Aminopeptidase P1, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

aminopeptidase P1, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IHX0_LEIDO

TriTrypDb:

LdBPK_365800.1 , LdCL_360065400 , LDHU3_36.7700

Length:

839

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IHX0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHX0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004177	aminopeptidase activity	5	7
GO:0005488	binding	1	7
GO:0008233	peptidase activity	3	7
GO:0008235	metalloexopeptidase activity	5	7
GO:0008237	metallopeptidase activity	4	7
GO:0008238	exopeptidase activity	4	7
GO:0016787	hydrolase activity	2	7
GO:0030145	manganese ion binding	6	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0046914	transition metal ion binding	5	7
GO:0070006	metalloaminopeptidase activity	6	7
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	268	272	PF00656	0.586
CLV_C14_Caspase3-7	367	371	PF00656	0.538
CLV_C14_Caspase3-7	469	473	PF00656	0.388
CLV_NRD_NRD_1	189	191	PF00675	0.551
CLV_NRD_NRD_1	3	5	PF00675	0.580
CLV_NRD_NRD_1	380	382	PF00675	0.416
CLV_NRD_NRD_1	49	51	PF00675	0.345
CLV_NRD_NRD_1	522	524	PF00675	0.342
CLV_NRD_NRD_1	558	560	PF00675	0.312
CLV_NRD_NRD_1	6	8	PF00675	0.583
CLV_NRD_NRD_1	96	98	PF00675	0.456
CLV_PCSK_FUR_1	4	8	PF00082	0.492
CLV_PCSK_FUR_1	47	51	PF00082	0.364
CLV_PCSK_KEX2_1	155	157	PF00082	0.539
CLV_PCSK_KEX2_1	189	191	PF00082	0.551
CLV_PCSK_KEX2_1	3	5	PF00082	0.537
CLV_PCSK_KEX2_1	341	343	PF00082	0.635
CLV_PCSK_KEX2_1	380	382	PF00082	0.416
CLV_PCSK_KEX2_1	47	49	PF00082	0.335
CLV_PCSK_KEX2_1	558	560	PF00082	0.312
CLV_PCSK_KEX2_1	6	8	PF00082	0.542
CLV_PCSK_KEX2_1	96	98	PF00082	0.454
CLV_PCSK_PC1ET2_1	155	157	PF00082	0.539
CLV_PCSK_PC1ET2_1	341	343	PF00082	0.621
CLV_PCSK_PC7_1	92	98	PF00082	0.453
CLV_PCSK_SKI1_1	119	123	PF00082	0.541
CLV_PCSK_SKI1_1	155	159	PF00082	0.538
CLV_PCSK_SKI1_1	190	194	PF00082	0.500
CLV_PCSK_SKI1_1	262	266	PF00082	0.534
CLV_PCSK_SKI1_1	390	394	PF00082	0.346
CLV_PCSK_SKI1_1	49	53	PF00082	0.422
CLV_PCSK_SKI1_1	523	527	PF00082	0.317
CLV_PCSK_SKI1_1	547	551	PF00082	0.328
CLV_PCSK_SKI1_1	657	661	PF00082	0.340
CLV_PCSK_SKI1_1	763	767	PF00082	0.480
DEG_APCC_DBOX_1	48	56	PF00400	0.340
DEG_APCC_DBOX_1	522	530	PF00400	0.319
