UBA3_1	14	23	PF00899	0.416
LIG_UBA3_1	281	286	PF00899	0.502
MOD_CDK_SPxK_1	144	150	PF00069	0.767
MOD_CDK_SPxxK_3	144	151	PF00069	0.769
MOD_CDK_SPxxK_3	185	192	PF00069	0.632
MOD_CK1_1	135	141	PF00069	0.738
MOD_CK1_1	143	149	PF00069	0.789
MOD_CK1_1	170	176	PF00069	0.641
MOD_CK1_1	185	191	PF00069	0.415
MOD_CK1_1	56	62	PF00069	0.630
MOD_Cter_Amidation	27	30	PF01082	0.515
MOD_DYRK1A_RPxSP_1	132	136	PF00069	0.644
MOD_GlcNHglycan	137	140	PF01048	0.697
MOD_GlcNHglycan	160	163	PF01048	0.586
MOD_GlcNHglycan	169	172	PF01048	0.450
MOD_GlcNHglycan	195	198	PF01048	0.463
MOD_GlcNHglycan	210	213	PF01048	0.637
MOD_GlcNHglycan	244	247	PF01048	0.653
MOD_GlcNHglycan	36	39	PF01048	0.723
MOD_GSK3_1	140	147	PF00069	0.801
MOD_GSK3_1	156	163	PF00069	0.592
MOD_GSK3_1	176	183	PF00069	0.651
MOD_GSK3_1	255	262	PF00069	0.726
MOD_GSK3_1	264	271	PF00069	0.615
MOD_GSK3_1	30	37	PF00069	0.731
MOD_N-GLC_1	303	308	PF02516	0.590
MOD_NEK2_1	10	15	PF00069	0.516
MOD_NEK2_1	103	108	PF00069	0.548
MOD_NEK2_1	320	325	PF00069	0.567
MOD_NEK2_2	198	203	PF00069	0.514
MOD_PIKK_1	182	188	PF00454	0.443
MOD_PIKK_1	320	326	PF00454	0.589
MOD_PKA_1	34	40	PF00069	0.701
MOD_PKA_2	141	147	PF00069	0.717
MOD_PKA_2	297	303	PF00069	0.582
MOD_Plk_1	101	107	PF00069	0.550
MOD_Plk_1	180	186	PF00069	0.566
MOD_Plk_4	198	204	PF00069	0.455
MOD_Plk_4	277	283	PF00069	0.517
MOD_ProDKin_1	132	138	PF00069	0.680
MOD_ProDKin_1	144	150	PF00069	0.656
MOD_ProDKin_1	156	162	PF00069	0.675
MOD_ProDKin_1	185	191	PF00069	0.637
MOD_ProDKin_1	265	271	PF00069	0.599
MOD_ProDKin_1	56	62	PF00069	0.573
MOD_SUMO_for_1	96	99	PF00179	0.563
MOD_SUMO_rev_2	262	267	PF00179	0.697
TRG_ER_diArg_1	272	274	PF00400	0.588
TRG_ER_diArg_1	291	293	PF00400	0.427
TRG_ER_diArg_1	63	66	PF00400	0.596
TRG_ER_diArg_1	8	10	PF00400	0.551
TRG_NES_CRM1_1	167	181	PF08389	0.530
TRG_NLS_MonoExtN_4	148	154	PF00514	0.713
TRG_Pf-PMV_PEXEL_1	98	102	PF00026	0.517

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBH1	Leptomonas seymouri	41%	100%
A0A1X0P3B5	Trypanosomatidae	27%	100%
A4HIB2	Leishmania braziliensis	65%	100%
A4I5J6	Leishmania infantum	99%	100%
E9B0U1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q7C5	Leishmania major	89%	100%