EF-hand domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IHW6_LEIDO

TriTrypDb:

LdBPK_280230.1 , LdCL_280007200 , LDHU3_28.0310

Length:

328

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IHW6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHW6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	250	252	PF00675	0.751
CLV_PCSK_KEX2_1	249	251	PF00082	0.762
CLV_PCSK_KEX2_1	301	303	PF00082	0.662
CLV_PCSK_PC1ET2_1	301	303	PF00082	0.662
CLV_Separin_Metazoa	246	250	PF03568	0.585
DOC_CKS1_1	15	20	PF01111	0.763
DOC_USP7_MATH_1	174	178	PF00917	0.754
DOC_USP7_MATH_1	199	203	PF00917	0.701
DOC_USP7_MATH_1	97	101	PF00917	0.718
DOC_WW_Pin1_4	137	142	PF00397	0.754
DOC_WW_Pin1_4	14	19	PF00397	0.767
DOC_WW_Pin1_4	28	33	PF00397	0.842
LIG_14-3-3_CanoR_1	153	160	PF00244	0.624
LIG_14-3-3_CanoR_1	175	183	PF00244	0.705
LIG_14-3-3_CanoR_1	215	220	PF00244	0.808
LIG_14-3-3_CanoR_1	69	79	PF00244	0.771
LIG_BIR_II_1	1	5	PF00653	0.768
LIG_BIR_III_4	121	125	PF00653	0.607
LIG_BRCT_BRCA1_1	309	313	PF00533	0.752
LIG_FHA_1	153	159	PF00498	0.687
LIG_FHA_1	216	222	PF00498	0.808
LIG_FHA_1	243	249	PF00498	0.763
LIG_FHA_1	29	35	PF00498	0.843
LIG_FHA_1	41	47	PF00498	0.723
LIG_FHA_1	56	62	PF00498	0.629
LIG_FHA_2	131	137	PF00498	0.715
LIG_FHA_2	6	12	PF00498	0.771
LIG_FXI_DFP_1	321	325	PF00024	0.671
LIG_LIR_Gen_1	146	154	PF02991	0.601
LIG_LIR_Gen_1	76	84	PF02991	0.841
LIG_LIR_Nem_3	146	152	PF02991	0.605
LIG_LIR_Nem_3	291	296	PF02991	0.699
LIG_LIR_Nem_3	76	81	PF02991	0.840
LIG_PDZ_Class_2	323	328	PF00595	0.756
LIG_Pex14_2	276	280	PF04695	0.515
LIG_Pex14_2	320	324	PF04695	0.745
LIG_SH2_CRK	149	153	PF00017	0.710
LIG_SH2_STAT5	149	152	PF00017	0.710
LIG_SH3_3	105	111	PF00018	0.811
LIG_SH3_3	136	142	PF00018	0.835
LIG_SUMO_SIM_par_1	224	232	PF11976	0.724
LIG_TRAF2_1	133	136	PF00917	0.796
LIG_TRAF2_1	143	146	PF00917	0.631
LIG_TRAF2_1	154	157	PF00917	0.610
LIG_TRAF2_1	268	271	PF00917	0.590
LIG_TRAF2_1	60	63	PF00917	0.695
MOD_CDK_SPxxK_3	14	21	PF00069	0.766
MOD_CDK_SPxxK_3	28	35	PF00069	0.765
MOD_CK1_1	100	106	PF00069	0.741
MOD_CK1_1	193	199	PF00069	0.816
MOD_CK1_1	225	231	PF00069	0.800
MOD_CK1_1	71	77	PF00069	0.837
MOD_CK2_1	130	136	PF00069	0.684
MOD_CK2_1	174	180	PF00069	0.621
MOD_CK2_1	225	231	PF00069	0.644
MOD_CK2_1	5	11	PF00069	0.767
MOD_CK2_1	57	63	PF00069	0.738
MOD_CK2_1	70	76	PF00069	0.759
MOD_CK2_1	87	93	PF00069	0.810
MOD_GlcNHglycan	159	163	PF01048	0.654
MOD_GlcNHglycan	288	291	PF01048	0.708
MOD_GlcNHglycan	44	49	PF01048	0.632
MOD_GlcNHglycan	73	76	PF01048	0.700
MOD_GlcNHglycan	98	102	PF01048	0.795
MOD_GSK3_1	189	196	PF00069	0.813
MOD_GSK3_1	225	232	PF00069	0.773
MOD_GSK3_1	40	47	PF00069	0.796
MOD_GSK3_1	70	77	PF00069	0.848
MOD_N-GLC_1	55	60	PF02516	0.785
MOD_NEK2_1	307	312	PF00069	0.761
MOD_NEK2_1	70	75	PF00069	0.851
MOD_PIKK_1	130	136	PF00454	0.736
MOD_PIKK_1	147	153	PF00454	0.681
MOD_PIKK_1	210	216	PF00454	0.781
MOD_PIKK_1	68	74	PF00454	0.717
MOD_PKA_2	152	158	PF00069	0.702
MOD_PKA_2	174	180	PF00069	0.777
MOD_PKA_2	68	74	PF00069	0.778
MOD_PKB_1	35	43	PF00069	0.766
MOD_Plk_1	124	130	PF00069	0.800
MOD_Plk_1	158	164	PF00069	0.730
MOD_Plk_1	37	43	PF00069	0.839
MOD_Plk_4	100	106	PF00069	0.531
MOD_Plk_4	190	196	PF00069	0.736
MOD_Plk_4	204	210	PF00069	0.495
MOD_Plk_4	222	228	PF00069	0.721
MOD_Plk_4	37	43	PF00069	0.765
MOD_Plk_4	46	52	PF00069	0.631
MOD_Plk_4	74	80	PF00069	0.840
MOD_ProDKin_1	137	143	PF00069	0.752
MOD_ProDKin_1	14	20	PF00069	0.766
MOD_ProDKin_1	28	34	PF00069	0.842
TRG_DiLeu_BaEn_1	159	164	PF01217	0.731
TRG_DiLeu_BaLyEn_6	162	167	PF01217	0.761
TRG_ENDOCYTIC_2	149	152	PF00928	0.632
TRG_ER_diArg_1	248	251	PF00400	0.759
TRG_Pf-PMV_PEXEL_1	251	255	PF00026	0.763

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HG64	Leishmania braziliensis	55%	100%
A4I396	Leishmania infantum	99%	100%
E9AZI4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q8P7	Leishmania major	88%	100%