DEG_APCC_DBOX_1	546	554	PF00400	0.291
DEG_APCC_DBOX_1	656	664	PF00400	0.318
DEG_COP1_1	740	749	PF00400	0.303
DEG_Nend_Nbox_1	1	3	PF02207	0.595
DEG_ODPH_VHL_1	99	112	PF01847	0.600
DEG_SPOP_SBC_1	270	274	PF00917	0.573
DEG_SPOP_SBC_1	560	564	PF00917	0.255
DOC_ANK_TNKS_1	497	504	PF00023	0.312
DOC_CYCLIN_RxL_1	152	161	PF00134	0.480
DOC_CYCLIN_RxL_1	295	304	PF00134	0.529
DOC_CYCLIN_yClb1_LxF_4	759	765	PF00134	0.417
DOC_CYCLIN_yCln2_LP_2	296	302	PF00134	0.516
DOC_MAPK_MEF2A_6	16	23	PF00069	0.656
DOC_MAPK_MEF2A_6	665	672	PF00069	0.340
DOC_PP2B_LxvP_1	130	133	PF13499	0.452
DOC_PP2B_LxvP_1	375	378	PF13499	0.495
DOC_PP2B_LxvP_1	685	688	PF13499	0.363
DOC_PP2B_LxvP_1	99	102	PF13499	0.552
DOC_PP4_FxxP_1	276	279	PF00568	0.440
DOC_PP4_FxxP_1	392	395	PF00568	0.303
DOC_USP7_MATH_1	204	208	PF00917	0.582
DOC_USP7_MATH_1	257	261	PF00917	0.584
DOC_USP7_MATH_1	312	316	PF00917	0.436
DOC_USP7_MATH_1	359	363	PF00917	0.603
DOC_USP7_MATH_1	501	505	PF00917	0.345
DOC_USP7_MATH_1	531	535	PF00917	0.466
DOC_USP7_MATH_1	56	60	PF00917	0.436
DOC_USP7_MATH_1	560	564	PF00917	0.385
DOC_USP7_MATH_1	571	575	PF00917	0.277
DOC_USP7_MATH_1	66	70	PF00917	0.385
DOC_USP7_MATH_1	778	782	PF00917	0.426
DOC_USP7_MATH_1	809	813	PF00917	0.489
DOC_USP7_MATH_1	816	820	PF00917	0.484
DOC_WW_Pin1_4	165	170	PF00397	0.677
DOC_WW_Pin1_4	325	330	PF00397	0.582
DOC_WW_Pin1_4	351	356	PF00397	0.645
DOC_WW_Pin1_4	563	568	PF00397	0.383
DOC_WW_Pin1_4	577	582	PF00397	0.331
DOC_WW_Pin1_4	631	636	PF00397	0.291
DOC_WW_Pin1_4	686	691	PF00397	0.599
LIG_14-3-3_CanoR_1	16	20	PF00244	0.591
LIG_14-3-3_CanoR_1	380	388	PF00244	0.445
LIG_14-3-3_CanoR_1	406	413	PF00244	0.324
LIG_14-3-3_CanoR_1	418	424	PF00244	0.343
LIG_14-3-3_CanoR_1	506	512	PF00244	0.340
LIG_14-3-3_CanoR_1	558	567	PF00244	0.397
LIG_14-3-3_CanoR_1	7	13	PF00244	0.559
LIG_APCC_ABBA_1	605	610	PF00400	0.312
LIG_BIR_III_4	161	165	PF00653	0.533
LIG_BRCT_BRCA1_1	503	507	PF00533	0.436
LIG_CaM_IQ_9	755	771	PF13499	0.375
LIG_Clathr_ClatBox_1	552	556	PF01394	0.315
LIG_Clathr_ClatBox_1	660	664	PF01394	0.388
LIG_deltaCOP1_diTrp_1	82	89	PF00928	0.312
LIG_FHA_1	105	111	PF00498	0.539
LIG_FHA_1	124	130	PF00498	0.342
LIG_FHA_1	137	143	PF00498	0.571
LIG_FHA_1	176	182	PF00498	0.578
LIG_FHA_1	24	30	PF00498	0.642
LIG_FHA_1	311	317	PF00498	0.580
LIG_FHA_1	326	332	PF00498	0.551
LIG_FHA_1	370	376	PF00498	0.525
LIG_FHA_1	497	503	PF00498	0.307
LIG_FHA_1	544	550	PF00498	0.312
LIG_FHA_1	632	638	PF00498	0.340
LIG_FHA_1	756	762	PF00498	0.436
LIG_FHA_1	821	827	PF00498	0.325
LIG_FHA_2	175	181	PF00498	0.505
LIG_FHA_2	420	426	PF00498	0.388
LIG_FHA_2	467	473	PF00498	0.355
LIG_Integrin_RGD_1	711	713	PF01839	0.349
LIG_LIR_Apic_2	273	279	PF02991	0.466
LIG_LIR_Gen_1	281	292	PF02991	0.409
LIG_LIR_Gen_1	382	392	PF02991	0.473
LIG_LIR_Gen_1	409	420	PF02991	0.312
LIG_LIR_Gen_1	83	94	PF02991	0.312
LIG_LIR_Nem_3	152	157	PF02991	0.635
LIG_LIR_Nem_3	281	287	PF02991	0.417
LIG_LIR_Nem_3	382	388	PF02991	0.484
LIG_LIR_Nem_3	409	415	PF02991	0.312
LIG_LIR_Nem_3	509	514	PF02991	0.500
LIG_LIR_Nem_3	812	817	PF02991	0.375
LIG_LIR_Nem_3	82	88	PF02991	0.312
LIG_MYND_1	329	333	PF01753	0.650
LIG_NRBOX	548	554	PF00104	0.315
LIG_PCNA_TLS_4	277	284	PF02747	0.372
LIG_Pex14_1	85	89	PF04695	0.312
LIG_Pex14_2	599	603	PF04695	0.388
LIG_PTB_Apo_2	794	801	PF02174	0.514
LIG_PTB_Phospho_1	794	800	PF10480	0.504
LIG_SH2_CRK	154	158	PF00017	0.522
LIG_SH2_CRK	321	325	PF00017	0.519
LIG_SH2_CRK	417	421	PF00017	0.255
LIG_SH2_CRK	817	821	PF00017	0.338
LIG_SH2_GRB2like	800	803	PF00017	0.470
LIG_SH2_NCK_1	321	325	PF00017	0.567
LIG_SH2_PTP2	453	456	PF00017	0.312
LIG_SH2_PTP2	511	514	PF00017	0.388
LIG_SH2_SRC	453	456	PF00017	0.312
LIG_SH2_SRC	651	654	PF00017	0.455
LIG_SH2_STAP1	321	325	PF00017	0.458
LIG_SH2_STAP1	385	389	PF00017	0.474
LIG_SH2_STAP1	71	75	PF00017	0.312
LIG_SH2_STAP1	817	821	PF00017	0.338
LIG_SH2_STAT3	241	244	PF00017	0.466
LIG_SH2_STAT5	453	456	PF00017	0.312
LIG_SH2_STAT5	511	514	PF00017	0.496
LIG_SH2_STAT5	651	654	PF00017	0.472
LIG_SH2_STAT5	714	717	PF00017	0.346
LIG_SH3_3	291	297	PF00018	0.434
LIG_SH3_3	342	348	PF00018	0.805
LIG_SH3_3	471	477	PF00018	0.327
LIG_SH3_3	58	64	PF00018	0.388
LIG_SH3_3	611	617	PF00018	0.340
LIG_SH3_3	647	653	PF00018	0.388
LIG_SH3_3	702	708	PF00018	0.482
LIG_SH3_3	792	798	PF00018	0.421
LIG_SH3_3	801	807	PF00018	0.467
LIG_SUMO_SIM_anti_2	59	64	PF11976	0.312
LIG_SUMO_SIM_anti_2	681	689	PF11976	0.312
LIG_SUMO_SIM_anti_2	829	834	PF11976	0.425
LIG_SUMO_SIM_par_1	18	26	PF11976	0.528
LIG_SUMO_SIM_par_1	681	689	PF11976	0.388
LIG_SUMO_SIM_par_1	736	743	PF11976	0.390
LIG_TRAF2_1	40	43	PF00917	0.515
LIG_TRAF2_1	623	626	PF00917	0.315
LIG_UBA3_1	518	524	PF00899	0.388
LIG_UBA3_1	525	530	PF00899	0.255
MOD_CDK_SPK_2	631	636	PF00069	0.340
MOD_CK1_1	104	110	PF00069	0.530
MOD_CK1_1	168	174	PF00069	0.551
MOD_CK1_1	212	218	PF00069	0.518
MOD_CK1_1	285	291	PF00069	0.554
MOD_CK1_1	364	370	PF00069	0.612
MOD_CK1_1	563	569	PF00069	0.245
MOD_CK1_1	612	618	PF00069	0.454
MOD_CK1_1	69	75	PF00069	0.388
MOD_CK1_1	781	787	PF00069	0.423
MOD_CK2_1	174	180	PF00069	0.513
MOD_CK2_1	204	210	PF00069	0.539
MOD_CK2_1	37	43	PF00069	0.440
MOD_CK2_1	419	425	PF00069	0.402
MOD_CK2_1	576	582	PF00069	0.406
MOD_GlcNHglycan	103	106	PF01048	0.635
MOD_GlcNHglycan	205	209	PF01048	0.571
MOD_GlcNHglycan	214	217	PF01048	0.520
MOD_GlcNHglycan	287	290	PF01048	0.518
MOD_GlcNHglycan	31	34	PF01048	0.550
MOD_GlcNHglycan	321	324	PF01048	0.514
MOD_GlcNHglycan	361	364	PF01048	0.658
MOD_GlcNHglycan	37	42	PF01048	0.434
MOD_GlcNHglycan	403	406	PF01048	0.312
MOD_GlcNHglycan	438	442	PF01048	0.289
MOD_GlcNHglycan	458	461	PF01048	0.248
MOD_GlcNHglycan	563	566	PF01048	0.304
MOD_GlcNHglycan	573	576	PF01048	0.341
MOD_GlcNHglycan	653	656	PF01048	0.371
MOD_GlcNHglycan	727	730	PF01048	0.629
MOD_GSK3_1	100	107	PF00069	0.521
MOD_GSK3_1	134	141	PF00069	0.682
MOD_GSK3_1	15	22	PF00069	0.663
MOD_GSK3_1	357	364	PF00069	0.644
MOD_GSK3_1	401	408	PF00069	0.309
MOD_GSK3_1	502	509	PF00069	0.340
MOD_GSK3_1	559	566	PF00069	0.345
MOD_GSK3_1	571	578	PF00069	0.366
MOD_GSK3_1	733	740	PF00069	0.441
MOD_GSK3_1	816	823	PF00069	0.418
MOD_NEK2_1	23	28	PF00069	0.584
MOD_NEK2_1	283	288	PF00069	0.485
MOD_NEK2_1	319	324	PF00069	0.560
MOD_NEK2_1	589	594	PF00069	0.423
MOD_NEK2_1	737	742	PF00069	0.441
MOD_NEK2_1	822	827	PF00069	0.334
MOD_NEK2_2	257	262	PF00069	0.505
MOD_NEK2_2	531	536	PF00069	0.340
MOD_NEK2_2	66	71	PF00069	0.388
MOD_PIKK_1	123	129	PF00454	0.488
MOD_PIKK_1	149	155	PF00454	0.453
MOD_PIKK_1	393	399	PF00454	0.366
MOD_PIKK_1	755	761	PF00454	0.436
MOD_PKA_2	110	116	PF00069	0.408
MOD_PKA_2	15	21	PF00069	0.599
MOD_PKA_2	319	325	PF00069	0.555
MOD_PKA_2	379	385	PF00069	0.477
MOD_PKA_2	405	411	PF00069	0.324
MOD_PKA_2	461	467	PF00069	0.352
MOD_Plk_1	209	215	PF00069	0.579
MOD_Plk_1	270	276	PF00069	0.604
MOD_Plk_1	369	375	PF00069	0.505
MOD_Plk_1	56	62	PF00069	0.403
MOD_Plk_1	609	615	PF00069	0.448
MOD_Plk_1	66	72	PF00069	0.315
MOD_Plk_4	125	131	PF00069	0.446
MOD_Plk_4	138	144	PF00069	0.528
MOD_Plk_4	271	277	PF00069	0.472
MOD_Plk_4	312	318	PF00069	0.592
MOD_Plk_4	507	513	PF00069	0.509
MOD_Plk_4	56	62	PF00069	0.436
MOD_Plk_4	66	72	PF00069	0.385
MOD_Plk_4	733	739	PF00069	0.465
MOD_Plk_4	745	751	PF00069	0.359
MOD_Plk_4	790	796	PF00069	0.423
MOD_Plk_4	80	86	PF00069	0.326
MOD_Plk_4	816	822	PF00069	0.349
MOD_ProDKin_1	165	171	PF00069	0.678
MOD_ProDKin_1	325	331	PF00069	0.580
MOD_ProDKin_1	351	357	PF00069	0.645
MOD_ProDKin_1	563	569	PF00069	0.383
MOD_ProDKin_1	577	583	PF00069	0.331
MOD_ProDKin_1	631	637	PF00069	0.291
MOD_ProDKin_1	686	692	PF00069	0.613
MOD_SUMO_for_1	623	626	PF00179	0.315
TRG_DiLeu_BaEn_1	545	550	PF01217	0.312
TRG_DiLeu_BaEn_1	681	686	PF01217	0.312
TRG_DiLeu_BaLyEn_6	153	158	PF01217	0.473
TRG_DiLeu_BaLyEn_6	187	192	PF01217	0.449
TRG_DiLeu_BaLyEn_6	224	229	PF01217	0.637
TRG_ENDOCYTIC_2	154	157	PF00928	0.625
TRG_ENDOCYTIC_2	321	324	PF00928	0.551
TRG_ENDOCYTIC_2	385	388	PF00928	0.421
TRG_ENDOCYTIC_2	389	392	PF00928	0.359
TRG_ENDOCYTIC_2	453	456	PF00928	0.312
TRG_ENDOCYTIC_2	511	514	PF00928	0.331
TRG_ENDOCYTIC_2	515	518	PF00928	0.294
TRG_ENDOCYTIC_2	817	820	PF00928	0.342
TRG_ENDOCYTIC_2	86	89	PF00928	0.312
TRG_ER_diArg_1	188	190	PF00400	0.584
TRG_ER_diArg_1	2	4	PF00400	0.541
TRG_ER_diArg_1	252	255	PF00400	0.541
TRG_ER_diArg_1	342	345	PF00400	0.671
TRG_ER_diArg_1	349	352	PF00400	0.621
TRG_ER_diArg_1	379	381	PF00400	0.430
TRG_ER_diArg_1	47	50	PF00400	0.312
TRG_ER_diArg_1	5	7	PF00400	0.543
TRG_ER_diArg_1	557	559	PF00400	0.312
TRG_ER_diArg_1	630	633	PF00400	0.338
TRG_ER_diArg_1	95	97	PF00400	0.416
TRG_NLS_MonoExtN_4	340	345	PF00514	0.623
TRG_Pf-PMV_PEXEL_1	156	161	PF00026	0.539
TRG_Pf-PMV_PEXEL_1	189	194	PF00026	0.438
TRG_Pf-PMV_PEXEL_1	763	768	PF00026	0.410

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P918	Leptomonas seymouri	49%	98%
A4HQ72	Leishmania braziliensis	75%	98%
A4IDX0	Leishmania infantum	99%	100%
E9ATZ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	98%
Q4Q0K5	Leishmania major	93%	100%